Incidental Mutation 'IGL02403:Alox15'
ID 291979
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Alox15
Ensembl Gene ENSMUSG00000018924
Gene Name arachidonate 15-lipoxygenase
Synonyms Alox12l, 12-LO, L-12LO
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02403
Quality Score
Status
Chromosome 11
Chromosomal Location 70234978-70242857 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 70236727 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 446 (D446G)
Ref Sequence ENSEMBL: ENSMUSP00000019068 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019068]
AlphaFold P39654
Predicted Effect probably damaging
Transcript: ENSMUST00000019068
AA Change: D446G

PolyPhen 2 Score 0.962 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000019068
Gene: ENSMUSG00000018924
AA Change: D446G

DomainStartEndE-ValueType
LH2 2 112 2.18e-37 SMART
low complexity region 124 141 N/A INTRINSIC
Pfam:Lipoxygenase 156 649 1.8e-63 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130000
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele show altered arachidonic acid metabolism and develop a myeloproliferative disorder associated with splenomegaly, abnormal splenic architecture, leukocystosis, basophilia, abnormal lymph node morphology, dermatitis, and premature death likely due to anemia. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc8 A G 7: 45,755,227 (GRCm39) probably null Het
Alk C A 17: 72,208,388 (GRCm39) G944V probably damaging Het
Apof A G 10: 128,105,353 (GRCm39) probably null Het
Arhgap28 T G 17: 68,180,154 (GRCm39) D81A possibly damaging Het
Bltp1 T C 3: 37,084,813 (GRCm39) S3922P probably benign Het
Bms1 T C 6: 118,382,185 (GRCm39) E451G possibly damaging Het
C9orf72 A G 4: 35,205,887 (GRCm39) probably benign Het
Capn13 T A 17: 73,658,421 (GRCm39) T216S possibly damaging Het
Ccdc28a A T 10: 18,089,931 (GRCm39) probably benign Het
Cdip1 T C 16: 4,586,676 (GRCm39) T150A probably damaging Het
Chrnb3 T A 8: 27,883,836 (GRCm39) L191Q probably damaging Het
Chst2 G A 9: 95,287,285 (GRCm39) Q354* probably null Het
Cldn11 T C 3: 31,204,345 (GRCm39) V16A probably benign Het
Cyp4f18 A G 8: 72,752,072 (GRCm39) M198T probably damaging Het
Dhx30 A G 9: 109,920,587 (GRCm39) L280P probably damaging Het
Disc1 A G 8: 125,862,258 (GRCm39) probably benign Het
Dnm1l T C 16: 16,154,840 (GRCm39) I172V possibly damaging Het
Edem2 T C 2: 155,550,983 (GRCm39) D328G possibly damaging Het
Fbxo10 G A 4: 45,062,517 (GRCm39) T3M probably benign Het
Fdxacb1 T A 9: 50,682,863 (GRCm39) S275R possibly damaging Het
Gm7275 C A 16: 47,893,991 (GRCm39) noncoding transcript Het
Helz2 A T 2: 180,872,815 (GRCm39) I2468N probably damaging Het
Ift46 C A 9: 44,698,176 (GRCm39) P213Q probably damaging Het
Ift56 A G 6: 38,386,373 (GRCm39) M365V possibly damaging Het
Irf2 G T 8: 47,299,207 (GRCm39) V334F probably damaging Het
Lrp4 T A 2: 91,338,927 (GRCm39) V1786E probably benign Het
Mfsd5 A G 15: 102,188,973 (GRCm39) Y115C probably benign Het
Muc5ac A G 7: 141,357,187 (GRCm39) R1154G possibly damaging Het
Nek4 G T 14: 30,686,008 (GRCm39) E314* probably null Het
Oas2 C T 5: 120,886,815 (GRCm39) G117D possibly damaging Het
Or8j3b A T 2: 86,204,867 (GRCm39) D296E probably benign Het
Pikfyve C T 1: 65,283,663 (GRCm39) H767Y probably damaging Het
Pkhd1 T C 1: 20,632,642 (GRCm39) H591R probably benign Het
Pygl T A 12: 70,241,032 (GRCm39) I672F probably benign Het
Rft1 G T 14: 30,382,278 (GRCm39) probably benign Het
Ripor3 A C 2: 167,831,250 (GRCm39) L517R probably damaging Het
Serpina3b A G 12: 104,096,721 (GRCm39) M1V probably null Het
Sgce C T 6: 4,694,059 (GRCm39) R263Q probably damaging Het
Stard6 A T 18: 70,629,183 (GRCm39) probably null Het
Them4 T C 3: 94,230,978 (GRCm39) F117L probably damaging Het
Tmem214 G A 5: 31,030,090 (GRCm39) A296T probably benign Het
Vmn2r116 G T 17: 23,606,338 (GRCm39) D417Y probably damaging Het
Other mutations in Alox15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01364:Alox15 APN 11 70,235,992 (GRCm39) missense possibly damaging 0.95
IGL02231:Alox15 APN 11 70,240,382 (GRCm39) missense probably benign
IGL03377:Alox15 APN 11 70,240,488 (GRCm39) missense probably damaging 1.00
R0011:Alox15 UTSW 11 70,240,422 (GRCm39) missense possibly damaging 0.66
R0013:Alox15 UTSW 11 70,240,461 (GRCm39) missense possibly damaging 0.95
R0267:Alox15 UTSW 11 70,236,979 (GRCm39) missense probably damaging 0.99
R0646:Alox15 UTSW 11 70,236,450 (GRCm39) nonsense probably null
R0726:Alox15 UTSW 11 70,241,021 (GRCm39) missense probably damaging 1.00
R1553:Alox15 UTSW 11 70,240,458 (GRCm39) missense possibly damaging 0.46
R1687:Alox15 UTSW 11 70,240,744 (GRCm39) missense probably benign 0.10
R1848:Alox15 UTSW 11 70,241,578 (GRCm39) missense probably damaging 0.99
R1974:Alox15 UTSW 11 70,240,799 (GRCm39) missense probably benign 0.06
R3113:Alox15 UTSW 11 70,235,703 (GRCm39) missense probably benign 0.20
R4551:Alox15 UTSW 11 70,235,422 (GRCm39) missense probably benign
R5511:Alox15 UTSW 11 70,240,808 (GRCm39) missense probably benign 0.00
R5809:Alox15 UTSW 11 70,241,708 (GRCm39) missense probably damaging 1.00
R6479:Alox15 UTSW 11 70,236,011 (GRCm39) missense probably damaging 0.98
R6800:Alox15 UTSW 11 70,235,645 (GRCm39) critical splice donor site probably null
R7243:Alox15 UTSW 11 70,241,540 (GRCm39) missense probably null 1.00
R7253:Alox15 UTSW 11 70,236,724 (GRCm39) missense probably damaging 1.00
R7644:Alox15 UTSW 11 70,236,368 (GRCm39) missense probably null 1.00
R7712:Alox15 UTSW 11 70,241,079 (GRCm39) critical splice acceptor site probably null
R7823:Alox15 UTSW 11 70,235,494 (GRCm39) missense possibly damaging 0.86
R8192:Alox15 UTSW 11 70,241,736 (GRCm39) missense probably benign 0.38
R8410:Alox15 UTSW 11 70,235,753 (GRCm39) missense probably benign 0.25
R8765:Alox15 UTSW 11 70,240,819 (GRCm39) missense probably benign 0.00
R9256:Alox15 UTSW 11 70,236,370 (GRCm39) missense possibly damaging 0.49
R9361:Alox15 UTSW 11 70,241,679 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16