Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02399:Fam98a'

291839

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fam98a

Ensembl Gene

ENSMUSG00000002017

Gene Name

family with sequence similarity 98, member A

Synonyms

2810405J04Rik

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.678) question?

Stock #

IGL02399

Quality Score

Status

Chromosome

Chromosomal Location

75844081-75858941 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to G at 75845936 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000108126 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000112507]

AlphaFold

Q3TJZ6

Predicted Effect

probably benign
Transcript: ENSMUST00000112507

SMART Domains

Protein: ENSMUSP00000108126
Gene: ENSMUSG00000002017

Domain	Start	End	E-Value	Type
Pfam:DUF2465	11	328	1.1e-137	PFAM
low complexity region	334	396	N/A	INTRINSIC
low complexity region	401	441	N/A	INTRINSIC
low complexity region	448	481	N/A	INTRINSIC
low complexity region	485	501	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000140729

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abhd12	C	T	2: 150,700,413 (GRCm39)		probably benign	Het
Adarb1	G	A	10: 77,131,588 (GRCm39)	P624S	probably benign	Het
Afg3l2	A	T	18: 67,562,110 (GRCm39)	F322I	possibly damaging	Het
Arhgap23	A	G	11: 97,381,831 (GRCm39)		probably benign	Het
Atp13a1	A	G	8: 70,259,751 (GRCm39)	N1114S	probably damaging	Het
C3ar1	T	C	6: 122,826,838 (GRCm39)	N460D	probably benign	Het
Cacna1e	A	G	1: 154,279,493 (GRCm39)	Y1988H	probably damaging	Het
Calr	T	C	8: 85,569,415 (GRCm39)		probably benign	Het
D5Ertd579e	A	G	5: 36,773,529 (GRCm39)	S289P	probably damaging	Het
Erbb4	G	A	1: 68,081,596 (GRCm39)		probably benign	Het
Gm3739	A	T	14: 18,505,274 (GRCm39)	D83E	possibly damaging	Het
Gm5420	A	T	10: 21,567,071 (GRCm39)		noncoding transcript	Het
Heatr5b	A	G	17: 79,135,396 (GRCm39)	V245A	probably damaging	Het
Kptn	C	A	7: 15,861,038 (GRCm39)		probably benign	Het
Llgl2	T	C	11: 115,735,661 (GRCm39)	C86R	probably damaging	Het
Lrr1	T	A	12: 69,215,665 (GRCm39)	C12*	probably null	Het
Mcf2	T	C	X: 59,180,812 (GRCm39)	D255G	probably damaging	Het
Med13	A	T	11: 86,174,771 (GRCm39)		probably benign	Het
Mthfd1	C	T	12: 76,364,406 (GRCm39)	T735M	probably damaging	Het
Nlrp2	C	T	7: 5,331,809 (GRCm39)	A196T	probably damaging	Het
Nnmt	T	C	9: 48,514,838 (GRCm39)	I60V	probably damaging	Het
Odad2	G	T	18: 7,285,719 (GRCm39)	Q215K	probably benign	Het
Or4c110	T	A	2: 88,832,507 (GRCm39)	T42S	probably benign	Het
Or6ae1	A	T	7: 139,742,513 (GRCm39)	S117T	probably benign	Het
P2rx3	T	C	2: 84,853,571 (GRCm39)	I140V	probably benign	Het
Patj	A	G	4: 98,480,173 (GRCm39)	N1293D	probably damaging	Het
Pitpnm2	G	A	5: 124,278,821 (GRCm39)		probably benign	Het
Ppp1r26	T	G	2: 28,343,292 (GRCm39)	V974G	probably benign	Het
Prrc2b	T	A	2: 32,116,973 (GRCm39)	L1376*	probably null	Het
Rab33a	T	A	X: 47,608,584 (GRCm39)	I36N	probably damaging	Het
Rab3gap1	A	T	1: 127,855,840 (GRCm39)	N493I	possibly damaging	Het
Scara3	C	A	14: 66,170,559 (GRCm39)	G107*	probably null	Het
Siglec1	T	C	2: 130,913,098 (GRCm39)	E1606G	probably benign	Het
Skint9	A	T	4: 112,246,447 (GRCm39)	Y222N	possibly damaging	Het
Slc47a1	A	T	11: 61,253,884 (GRCm39)	I185N	probably damaging	Het
Slc47a2	C	A	11: 61,193,020 (GRCm39)		probably benign	Het
Slc4a2	A	G	5: 24,639,711 (GRCm39)	I506V	probably damaging	Het
Slc9a4	A	C	1: 40,639,942 (GRCm39)	I245L	probably benign	Het
Smarcb1	T	C	10: 75,733,328 (GRCm39)	T357A	probably damaging	Het
Spata31d1d	A	G	13: 59,877,954 (GRCm39)		probably benign	Het
Stox2	T	A	8: 47,639,573 (GRCm39)	I874F	probably damaging	Het
Taar7b	A	T	10: 23,876,050 (GRCm39)	I72F	probably damaging	Het
Tacc2	G	A	7: 130,225,129 (GRCm39)	V605I	probably benign	Het
Tef	T	C	15: 81,699,301 (GRCm39)	L34P	probably damaging	Het
Trak2	A	G	1: 58,949,204 (GRCm39)	V532A	probably benign	Het
Usp13	T	A	3: 32,973,209 (GRCm39)	D795E	probably damaging	Het
Vmn1r32	T	A	6: 66,529,913 (GRCm39)	I288F	probably benign	Het
Vmn1r75	T	C	7: 11,615,093 (GRCm39)	I275T	possibly damaging	Het
Zfp871	A	T	17: 32,993,329 (GRCm39)	F615L	probably benign	Het
Zfp941	G	A	7: 140,392,612 (GRCm39)	T249M	probably benign	Het
Zhx1	T	C	15: 57,917,137 (GRCm39)	I370V	probably damaging	Het

Other mutations in Fam98a

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00337:Fam98a	APN	17	75,858,742 (GRCm39)	missense	probably damaging	1.00
IGL00548:Fam98a	APN	17	75,845,813 (GRCm39)	missense	probably damaging	1.00
IGL02170:Fam98a	APN	17	75,847,187 (GRCm39)	critical splice acceptor site	probably null
IGL03062:Fam98a	APN	17	75,847,100 (GRCm39)	splice site	probably benign
IGL03246:Fam98a	APN	17	75,845,848 (GRCm39)	missense	probably damaging	0.99
R0584:Fam98a	UTSW	17	75,851,772 (GRCm39)	missense	probably damaging	1.00
R0594:Fam98a	UTSW	17	75,845,482 (GRCm39)	nonsense	probably null
R1121:Fam98a	UTSW	17	75,845,529 (GRCm39)	missense	unknown
R1366:Fam98a	UTSW	17	75,846,381 (GRCm39)	splice site	probably benign
R1387:Fam98a	UTSW	17	75,845,264 (GRCm39)	missense	unknown
R1424:Fam98a	UTSW	17	75,847,173 (GRCm39)	missense	probably damaging	1.00
R1533:Fam98a	UTSW	17	75,848,276 (GRCm39)	missense	probably damaging	1.00
R1651:Fam98a	UTSW	17	75,854,710 (GRCm39)	missense	probably benign	0.16
R2211:Fam98a	UTSW	17	75,845,940 (GRCm39)	critical splice donor site	probably null
R4295:Fam98a	UTSW	17	75,848,342 (GRCm39)	missense	probably damaging	1.00
R4350:Fam98a	UTSW	17	75,848,220 (GRCm39)	missense	probably damaging	1.00
R4963:Fam98a	UTSW	17	75,845,977 (GRCm39)	missense	probably damaging	0.99
R5320:Fam98a	UTSW	17	75,845,810 (GRCm39)	missense	probably damaging	1.00
R5383:Fam98a	UTSW	17	75,845,576 (GRCm39)	missense	unknown
R6031:Fam98a	UTSW	17	75,846,427 (GRCm39)	missense	probably damaging	0.98
R6031:Fam98a	UTSW	17	75,846,427 (GRCm39)	missense	probably damaging	0.98
R7058:Fam98a	UTSW	17	75,845,384 (GRCm39)	missense	unknown
R7182:Fam98a	UTSW	17	75,846,013 (GRCm39)	nonsense	probably null
R7505:Fam98a	UTSW	17	75,845,233 (GRCm39)	missense	unknown
R7554:Fam98a	UTSW	17	75,854,670 (GRCm39)	nonsense	probably null
R7566:Fam98a	UTSW	17	75,854,657 (GRCm39)	missense	probably damaging	1.00
R8095:Fam98a	UTSW	17	75,845,766 (GRCm39)	missense	probably damaging	1.00
R8467:Fam98a	UTSW	17	75,851,830 (GRCm39)	missense	probably damaging	1.00
R8790:Fam98a	UTSW	17	75,854,684 (GRCm39)	missense	possibly damaging	0.93
R8827:Fam98a	UTSW	17	75,851,824 (GRCm39)	missense	possibly damaging	0.74
R9375:Fam98a	UTSW	17	75,848,330 (GRCm39)	missense	possibly damaging	0.55
R9625:Fam98a	UTSW	17	75,845,474 (GRCm39)	missense	unknown

Posted On

2015-04-16