Incidental Mutation 'IGL02399:Vmn1r75'
ID 291794
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r75
Ensembl Gene ENSMUSG00000043308
Gene Name vomeronasal 1 receptor 75
Synonyms V1rg6
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # IGL02399
Quality Score
Status
Chromosome 7
Chromosomal Location 11614270-11615187 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 11615093 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 275 (I275T)
Ref Sequence ENSEMBL: ENSMUSP00000154577 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057229] [ENSMUST00000226622] [ENSMUST00000226855] [ENSMUST00000227611] [ENSMUST00000228268] [ENSMUST00000228463] [ENSMUST00000228646]
AlphaFold Q8R289
Predicted Effect possibly damaging
Transcript: ENSMUST00000057229
AA Change: I275T

PolyPhen 2 Score 0.818 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000051510
Gene: ENSMUSG00000043308
AA Change: I275T

DomainStartEndE-ValueType
Pfam:TAS2R 1 294 2.9e-10 PFAM
Pfam:V1R 35 293 1e-29 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000226622
AA Change: I275T

PolyPhen 2 Score 0.818 (Sensitivity: 0.84; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000226855
AA Change: I275T

PolyPhen 2 Score 0.818 (Sensitivity: 0.84; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000227611
AA Change: I233T

PolyPhen 2 Score 0.585 (Sensitivity: 0.88; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000228268
AA Change: I233T

PolyPhen 2 Score 0.585 (Sensitivity: 0.88; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000228463
AA Change: I275T

PolyPhen 2 Score 0.818 (Sensitivity: 0.84; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000228646
AA Change: I233T

PolyPhen 2 Score 0.585 (Sensitivity: 0.88; Specificity: 0.91)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd12 C T 2: 150,700,413 (GRCm39) probably benign Het
Adarb1 G A 10: 77,131,588 (GRCm39) P624S probably benign Het
Afg3l2 A T 18: 67,562,110 (GRCm39) F322I possibly damaging Het
Arhgap23 A G 11: 97,381,831 (GRCm39) probably benign Het
Atp13a1 A G 8: 70,259,751 (GRCm39) N1114S probably damaging Het
C3ar1 T C 6: 122,826,838 (GRCm39) N460D probably benign Het
Cacna1e A G 1: 154,279,493 (GRCm39) Y1988H probably damaging Het
Calr T C 8: 85,569,415 (GRCm39) probably benign Het
D5Ertd579e A G 5: 36,773,529 (GRCm39) S289P probably damaging Het
Erbb4 G A 1: 68,081,596 (GRCm39) probably benign Het
Fam98a A G 17: 75,845,936 (GRCm39) probably benign Het
Gm3739 A T 14: 18,505,274 (GRCm39) D83E possibly damaging Het
Gm5420 A T 10: 21,567,071 (GRCm39) noncoding transcript Het
Heatr5b A G 17: 79,135,396 (GRCm39) V245A probably damaging Het
Kptn C A 7: 15,861,038 (GRCm39) probably benign Het
Llgl2 T C 11: 115,735,661 (GRCm39) C86R probably damaging Het
Lrr1 T A 12: 69,215,665 (GRCm39) C12* probably null Het
Mcf2 T C X: 59,180,812 (GRCm39) D255G probably damaging Het
Med13 A T 11: 86,174,771 (GRCm39) probably benign Het
Mthfd1 C T 12: 76,364,406 (GRCm39) T735M probably damaging Het
Nlrp2 C T 7: 5,331,809 (GRCm39) A196T probably damaging Het
Nnmt T C 9: 48,514,838 (GRCm39) I60V probably damaging Het
Odad2 G T 18: 7,285,719 (GRCm39) Q215K probably benign Het
Or4c110 T A 2: 88,832,507 (GRCm39) T42S probably benign Het
Or6ae1 A T 7: 139,742,513 (GRCm39) S117T probably benign Het
P2rx3 T C 2: 84,853,571 (GRCm39) I140V probably benign Het
Patj A G 4: 98,480,173 (GRCm39) N1293D probably damaging Het
Pitpnm2 G A 5: 124,278,821 (GRCm39) probably benign Het
Ppp1r26 T G 2: 28,343,292 (GRCm39) V974G probably benign Het
Prrc2b T A 2: 32,116,973 (GRCm39) L1376* probably null Het
Rab33a T A X: 47,608,584 (GRCm39) I36N probably damaging Het
Rab3gap1 A T 1: 127,855,840 (GRCm39) N493I possibly damaging Het
Scara3 C A 14: 66,170,559 (GRCm39) G107* probably null Het
Siglec1 T C 2: 130,913,098 (GRCm39) E1606G probably benign Het
Skint9 A T 4: 112,246,447 (GRCm39) Y222N possibly damaging Het
Slc47a1 A T 11: 61,253,884 (GRCm39) I185N probably damaging Het
Slc47a2 C A 11: 61,193,020 (GRCm39) probably benign Het
Slc4a2 A G 5: 24,639,711 (GRCm39) I506V probably damaging Het
Slc9a4 A C 1: 40,639,942 (GRCm39) I245L probably benign Het
Smarcb1 T C 10: 75,733,328 (GRCm39) T357A probably damaging Het
Spata31d1d A G 13: 59,877,954 (GRCm39) probably benign Het
Stox2 T A 8: 47,639,573 (GRCm39) I874F probably damaging Het
Taar7b A T 10: 23,876,050 (GRCm39) I72F probably damaging Het
Tacc2 G A 7: 130,225,129 (GRCm39) V605I probably benign Het
Tef T C 15: 81,699,301 (GRCm39) L34P probably damaging Het
Trak2 A G 1: 58,949,204 (GRCm39) V532A probably benign Het
Usp13 T A 3: 32,973,209 (GRCm39) D795E probably damaging Het
Vmn1r32 T A 6: 66,529,913 (GRCm39) I288F probably benign Het
Zfp871 A T 17: 32,993,329 (GRCm39) F615L probably benign Het
Zfp941 G A 7: 140,392,612 (GRCm39) T249M probably benign Het
Zhx1 T C 15: 57,917,137 (GRCm39) I370V probably damaging Het
Other mutations in Vmn1r75
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01901:Vmn1r75 APN 7 11,614,739 (GRCm39) missense probably damaging 1.00
IGL02175:Vmn1r75 APN 7 11,614,774 (GRCm39) missense probably damaging 1.00
IGL02648:Vmn1r75 APN 7 11,615,091 (GRCm39) missense probably benign 0.04
IGL03372:Vmn1r75 APN 7 11,614,496 (GRCm39) missense probably benign 0.29
R0538:Vmn1r75 UTSW 7 11,614,797 (GRCm39) missense probably damaging 0.97
R0599:Vmn1r75 UTSW 7 11,615,189 (GRCm39) splice site probably null
R3910:Vmn1r75 UTSW 7 11,614,757 (GRCm39) missense possibly damaging 0.92
R4491:Vmn1r75 UTSW 7 11,614,909 (GRCm39) missense probably damaging 0.97
R5566:Vmn1r75 UTSW 7 11,614,407 (GRCm39) missense probably damaging 1.00
R6051:Vmn1r75 UTSW 7 11,614,978 (GRCm39) missense probably damaging 1.00
R6230:Vmn1r75 UTSW 7 11,614,966 (GRCm39) missense probably damaging 0.98
R6490:Vmn1r75 UTSW 7 11,615,003 (GRCm39) missense probably damaging 1.00
R6570:Vmn1r75 UTSW 7 11,614,883 (GRCm39) missense probably damaging 0.98
R7184:Vmn1r75 UTSW 7 11,614,915 (GRCm39) nonsense probably null
R7189:Vmn1r75 UTSW 7 11,614,475 (GRCm39) missense possibly damaging 0.93
R7501:Vmn1r75 UTSW 7 11,614,997 (GRCm39) missense possibly damaging 0.67
R7973:Vmn1r75 UTSW 7 11,614,961 (GRCm39) missense probably benign 0.04
R7997:Vmn1r75 UTSW 7 11,614,600 (GRCm39) missense probably damaging 1.00
R8372:Vmn1r75 UTSW 7 11,614,657 (GRCm39) missense probably benign 0.10
R8812:Vmn1r75 UTSW 7 11,614,630 (GRCm39) missense possibly damaging 0.54
R8932:Vmn1r75 UTSW 7 11,614,838 (GRCm39) missense probably damaging 1.00
R9089:Vmn1r75 UTSW 7 11,614,453 (GRCm39) missense probably damaging 1.00
R9129:Vmn1r75 UTSW 7 11,614,513 (GRCm39) missense probably benign 0.15
Posted On 2015-04-16