Incidental Mutation 'IGL02385:Olfr742'
ID291482
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr742
Ensembl Gene ENSMUSG00000068431
Gene Nameolfactory receptor 742
SynonymsGA_x6K02T2PMLR-6224293-6225228, MOR106-6
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.068) question?
Stock #IGL02385
Quality Score
Status
Chromosome14
Chromosomal Location50503600-50517145 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 50515443 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 80 (S80P)
Ref Sequence ENSEMBL: ENSMUSP00000150814 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089836] [ENSMUST00000213935] [ENSMUST00000217437]
Predicted Effect probably damaging
Transcript: ENSMUST00000089836
AA Change: S80P

PolyPhen 2 Score 0.967 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000087273
Gene: ENSMUSG00000068431
AA Change: S80P

DomainStartEndE-ValueType
Pfam:7tm_4 35 311 1.9e-55 PFAM
Pfam:7tm_1 45 294 1.5e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213935
AA Change: S80P

PolyPhen 2 Score 0.967 (Sensitivity: 0.77; Specificity: 0.95)
Predicted Effect probably damaging
Transcript: ENSMUST00000217437
AA Change: S80P

PolyPhen 2 Score 0.967 (Sensitivity: 0.77; Specificity: 0.95)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik T A 12: 71,154,856 D351E probably damaging Het
4930452B06Rik A G 14: 8,510,920 V498A possibly damaging Het
Adad2 A G 8: 119,615,034 probably benign Het
Adamts8 A G 9: 30,961,730 N744D probably benign Het
Atad5 C T 11: 80,094,627 T180I probably benign Het
Atp2a3 C A 11: 72,975,339 H262N probably benign Het
Bcl9 A T 3: 97,209,278 I700K probably benign Het
Bcr T C 10: 75,145,403 S685P probably damaging Het
Cd36 A G 5: 17,814,719 V128A probably benign Het
Chd2 T C 7: 73,435,822 Y1688C probably damaging Het
Csmd1 A G 8: 15,903,275 V3402A probably benign Het
Dsg3 T C 18: 20,527,714 V370A probably damaging Het
Dus4l A G 12: 31,640,675 probably benign Het
Fcrlb A G 1: 170,907,599 S320P probably damaging Het
Fer1l4 T C 2: 156,045,428 D616G probably benign Het
Fxr2 C T 11: 69,652,269 R631C possibly damaging Het
Gltpd2 T A 11: 70,519,996 F152I probably damaging Het
Gpt2 T A 8: 85,516,153 probably null Het
Hsd3b6 A T 3: 98,806,572 I137K possibly damaging Het
Kcna6 A G 6: 126,738,954 V324A probably benign Het
Kcnu1 C T 8: 25,932,270 L188F probably damaging Het
Kdm1b A G 13: 47,068,506 I474V possibly damaging Het
Kifap3 C T 1: 163,865,444 Q602* probably null Het
Lrp4 T A 2: 91,474,720 C231S possibly damaging Het
Lrrc63 T C 14: 75,086,200 D528G probably benign Het
Nosip C A 7: 45,076,732 R240S possibly damaging Het
Olfr1287 A G 2: 111,449,350 D70G probably damaging Het
Olfr1308 G A 2: 111,960,258 P272S probably benign Het
Orc5 A T 5: 22,526,440 D231E probably damaging Het
Poli A T 18: 70,526,574 M62K possibly damaging Het
Ppp1r13b A C 12: 111,835,043 S402R probably damaging Het
Prl3b1 T C 13: 27,249,383 S174P possibly damaging Het
Ptpra T C 2: 130,540,473 probably benign Het
Sfpq T A 4: 127,026,136 probably null Het
Sh3bp1 T A 15: 78,905,888 probably benign Het
Slc7a2 T G 8: 40,899,011 V37G probably damaging Het
Smc1a A T X: 152,037,659 E794D possibly damaging Het
Sox6 T C 7: 115,550,039 R366G possibly damaging Het
Spaca7 A G 8: 12,586,498 N108S possibly damaging Het
Spon1 T G 7: 113,766,330 M1R probably null Het
Sult6b2 T C 6: 142,801,772 R84G probably benign Het
Syt2 A G 1: 134,745,815 N299S probably benign Het
Syvn1 T C 19: 6,048,540 V104A probably damaging Het
Tbpl1 A G 10: 22,707,669 L134P probably damaging Het
Tex11 A T X: 100,876,529 probably benign Het
Tnfrsf21 A G 17: 43,040,051 S369G probably damaging Het
Tram1l1 T C 3: 124,322,058 V289A probably benign Het
Ttyh3 A T 5: 140,633,305 F277L probably benign Het
Vmn2r17 T G 5: 109,434,381 N545K probably damaging Het
Wdr20 A T 12: 110,793,223 H181L probably benign Het
Zscan20 A G 4: 128,604,599 M2T possibly damaging Het
Other mutations in Olfr742
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0046:Olfr742 UTSW 14 50516139 makesense probably null
R0369:Olfr742 UTSW 14 50515825 missense probably benign 0.00
R0612:Olfr742 UTSW 14 50515482 missense probably benign
R1588:Olfr742 UTSW 14 50516127 missense probably benign
R1726:Olfr742 UTSW 14 50516179 utr 3 prime probably null
R1998:Olfr742 UTSW 14 50515356 missense probably benign 0.00
R2875:Olfr742 UTSW 14 50515812 missense probably benign 0.06
R4009:Olfr742 UTSW 14 50515962 missense possibly damaging 0.77
R5119:Olfr742 UTSW 14 50515509 missense probably benign 0.00
R5232:Olfr742 UTSW 14 50516038 missense probably damaging 0.99
R5627:Olfr742 UTSW 14 50515800 missense probably benign
R5930:Olfr742 UTSW 14 50515792 missense probably benign
R6597:Olfr742 UTSW 14 50515551 missense probably benign 0.11
R7441:Olfr742 UTSW 14 50515396 missense probably damaging 1.00
R7596:Olfr742 UTSW 14 50515545 missense probably benign 0.14
R8051:Olfr742 UTSW 14 50515643 missense probably benign 0.00
R8294:Olfr742 UTSW 14 50515626 missense possibly damaging 0.81
Z1088:Olfr742 UTSW 14 50515527 missense possibly damaging 0.90
Z1176:Olfr742 UTSW 14 50516065 missense probably damaging 1.00
Posted On2015-04-16