Incidental Mutation 'IGL02406:Abra'
ID292085
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Abra
Ensembl Gene ENSMUSG00000042895
Gene Nameactin-binding Rho activating protein
SynonymsSTARS, C130068O12Rik
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.339) question?
Stock #IGL02406
Quality Score
Status
Chromosome15
Chromosomal Location41864076-41869720 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 41869187 bp
ZygosityHeterozygous
Amino Acid Change Valine to Glutamic Acid at position 161 (V161E)
Ref Sequence ENSEMBL: ENSMUSP00000051973 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054742]
Predicted Effect probably damaging
Transcript: ENSMUST00000054742
AA Change: V161E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000051973
Gene: ENSMUSG00000042895
AA Change: V161E

DomainStartEndE-ValueType
Costars 298 374 6.22e-45 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired arteriogenesis following occlusion. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 G T 7: 120,540,602 A1496S probably damaging Het
Adcy4 G A 14: 55,770,047 T942I possibly damaging Het
Atrip A G 9: 109,065,419 V480A probably damaging Het
Azin1 A T 15: 38,491,565 D382E probably benign Het
BC034090 G T 1: 155,225,153 A455E probably benign Het
Clstn1 A G 4: 149,627,359 Y121C probably damaging Het
Cpq T A 15: 33,302,508 N268K probably damaging Het
Cpsf7 A G 19: 10,531,988 S88G probably damaging Het
Csgalnact1 C A 8: 68,401,492 G219V probably damaging Het
Cyp2j11 G A 4: 96,348,539 A10V possibly damaging Het
Dock4 T C 12: 40,777,207 V983A probably benign Het
Dspp G T 5: 104,177,366 E532* probably null Het
Ercc4 G T 16: 13,123,536 D243Y probably damaging Het
Fars2 C A 13: 36,410,162 D383E probably benign Het
Fip1l1 A G 5: 74,564,544 T280A probably benign Het
Gcgr T G 11: 120,537,184 N292K probably damaging Het
Gtpbp4 T A 13: 8,991,750 K85M possibly damaging Het
Jhy A G 9: 40,910,989 Y618H probably damaging Het
Mbd4 A T 6: 115,849,025 I314N possibly damaging Het
Mbtd1 C T 11: 93,908,858 T70M probably damaging Het
Mki67 T C 7: 135,698,793 H1504R probably benign Het
Mks1 T C 11: 87,862,785 V515A probably benign Het
Msantd2 G T 9: 37,523,459 V332L probably damaging Het
Myrip A T 9: 120,467,532 T836S probably benign Het
Nbea T C 3: 56,086,266 I238V probably benign Het
Plekhh1 T C 12: 79,069,009 probably benign Het
Prkdc A G 16: 15,670,535 N507S probably benign Het
Prss12 G A 3: 123,505,474 V632I possibly damaging Het
Puf60 A G 15: 76,074,609 S121P probably damaging Het
Raet1e G A 10: 22,180,636 C37Y probably damaging Het
Ralgps2 G T 1: 156,828,268 A362E possibly damaging Het
Scn1a A G 2: 66,326,036 S510P possibly damaging Het
Skap2 A C 6: 51,874,473 probably null Het
Slc4a10 G A 2: 62,190,769 V54M probably benign Het
Spata17 A G 1: 187,117,261 probably null Het
Stoml3 T A 3: 53,503,250 N128K probably damaging Het
Tatdn2 T A 6: 113,704,213 S402R probably benign Het
Tmprss11f A G 5: 86,533,666 W243R probably damaging Het
Vmn2r32 A G 7: 7,476,710 Y155H probably benign Het
Vmn2r86 T A 10: 130,448,639 T528S possibly damaging Het
Zfhx3 C T 8: 108,955,742 A3271V unknown Het
Zkscan3 T C 13: 21,388,178 N428S possibly damaging Het
Zxdc A G 6: 90,398,836 S765G probably benign Het
Other mutations in Abra
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01512:Abra APN 15 41866017 missense probably damaging 0.99
IGL02022:Abra APN 15 41869406 missense probably benign
IGL02370:Abra APN 15 41869244 missense probably damaging 1.00
R1860:Abra UTSW 15 41869034 missense probably damaging 1.00
R1861:Abra UTSW 15 41869034 missense probably damaging 1.00
R2385:Abra UTSW 15 41869353 missense probably damaging 0.97
R3718:Abra UTSW 15 41866293 missense probably benign
R4582:Abra UTSW 15 41869285 missense probably benign 0.16
R4621:Abra UTSW 15 41869224 missense probably benign 0.10
R4724:Abra UTSW 15 41865906 missense probably damaging 1.00
R5926:Abra UTSW 15 41866254 missense probably damaging 1.00
R6417:Abra UTSW 15 41866056 missense probably benign 0.01
R6649:Abra UTSW 15 41869233 missense probably benign
R7348:Abra UTSW 15 41866159 missense probably damaging 1.00
R7487:Abra UTSW 15 41869553 missense probably damaging 1.00
R7997:Abra UTSW 15 41866197 missense probably damaging 1.00
RF053:Abra UTSW 15 41866299 small deletion probably benign
Posted On2015-04-16