Incidental Mutation 'IGL02402:Lrrc74b'
ID291941
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lrrc74b
Ensembl Gene ENSMUSG00000022759
Gene Nameleucine rich repeat containing 74B
Synonyms4930451C15Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.204) question?
Stock #IGL02402
Quality Score
Status
Chromosome16
Chromosomal Location17544465-17561247 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) G to A at 17558164 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000155867 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023441] [ENSMUST00000023442] [ENSMUST00000065125] [ENSMUST00000100123] [ENSMUST00000171002] [ENSMUST00000231806] [ENSMUST00000232637]
Predicted Effect probably benign
Transcript: ENSMUST00000023441
SMART Domains Protein: ENSMUSP00000023441
Gene: ENSMUSG00000022758

DomainStartEndE-ValueType
low complexity region 12 18 N/A INTRINSIC
Pfam:P2X_receptor 25 385 7.9e-139 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000023442
SMART Domains Protein: ENSMUSP00000023442
Gene: ENSMUSG00000022759

DomainStartEndE-ValueType
LRR 71 103 3.9e0 SMART
LRR 104 131 1.04e-3 SMART
LRR 132 159 1.14e1 SMART
LRR 160 187 7.78e-3 SMART
LRR 188 215 3.9e0 SMART
LRR 216 243 7.89e-1 SMART
LRR 244 271 6.78e-3 SMART
LRR 272 299 5.51e-1 SMART
low complexity region 342 355 N/A INTRINSIC
Predicted Effect
SMART Domains Protein: ENSMUSP00000070127
Gene: ENSMUSG00000022759

DomainStartEndE-ValueType
LRR 71 103 3.9e0 SMART
LRR 104 131 1.04e-3 SMART
LRR 132 159 1.14e1 SMART
LRR 160 187 7.78e-3 SMART
LRR 188 215 3.9e0 SMART
LRR 216 243 7.89e-1 SMART
LRR 244 271 6.78e-3 SMART
LRR 272 299 5.51e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000100123
SMART Domains Protein: ENSMUSP00000097699
Gene: ENSMUSG00000022759

DomainStartEndE-ValueType
LRR 71 103 3.9e0 SMART
LRR 104 131 1.04e-3 SMART
LRR 132 159 1.14e1 SMART
LRR 160 187 7.78e-3 SMART
LRR 188 215 3.9e0 SMART
LRR 216 243 7.89e-1 SMART
LRR 244 271 6.78e-3 SMART
LRR 272 299 5.51e-1 SMART
LRR 300 327 4.16e0 SMART
low complexity region 374 387 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138839
Predicted Effect probably benign
Transcript: ENSMUST00000171002
SMART Domains Protein: ENSMUSP00000132727
Gene: ENSMUSG00000022758

DomainStartEndE-ValueType
low complexity region 12 18 N/A INTRINSIC
Pfam:P2X_receptor 25 197 1e-65 PFAM
Pfam:P2X_receptor 185 362 7e-63 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000231806
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232230
Predicted Effect probably benign
Transcript: ENSMUST00000232637
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 A G 13: 81,559,424 F568L probably benign Het
Arntl2 T C 6: 146,809,768 V90A possibly damaging Het
AW112010 T A 19: 11,048,377 noncoding transcript Het
Bbs4 A T 9: 59,330,446 L205H probably benign Het
C2cd2l T C 9: 44,316,581 K121R probably benign Het
Car14 A G 3: 95,899,558 V198A possibly damaging Het
Cd22 G T 7: 30,877,530 H117Q possibly damaging Het
Celf1 T A 2: 90,998,723 I45N probably damaging Het
Cluh T C 11: 74,657,171 S103P probably damaging Het
Cyp39a1 T A 17: 43,691,722 L276Q probably benign Het
Ddx27 T G 2: 167,015,325 probably benign Het
Defb4 A T 8: 19,201,263 I49F possibly damaging Het
Dock8 C A 19: 25,078,145 T157K probably benign Het
Dpp6 T C 5: 27,634,543 V352A probably damaging Het
Elmo2 C T 2: 165,297,392 E412K probably damaging Het
Eme1 G A 11: 94,650,907 P30S possibly damaging Het
Espnl G T 1: 91,344,813 A632S probably benign Het
Gfod1 C A 13: 43,200,735 A255S probably benign Het
Helz2 T A 2: 181,230,911 K2432M probably damaging Het
Idua T C 5: 108,679,791 L157P probably damaging Het
Ifi207 T A 1: 173,727,593 D848V probably damaging Het
Jag1 C T 2: 137,085,938 S851N possibly damaging Het
Kat6b T A 14: 21,631,347 F571I probably damaging Het
Mst1r A G 9: 107,916,827 K1160E probably damaging Het
Muc19 C A 15: 91,893,998 noncoding transcript Het
Nrg4 G A 9: 55,227,914 probably benign Het
Ociad1 T C 5: 73,300,694 I12T possibly damaging Het
Olfr98 A G 17: 37,263,220 V148A possibly damaging Het
Pold3 A G 7: 100,100,411 probably benign Het
Psmd5 T C 2: 34,857,772 E291G probably damaging Het
Ptpn23 A G 9: 110,393,713 V92A possibly damaging Het
Rab44 T A 17: 29,140,516 H559Q probably benign Het
Rbm6 T C 9: 107,852,852 D199G probably damaging Het
Rps18-ps3 C T 8: 107,263,122 noncoding transcript Het
Sept10 T C 10: 59,170,936 T93A probably benign Het
Slmap T C 14: 26,463,710 T111A probably damaging Het
Spata25 C T 2: 164,828,457 M1I probably null Het
Spink5 T A 18: 43,967,104 C63S probably damaging Het
Sycp3 T C 10: 88,466,563 probably benign Het
Tarbp1 A G 8: 126,450,828 probably benign Het
Thbs2 A T 17: 14,671,454 N940K probably benign Het
Tmem106b A T 6: 13,081,601 Q169L possibly damaging Het
Trpm6 G T 19: 18,786,756 C242F probably benign Het
Ush2a T A 1: 188,267,108 M205K probably benign Het
Utp18 A C 11: 93,883,791 probably benign Het
Other mutations in Lrrc74b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01810:Lrrc74b APN 16 17545558 missense probably benign 0.00
P0043:Lrrc74b UTSW 16 17558159 splice site probably benign
R0131:Lrrc74b UTSW 16 17553152 missense probably damaging 1.00
R0131:Lrrc74b UTSW 16 17553152 missense probably damaging 1.00
R0132:Lrrc74b UTSW 16 17553152 missense probably damaging 1.00
R0829:Lrrc74b UTSW 16 17558390 splice site probably benign
R1463:Lrrc74b UTSW 16 17559873 missense probably benign 0.00
R1681:Lrrc74b UTSW 16 17559753 missense probably damaging 1.00
R1938:Lrrc74b UTSW 16 17553194 missense probably benign 0.41
R4790:Lrrc74b UTSW 16 17549853 missense probably damaging 1.00
R5428:Lrrc74b UTSW 16 17558261 missense probably damaging 0.99
R6198:Lrrc74b UTSW 16 17548786 missense probably damaging 0.96
R7910:Lrrc74b UTSW 16 17558349 nonsense probably null
R7991:Lrrc74b UTSW 16 17558349 nonsense probably null
X0063:Lrrc74b UTSW 16 17553208 missense probably benign 0.05
Z1177:Lrrc74b UTSW 16 17558168 critical splice donor site probably null
Z1177:Lrrc74b UTSW 16 17558172 missense probably damaging 1.00
Posted On2015-04-16