Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02407:Zfp563'

292133

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp563

Ensembl Gene

ENSMUSG00000067424

Gene Name

zinc finger protein 563

Synonyms

zinc finger protein, Zfp413

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

IGL02407

Quality Score

Status

Chromosome

Chromosomal Location

33308284-33329679 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 33323795 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Glutamine at position 130 (R130Q)

Ref Sequence

ENSEMBL: ENSMUSP00000121678 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000131722] [ENSMUST00000140829]

AlphaFold

B8JJZ9

Predicted Effect

probably benign
Transcript: ENSMUST00000131722
AA Change: R130Q

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000118809
Gene: ENSMUSG00000067424
AA Change: R130Q

Domain	Start	End	E-Value	Type
KRAB	4	61	5.45e-16	SMART
ZnF_C2H2	141	163	2.63e2	SMART
ZnF_C2H2	169	191	9.08e-4	SMART
ZnF_C2H2	197	219	9.88e-5	SMART
ZnF_C2H2	225	247	3.16e-3	SMART
ZnF_C2H2	253	275	5.81e-2	SMART
ZnF_C2H2	281	303	2.4e-3	SMART
ZnF_C2H2	309	331	1.82e-3	SMART
ZnF_C2H2	337	359	1.72e-4	SMART
ZnF_C2H2	365	387	4.54e-4	SMART
ZnF_C2H2	393	415	7.78e-3	SMART
ZnF_C2H2	421	443	3.63e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000140829
AA Change: R130Q

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

SMART Domains

Protein: ENSMUSP00000121678
Gene: ENSMUSG00000067424
AA Change: R130Q

Domain	Start	End	E-Value	Type
KRAB	4	61	5.45e-16	SMART
ZnF_C2H2	141	163	2.63e2	SMART
ZnF_C2H2	169	191	9.08e-4	SMART
Pfam:zf-C2H2_4	197	209	9.4e-2	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000153072

SMART Domains

Protein: ENSMUSP00000119142
Gene: ENSMUSG00000067424

Domain	Start	End	E-Value	Type
low complexity region	30	41	N/A	INTRINSIC
KRAB	45	102	5.45e-16	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	G	A	6: 121,645,575 (GRCm39)	W1040*	probably null	Het
Adgrv1	C	A	13: 81,627,789 (GRCm39)	A3691S	probably damaging	Het
Als2cl	T	A	9: 110,718,295 (GRCm39)	Y345*	probably null	Het
Aplp2	A	T	9: 31,069,823 (GRCm39)	Y496*	probably null	Het
Ash1l	T	C	3: 88,979,855 (GRCm39)	V2793A	probably damaging	Het
Bfsp1	A	T	2: 143,668,853 (GRCm39)	D575E	probably benign	Het
Ceacam20	G	T	7: 19,704,332 (GRCm39)	V128F	probably benign	Het
Cers4	A	T	8: 4,570,306 (GRCm39)	K204*	probably null	Het
Cog1	T	C	11: 113,544,852 (GRCm39)	Y345H	probably benign	Het
Col14a1	T	C	15: 55,312,272 (GRCm39)		probably benign	Het
Col19a1	A	T	1: 24,351,453 (GRCm39)		probably null	Het
Ctnnd2	T	A	15: 30,966,914 (GRCm39)	M955K	probably damaging	Het
Cyp3a16	A	T	5: 145,388,652 (GRCm39)	M275K	probably damaging	Het
Degs2	T	G	12: 108,658,254 (GRCm39)	T242P	probably damaging	Het
Elac2	T	C	11: 64,890,001 (GRCm39)	V612A	probably benign	Het
Elovl6	T	A	3: 129,398,733 (GRCm39)	F45I	probably damaging	Het
Exoc1	A	C	5: 76,693,193 (GRCm39)	N360H	probably damaging	Het
Fam221b	A	T	4: 43,666,309 (GRCm39)	S101T	possibly damaging	Het
Garre1	A	T	7: 33,955,909 (GRCm39)	N393K	probably damaging	Het
Glyr1	A	G	16: 4,854,812 (GRCm39)	F89L	probably benign	Het
Herc4	C	A	10: 63,142,203 (GRCm39)	T668K	probably damaging	Het
Hibadh	C	T	6: 52,525,874 (GRCm39)	V259I	possibly damaging	Het
Hp1bp3	T	A	4: 137,967,983 (GRCm39)	D397E	probably damaging	Het
Ift80	G	T	3: 68,805,869 (GRCm39)	D724E	probably benign	Het
Igkv3-10	T	C	6: 70,550,223 (GRCm39)		probably benign	Het
Irf9	G	T	14: 55,842,678 (GRCm39)	A75S	possibly damaging	Het
Kif13a	C	T	13: 46,938,769 (GRCm39)	V76M	probably damaging	Het
Krt4	T	C	15: 101,829,740 (GRCm39)	I263V	probably benign	Het
Lgals8	A	G	13: 12,469,699 (GRCm39)	W87R	probably benign	Het
Mccc2	G	A	13: 100,127,816 (GRCm39)	P96L	probably damaging	Het
Megf11	A	C	9: 64,587,531 (GRCm39)	D443A	probably damaging	Het
Nckap5l	T	C	15: 99,321,008 (GRCm39)		probably benign	Het
Ndor1	A	G	2: 25,139,281 (GRCm39)	V230A	probably benign	Het
Nif3l1	G	T	1: 58,496,956 (GRCm39)	V294L	possibly damaging	Het
Or4k39	T	A	2: 111,238,923 (GRCm39)		noncoding transcript	Het
Pcdhb13	T	A	18: 37,576,128 (GRCm39)	Y169N	probably damaging	Het
Peg3	A	G	7: 6,710,635 (GRCm39)	I1529T	probably damaging	Het
Piezo2	T	A	18: 63,279,915 (GRCm39)	I219F	probably damaging	Het
Prpf38a	G	A	4: 108,424,836 (GRCm39)	R242W	unknown	Het
Prrc2a	A	T	17: 35,379,480 (GRCm39)	D255E	unknown	Het
Rapgef6	G	T	11: 54,567,181 (GRCm39)	D1121Y	possibly damaging	Het
Ryr3	T	A	2: 112,585,303 (GRCm39)	H2761L	probably damaging	Het
Sel1l	A	T	12: 91,810,042 (GRCm39)		probably benign	Het
Slc30a9	A	G	5: 67,510,065 (GRCm39)	D539G	probably damaging	Het
Slc38a9	A	G	13: 112,826,777 (GRCm39)	S172G	probably benign	Het
Slfn2	C	A	11: 82,960,402 (GRCm39)	T127K	probably benign	Het
Smurf1	A	T	5: 144,821,534 (GRCm39)	M496K	probably damaging	Het
Srgap2	A	T	1: 131,247,340 (GRCm39)	V564D	probably damaging	Het
Stk32a	T	C	18: 43,430,576 (GRCm39)	I162T	probably benign	Het
Tchhl1	A	T	3: 93,378,634 (GRCm39)	N446I	possibly damaging	Het
Tmem64	T	A	4: 15,266,584 (GRCm39)	H211Q	probably damaging	Het
Trim3	T	C	7: 105,262,218 (GRCm39)	N586S	probably benign	Het
Trpm1	A	G	7: 63,868,869 (GRCm39)	E507G	probably damaging	Het
Tyk2	G	T	9: 21,020,523 (GRCm39)		probably benign	Het
Ugt3a1	A	T	15: 9,365,316 (GRCm39)	K310*	probably null	Het
Unc13a	T	A	8: 72,101,586 (GRCm39)	N1022Y	probably damaging	Het
Vmn1r172	A	T	7: 23,359,228 (GRCm39)	N38Y	probably damaging	Het
Vmn2r100	A	T	17: 19,741,770 (GRCm39)	I161F	probably damaging	Het
Zcchc17	A	G	4: 130,243,108 (GRCm39)	M25T	probably benign	Het
Zhx2	A	G	15: 57,686,802 (GRCm39)	S724G	probably benign	Het

Other mutations in Zfp563

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01629:Zfp563	APN	17	33,323,600 (GRCm39)	missense	probably damaging	1.00
IGL01981:Zfp563	APN	17	33,324,383 (GRCm39)	missense	probably benign	0.16
IGL02662:Zfp563	APN	17	33,321,253 (GRCm39)	missense	probably damaging	1.00
IGL03220:Zfp563	APN	17	33,323,661 (GRCm39)	missense	probably benign	0.44
R0241:Zfp563	UTSW	17	33,323,659 (GRCm39)	missense	possibly damaging	0.61
R0241:Zfp563	UTSW	17	33,323,659 (GRCm39)	missense	possibly damaging	0.61
R0537:Zfp563	UTSW	17	33,323,659 (GRCm39)	missense	possibly damaging	0.61
R0552:Zfp563	UTSW	17	33,323,659 (GRCm39)	missense	possibly damaging	0.61
R1544:Zfp563	UTSW	17	33,324,187 (GRCm39)	missense	probably benign	0.01
R3763:Zfp563	UTSW	17	33,323,902 (GRCm39)	nonsense	probably null
R3979:Zfp563	UTSW	17	33,324,701 (GRCm39)	missense	probably benign	0.03
R4938:Zfp563	UTSW	17	33,324,683 (GRCm39)	missense	probably damaging	1.00
R5280:Zfp563	UTSW	17	33,323,812 (GRCm39)	missense	probably damaging	0.99
R5383:Zfp563	UTSW	17	33,323,681 (GRCm39)	missense	probably benign
R5485:Zfp563	UTSW	17	33,308,540 (GRCm39)	unclassified	probably benign
R5524:Zfp563	UTSW	17	33,321,515 (GRCm39)	critical splice acceptor site	probably null
R5567:Zfp563	UTSW	17	33,308,431 (GRCm39)	unclassified	probably benign
R5736:Zfp563	UTSW	17	33,323,960 (GRCm39)	missense	possibly damaging	0.91
R5758:Zfp563	UTSW	17	33,323,894 (GRCm39)	missense	probably damaging	1.00
R6034:Zfp563	UTSW	17	33,323,935 (GRCm39)	missense	probably damaging	0.96
R6034:Zfp563	UTSW	17	33,323,935 (GRCm39)	missense	probably damaging	0.96
R6532:Zfp563	UTSW	17	33,324,672 (GRCm39)	missense	probably benign	0.21
R9241:Zfp563	UTSW	17	33,321,520 (GRCm39)	missense	probably benign	0.10
R9360:Zfp563	UTSW	17	33,324,428 (GRCm39)	missense	probably benign	0.38
R9410:Zfp563	UTSW	17	33,321,320 (GRCm39)	missense	probably damaging	1.00
R9453:Zfp563	UTSW	17	33,308,565 (GRCm39)	missense
RF007:Zfp563	UTSW	17	33,323,999 (GRCm39)	missense	probably benign
X0023:Zfp563	UTSW	17	33,324,695 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16