Incidental Mutation 'IGL02398:Pglyrp4'
ID291790
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pglyrp4
Ensembl Gene ENSMUSG00000042250
Gene Namepeptidoglycan recognition protein 4
SynonymsLOC384997, LOC242097
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02398
Quality Score
Status
Chromosome3
Chromosomal Location90726906-90741517 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) G to A at 90739117 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000128113 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047745] [ENSMUST00000169698]
Predicted Effect probably benign
Transcript: ENSMUST00000047745
SMART Domains Protein: ENSMUSP00000040755
Gene: ENSMUSG00000042250

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
PGRP 55 196 1.5e-58 SMART
Ami_2 66 213 1.14e-7 SMART
PGRP 212 353 2.13e-72 SMART
Ami_2 222 359 1.62e-21 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156268
Predicted Effect probably benign
Transcript: ENSMUST00000169698
SMART Domains Protein: ENSMUSP00000128113
Gene: ENSMUSG00000042250

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
PGRP 55 196 1.5e-58 SMART
Ami_2 66 200 2.12e-7 SMART
PGRP 213 354 2.13e-72 SMART
Ami_2 223 360 1.62e-21 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Summary: This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to DSS-induced colitis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgre1 T A 17: 57,402,824 C160* probably null Het
Alkbh8 C T 9: 3,345,870 P197S possibly damaging Het
Ankef1 A C 2: 136,555,782 N761T probably damaging Het
Ankrd7 A G 6: 18,866,697 Y72C probably damaging Het
Cfap36 T G 11: 29,222,833 M231L probably benign Het
Cog7 A G 7: 121,964,209 C227R probably damaging Het
Csgalnact1 C A 8: 68,401,492 G219V probably damaging Het
Cspg4 A T 9: 56,886,686 E568D probably benign Het
Cwc27 G A 13: 104,804,254 T199I possibly damaging Het
Cyp26a1 A G 19: 37,700,019 I330V probably benign Het
Dcaf7 T C 11: 106,053,753 V254A probably benign Het
Dhrs7 G A 12: 72,664,692 R24C probably damaging Het
Ehmt2 T A 17: 34,908,479 C838S probably damaging Het
Fn1 A T 1: 71,618,670 probably null Het
Gjb3 T A 4: 127,326,062 S226C probably benign Het
Gm14496 A G 2: 181,996,170 I346V probably benign Het
Gm5926 A G X: 32,651,386 D224G probably damaging Het
Gm8050 T C 14: 6,717,330 E172G probably damaging Het
Higd1a G A 9: 121,852,524 R22W probably damaging Het
Hmcn1 A G 1: 150,802,897 L491S possibly damaging Het
Igsf9b T C 9: 27,333,130 S794P possibly damaging Het
Irgm2 A T 11: 58,219,929 I161F probably damaging Het
Lrp8 G T 4: 107,847,494 V304F probably damaging Het
Lrp8 C A 4: 107,869,048 S850R probably damaging Het
Lrrc9 A T 12: 72,466,903 M513L probably benign Het
Myo18b A T 5: 112,830,312 V1248E possibly damaging Het
Myo1b A T 1: 51,757,891 N945K probably damaging Het
Nipbl A G 15: 8,327,090 L1604P probably damaging Het
Oas1f A T 5: 120,851,505 Y169F probably benign Het
Ogfod3 G A 11: 121,203,025 T53I probably benign Het
Olfr1054 A T 2: 86,332,524 Y277* probably null Het
Olfr444 A T 6: 42,956,112 I205F probably benign Het
Olfr584 G A 7: 103,086,106 C191Y probably damaging Het
Parp8 A G 13: 116,910,863 probably null Het
Pde4dip T C 3: 97,766,781 Y273C probably benign Het
Pgbd5 C T 8: 124,384,518 A54T probably damaging Het
Piezo1 A T 8: 122,486,563 S1819R probably benign Het
Polr1a T C 6: 71,936,556 probably benign Het
Polr1b A G 2: 129,102,966 I61V probably benign Het
Prlhr G T 19: 60,467,315 A271E probably damaging Het
Rad23b C T 4: 55,350,360 probably benign Het
Rad51ap1 A T 6: 126,928,151 S132R probably damaging Het
Ros1 T A 10: 52,144,884 probably benign Het
Ryr3 T C 2: 112,847,422 D1327G probably benign Het
Slit1 A C 19: 41,602,237 V1332G probably damaging Het
Tmem178b A G 6: 40,207,527 M120V probably damaging Het
Trim25 T C 11: 88,999,804 C106R probably damaging Het
Trim35 A G 14: 66,309,248 Y488C probably damaging Het
Tsc2 A T 17: 24,621,729 H326Q probably damaging Het
Yap1 A T 9: 7,950,535 I315K probably benign Het
Zfp654 A G 16: 64,786,018 V607A probably benign Het
Other mutations in Pglyrp4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00432:Pglyrp4 APN 3 90739028 missense probably damaging 1.00
IGL00575:Pglyrp4 APN 3 90730791 missense probably damaging 1.00
IGL01892:Pglyrp4 APN 3 90739041 missense probably benign 0.00
IGL02097:Pglyrp4 APN 3 90735603 missense probably benign 0.01
IGL02159:Pglyrp4 APN 3 90730853 missense possibly damaging 0.87
IGL02565:Pglyrp4 APN 3 90735487 missense probably benign
IGL02619:Pglyrp4 APN 3 90735648 splice site probably null
R1160:Pglyrp4 UTSW 3 90728831 splice site probably null
R1420:Pglyrp4 UTSW 3 90728714 missense probably damaging 0.96
R1828:Pglyrp4 UTSW 3 90733003 missense probably damaging 1.00
R4974:Pglyrp4 UTSW 3 90733007 missense probably benign 0.04
R5268:Pglyrp4 UTSW 3 90726964 missense probably damaging 1.00
R5704:Pglyrp4 UTSW 3 90740274 splice site probably null
R7286:Pglyrp4 UTSW 3 90732974 missense probably damaging 1.00
Posted On2015-04-16