Incidental Mutation 'IGL02399:C3ar1'
| ID |
291810 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
C3ar1
|
| Ensembl Gene |
ENSMUSG00000040552 |
| Gene Name |
complement component 3a receptor 1 |
| Synonyms |
C3aR, anaphylatoxin C3a receptor |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL02399
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
122824099-122833116 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 122826838 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Aspartic acid
at position 460
(N460D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000048092
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000003238]
[ENSMUST00000042081]
[ENSMUST00000177927]
|
| AlphaFold |
O09047 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000003238
|
| SMART Domains |
Protein: ENSMUSP00000003238
Gene: ENSMUSG00000003154
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
28 |
39 |
N/A |
INTRINSIC |
|
FH
|
64 |
153 |
1.77e-47 |
SMART |
|
low complexity region
|
207 |
222 |
N/A |
INTRINSIC |
|
low complexity region
|
266 |
275 |
N/A |
INTRINSIC |
|
low complexity region
|
290 |
314 |
N/A |
INTRINSIC |
|
low complexity region
|
359 |
393 |
N/A |
INTRINSIC |
|
low complexity region
|
535 |
549 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000042081
AA Change: N460D
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000048092
Gene: ENSMUSG00000040552
AA Change: N460D
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
40 |
193 |
8.1e-25 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
281 |
443 |
7.8e-8 |
PFAM |
|
Pfam:7tm_1
|
313 |
428 |
6.5e-17 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177927
|
| SMART Domains |
Protein: ENSMUSP00000137645
Gene: ENSMUSG00000003154
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
28 |
39 |
N/A |
INTRINSIC |
|
FH
|
64 |
153 |
1.77e-47 |
SMART |
|
low complexity region
|
207 |
222 |
N/A |
INTRINSIC |
|
low complexity region
|
266 |
275 |
N/A |
INTRINSIC |
|
low complexity region
|
290 |
314 |
N/A |
INTRINSIC |
|
low complexity region
|
359 |
393 |
N/A |
INTRINSIC |
|
low complexity region
|
535 |
549 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] C3a is an anaphylatoxin released during activation of the complement system. The protein encoded by this gene is an orphan G protein-coupled receptor for C3a. Binding of C3a by the encoded receptor activates chemotaxis, granule enzyme release, superoxide anion production, and bacterial opsonization. [provided by RefSeq, May 2016]
PHENOTYPE: Homozygous targeted mutants display protective effects against the changes in lung physiology after allergen challenge, increased lethality to endotoxin shock, and elevated IL1B following LPS challenge, supporting the role of C3arin proinflammatory responses. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 51 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abhd12 |
C |
T |
2: 150,700,413 (GRCm39) |
|
probably benign |
Het |
| Adarb1 |
G |
A |
10: 77,131,588 (GRCm39) |
P624S |
probably benign |
Het |
| Afg3l2 |
A |
T |
18: 67,562,110 (GRCm39) |
F322I |
possibly damaging |
Het |
| Arhgap23 |
A |
G |
11: 97,381,831 (GRCm39) |
|
probably benign |
Het |
| Atp13a1 |
A |
G |
8: 70,259,751 (GRCm39) |
N1114S |
probably damaging |
Het |
| Cacna1e |
A |
G |
1: 154,279,493 (GRCm39) |
Y1988H |
probably damaging |
Het |
| Calr |
T |
C |
8: 85,569,415 (GRCm39) |
|
probably benign |
Het |
| D5Ertd579e |
A |
G |
5: 36,773,529 (GRCm39) |
S289P |
probably damaging |
Het |
| Erbb4 |
G |
A |
1: 68,081,596 (GRCm39) |
|
probably benign |
Het |
| Fam98a |
A |
G |
17: 75,845,936 (GRCm39) |
|
probably benign |
Het |
| Gm3739 |
A |
T |
14: 18,505,274 (GRCm39) |
D83E |
possibly damaging |
Het |
| Gm5420 |
A |
T |
10: 21,567,071 (GRCm39) |
|
noncoding transcript |
Het |
| Heatr5b |
A |
G |
17: 79,135,396 (GRCm39) |
V245A |
probably damaging |
Het |
| Kptn |
C |
A |
7: 15,861,038 (GRCm39) |
|
probably benign |
Het |
| Llgl2 |
T |
C |
11: 115,735,661 (GRCm39) |
C86R |
probably damaging |
Het |
| Lrr1 |
T |
A |
12: 69,215,665 (GRCm39) |
C12* |
probably null |
Het |
| Mcf2 |
T |
C |
X: 59,180,812 (GRCm39) |
D255G |
probably damaging |
Het |
| Med13 |
A |
T |
11: 86,174,771 (GRCm39) |
|
probably benign |
Het |
| Mthfd1 |
C |
T |
12: 76,364,406 (GRCm39) |
T735M |
probably damaging |
Het |
| Nlrp2 |
C |
T |
7: 5,331,809 (GRCm39) |
A196T |
probably damaging |
Het |
| Nnmt |
T |
C |
9: 48,514,838 (GRCm39) |
I60V |
probably damaging |
Het |
| Odad2 |
G |
T |
18: 7,285,719 (GRCm39) |
Q215K |
probably benign |
Het |
| Or4c110 |
T |
A |
2: 88,832,507 (GRCm39) |
T42S |
probably benign |
Het |
| Or6ae1 |
A |
T |
7: 139,742,513 (GRCm39) |
S117T |
probably benign |
Het |
| P2rx3 |
T |
C |
2: 84,853,571 (GRCm39) |
I140V |
probably benign |
Het |
| Patj |
A |
G |
4: 98,480,173 (GRCm39) |
N1293D |
probably damaging |
Het |
| Pitpnm2 |
G |
A |
5: 124,278,821 (GRCm39) |
|
probably benign |
Het |
| Ppp1r26 |
T |
G |
2: 28,343,292 (GRCm39) |
V974G |
probably benign |
Het |
| Prrc2b |
T |
A |
2: 32,116,973 (GRCm39) |
L1376* |
probably null |
Het |
| Rab33a |
T |
A |
X: 47,608,584 (GRCm39) |
I36N |
probably damaging |
Het |
| Rab3gap1 |
A |
T |
1: 127,855,840 (GRCm39) |
N493I |
possibly damaging |
Het |
| Scara3 |
C |
A |
14: 66,170,559 (GRCm39) |
G107* |
probably null |
Het |
| Siglec1 |
T |
C |
2: 130,913,098 (GRCm39) |
E1606G |
probably benign |
Het |
| Skint9 |
A |
T |
4: 112,246,447 (GRCm39) |
Y222N |
possibly damaging |
Het |
| Slc47a1 |
A |
T |
11: 61,253,884 (GRCm39) |
I185N |
probably damaging |
Het |
| Slc47a2 |
C |
A |
11: 61,193,020 (GRCm39) |
|
probably benign |
Het |
| Slc4a2 |
A |
G |
5: 24,639,711 (GRCm39) |
I506V |
probably damaging |
Het |
| Slc9a4 |
A |
C |
1: 40,639,942 (GRCm39) |
I245L |
probably benign |
Het |
| Smarcb1 |
T |
C |
10: 75,733,328 (GRCm39) |
T357A |
probably damaging |
Het |
| Spata31d1d |
A |
G |
13: 59,877,954 (GRCm39) |
|
probably benign |
Het |
| Stox2 |
T |
A |
8: 47,639,573 (GRCm39) |
I874F |
probably damaging |
Het |
| Taar7b |
A |
T |
10: 23,876,050 (GRCm39) |
I72F |
probably damaging |
Het |
| Tacc2 |
G |
A |
7: 130,225,129 (GRCm39) |
V605I |
probably benign |
Het |
| Tef |
T |
C |
15: 81,699,301 (GRCm39) |
L34P |
probably damaging |
Het |
| Trak2 |
A |
G |
1: 58,949,204 (GRCm39) |
V532A |
probably benign |
Het |
| Usp13 |
T |
A |
3: 32,973,209 (GRCm39) |
D795E |
probably damaging |
Het |
| Vmn1r32 |
T |
A |
6: 66,529,913 (GRCm39) |
I288F |
probably benign |
Het |
| Vmn1r75 |
T |
C |
7: 11,615,093 (GRCm39) |
I275T |
possibly damaging |
Het |
| Zfp871 |
A |
T |
17: 32,993,329 (GRCm39) |
F615L |
probably benign |
Het |
| Zfp941 |
G |
A |
7: 140,392,612 (GRCm39) |
T249M |
probably benign |
Het |
| Zhx1 |
T |
C |
15: 57,917,137 (GRCm39) |
I370V |
probably damaging |
Het |
|
| Other mutations in C3ar1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01818:C3ar1
|
APN |
6 |
122,827,378 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01936:C3ar1
|
APN |
6 |
122,828,194 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01998:C3ar1
|
APN |
6 |
122,827,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02351:C3ar1
|
APN |
6 |
122,826,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02358:C3ar1
|
APN |
6 |
122,826,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4618001:C3ar1
|
UTSW |
6 |
122,827,746 (GRCm39) |
missense |
probably benign |
0.25 |
|
R0014:C3ar1
|
UTSW |
6 |
122,827,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0195:C3ar1
|
UTSW |
6 |
122,828,114 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0257:C3ar1
|
UTSW |
6 |
122,827,746 (GRCm39) |
missense |
probably benign |
0.25 |
|
R0344:C3ar1
|
UTSW |
6 |
122,827,731 (GRCm39) |
missense |
probably benign |
0.45 |
|
R4345:C3ar1
|
UTSW |
6 |
122,827,659 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4614:C3ar1
|
UTSW |
6 |
122,827,680 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4643:C3ar1
|
UTSW |
6 |
122,827,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4840:C3ar1
|
UTSW |
6 |
122,827,723 (GRCm39) |
missense |
probably benign |
|
|
R5235:C3ar1
|
UTSW |
6 |
122,827,881 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5303:C3ar1
|
UTSW |
6 |
122,826,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5610:C3ar1
|
UTSW |
6 |
122,827,537 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5762:C3ar1
|
UTSW |
6 |
122,827,321 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5873:C3ar1
|
UTSW |
6 |
122,827,381 (GRCm39) |
missense |
probably benign |
0.24 |
|
R5877:C3ar1
|
UTSW |
6 |
122,827,581 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6327:C3ar1
|
UTSW |
6 |
122,827,105 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6440:C3ar1
|
UTSW |
6 |
122,827,467 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6505:C3ar1
|
UTSW |
6 |
122,827,599 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6636:C3ar1
|
UTSW |
6 |
122,828,013 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6755:C3ar1
|
UTSW |
6 |
122,826,817 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6953:C3ar1
|
UTSW |
6 |
122,827,591 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7985:C3ar1
|
UTSW |
6 |
122,826,964 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8049:C3ar1
|
UTSW |
6 |
122,827,059 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8936:C3ar1
|
UTSW |
6 |
122,828,044 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9337:C3ar1
|
UTSW |
6 |
122,827,278 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0065:C3ar1
|
UTSW |
6 |
122,827,724 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation