Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02389:Tyro3'

291701

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tyro3

Ensembl Gene

ENSMUSG00000027298

Gene Name

TYRO3 protein tyrosine kinase 3

Synonyms

Brt, Etk-2, Sky, Sky, Dtk, Rse, Tif

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02389

Quality Score

Status

Chromosome

Chromosomal Location

119797733-119818104 bp(+) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

C to T at 119804864 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000106410 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000028763] [ENSMUST00000110783]

Predicted Effect

probably benign
Transcript: ENSMUST00000028763

SMART Domains

Protein: ENSMUSP00000028763
Gene: ENSMUSG00000027298

Domain	Start	End	E-Value	Type
signal peptide	1	30	N/A	INTRINSIC
IGc2	45	114	1.29e-15	SMART
IG	135	212	1.3e-2	SMART
FN3	215	297	1.5e-5	SMART
FN3	313	393	1.9e0	SMART
transmembrane domain	419	441	N/A	INTRINSIC
TyrKc	508	776	1.18e-125	SMART
low complexity region	817	832	N/A	INTRINSIC
low complexity region	865	875	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000110783

SMART Domains

Protein: ENSMUSP00000106410
Gene: ENSMUSG00000027298

Domain	Start	End	E-Value	Type
IGc2	41	110	1.29e-15	SMART
IG	131	208	1.3e-2	SMART
FN3	211	293	1.5e-5	SMART
FN3	309	389	1.9e0	SMART
transmembrane domain	415	437	N/A	INTRINSIC
TyrKc	504	772	1.18e-125	SMART
low complexity region	813	828	N/A	INTRINSIC
low complexity region	861	871	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000130456

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000135726

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000147636

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000147761

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000148343

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010]
PHENOTYPE: Homozygous mutant mice are phenotypically normal, however in conjunction with mutations in other related receptor tyrosine kinases, mutations of this gene results in fertility defects, autoimmunity, and aberrant apoptosis. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
0610040J01Rik	G	A	5: 63,896,483	S11N	probably null	Het
Aqp9	T	C	9: 71,122,906	I200V	possibly damaging	Het
BC100530	C	A	16: 36,367,486	V6F	possibly damaging	Het
Cntn2	T	C	1: 132,525,321	E411G	probably damaging	Het
Csgalnact1	C	A	8: 68,401,492	G219V	probably damaging	Het
Dennd3	A	G	15: 73,567,056	D1091G	probably damaging	Het
Dock2	T	C	11: 34,698,740		probably benign	Het
Dscam	T	A	16: 96,640,897	I1577F	probably benign	Het
Egflam	A	T	15: 7,250,078	N482K	probably benign	Het
Fam216a	T	C	5: 122,367,511	T129A	probably damaging	Het
Fbxo40	T	C	16: 36,969,774	M325V	probably benign	Het
Fbxw8	C	T	5: 118,128,955	V148M	possibly damaging	Het
Fcgbp	C	T	7: 28,075,171	R57C	probably damaging	Het
Gnpnat1	A	G	14: 45,380,931		probably null	Het
Gria2	T	C	3: 80,709,422	T408A	probably benign	Het
H2-T3	A	G	17: 36,186,608	M59T	probably benign	Het
Jakmip1	C	T	5: 37,100,843	Q278*	probably null	Het
Krtap21-1	C	T	16: 89,403,424	G110D	unknown	Het
Myo7a	C	T	7: 98,106,991		probably null	Het
Nlrp9c	T	A	7: 26,394,207	Q11L	probably benign	Het
Olfr1442	A	T	19: 12,674,535	D110V	probably benign	Het
Olfr298	A	G	7: 86,489,128	L141P	probably damaging	Het
Olfr767	A	C	10: 129,079,230	I244M	probably damaging	Het
Olfr790	T	A	10: 129,501,070	M62K	probably benign	Het
Pdzd8	A	G	19: 59,301,393	I525T	probably benign	Het
Pign	A	T	1: 105,646,781	L280*	probably null	Het
Pik3r4	T	G	9: 105,650,331	I294M	possibly damaging	Het
Pkhd1	T	A	1: 20,117,720	I3455F	probably damaging	Het
Prmt3	C	T	7: 49,848,758	Q471*	probably null	Het
Prrc2c	A	G	1: 162,692,870	F2006L	probably damaging	Het
Ptger3	C	T	3: 157,567,171	R52C	probably damaging	Het
Rfx2	T	C	17: 56,808,325		probably benign	Het
Sh3bp4	T	C	1: 89,145,148	F573L	probably damaging	Het
Slc18a2	G	T	19: 59,263,301		probably benign	Het
Slc26a8	T	A	17: 28,638,650	I840F	probably benign	Het
Slc5a4b	A	T	10: 76,072,465	Y364*	probably null	Het
Slitrk1	A	G	14: 108,912,322	I319T	probably benign	Het
Stxbp5l	C	T	16: 37,208,205	A499T	probably benign	Het
Tnks2	T	A	19: 36,884,103	S951R	probably benign	Het
Trim30c	A	G	7: 104,382,174	F478S	probably benign	Het
Vmn1r34	A	T	6: 66,637,058	L232Q	probably damaging	Het
Zfp148	T	A	16: 33,495,446	C215S	probably damaging	Het
Zzef1	T	A	11: 72,899,538	V2106D	possibly damaging	Het
Zzef1	C	T	11: 72,891,217	P1995S	probably benign	Het

Other mutations in Tyro3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02104:Tyro3	APN	2	119813200	missense	probably damaging	1.00
IGL02221:Tyro3	APN	2	119812590	missense	probably benign	0.00
IGL02442:Tyro3	APN	2	119808868	missense	probably benign	0.16
PIT4382001:Tyro3	UTSW	2	119802364	missense	probably damaging	1.00
R0078:Tyro3	UTSW	2	119817006	missense	probably damaging	1.00
R0087:Tyro3	UTSW	2	119801701	missense	probably benign	0.38
R0503:Tyro3	UTSW	2	119803230	splice site	probably benign
R0551:Tyro3	UTSW	2	119816904	missense	probably damaging	1.00
R1858:Tyro3	UTSW	2	119801695	missense	possibly damaging	0.95
R1902:Tyro3	UTSW	2	119801695	missense	possibly damaging	0.73
R1980:Tyro3	UTSW	2	119808817	missense	probably benign
R2294:Tyro3	UTSW	2	119805645	missense	probably damaging	0.99
R3877:Tyro3	UTSW	2	119813293	missense	probably damaging	0.98
R4651:Tyro3	UTSW	2	119816868	missense	probably benign	0.01
R4652:Tyro3	UTSW	2	119816868	missense	probably benign	0.01
R4698:Tyro3	UTSW	2	119803270	missense	probably damaging	1.00
R4757:Tyro3	UTSW	2	119810938	missense	probably damaging	1.00
R4894:Tyro3	UTSW	2	119802298	missense	probably damaging	0.96
R5193:Tyro3	UTSW	2	119810517	missense	probably damaging	1.00
R5366:Tyro3	UTSW	2	119804831	missense	probably damaging	1.00
R5693:Tyro3	UTSW	2	119810868	missense	probably damaging	1.00
R6017:Tyro3	UTSW	2	119816666	missense	probably damaging	1.00
R6110:Tyro3	UTSW	2	119812823	missense	probably damaging	1.00
R6160:Tyro3	UTSW	2	119803270	missense	probably damaging	0.98
R6290:Tyro3	UTSW	2	119816840	missense	probably benign
R6293:Tyro3	UTSW	2	119808000	missense	possibly damaging	0.89
R6366:Tyro3	UTSW	2	119816675	missense	probably damaging	0.96
R6712:Tyro3	UTSW	2	119804854	missense	probably null	0.44
R7645:Tyro3	UTSW	2	119816906	missense	probably damaging	1.00
Z1088:Tyro3	UTSW	2	119809467	missense	probably benign	0.31

Posted On

2015-04-16