Incidental Mutation 'IGL02402:Or1o3'
ID 291912
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or1o3
Ensembl Gene ENSMUSG00000063660
Gene Name olfactory receptor family 1 subfamily O member 3
Synonyms Olfr98, GA_x6K02T2PSCP-1703582-1702653, MOR156-4
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # IGL02402
Quality Score
Status
Chromosome 17
Chromosomal Location 37573624-37574553 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 37574111 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 148 (V148A)
Ref Sequence ENSEMBL: ENSMUSP00000094936 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080759]
AlphaFold Q8VFD9
Predicted Effect possibly damaging
Transcript: ENSMUST00000080759
AA Change: V148A

PolyPhen 2 Score 0.459 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000094936
Gene: ENSMUSG00000063660
AA Change: V148A

DomainStartEndE-ValueType
Pfam:7tm_4 28 305 9.2e-53 PFAM
Pfam:7TM_GPCR_Srsx 32 302 1.9e-5 PFAM
Pfam:7tm_1 38 287 2.4e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000122476
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174168
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 A G 13: 81,707,543 (GRCm39) F568L probably benign Het
AW112010 T A 19: 11,025,741 (GRCm39) noncoding transcript Het
Bbs4 A T 9: 59,237,729 (GRCm39) L205H probably benign Het
Bmal2 T C 6: 146,711,266 (GRCm39) V90A possibly damaging Het
C2cd2l T C 9: 44,227,878 (GRCm39) K121R probably benign Het
Car14 A G 3: 95,806,870 (GRCm39) V198A possibly damaging Het
Cd22 G T 7: 30,576,955 (GRCm39) H117Q possibly damaging Het
Celf1 T A 2: 90,829,068 (GRCm39) I45N probably damaging Het
Cluh T C 11: 74,547,997 (GRCm39) S103P probably damaging Het
Cyp39a1 T A 17: 44,002,613 (GRCm39) L276Q probably benign Het
Ddx27 T G 2: 166,857,245 (GRCm39) probably benign Het
Defb4 A T 8: 19,251,279 (GRCm39) I49F possibly damaging Het
Dock8 C A 19: 25,055,509 (GRCm39) T157K probably benign Het
Dpp6 T C 5: 27,839,541 (GRCm39) V352A probably damaging Het
Elmo2 C T 2: 165,139,312 (GRCm39) E412K probably damaging Het
Eme1 G A 11: 94,541,733 (GRCm39) P30S possibly damaging Het
Espnl G T 1: 91,272,535 (GRCm39) A632S probably benign Het
Gfod1 C A 13: 43,354,211 (GRCm39) A255S probably benign Het
Helz2 T A 2: 180,872,704 (GRCm39) K2432M probably damaging Het
Idua T C 5: 108,827,657 (GRCm39) L157P probably damaging Het
Ifi207 T A 1: 173,555,159 (GRCm39) D848V probably damaging Het
Jag1 C T 2: 136,927,858 (GRCm39) S851N possibly damaging Het
Kat6b T A 14: 21,681,415 (GRCm39) F571I probably damaging Het
Lrrc74b G A 16: 17,376,028 (GRCm39) probably benign Het
Mst1r A G 9: 107,794,026 (GRCm39) K1160E probably damaging Het
Muc19 C A 15: 91,778,192 (GRCm39) noncoding transcript Het
Nrg4 G A 9: 55,135,198 (GRCm39) probably benign Het
Ociad1 T C 5: 73,458,037 (GRCm39) I12T possibly damaging Het
Pold3 A G 7: 99,749,618 (GRCm39) probably benign Het
Psmd5 T C 2: 34,747,784 (GRCm39) E291G probably damaging Het
Ptpn23 A G 9: 110,222,781 (GRCm39) V92A possibly damaging Het
Rab44 T A 17: 29,359,490 (GRCm39) H559Q probably benign Het
Rbm6 T C 9: 107,730,051 (GRCm39) D199G probably damaging Het
Rps18-ps3 C T 8: 107,989,754 (GRCm39) noncoding transcript Het
Septin10 T C 10: 59,006,758 (GRCm39) T93A probably benign Het
Slmap T C 14: 26,184,865 (GRCm39) T111A probably damaging Het
Spata25 C T 2: 164,670,377 (GRCm39) M1I probably null Het
Spink5 T A 18: 44,100,171 (GRCm39) C63S probably damaging Het
Sycp3 T C 10: 88,302,425 (GRCm39) probably benign Het
Tarbp1 A G 8: 127,177,567 (GRCm39) probably benign Het
Thbs2 A T 17: 14,891,716 (GRCm39) N940K probably benign Het
Tmem106b A T 6: 13,081,600 (GRCm39) Q169L possibly damaging Het
Trpm6 G T 19: 18,764,120 (GRCm39) C242F probably benign Het
Ush2a T A 1: 187,999,305 (GRCm39) M205K probably benign Het
Utp18 A C 11: 93,774,617 (GRCm39) probably benign Het
Other mutations in Or1o3
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4495001:Or1o3 UTSW 17 37,573,721 (GRCm39) missense possibly damaging 0.88
R0574:Or1o3 UTSW 17 37,573,772 (GRCm39) missense probably damaging 1.00
R1490:Or1o3 UTSW 17 37,573,733 (GRCm39) missense probably benign 0.00
R1633:Or1o3 UTSW 17 37,574,553 (GRCm39) start codon destroyed probably benign 0.02
R2105:Or1o3 UTSW 17 37,573,964 (GRCm39) missense probably benign 0.26
R4996:Or1o3 UTSW 17 37,573,758 (GRCm39) missense probably benign 0.02
R5114:Or1o3 UTSW 17 37,573,730 (GRCm39) missense probably damaging 1.00
R5225:Or1o3 UTSW 17 37,573,919 (GRCm39) missense probably benign 0.30
R5338:Or1o3 UTSW 17 37,574,532 (GRCm39) missense probably benign 0.00
R5995:Or1o3 UTSW 17 37,574,539 (GRCm39) missense probably benign 0.01
R6190:Or1o3 UTSW 17 37,573,635 (GRCm39) missense probably benign 0.00
R7006:Or1o3 UTSW 17 37,573,625 (GRCm39) makesense probably null
R7246:Or1o3 UTSW 17 37,573,905 (GRCm39) missense probably benign 0.00
R7261:Or1o3 UTSW 17 37,574,076 (GRCm39) missense probably benign
R7611:Or1o3 UTSW 17 37,573,745 (GRCm39) missense probably benign 0.02
R7642:Or1o3 UTSW 17 37,573,964 (GRCm39) missense probably benign 0.26
R8837:Or1o3 UTSW 17 37,573,807 (GRCm39) nonsense probably null
R9528:Or1o3 UTSW 17 37,574,087 (GRCm39) missense probably benign 0.16
Posted On 2015-04-16