Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02408:Taar7a'

292181

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Taar7a

Ensembl Gene

ENSMUSG00000095647

Gene Name

trace amine-associated receptor 7A

Synonyms

Taar7a, LOC215856

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.088) question?

Stock #

IGL02408

Quality Score

Status

Chromosome

Chromosomal Location

23992405-23993481 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 23992602 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Leucine at position 294 (I294L)

Ref Sequence

ENSEMBL: ENSMUSP00000077616 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078532]

AlphaFold

Q5QD12

Predicted Effect

probably benign
Transcript: ENSMUST00000078532
AA Change: I294L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000077616
Gene: ENSMUSG00000095647
AA Change: I294L

Domain	Start	End	E-Value	Type
Pfam:7tm_4	54	344	9.2e-10	PFAM
Pfam:7TM_GPCR_Srx	56	261	5.2e-9	PFAM
Pfam:7tm_1	64	326	3.2e-58	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	A	G	6: 121,644,171	Y278C	probably damaging	Het
Abcd2	A	G	15: 91,178,241	L498P	possibly damaging	Het
Acot11	A	G	4: 106,758,381	F271S	probably damaging	Het
Acr	T	A	15: 89,570,014	Y185N	probably damaging	Het
Adcy10	C	T	1: 165,538,380	R489C	probably damaging	Het
Arsb	A	G	13: 93,794,162	T213A	probably benign	Het
Atg2a	T	A	19: 6,241,828	C11*	probably null	Het
B3galt6	A	T	4: 155,991,695	Y308N	probably damaging	Het
Cd226	A	G	18: 89,207,327	N116S	probably benign	Het
Crat	T	A	2: 30,407,134	D269V	probably damaging	Het
Crim1	T	A	17: 78,315,654	I427N	possibly damaging	Het
Dock3	T	C	9: 106,913,099		probably benign	Het
Dsg1c	T	A	18: 20,274,719	V374E	probably damaging	Het
Dtl	A	G	1: 191,541,240	S519P	probably benign	Het
Fastkd1	C	T	2: 69,702,601	R474H	probably benign	Het
Fbxo10	T	C	4: 45,058,361	T459A	possibly damaging	Het
Frmd4b	A	G	6: 97,295,809	L828P	probably damaging	Het
Gc	T	C	5: 89,445,396	S55G	probably benign	Het
Gm6455	T	G	5: 10,867,290		noncoding transcript	Het
Gnai2	T	C	9: 107,616,194	T280A	probably benign	Het
Hmgn2	A	G	4: 133,965,949		probably null	Het
Jmjd1c	G	T	10: 67,226,382	A1505S	probably benign	Het
Lrriq1	T	C	10: 103,146,281	K1393E	probably benign	Het
Mcam	A	G	9: 44,140,250	N469D	probably benign	Het
Mrpl47	A	G	3: 32,736,640		probably null	Het
Mslnl	C	T	17: 25,747,998	A659V	possibly damaging	Het
Nlrp1a	A	G	11: 71,122,630	V598A	probably benign	Het
Npff	A	T	15: 102,524,565	L15Q	probably null	Het
Obsl1	G	T	1: 75,505,246	Q327K	probably damaging	Het
Olfr46	T	C	7: 140,610,931	V255A	probably damaging	Het
Olfr48	T	A	2: 89,844,971	M1L	probably benign	Het
Olfr58	A	T	9: 19,783,415	Y94F	probably benign	Het
Olfr591	T	C	7: 103,173,451	Y62C	probably damaging	Het
Olfr914	G	A	9: 38,607,121	G219S	possibly damaging	Het
Pdzd2	T	A	15: 12,375,765	H1428L	probably benign	Het
Phldb1	T	C	9: 44,715,906	E414G	possibly damaging	Het
Reln	T	C	5: 21,901,619	D3251G	probably benign	Het
Secisbp2l	G	T	2: 125,740,869	S889*	probably null	Het
Setx	T	A	2: 29,133,930	C133S	probably damaging	Het
Slc22a29	A	C	19: 8,207,285	S214A	probably benign	Het
Slc30a5	A	C	13: 100,813,724	L285R	probably damaging	Het
Tfap2b	T	A	1: 19,234,261	F414I	probably damaging	Het
Trpc4ap	A	T	2: 155,671,069	Y129N	possibly damaging	Het
Vmn2r94	T	C	17: 18,253,261	E501G	probably benign	Het
Xpot	T	C	10: 121,603,165	H709R	probably damaging	Het
Zfhx3	T	A	8: 108,955,372		probably benign	Het
Zscan22	T	G	7: 12,906,499	H223Q	probably benign	Het

Other mutations in Taar7a

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00476:Taar7a	APN	10	23992396	unclassified	probably benign
PIT4434001:Taar7a	UTSW	10	23993421	missense	probably benign
R0422:Taar7a	UTSW	10	23993274	missense	probably benign	0.02
R1029:Taar7a	UTSW	10	23992541	missense	possibly damaging	0.65
R1742:Taar7a	UTSW	10	23993219	missense	probably damaging	0.98
R2104:Taar7a	UTSW	10	23993061	missense	probably damaging	0.99
R2421:Taar7a	UTSW	10	23992517	missense	probably damaging	1.00
R3907:Taar7a	UTSW	10	23992559	missense	probably benign	0.25
R4021:Taar7a	UTSW	10	23993386	missense	probably benign	0.00
R5180:Taar7a	UTSW	10	23993148	missense	probably damaging	1.00
R5486:Taar7a	UTSW	10	23992458	missense	probably benign	0.00
R5507:Taar7a	UTSW	10	23992631	missense	probably damaging	0.98
R5587:Taar7a	UTSW	10	23992828	missense	probably benign	0.00
R5766:Taar7a	UTSW	10	23993362	missense	probably benign	0.01
R5861:Taar7a	UTSW	10	23992439	missense	probably benign
R7201:Taar7a	UTSW	10	23992460	missense	probably benign	0.04
R7506:Taar7a	UTSW	10	23992994	missense	possibly damaging	0.50
R8810:Taar7a	UTSW	10	23993381	missense	probably benign	0.20
R9015:Taar7a	UTSW	10	23992835	missense	probably damaging	0.97
R9172:Taar7a	UTSW	10	23992779	missense	probably benign	0.16
R9686:Taar7a	UTSW	10	23993411	missense	probably benign	0.01
R9717:Taar7a	UTSW	10	23992901	missense	probably benign	0.01
R9720:Taar7a	UTSW	10	23992835	missense	probably benign	0.10
X0064:Taar7a	UTSW	10	23992617	missense	probably damaging	1.00
Z1177:Taar7a	UTSW	10	23992892	missense	probably benign	0.01

Posted On

2015-04-16