Incidental Mutation 'IGL02388:Zfp605'
ID291640
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp605
Ensembl Gene ENSMUSG00000023284
Gene Namezinc finger protein 605
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.076) question?
Stock #IGL02388
Quality Score
Status
Chromosome5
Chromosomal Location110110092-110129794 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 110127640 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Asparagine at position 208 (I208N)
Ref Sequence ENSEMBL: ENSMUSP00000108147 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086686] [ENSMUST00000112528] [ENSMUST00000147631]
Predicted Effect possibly damaging
Transcript: ENSMUST00000086686
AA Change: I208N

PolyPhen 2 Score 0.950 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000083891
Gene: ENSMUSG00000023284
AA Change: I208N

DomainStartEndE-ValueType
KRAB 6 66 3.75e-28 SMART
low complexity region 147 159 N/A INTRINSIC
ZnF_C2H2 200 222 1.36e-2 SMART
ZnF_C2H2 228 250 4.38e1 SMART
ZnF_C2H2 305 327 1.18e-2 SMART
ZnF_C2H2 333 355 5.14e-3 SMART
ZnF_C2H2 361 383 9.73e-4 SMART
ZnF_C2H2 389 411 4.99e1 SMART
ZnF_C2H2 443 465 5.4e1 SMART
ZnF_C2H2 471 493 1.3e-4 SMART
ZnF_C2H2 499 521 4.24e-4 SMART
ZnF_C2H2 527 549 1.95e-3 SMART
ZnF_C2H2 555 577 2.09e-3 SMART
ZnF_C2H2 583 605 1.2e-3 SMART
ZnF_C2H2 611 633 1.79e-2 SMART
ZnF_C2H2 639 661 2.53e-2 SMART
ZnF_C2H2 667 689 2.09e-3 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000112528
AA Change: I208N

PolyPhen 2 Score 0.950 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000108147
Gene: ENSMUSG00000023284
AA Change: I208N

DomainStartEndE-ValueType
KRAB 6 66 3.75e-28 SMART
low complexity region 147 159 N/A INTRINSIC
ZnF_C2H2 200 222 1.36e-2 SMART
ZnF_C2H2 228 250 4.38e1 SMART
ZnF_C2H2 305 327 1.18e-2 SMART
ZnF_C2H2 333 355 5.14e-3 SMART
ZnF_C2H2 361 383 9.73e-4 SMART
ZnF_C2H2 389 411 4.99e1 SMART
ZnF_C2H2 443 465 5.4e1 SMART
ZnF_C2H2 471 493 1.3e-4 SMART
ZnF_C2H2 499 521 4.24e-4 SMART
ZnF_C2H2 527 549 1.95e-3 SMART
ZnF_C2H2 555 577 2.09e-3 SMART
ZnF_C2H2 583 605 1.2e-3 SMART
ZnF_C2H2 611 633 1.79e-2 SMART
ZnF_C2H2 639 661 2.53e-2 SMART
ZnF_C2H2 667 689 2.09e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144089
Predicted Effect probably benign
Transcript: ENSMUST00000147631
SMART Domains Protein: ENSMUSP00000122236
Gene: ENSMUSG00000023284

DomainStartEndE-ValueType
KRAB 6 66 3.75e-28 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930597O21Rik A T 6: 66,896,113 probably benign Het
9230019H11Rik A T 10: 3,125,050 noncoding transcript Het
Abca8a A G 11: 110,078,815 probably benign Het
Asphd1 A T 7: 126,946,712 probably benign Het
Ccdc77 G A 6: 120,331,897 A301V probably benign Het
Cep350 G T 1: 155,953,753 T135K probably benign Het
Chrna7 A T 7: 63,107,691 D153E probably damaging Het
Clec4b2 G T 6: 123,202,228 probably null Het
Cyp2c67 T C 19: 39,643,355 N133D probably benign Het
Dglucy T C 12: 100,856,998 I484T probably damaging Het
Dtna G T 18: 23,597,514 M319I probably benign Het
E2f5 T A 3: 14,588,280 M152K probably benign Het
Emsy A T 7: 98,641,666 M58K probably damaging Het
Epha1 A G 6: 42,365,016 Y367H probably damaging Het
Etv1 A G 12: 38,781,799 S32G possibly damaging Het
Fam114a1 A T 5: 65,008,980 probably benign Het
Fbxo30 T A 10: 11,290,378 N281K probably benign Het
Galnt12 G T 4: 47,117,941 R412L probably damaging Het
Gm5786 T A 12: 59,081,596 noncoding transcript Het
Gm9845 T C 3: 39,358,467 noncoding transcript Het
Hecw2 A G 1: 53,925,699 V656A probably benign Het
Hpse2 A T 19: 43,294,253 V187D probably damaging Het
Itsn2 T A 12: 4,629,557 M122K possibly damaging Het
Kcnj11 A G 7: 46,099,789 S37P probably benign Het
Kif13b T C 14: 64,800,358 I1491T probably damaging Het
Krt36 T A 11: 100,105,164 K145* probably null Het
Loxhd1 A G 18: 77,369,137 I499V probably benign Het
Map3k4 G T 17: 12,271,610 N311K probably damaging Het
Mical2 C A 7: 112,335,413 H880N probably benign Het
Myo1d A T 11: 80,637,997 C666* probably null Het
Nlrx1 C T 9: 44,264,005 R158H probably benign Het
Olfr1115 T A 2: 87,251,951 Y5N probably benign Het
Olfr1251 T C 2: 89,666,972 S305G probably benign Het
Olfr1494 C A 19: 13,749,630 H175N possibly damaging Het
Olfr380 A T 11: 73,453,280 L311I probably benign Het
Olfr45 A G 7: 140,691,111 T69A probably benign Het
Pdgfrl A G 8: 40,977,057 R154G probably benign Het
Pitpnb T C 5: 111,330,833 F7S possibly damaging Het
Ppm1n G A 7: 19,279,172 R285C probably damaging Het
Prdm11 A T 2: 92,975,612 I331N possibly damaging Het
Ptprb C T 10: 116,367,521 P2066L probably damaging Het
Ric8b T C 10: 84,992,271 probably benign Het
Setx A G 2: 29,173,653 I2320M probably damaging Het
Skil C A 3: 31,111,638 S368* probably null Het
Slc1a5 G T 7: 16,785,719 probably null Het
Trpm7 A C 2: 126,819,891 V1079G possibly damaging Het
Tulp1 A G 17: 28,358,659 F2L probably damaging Het
Zbtb17 A G 4: 141,461,913 Y48C probably damaging Het
Other mutations in Zfp605
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0010:Zfp605 UTSW 5 110127534 missense probably benign 0.03
R0357:Zfp605 UTSW 5 110124379 missense probably benign
R0383:Zfp605 UTSW 5 110128854 missense probably damaging 1.00
R1017:Zfp605 UTSW 5 110127994 missense probably benign 0.42
R1663:Zfp605 UTSW 5 110127585 missense probably benign 0.02
R1688:Zfp605 UTSW 5 110129041 missense possibly damaging 0.83
R1752:Zfp605 UTSW 5 110123773 missense probably damaging 1.00
R1994:Zfp605 UTSW 5 110127552 missense probably damaging 1.00
R2173:Zfp605 UTSW 5 110127457 missense probably benign 0.00
R3740:Zfp605 UTSW 5 110128698 missense probably damaging 1.00
R3742:Zfp605 UTSW 5 110128698 missense probably damaging 1.00
R3981:Zfp605 UTSW 5 110127738 missense probably damaging 1.00
R4095:Zfp605 UTSW 5 110127736 missense probably damaging 1.00
R4349:Zfp605 UTSW 5 110128686 missense probably damaging 1.00
R4669:Zfp605 UTSW 5 110127361 missense possibly damaging 0.94
R4914:Zfp605 UTSW 5 110127701 nonsense probably null
R4994:Zfp605 UTSW 5 110127486 missense probably damaging 1.00
R6672:Zfp605 UTSW 5 110127997 missense probably damaging 1.00
R6814:Zfp605 UTSW 5 110127445 missense probably benign 0.00
R6872:Zfp605 UTSW 5 110127445 missense probably benign 0.00
R7251:Zfp605 UTSW 5 110127960 missense probably damaging 1.00
R7395:Zfp605 UTSW 5 110112019 start gained probably benign
R7560:Zfp605 UTSW 5 110127291 nonsense probably null
R7623:Zfp605 UTSW 5 110127520 missense probably benign 0.03
R7999:Zfp605 UTSW 5 110128434 missense probably damaging 1.00
X0063:Zfp605 UTSW 5 110123848 missense probably damaging 0.99
Posted On2015-04-16