Incidental Mutation 'IGL02399:Taar7b'
ID291792
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Taar7b
Ensembl Gene ENSMUSG00000095171
Gene Nametrace amine-associated receptor 7B
SynonymsLOC209517
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.103) question?
Stock #IGL02399
Quality Score
Status
Chromosome10
Chromosomal Location23999939-24001015 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 24000152 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 72 (I72F)
Ref Sequence ENSEMBL: ENSMUSP00000090328 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000092658]
Predicted Effect probably damaging
Transcript: ENSMUST00000092658
AA Change: I72F

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000090328
Gene: ENSMUSG00000095171
AA Change: I72F

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 56 261 1.9e-7 PFAM
Pfam:7tm_1 64 326 7.3e-59 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd12 C T 2: 150,858,493 probably benign Het
Adarb1 G A 10: 77,295,754 P624S probably benign Het
Afg3l2 A T 18: 67,429,040 F322I possibly damaging Het
Arhgap23 A G 11: 97,491,005 probably benign Het
Armc4 G T 18: 7,285,719 Q215K probably benign Het
Atp13a1 A G 8: 69,807,101 N1114S probably damaging Het
C3ar1 T C 6: 122,849,879 N460D probably benign Het
Cacna1e A G 1: 154,403,747 Y1988H probably damaging Het
Calr T C 8: 84,842,786 probably benign Het
D5Ertd579e A G 5: 36,616,185 S289P probably damaging Het
Erbb4 G A 1: 68,042,437 probably benign Het
Fam98a A G 17: 75,538,941 probably benign Het
Gm3739 A T 14: 7,299,405 D83E possibly damaging Het
Gm5420 A T 10: 21,691,172 noncoding transcript Het
Heatr5b A G 17: 78,827,967 V245A probably damaging Het
Kptn C A 7: 16,127,113 probably benign Het
Llgl2 T C 11: 115,844,835 C86R probably damaging Het
Lrr1 T A 12: 69,168,891 C12* probably null Het
Mcf2 T C X: 60,135,452 D255G probably damaging Het
Med13 A T 11: 86,283,945 probably benign Het
Mthfd1 C T 12: 76,317,632 T735M probably damaging Het
Nlrp2 C T 7: 5,328,810 A196T probably damaging Het
Nnmt T C 9: 48,603,538 I60V probably damaging Het
Olfr1215 T A 2: 89,002,163 T42S probably benign Het
Olfr522 A T 7: 140,162,600 S117T probably benign Het
P2rx3 T C 2: 85,023,227 I140V probably benign Het
Patj A G 4: 98,591,936 N1293D probably damaging Het
Pitpnm2 G A 5: 124,140,758 probably benign Het
Ppp1r26 T G 2: 28,453,280 V974G probably benign Het
Prrc2b T A 2: 32,226,961 L1376* probably null Het
Rab33a T A X: 48,519,707 I36N probably damaging Het
Rab3gap1 A T 1: 127,928,103 N493I possibly damaging Het
Scara3 C A 14: 65,933,110 G107* probably null Het
Siglec1 T C 2: 131,071,178 E1606G probably benign Het
Skint9 A T 4: 112,389,250 Y222N possibly damaging Het
Slc47a1 A T 11: 61,363,058 I185N probably damaging Het
Slc47a2 C A 11: 61,302,194 probably benign Het
Slc4a2 A G 5: 24,434,713 I506V probably damaging Het
Slc9a4 A C 1: 40,600,782 I245L probably benign Het
Smarcb1 T C 10: 75,897,494 T357A probably damaging Het
Spata31d1d A G 13: 59,730,140 probably benign Het
Stox2 T A 8: 47,186,538 I874F probably damaging Het
Tacc2 G A 7: 130,623,399 V605I probably benign Het
Tef T C 15: 81,815,100 L34P probably damaging Het
Trak2 A G 1: 58,910,045 V532A probably benign Het
Usp13 T A 3: 32,919,060 D795E probably damaging Het
Vmn1r32 T A 6: 66,552,929 I288F probably benign Het
Vmn1r75 T C 7: 11,881,166 I275T possibly damaging Het
Zfp871 A T 17: 32,774,355 F615L probably benign Het
Zfp941 G A 7: 140,812,699 T249M probably benign Het
Zhx1 T C 15: 58,053,741 I370V probably damaging Het
Other mutations in Taar7b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00330:Taar7b APN 10 24000842 missense probably benign 0.01
IGL00771:Taar7b APN 10 24000198 missense probably benign 0.01
IGL01662:Taar7b APN 10 23999976 missense probably benign 0.02
IGL02186:Taar7b APN 10 23999981 missense probably benign 0.00
IGL02514:Taar7b APN 10 24000984 missense probably benign 0.00
IGL02601:Taar7b APN 10 24000306 missense probably damaging 1.00
IGL02717:Taar7b APN 10 24000360 missense probably damaging 1.00
IGL02724:Taar7b APN 10 24000683 missense probably benign
IGL02725:Taar7b APN 10 24000063 missense probably benign 0.03
R0103:Taar7b UTSW 10 24000294 missense probably benign 0.00
R2060:Taar7b UTSW 10 24000675 missense possibly damaging 0.95
R4973:Taar7b UTSW 10 24000345 missense probably benign 0.08
R5055:Taar7b UTSW 10 24000947 missense possibly damaging 0.75
R5068:Taar7b UTSW 10 24000461 missense probably benign 0.00
R5069:Taar7b UTSW 10 24000461 missense probably benign 0.00
R5070:Taar7b UTSW 10 24000461 missense probably benign 0.00
R5205:Taar7b UTSW 10 24000018 missense probably benign 0.05
R5994:Taar7b UTSW 10 24000348 missense probably damaging 1.00
R6131:Taar7b UTSW 10 24000717 missense probably benign 0.20
R6302:Taar7b UTSW 10 24000260 missense possibly damaging 0.57
R6332:Taar7b UTSW 10 23999951 missense probably benign 0.05
R6809:Taar7b UTSW 10 24000858 missense probably benign 0.03
R7126:Taar7b UTSW 10 24000062 missense possibly damaging 0.93
R7520:Taar7b UTSW 10 24000483 missense probably damaging 0.99
Posted On2015-04-16