Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02399:Zfp871'

291818

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp871

Ensembl Gene

ENSMUSG00000024298

Gene Name

zinc finger protein 871

Synonyms

9030612M13Rik

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL02399

Quality Score

Status

Chromosome

Chromosomal Location

32984470-33007261 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 32993329 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 615 (F615L)

Ref Sequence

ENSEMBL: ENSMUSP00000127178 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000057501] [ENSMUST00000159086]

AlphaFold

G5E905

Predicted Effect

probably benign
Transcript: ENSMUST00000057501
AA Change: F596L

PolyPhen 2 Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000050501
Gene: ENSMUSG00000024298
AA Change: F596L

Domain	Start	End	E-Value	Type
KRAB	1	42	1.32e0	SMART
ZnF_C2H2	174	196	5.9e-3	SMART
ZnF_C2H2	202	224	6.32e-3	SMART
ZnF_C2H2	230	252	1.47e-3	SMART
ZnF_C2H2	258	280	3.63e-3	SMART
ZnF_C2H2	286	308	1.79e-2	SMART
ZnF_C2H2	314	336	4.79e-3	SMART
ZnF_C2H2	342	364	1.69e-3	SMART
ZnF_C2H2	370	392	2.79e-4	SMART
ZnF_C2H2	398	420	1.23e-5	SMART
ZnF_C2H2	426	448	1.2e-3	SMART
ZnF_C2H2	454	476	5.42e-2	SMART
ZnF_C2H2	482	504	8.6e-5	SMART
ZnF_C2H2	510	532	5.21e-4	SMART
ZnF_C2H2	538	560	3.11e-2	SMART
ZnF_C2H2	566	588	2.86e-1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000159086
AA Change: F615L

PolyPhen 2 Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000127178
Gene: ENSMUSG00000024298
AA Change: F615L

Domain	Start	End	E-Value	Type
KRAB	4	61	2.18e-15	SMART
ZnF_C2H2	193	215	5.9e-3	SMART
ZnF_C2H2	221	243	6.32e-3	SMART
ZnF_C2H2	249	271	1.47e-3	SMART
ZnF_C2H2	277	299	3.63e-3	SMART
ZnF_C2H2	305	327	1.79e-2	SMART
ZnF_C2H2	333	355	4.79e-3	SMART
ZnF_C2H2	361	383	1.69e-3	SMART
ZnF_C2H2	389	411	2.79e-4	SMART
ZnF_C2H2	417	439	1.23e-5	SMART
ZnF_C2H2	445	467	1.2e-3	SMART
ZnF_C2H2	473	495	5.42e-2	SMART
ZnF_C2H2	501	523	8.6e-5	SMART
ZnF_C2H2	529	551	5.21e-4	SMART
ZnF_C2H2	557	579	3.11e-2	SMART
ZnF_C2H2	585	607	2.86e-1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000168337

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abhd12	C	T	2: 150,700,413 (GRCm39)		probably benign	Het
Adarb1	G	A	10: 77,131,588 (GRCm39)	P624S	probably benign	Het
Afg3l2	A	T	18: 67,562,110 (GRCm39)	F322I	possibly damaging	Het
Arhgap23	A	G	11: 97,381,831 (GRCm39)		probably benign	Het
Atp13a1	A	G	8: 70,259,751 (GRCm39)	N1114S	probably damaging	Het
C3ar1	T	C	6: 122,826,838 (GRCm39)	N460D	probably benign	Het
Cacna1e	A	G	1: 154,279,493 (GRCm39)	Y1988H	probably damaging	Het
Calr	T	C	8: 85,569,415 (GRCm39)		probably benign	Het
D5Ertd579e	A	G	5: 36,773,529 (GRCm39)	S289P	probably damaging	Het
Erbb4	G	A	1: 68,081,596 (GRCm39)		probably benign	Het
Fam98a	A	G	17: 75,845,936 (GRCm39)		probably benign	Het
Gm3739	A	T	14: 18,505,274 (GRCm39)	D83E	possibly damaging	Het
Gm5420	A	T	10: 21,567,071 (GRCm39)		noncoding transcript	Het
Heatr5b	A	G	17: 79,135,396 (GRCm39)	V245A	probably damaging	Het
Kptn	C	A	7: 15,861,038 (GRCm39)		probably benign	Het
Llgl2	T	C	11: 115,735,661 (GRCm39)	C86R	probably damaging	Het
Lrr1	T	A	12: 69,215,665 (GRCm39)	C12*	probably null	Het
Mcf2	T	C	X: 59,180,812 (GRCm39)	D255G	probably damaging	Het
Med13	A	T	11: 86,174,771 (GRCm39)		probably benign	Het
Mthfd1	C	T	12: 76,364,406 (GRCm39)	T735M	probably damaging	Het
Nlrp2	C	T	7: 5,331,809 (GRCm39)	A196T	probably damaging	Het
Nnmt	T	C	9: 48,514,838 (GRCm39)	I60V	probably damaging	Het
Odad2	G	T	18: 7,285,719 (GRCm39)	Q215K	probably benign	Het
Or4c110	T	A	2: 88,832,507 (GRCm39)	T42S	probably benign	Het
Or6ae1	A	T	7: 139,742,513 (GRCm39)	S117T	probably benign	Het
P2rx3	T	C	2: 84,853,571 (GRCm39)	I140V	probably benign	Het
Patj	A	G	4: 98,480,173 (GRCm39)	N1293D	probably damaging	Het
Pitpnm2	G	A	5: 124,278,821 (GRCm39)		probably benign	Het
Ppp1r26	T	G	2: 28,343,292 (GRCm39)	V974G	probably benign	Het
Prrc2b	T	A	2: 32,116,973 (GRCm39)	L1376*	probably null	Het
Rab33a	T	A	X: 47,608,584 (GRCm39)	I36N	probably damaging	Het
Rab3gap1	A	T	1: 127,855,840 (GRCm39)	N493I	possibly damaging	Het
Scara3	C	A	14: 66,170,559 (GRCm39)	G107*	probably null	Het
Siglec1	T	C	2: 130,913,098 (GRCm39)	E1606G	probably benign	Het
Skint9	A	T	4: 112,246,447 (GRCm39)	Y222N	possibly damaging	Het
Slc47a1	A	T	11: 61,253,884 (GRCm39)	I185N	probably damaging	Het
Slc47a2	C	A	11: 61,193,020 (GRCm39)		probably benign	Het
Slc4a2	A	G	5: 24,639,711 (GRCm39)	I506V	probably damaging	Het
Slc9a4	A	C	1: 40,639,942 (GRCm39)	I245L	probably benign	Het
Smarcb1	T	C	10: 75,733,328 (GRCm39)	T357A	probably damaging	Het
Spata31d1d	A	G	13: 59,877,954 (GRCm39)		probably benign	Het
Stox2	T	A	8: 47,639,573 (GRCm39)	I874F	probably damaging	Het
Taar7b	A	T	10: 23,876,050 (GRCm39)	I72F	probably damaging	Het
Tacc2	G	A	7: 130,225,129 (GRCm39)	V605I	probably benign	Het
Tef	T	C	15: 81,699,301 (GRCm39)	L34P	probably damaging	Het
Trak2	A	G	1: 58,949,204 (GRCm39)	V532A	probably benign	Het
Usp13	T	A	3: 32,973,209 (GRCm39)	D795E	probably damaging	Het
Vmn1r32	T	A	6: 66,529,913 (GRCm39)	I288F	probably benign	Het
Vmn1r75	T	C	7: 11,615,093 (GRCm39)	I275T	possibly damaging	Het
Zfp941	G	A	7: 140,392,612 (GRCm39)	T249M	probably benign	Het
Zhx1	T	C	15: 57,917,137 (GRCm39)	I370V	probably damaging	Het

Other mutations in Zfp871

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00849:Zfp871	APN	17	32,994,873 (GRCm39)	missense	probably benign
IGL00963:Zfp871	APN	17	32,993,726 (GRCm39)	missense	probably benign	0.25
IGL01687:Zfp871	APN	17	32,994,618 (GRCm39)	missense	probably benign	0.00
IGL02170:Zfp871	APN	17	32,994,662 (GRCm39)	missense	possibly damaging	0.72
R0304:Zfp871	UTSW	17	32,993,408 (GRCm39)	missense	probably damaging	0.99
R1215:Zfp871	UTSW	17	32,994,946 (GRCm39)	missense	possibly damaging	0.70
R1444:Zfp871	UTSW	17	32,993,900 (GRCm39)	missense	possibly damaging	0.85
R1754:Zfp871	UTSW	17	32,994,308 (GRCm39)	missense	probably damaging	1.00
R1913:Zfp871	UTSW	17	32,994,891 (GRCm39)	missense	possibly damaging	0.53
R2018:Zfp871	UTSW	17	32,993,751 (GRCm39)	missense	probably damaging	1.00
R2180:Zfp871	UTSW	17	32,994,275 (GRCm39)	missense	probably damaging	1.00
R2881:Zfp871	UTSW	17	32,994,407 (GRCm39)	missense	probably damaging	1.00
R4422:Zfp871	UTSW	17	32,993,808 (GRCm39)	missense	probably benign	0.37
R4422:Zfp871	UTSW	17	32,993,807 (GRCm39)	missense	probably benign	0.39
R4979:Zfp871	UTSW	17	32,994,829 (GRCm39)	missense	probably damaging	0.99
R5564:Zfp871	UTSW	17	32,994,842 (GRCm39)	missense	possibly damaging	0.70
R6228:Zfp871	UTSW	17	32,994,858 (GRCm39)	missense	possibly damaging	0.50
R6232:Zfp871	UTSW	17	32,994,494 (GRCm39)	frame shift	probably null
R6233:Zfp871	UTSW	17	32,994,494 (GRCm39)	frame shift	probably null
R6234:Zfp871	UTSW	17	32,994,494 (GRCm39)	frame shift	probably null
R6474:Zfp871	UTSW	17	32,994,647 (GRCm39)	missense	possibly damaging	0.85
R7237:Zfp871	UTSW	17	32,994,289 (GRCm39)	missense	probably damaging	1.00
R7809:Zfp871	UTSW	17	32,993,826 (GRCm39)	missense	probably damaging	1.00
R8830:Zfp871	UTSW	17	32,993,901 (GRCm39)	missense	probably benign	0.03
R9219:Zfp871	UTSW	17	32,993,914 (GRCm39)	missense	probably benign	0.02

Posted On

2015-04-16