Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02403:Chst2'

291963

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Chst2

Ensembl Gene

ENSMUSG00000033350

Gene Name

carbohydrate sulfotransferase 2

Synonyms

C130041E03Rik, N-acetylglucosamine-6-O-sulfotransferase, Gn6st, GST-2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.082) question?

Stock #

IGL02403

Quality Score

Status

Chromosome

Chromosomal Location

95282979-95289323 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 95287285 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 354 (Q354*)

Ref Sequence

ENSEMBL: ENSMUSP00000040775 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000036267]

AlphaFold

Q80WV3

Predicted Effect

probably null
Transcript: ENSMUST00000036267
AA Change: Q354*

SMART Domains

Protein: ENSMUSP00000040775
Gene: ENSMUSG00000033350
AA Change: Q354*

Domain	Start	End	E-Value	Type
low complexity region	6	45	N/A	INTRINSIC
transmembrane domain	55	74	N/A	INTRINSIC
low complexity region	88	114	N/A	INTRINSIC
low complexity region	129	149	N/A	INTRINSIC
Pfam:Sulfotransfer_1	164	507	7e-27	PFAM
Pfam:Sulfotransfer_3	165	446	6.6e-18	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000192612

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This locus encodes a sulfotransferase protein. The encoded enzyme catalyzes the sulfation of a nonreducing N-acetylglucosamine residue, and may play a role in biosynthesis of 6-sulfosialyl Lewis X antigen. [provided by RefSeq, Aug 2011]
PHENOTYPE: Mice homozygous for a knock-out allele display decreased lymphocyte binding to peripheral lymph node high endothelial venules, and significantly reduced lymphocyte homing to Peyer's patches, peripheral and mesenteric lymph nodes. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc8	A	G	7: 45,755,227 (GRCm39)		probably null	Het
Alk	C	A	17: 72,208,388 (GRCm39)	G944V	probably damaging	Het
Alox15	T	C	11: 70,236,727 (GRCm39)	D446G	probably damaging	Het
Apof	A	G	10: 128,105,353 (GRCm39)		probably null	Het
Arhgap28	T	G	17: 68,180,154 (GRCm39)	D81A	possibly damaging	Het
Bltp1	T	C	3: 37,084,813 (GRCm39)	S3922P	probably benign	Het
Bms1	T	C	6: 118,382,185 (GRCm39)	E451G	possibly damaging	Het
C9orf72	A	G	4: 35,205,887 (GRCm39)		probably benign	Het
Capn13	T	A	17: 73,658,421 (GRCm39)	T216S	possibly damaging	Het
Ccdc28a	A	T	10: 18,089,931 (GRCm39)		probably benign	Het
Cdip1	T	C	16: 4,586,676 (GRCm39)	T150A	probably damaging	Het
Chrnb3	T	A	8: 27,883,836 (GRCm39)	L191Q	probably damaging	Het
Cldn11	T	C	3: 31,204,345 (GRCm39)	V16A	probably benign	Het
Cyp4f18	A	G	8: 72,752,072 (GRCm39)	M198T	probably damaging	Het
Dhx30	A	G	9: 109,920,587 (GRCm39)	L280P	probably damaging	Het
Disc1	A	G	8: 125,862,258 (GRCm39)		probably benign	Het
Dnm1l	T	C	16: 16,154,840 (GRCm39)	I172V	possibly damaging	Het
Edem2	T	C	2: 155,550,983 (GRCm39)	D328G	possibly damaging	Het
Fbxo10	G	A	4: 45,062,517 (GRCm39)	T3M	probably benign	Het
Fdxacb1	T	A	9: 50,682,863 (GRCm39)	S275R	possibly damaging	Het
Gm7275	C	A	16: 47,893,991 (GRCm39)		noncoding transcript	Het
Helz2	A	T	2: 180,872,815 (GRCm39)	I2468N	probably damaging	Het
Ift46	C	A	9: 44,698,176 (GRCm39)	P213Q	probably damaging	Het
Ift56	A	G	6: 38,386,373 (GRCm39)	M365V	possibly damaging	Het
Irf2	G	T	8: 47,299,207 (GRCm39)	V334F	probably damaging	Het
Lrp4	T	A	2: 91,338,927 (GRCm39)	V1786E	probably benign	Het
Mfsd5	A	G	15: 102,188,973 (GRCm39)	Y115C	probably benign	Het
Muc5ac	A	G	7: 141,357,187 (GRCm39)	R1154G	possibly damaging	Het
Nek4	G	T	14: 30,686,008 (GRCm39)	E314*	probably null	Het
Oas2	C	T	5: 120,886,815 (GRCm39)	G117D	possibly damaging	Het
Or8j3b	A	T	2: 86,204,867 (GRCm39)	D296E	probably benign	Het
Pikfyve	C	T	1: 65,283,663 (GRCm39)	H767Y	probably damaging	Het
Pkhd1	T	C	1: 20,632,642 (GRCm39)	H591R	probably benign	Het
Pygl	T	A	12: 70,241,032 (GRCm39)	I672F	probably benign	Het
Rft1	G	T	14: 30,382,278 (GRCm39)		probably benign	Het
Ripor3	A	C	2: 167,831,250 (GRCm39)	L517R	probably damaging	Het
Serpina3b	A	G	12: 104,096,721 (GRCm39)	M1V	probably null	Het
Sgce	C	T	6: 4,694,059 (GRCm39)	R263Q	probably damaging	Het
Stard6	A	T	18: 70,629,183 (GRCm39)		probably null	Het
Them4	T	C	3: 94,230,978 (GRCm39)	F117L	probably damaging	Het
Tmem214	G	A	5: 31,030,090 (GRCm39)	A296T	probably benign	Het
Vmn2r116	G	T	17: 23,606,338 (GRCm39)	D417Y	probably damaging	Het

Other mutations in Chst2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R1240:Chst2	UTSW	9	95,287,536 (GRCm39)	missense	possibly damaging	0.68
R1537:Chst2	UTSW	9	95,288,194 (GRCm39)	missense	probably benign	0.04
R1884:Chst2	UTSW	9	95,287,611 (GRCm39)	missense	probably damaging	1.00
R2355:Chst2	UTSW	9	95,288,148 (GRCm39)	missense	probably damaging	0.99
R4576:Chst2	UTSW	9	95,287,224 (GRCm39)	missense	probably damaging	0.99
R4818:Chst2	UTSW	9	95,287,417 (GRCm39)	missense	probably damaging	1.00
R4928:Chst2	UTSW	9	95,288,059 (GRCm39)	missense	probably benign	0.10
R5366:Chst2	UTSW	9	95,287,518 (GRCm39)	missense	probably damaging	1.00
R5703:Chst2	UTSW	9	95,286,985 (GRCm39)	missense	probably damaging	0.99
R5902:Chst2	UTSW	9	95,287,662 (GRCm39)	missense	probably damaging	1.00
R6339:Chst2	UTSW	9	95,287,803 (GRCm39)	missense	probably damaging	1.00
R6752:Chst2	UTSW	9	95,286,802 (GRCm39)	nonsense	probably null
R7063:Chst2	UTSW	9	95,287,621 (GRCm39)	missense	probably benign	0.28
R8061:Chst2	UTSW	9	95,287,224 (GRCm39)	missense	probably damaging	0.99
R9008:Chst2	UTSW	9	95,288,347 (GRCm39)	start gained	probably benign
R9204:Chst2	UTSW	9	95,287,155 (GRCm39)	missense	probably damaging	0.99
R9400:Chst2	UTSW	9	95,287,642 (GRCm39)	missense	probably benign	0.14
R9732:Chst2	UTSW	9	95,287,951 (GRCm39)	missense	probably benign	0.02
Z1177:Chst2	UTSW	9	95,286,894 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16