Incidental Mutation 'IGL02406:Myrip'
ID 292058
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Myrip
Ensembl Gene ENSMUSG00000041794
Gene Name myosin VIIA and Rab interacting protein
Synonyms A230081N12Rik, Slac2-c
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02406
Quality Score
Status
Chromosome 9
Chromosomal Location 120132996-120305167 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 120296598 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 836 (T836S)
Ref Sequence ENSEMBL: ENSMUSP00000046891 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048121]
AlphaFold Q8K3I4
Predicted Effect probably benign
Transcript: ENSMUST00000048121
AA Change: T836S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000046891
Gene: ENSMUSG00000041794
AA Change: T836S

DomainStartEndE-ValueType
Pfam:FYVE_2 8 125 3.8e-46 PFAM
Pfam:Rab_eff_C 152 856 N/A PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 G T 7: 120,139,825 (GRCm39) A1496S probably damaging Het
Abra A T 15: 41,732,583 (GRCm39) V161E probably damaging Het
Adcy4 G A 14: 56,007,504 (GRCm39) T942I possibly damaging Het
Atrip A G 9: 108,894,487 (GRCm39) V480A probably damaging Het
Azin1 A T 15: 38,491,809 (GRCm39) D382E probably benign Het
BC034090 G T 1: 155,100,899 (GRCm39) A455E probably benign Het
Clstn1 A G 4: 149,711,816 (GRCm39) Y121C probably damaging Het
Cpq T A 15: 33,302,654 (GRCm39) N268K probably damaging Het
Cpsf7 A G 19: 10,509,352 (GRCm39) S88G probably damaging Het
Csgalnact1 C A 8: 68,854,144 (GRCm39) G219V probably damaging Het
Cyp2j11 G A 4: 96,236,776 (GRCm39) A10V possibly damaging Het
Dock4 T C 12: 40,827,206 (GRCm39) V983A probably benign Het
Dspp G T 5: 104,325,232 (GRCm39) E532* probably null Het
Ercc4 G T 16: 12,941,400 (GRCm39) D243Y probably damaging Het
Fars2 C A 13: 36,594,145 (GRCm39) D383E probably benign Het
Fip1l1 A G 5: 74,725,205 (GRCm39) T280A probably benign Het
Gcgr T G 11: 120,428,010 (GRCm39) N292K probably damaging Het
Gtpbp4 T A 13: 9,041,786 (GRCm39) K85M possibly damaging Het
Jhy A G 9: 40,822,285 (GRCm39) Y618H probably damaging Het
Mbd4 A T 6: 115,825,986 (GRCm39) I314N possibly damaging Het
Mbtd1 C T 11: 93,799,684 (GRCm39) T70M probably damaging Het
Mki67 T C 7: 135,300,522 (GRCm39) H1504R probably benign Het
Mks1 T C 11: 87,753,611 (GRCm39) V515A probably benign Het
Msantd2 G T 9: 37,434,755 (GRCm39) V332L probably damaging Het
Nbea T C 3: 55,993,687 (GRCm39) I238V probably benign Het
Plekhh1 T C 12: 79,115,783 (GRCm39) probably benign Het
Prkdc A G 16: 15,488,399 (GRCm39) N507S probably benign Het
Prss12 G A 3: 123,299,123 (GRCm39) V632I possibly damaging Het
Puf60 A G 15: 75,946,458 (GRCm39) S121P probably damaging Het
Raet1e G A 10: 22,056,535 (GRCm39) C37Y probably damaging Het
Ralgps2 G T 1: 156,655,838 (GRCm39) A362E possibly damaging Het
Scn1a A G 2: 66,156,380 (GRCm39) S510P possibly damaging Het
Skap2 A C 6: 51,851,453 (GRCm39) probably null Het
Slc4a10 G A 2: 62,021,113 (GRCm39) V54M probably benign Het
Spata17 A G 1: 186,849,458 (GRCm39) probably null Het
Stoml3 T A 3: 53,410,671 (GRCm39) N128K probably damaging Het
Tatdn2 T A 6: 113,681,174 (GRCm39) S402R probably benign Het
Tmprss11f A G 5: 86,681,525 (GRCm39) W243R probably damaging Het
Vmn2r32 A G 7: 7,479,709 (GRCm39) Y155H probably benign Het
Vmn2r86 T A 10: 130,284,508 (GRCm39) T528S possibly damaging Het
Zfhx3 C T 8: 109,682,374 (GRCm39) A3271V unknown Het
Zkscan3 T C 13: 21,572,348 (GRCm39) N428S possibly damaging Het
Zxdc A G 6: 90,375,818 (GRCm39) S765G probably benign Het
Other mutations in Myrip
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01924:Myrip APN 9 120,217,330 (GRCm39) missense probably damaging 1.00
IGL02108:Myrip APN 9 120,296,631 (GRCm39) critical splice donor site probably null
IGL02876:Myrip APN 9 120,261,740 (GRCm39) missense probably damaging 1.00
IGL03109:Myrip APN 9 120,282,790 (GRCm39) splice site probably null
IGL03258:Myrip APN 9 120,270,418 (GRCm39) missense probably benign 0.45
PIT4581001:Myrip UTSW 9 120,296,583 (GRCm39) missense probably damaging 0.98
R0485:Myrip UTSW 9 120,270,443 (GRCm39) missense probably benign 0.01
R0633:Myrip UTSW 9 120,217,302 (GRCm39) missense probably damaging 1.00
R1489:Myrip UTSW 9 120,261,595 (GRCm39) missense probably damaging 1.00
R1539:Myrip UTSW 9 120,253,689 (GRCm39) missense probably benign 0.00
R1708:Myrip UTSW 9 120,293,840 (GRCm39) missense possibly damaging 0.65
R1817:Myrip UTSW 9 120,217,228 (GRCm39) missense probably damaging 1.00
R1818:Myrip UTSW 9 120,217,228 (GRCm39) missense probably damaging 1.00
R1878:Myrip UTSW 9 120,253,721 (GRCm39) missense probably damaging 0.99
R2484:Myrip UTSW 9 120,253,685 (GRCm39) missense probably benign 0.00
R3237:Myrip UTSW 9 120,270,473 (GRCm39) missense possibly damaging 0.91
R3890:Myrip UTSW 9 120,251,324 (GRCm39) missense probably damaging 1.00
R3912:Myrip UTSW 9 120,261,682 (GRCm39) missense probably benign
R3919:Myrip UTSW 9 120,261,695 (GRCm39) missense probably damaging 1.00
R4125:Myrip UTSW 9 120,293,764 (GRCm39) nonsense probably null
R4126:Myrip UTSW 9 120,293,764 (GRCm39) nonsense probably null
R4128:Myrip UTSW 9 120,293,764 (GRCm39) nonsense probably null
R4435:Myrip UTSW 9 120,164,680 (GRCm39) start gained probably benign
R4599:Myrip UTSW 9 120,293,850 (GRCm39) missense probably damaging 0.97
R5014:Myrip UTSW 9 120,251,534 (GRCm39) missense probably damaging 1.00
R5665:Myrip UTSW 9 120,290,499 (GRCm39) missense probably damaging 1.00
R5814:Myrip UTSW 9 120,253,734 (GRCm39) missense probably benign 0.06
R5849:Myrip UTSW 9 120,282,759 (GRCm39) missense probably damaging 0.99
R5986:Myrip UTSW 9 120,290,487 (GRCm39) missense probably damaging 1.00
R6706:Myrip UTSW 9 120,217,359 (GRCm39) missense possibly damaging 0.93
R7019:Myrip UTSW 9 120,251,573 (GRCm39) missense probably damaging 1.00
R7291:Myrip UTSW 9 120,246,207 (GRCm39) missense probably damaging 0.97
R8204:Myrip UTSW 9 120,262,045 (GRCm39) critical splice donor site probably null
R8557:Myrip UTSW 9 120,246,252 (GRCm39) missense probably benign 0.32
R8853:Myrip UTSW 9 120,290,487 (GRCm39) missense probably damaging 1.00
R8911:Myrip UTSW 9 120,270,484 (GRCm39) missense possibly damaging 0.94
R9106:Myrip UTSW 9 120,261,544 (GRCm39) missense probably benign 0.37
R9225:Myrip UTSW 9 120,293,850 (GRCm39) missense probably damaging 0.97
Z1177:Myrip UTSW 9 120,270,547 (GRCm39) missense probably damaging 1.00
Z1177:Myrip UTSW 9 120,261,844 (GRCm39) missense probably benign
Posted On 2015-04-16