Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02407:Zfp563'

292133

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp563

Ensembl Gene

ENSMUSG00000067424

Gene Name

zinc finger protein 563

Synonyms

zinc finger protein, Zfp413

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.071) question?

Stock #

IGL02407

Quality Score

Status

Chromosome

Chromosomal Location

33089310-33106203 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 33104821 bp

Zygosity

Heterozygous

Amino Acid Change

Arginine to Glutamine at position 130 (R130Q)

Ref Sequence

ENSEMBL: ENSMUSP00000121678 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000131722] [ENSMUST00000140829]

Predicted Effect

probably benign
Transcript: ENSMUST00000131722
AA Change: R130Q

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000118809
Gene: ENSMUSG00000067424
AA Change: R130Q

Domain	Start	End	E-Value	Type
KRAB	4	61	5.45e-16	SMART
ZnF_C2H2	141	163	2.63e2	SMART
ZnF_C2H2	169	191	9.08e-4	SMART
ZnF_C2H2	197	219	9.88e-5	SMART
ZnF_C2H2	225	247	3.16e-3	SMART
ZnF_C2H2	253	275	5.81e-2	SMART
ZnF_C2H2	281	303	2.4e-3	SMART
ZnF_C2H2	309	331	1.82e-3	SMART
ZnF_C2H2	337	359	1.72e-4	SMART
ZnF_C2H2	365	387	4.54e-4	SMART
ZnF_C2H2	393	415	7.78e-3	SMART
ZnF_C2H2	421	443	3.63e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000140829
AA Change: R130Q

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

SMART Domains

Protein: ENSMUSP00000121678
Gene: ENSMUSG00000067424
AA Change: R130Q

Domain	Start	End	E-Value	Type
KRAB	4	61	5.45e-16	SMART
ZnF_C2H2	141	163	2.63e2	SMART
ZnF_C2H2	169	191	9.08e-4	SMART
Pfam:zf-C2H2_4	197	209	9.4e-2	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000153072

SMART Domains

Protein: ENSMUSP00000119142
Gene: ENSMUSG00000067424

Domain	Start	End	E-Value	Type
low complexity region	30	41	N/A	INTRINSIC
KRAB	45	102	5.45e-16	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4931406P16Rik	A	T	7: 34,256,484	N393K	probably damaging	Het
A2m	G	A	6: 121,668,616	W1040*	probably null	Het
Adgrv1	C	A	13: 81,479,670	A3691S	probably damaging	Het
Als2cl	T	A	9: 110,889,227	Y345*	probably null	Het
Aplp2	A	T	9: 31,158,527	Y496*	probably null	Het
Ash1l	T	C	3: 89,072,548	V2793A	probably damaging	Het
Bfsp1	A	T	2: 143,826,933	D575E	probably benign	Het
Ceacam20	G	T	7: 19,970,407	V128F	probably benign	Het
Cers4	A	T	8: 4,520,306	K204*	probably null	Het
Cog1	T	C	11: 113,654,026	Y345H	probably benign	Het
Col14a1	T	C	15: 55,448,876		probably benign	Het
Col19a1	A	T	1: 24,312,372		probably null	Het
Ctnnd2	T	A	15: 30,966,768	M955K	probably damaging	Het
Cyp3a16	A	T	5: 145,451,842	M275K	probably damaging	Het
Degs2	T	G	12: 108,691,995	T242P	probably damaging	Het
Elac2	T	C	11: 64,999,175	V612A	probably benign	Het
Elovl6	T	A	3: 129,605,084	F45I	probably damaging	Het
Exoc1	A	C	5: 76,545,346	N360H	probably damaging	Het
Fam221b	A	T	4: 43,666,309	S101T	possibly damaging	Het
Glyr1	A	G	16: 5,036,948	F89L	probably benign	Het
Herc4	C	A	10: 63,306,424	T668K	probably damaging	Het
Hibadh	C	T	6: 52,548,889	V259I	possibly damaging	Het
Hp1bp3	T	A	4: 138,240,672	D397E	probably damaging	Het
Ift80	G	T	3: 68,898,536	D724E	probably benign	Het
Igkv3-10	T	C	6: 70,573,239		probably benign	Het
Irf9	G	T	14: 55,605,221	A75S	possibly damaging	Het
Kif13a	C	T	13: 46,785,293	V76M	probably damaging	Het
Krt4	T	C	15: 101,921,305	I263V	probably benign	Het
Lgals8	A	G	13: 12,454,818	W87R	probably benign	Het
Mccc2	G	A	13: 99,991,308	P96L	probably damaging	Het
Megf11	A	C	9: 64,680,249	D443A	probably damaging	Het
Nckap5l	T	C	15: 99,423,127		probably benign	Het
Ndor1	A	G	2: 25,249,269	V230A	probably benign	Het
Nif3l1	G	T	1: 58,457,797	V294L	possibly damaging	Het
Olfr1285	T	A	2: 111,408,578		noncoding transcript	Het
Pcdhb13	T	A	18: 37,443,075	Y169N	probably damaging	Het
Peg3	A	G	7: 6,707,636	I1529T	probably damaging	Het
Piezo2	T	A	18: 63,146,844	I219F	probably damaging	Het
Prpf38a	G	A	4: 108,567,639	R242W	unknown	Het
Prrc2a	A	T	17: 35,160,504	D255E	unknown	Het
Rapgef6	G	T	11: 54,676,355	D1121Y	possibly damaging	Het
Ryr3	T	A	2: 112,754,958	H2761L	probably damaging	Het
Sel1l	A	T	12: 91,843,268		probably benign	Het
Slc30a9	A	G	5: 67,352,722	D539G	probably damaging	Het
Slc38a9	A	G	13: 112,690,243	S172G	probably benign	Het
Slfn2	C	A	11: 83,069,576	T127K	probably benign	Het
Smurf1	A	T	5: 144,884,724	M496K	probably damaging	Het
Srgap2	A	T	1: 131,319,602	V564D	probably damaging	Het
Stk32a	T	C	18: 43,297,511	I162T	probably benign	Het
Tchhl1	A	T	3: 93,471,327	N446I	possibly damaging	Het
Tmem64	T	A	4: 15,266,584	H211Q	probably damaging	Het
Trim3	T	C	7: 105,613,011	N586S	probably benign	Het
Trpm1	A	G	7: 64,219,121	E507G	probably damaging	Het
Tyk2	G	T	9: 21,109,227		probably benign	Het
Ugt3a2	A	T	15: 9,365,230	K310*	probably null	Het
Unc13a	T	A	8: 71,648,942	N1022Y	probably damaging	Het
Vmn1r172	A	T	7: 23,659,803	N38Y	probably damaging	Het
Vmn2r100	A	T	17: 19,521,508	I161F	probably damaging	Het
Zcchc17	A	G	4: 130,349,315	M25T	probably benign	Het
Zhx2	A	G	15: 57,823,406	S724G	probably benign	Het

Other mutations in Zfp563

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01629:Zfp563	APN	17	33104626	missense	probably damaging	1.00
IGL01981:Zfp563	APN	17	33105409	missense	probably benign	0.16
IGL02662:Zfp563	APN	17	33102279	missense	probably damaging	1.00
IGL03220:Zfp563	APN	17	33104687	missense	probably benign	0.44
R0241:Zfp563	UTSW	17	33104685	missense	possibly damaging	0.61
R0241:Zfp563	UTSW	17	33104685	missense	possibly damaging	0.61
R0537:Zfp563	UTSW	17	33104685	missense	possibly damaging	0.61
R0552:Zfp563	UTSW	17	33104685	missense	possibly damaging	0.61
R1544:Zfp563	UTSW	17	33105213	missense	probably benign	0.01
R3763:Zfp563	UTSW	17	33104928	nonsense	probably null
R3979:Zfp563	UTSW	17	33105727	missense	probably benign	0.03
R4938:Zfp563	UTSW	17	33105709	missense	probably damaging	1.00
R5280:Zfp563	UTSW	17	33104838	missense	probably damaging	0.99
R5383:Zfp563	UTSW	17	33104707	missense	probably benign
R5485:Zfp563	UTSW	17	33089566	unclassified	probably benign
R5524:Zfp563	UTSW	17	33102541	critical splice acceptor site	probably null
R5567:Zfp563	UTSW	17	33089457	unclassified	probably benign
R5736:Zfp563	UTSW	17	33104986	missense	possibly damaging	0.91
R5758:Zfp563	UTSW	17	33104920	missense	probably damaging	1.00
R6034:Zfp563	UTSW	17	33104961	missense	probably damaging	0.96
R6034:Zfp563	UTSW	17	33104961	missense	probably damaging	0.96
R6532:Zfp563	UTSW	17	33105698	missense	probably benign	0.21
RF007:Zfp563	UTSW	17	33105025	missense	probably benign
X0023:Zfp563	UTSW	17	33105721	missense	probably damaging	1.00

Posted On

2015-04-16