Incidental Mutation 'IGL02408:Mslnl'
ID 292186
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mslnl
Ensembl Gene ENSMUSG00000041062
Gene Name mesothelin-like
Synonyms
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02408
Quality Score
Status
Chromosome 17
Chromosomal Location 25955016-25967304 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 25966972 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 659 (A659V)
Ref Sequence ENSEMBL: ENSMUSP00000049020 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047098] [ENSMUST00000075884]
AlphaFold Q8C160
Predicted Effect possibly damaging
Transcript: ENSMUST00000047098
AA Change: A659V

PolyPhen 2 Score 0.802 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000049020
Gene: ENSMUSG00000041062
AA Change: A659V

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:Mesothelin 29 589 2.8e-70 PFAM
low complexity region 633 653 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000075884
SMART Domains Protein: ENSMUSP00000075279
Gene: ENSMUSG00000063011

DomainStartEndE-ValueType
Pfam:Mesothelin 1 624 N/A PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000102319
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m A G 6: 121,621,130 (GRCm39) Y278C probably damaging Het
Abcd2 A G 15: 91,062,444 (GRCm39) L498P possibly damaging Het
Acot11 A G 4: 106,615,578 (GRCm39) F271S probably damaging Het
Acr T A 15: 89,454,217 (GRCm39) Y185N probably damaging Het
Adcy10 C T 1: 165,365,949 (GRCm39) R489C probably damaging Het
Arsb A G 13: 93,930,670 (GRCm39) T213A probably benign Het
Atg2a T A 19: 6,291,858 (GRCm39) C11* probably null Het
B3galt6 A T 4: 156,076,152 (GRCm39) Y308N probably damaging Het
Cd226 A G 18: 89,225,451 (GRCm39) N116S probably benign Het
Crat T A 2: 30,297,146 (GRCm39) D269V probably damaging Het
Crim1 T A 17: 78,623,083 (GRCm39) I427N possibly damaging Het
Dock3 T C 9: 106,790,298 (GRCm39) probably benign Het
Dsg1c T A 18: 20,407,776 (GRCm39) V374E probably damaging Het
Dtl A G 1: 191,273,352 (GRCm39) S519P probably benign Het
Fastkd1 C T 2: 69,532,945 (GRCm39) R474H probably benign Het
Fbxo10 T C 4: 45,058,361 (GRCm39) T459A possibly damaging Het
Frmd4b A G 6: 97,272,770 (GRCm39) L828P probably damaging Het
Gc T C 5: 89,593,255 (GRCm39) S55G probably benign Het
Gm6455 T G 5: 10,917,257 (GRCm39) noncoding transcript Het
Gnai2 T C 9: 107,493,393 (GRCm39) T280A probably benign Het
Hmgn2 A G 4: 133,693,260 (GRCm39) probably null Het
Jmjd1c G T 10: 67,062,161 (GRCm39) A1505S probably benign Het
Lrriq1 T C 10: 102,982,142 (GRCm39) K1393E probably benign Het
Mcam A G 9: 44,051,547 (GRCm39) N469D probably benign Het
Mrpl47 A G 3: 32,790,789 (GRCm39) probably null Het
Nlrp1a A G 11: 71,013,456 (GRCm39) V598A probably benign Het
Npff A T 15: 102,433,000 (GRCm39) L15Q probably null Het
Obsl1 G T 1: 75,481,890 (GRCm39) Q327K probably damaging Het
Or13a18 T C 7: 140,190,844 (GRCm39) V255A probably damaging Het
Or4c58 T A 2: 89,675,315 (GRCm39) M1L probably benign Het
Or52s1b T C 7: 102,822,658 (GRCm39) Y62C probably damaging Het
Or7e165 A T 9: 19,694,711 (GRCm39) Y94F probably benign Het
Or8b50 G A 9: 38,518,417 (GRCm39) G219S possibly damaging Het
Pdzd2 T A 15: 12,375,851 (GRCm39) H1428L probably benign Het
Phldb1 T C 9: 44,627,203 (GRCm39) E414G possibly damaging Het
Reln T C 5: 22,106,617 (GRCm39) D3251G probably benign Het
Secisbp2l G T 2: 125,582,789 (GRCm39) S889* probably null Het
Setx T A 2: 29,023,942 (GRCm39) C133S probably damaging Het
Slc22a29 A C 19: 8,184,649 (GRCm39) S214A probably benign Het
Slc30a5 A C 13: 100,950,232 (GRCm39) L285R probably damaging Het
Taar7a T G 10: 23,868,500 (GRCm39) I294L probably benign Het
Tfap2b T A 1: 19,304,485 (GRCm39) F414I probably damaging Het
Trpc4ap A T 2: 155,512,989 (GRCm39) Y129N possibly damaging Het
Vmn2r94 T C 17: 18,473,523 (GRCm39) E501G probably benign Het
Xpot T C 10: 121,439,070 (GRCm39) H709R probably damaging Het
Zfhx3 T A 8: 109,682,004 (GRCm39) probably benign Het
Zscan22 T G 7: 12,640,426 (GRCm39) H223Q probably benign Het
Other mutations in Mslnl
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01621:Mslnl APN 17 25,962,641 (GRCm39) unclassified probably benign
IGL01629:Mslnl APN 17 25,963,749 (GRCm39) missense possibly damaging 0.95
IGL02084:Mslnl APN 17 25,965,125 (GRCm39) missense probably benign 0.07
IGL02726:Mslnl APN 17 25,963,077 (GRCm39) critical splice donor site probably null
IGL03387:Mslnl APN 17 25,963,051 (GRCm39) missense probably benign 0.06
R0561:Mslnl UTSW 17 25,962,177 (GRCm39) nonsense probably null
R0881:Mslnl UTSW 17 25,961,939 (GRCm39) missense possibly damaging 0.82
R1295:Mslnl UTSW 17 25,962,214 (GRCm39) missense probably damaging 1.00
R1296:Mslnl UTSW 17 25,962,214 (GRCm39) missense probably damaging 1.00
R1582:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R1629:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R1630:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R1631:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R1632:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R1794:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R1850:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R1866:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R1876:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R1914:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R2166:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R2241:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R2243:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R2247:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R2282:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R2284:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R2852:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R2867:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R2867:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R2877:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R2878:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R2919:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R2920:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R3026:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R3405:Mslnl UTSW 17 25,965,155 (GRCm39) missense probably damaging 1.00
R3406:Mslnl UTSW 17 25,965,155 (GRCm39) missense probably damaging 1.00
R3411:Mslnl UTSW 17 25,963,491 (GRCm39) missense probably benign 0.05
R3434:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R3546:Mslnl UTSW 17 25,963,943 (GRCm39) missense probably damaging 0.98
R3612:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R3729:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R3730:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R3802:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R3804:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R3894:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R3895:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R4454:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R4455:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R4456:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R4457:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R4561:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R4562:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R4564:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R4600:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R4601:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R4610:Mslnl UTSW 17 25,961,908 (GRCm39) missense probably damaging 0.97
R4704:Mslnl UTSW 17 25,957,952 (GRCm39) missense possibly damaging 0.73
R5155:Mslnl UTSW 17 25,957,942 (GRCm39) nonsense probably null
R5257:Mslnl UTSW 17 25,965,139 (GRCm39) missense probably benign 0.00
R5456:Mslnl UTSW 17 25,962,133 (GRCm39) missense probably damaging 0.98
R5645:Mslnl UTSW 17 25,956,816 (GRCm39) missense possibly damaging 0.95
R6007:Mslnl UTSW 17 25,965,749 (GRCm39) missense probably benign 0.00
R6083:Mslnl UTSW 17 25,956,876 (GRCm39) missense possibly damaging 0.83
R6142:Mslnl UTSW 17 25,963,531 (GRCm39) missense probably damaging 1.00
R6761:Mslnl UTSW 17 25,965,047 (GRCm39) missense probably damaging 1.00
R7058:Mslnl UTSW 17 25,962,186 (GRCm39) missense probably benign 0.03
R7156:Mslnl UTSW 17 25,962,184 (GRCm39) missense probably benign 0.20
R7467:Mslnl UTSW 17 25,955,895 (GRCm39) start codon destroyed probably benign 0.33
R7687:Mslnl UTSW 17 25,962,157 (GRCm39) missense probably damaging 0.97
R7807:Mslnl UTSW 17 25,965,751 (GRCm39) missense probably benign 0.03
R8682:Mslnl UTSW 17 25,965,962 (GRCm39) missense probably benign
R8735:Mslnl UTSW 17 25,964,062 (GRCm39) missense probably benign 0.09
R8742:Mslnl UTSW 17 25,964,047 (GRCm39) missense probably damaging 1.00
R9208:Mslnl UTSW 17 25,961,694 (GRCm39) missense possibly damaging 0.94
R9264:Mslnl UTSW 17 25,961,506 (GRCm39) intron probably benign
RF007:Mslnl UTSW 17 25,962,202 (GRCm39) missense possibly damaging 0.87
Posted On 2015-04-16