Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02399:Taar7b'

291792

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Taar7b

Ensembl Gene

ENSMUSG00000095171

Gene Name

trace amine-associated receptor 7B

Synonyms

LOC209517

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.112) question?

Stock #

IGL02399

Quality Score

Status

Chromosome

Chromosomal Location

23999939-24001015 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 24000152 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 72 (I72F)

Ref Sequence

ENSEMBL: ENSMUSP00000090328 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000092658]

AlphaFold

Q5QD11

Predicted Effect

probably damaging
Transcript: ENSMUST00000092658
AA Change: I72F

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000090328
Gene: ENSMUSG00000095171
AA Change: I72F

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	56	261	1.9e-7	PFAM
Pfam:7tm_1	64	326	7.3e-59	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abhd12	C	T	2: 150,858,493		probably benign	Het
Adarb1	G	A	10: 77,295,754	P624S	probably benign	Het
Afg3l2	A	T	18: 67,429,040	F322I	possibly damaging	Het
Arhgap23	A	G	11: 97,491,005		probably benign	Het
Armc4	G	T	18: 7,285,719	Q215K	probably benign	Het
Atp13a1	A	G	8: 69,807,101	N1114S	probably damaging	Het
C3ar1	T	C	6: 122,849,879	N460D	probably benign	Het
Cacna1e	A	G	1: 154,403,747	Y1988H	probably damaging	Het
Calr	T	C	8: 84,842,786		probably benign	Het
D5Ertd579e	A	G	5: 36,616,185	S289P	probably damaging	Het
Erbb4	G	A	1: 68,042,437		probably benign	Het
Fam98a	A	G	17: 75,538,941		probably benign	Het
Gm3739	A	T	14: 7,299,405	D83E	possibly damaging	Het
Gm5420	A	T	10: 21,691,172		noncoding transcript	Het
Heatr5b	A	G	17: 78,827,967	V245A	probably damaging	Het
Kptn	C	A	7: 16,127,113		probably benign	Het
Llgl2	T	C	11: 115,844,835	C86R	probably damaging	Het
Lrr1	T	A	12: 69,168,891	C12*	probably null	Het
Mcf2	T	C	X: 60,135,452	D255G	probably damaging	Het
Med13	A	T	11: 86,283,945		probably benign	Het
Mthfd1	C	T	12: 76,317,632	T735M	probably damaging	Het
Nlrp2	C	T	7: 5,328,810	A196T	probably damaging	Het
Nnmt	T	C	9: 48,603,538	I60V	probably damaging	Het
Olfr1215	T	A	2: 89,002,163	T42S	probably benign	Het
Olfr522	A	T	7: 140,162,600	S117T	probably benign	Het
P2rx3	T	C	2: 85,023,227	I140V	probably benign	Het
Patj	A	G	4: 98,591,936	N1293D	probably damaging	Het
Pitpnm2	G	A	5: 124,140,758		probably benign	Het
Ppp1r26	T	G	2: 28,453,280	V974G	probably benign	Het
Prrc2b	T	A	2: 32,226,961	L1376*	probably null	Het
Rab33a	T	A	X: 48,519,707	I36N	probably damaging	Het
Rab3gap1	A	T	1: 127,928,103	N493I	possibly damaging	Het
Scara3	C	A	14: 65,933,110	G107*	probably null	Het
Siglec1	T	C	2: 131,071,178	E1606G	probably benign	Het
Skint9	A	T	4: 112,389,250	Y222N	possibly damaging	Het
Slc47a1	A	T	11: 61,363,058	I185N	probably damaging	Het
Slc47a2	C	A	11: 61,302,194		probably benign	Het
Slc4a2	A	G	5: 24,434,713	I506V	probably damaging	Het
Slc9a4	A	C	1: 40,600,782	I245L	probably benign	Het
Smarcb1	T	C	10: 75,897,494	T357A	probably damaging	Het
Spata31d1d	A	G	13: 59,730,140		probably benign	Het
Stox2	T	A	8: 47,186,538	I874F	probably damaging	Het
Tacc2	G	A	7: 130,623,399	V605I	probably benign	Het
Tef	T	C	15: 81,815,100	L34P	probably damaging	Het
Trak2	A	G	1: 58,910,045	V532A	probably benign	Het
Usp13	T	A	3: 32,919,060	D795E	probably damaging	Het
Vmn1r32	T	A	6: 66,552,929	I288F	probably benign	Het
Vmn1r75	T	C	7: 11,881,166	I275T	possibly damaging	Het
Zfp871	A	T	17: 32,774,355	F615L	probably benign	Het
Zfp941	G	A	7: 140,812,699	T249M	probably benign	Het
Zhx1	T	C	15: 58,053,741	I370V	probably damaging	Het

Other mutations in Taar7b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00330:Taar7b	APN	10	24000842	missense	probably benign	0.01
IGL00771:Taar7b	APN	10	24000198	missense	probably benign	0.01
IGL01662:Taar7b	APN	10	23999976	missense	probably benign	0.02
IGL02186:Taar7b	APN	10	23999981	missense	probably benign	0.00
IGL02514:Taar7b	APN	10	24000984	missense	probably benign	0.00
IGL02601:Taar7b	APN	10	24000306	missense	probably damaging	1.00
IGL02717:Taar7b	APN	10	24000360	missense	probably damaging	1.00
IGL02724:Taar7b	APN	10	24000683	missense	probably benign
IGL02725:Taar7b	APN	10	24000063	missense	probably benign	0.03
R0103:Taar7b	UTSW	10	24000294	missense	probably benign	0.00
R2060:Taar7b	UTSW	10	24000675	missense	possibly damaging	0.95
R4973:Taar7b	UTSW	10	24000345	missense	probably benign	0.08
R5055:Taar7b	UTSW	10	24000947	missense	possibly damaging	0.75
R5068:Taar7b	UTSW	10	24000461	missense	probably benign	0.00
R5069:Taar7b	UTSW	10	24000461	missense	probably benign	0.00
R5070:Taar7b	UTSW	10	24000461	missense	probably benign	0.00
R5205:Taar7b	UTSW	10	24000018	missense	probably benign	0.05
R5994:Taar7b	UTSW	10	24000348	missense	probably damaging	1.00
R6131:Taar7b	UTSW	10	24000717	missense	probably benign	0.20
R6302:Taar7b	UTSW	10	24000260	missense	possibly damaging	0.57
R6332:Taar7b	UTSW	10	23999951	missense	probably benign	0.05
R6809:Taar7b	UTSW	10	24000858	missense	probably benign	0.03
R7126:Taar7b	UTSW	10	24000062	missense	possibly damaging	0.93
R7520:Taar7b	UTSW	10	24000483	missense	probably damaging	0.99
R8962:Taar7b	UTSW	10	24000461	missense	probably benign	0.00

Posted On

2015-04-16