Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02408:Hmgn2'

292204

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Hmgn2

Ensembl Gene

ENSMUSG00000003038

Gene Name

high mobility group nucleosomal binding domain 2

Synonyms

HMG-17, Hmg17

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02408

Quality Score

Status

Chromosome

Chromosomal Location

133692050-133695302 bp(-) (GRCm39)

Type of Mutation

critical splice donor site (2 bp from exon)

DNA Base Change (assembly)

A to G at 133693260 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000012262] [ENSMUST00000100472] [ENSMUST00000102552] [ENSMUST00000102553] [ENSMUST00000105886] [ENSMUST00000105887] [ENSMUST00000105893] [ENSMUST00000136327] [ENSMUST00000130464] [ENSMUST00000144668]

AlphaFold

P09602

Predicted Effect

probably benign
Transcript: ENSMUST00000012262

SMART Domains

Protein: ENSMUSP00000012262
Gene: ENSMUSG00000012117

Domain	Start	End	E-Value	Type
Pfam:Prenyltransf	32	256	1.5e-84	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000100472

SMART Domains

Protein: ENSMUSP00000098040
Gene: ENSMUSG00000003038

Domain	Start	End	E-Value	Type
HMG17	2	88	1.67e-38	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000102552

SMART Domains

Protein: ENSMUSP00000099612
Gene: ENSMUSG00000003038

Domain	Start	End	E-Value	Type
HMG17	2	86	4.6e-41	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000102553

SMART Domains

Protein: ENSMUSP00000099613
Gene: ENSMUSG00000003038

Domain	Start	End	E-Value	Type
HMG17	2	86	4.6e-41	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000105886

SMART Domains

Protein: ENSMUSP00000101510
Gene: ENSMUSG00000012117

Domain	Start	End	E-Value	Type
Pfam:Prenyltransf	32	109	9.8e-32	PFAM
Pfam:Prenyltransf	104	217	6.2e-39	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000105887

SMART Domains

Protein: ENSMUSP00000101511
Gene: ENSMUSG00000012117

Domain	Start	End	E-Value	Type
Pfam:Prenyltransf	32	255	6.4e-79	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000105893

SMART Domains

Protein: ENSMUSP00000101513
Gene: ENSMUSG00000003038

Domain	Start	End	E-Value	Type
HMG17	12	92	1.13e-35	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000136327
AA Change: V80A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000114704
Gene: ENSMUSG00000003038
AA Change: V80A

Domain	Start	End	E-Value	Type
HMG17	2	86	1.99e-36	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000125266

Predicted Effect

probably null
Transcript: ENSMUST00000123234

SMART Domains

Protein: ENSMUSP00000120795
Gene: ENSMUSG00000003038

Domain	Start	End	E-Value	Type
HMG17	28	108	1.13e-35	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000145025

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000130809

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000137456

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138458

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000153622

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000136859

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000142660

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000146241

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134096

Predicted Effect

probably benign
Transcript: ENSMUST00000130464

SMART Domains

Protein: ENSMUSP00000121656
Gene: ENSMUSG00000012117

Domain	Start	End	E-Value	Type
Pfam:Prenyltransf	1	54	1.8e-8	PFAM
Pfam:Prenyltransf	50	99	2.6e-16	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000144668

SMART Domains

Protein: ENSMUSP00000116098
Gene: ENSMUSG00000012117

Domain	Start	End	E-Value	Type
Pfam:Prenyltransf	32	256	1.5e-84	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele are viable. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	A	G	6: 121,621,130 (GRCm39)	Y278C	probably damaging	Het
Abcd2	A	G	15: 91,062,444 (GRCm39)	L498P	possibly damaging	Het
Acot11	A	G	4: 106,615,578 (GRCm39)	F271S	probably damaging	Het
Acr	T	A	15: 89,454,217 (GRCm39)	Y185N	probably damaging	Het
Adcy10	C	T	1: 165,365,949 (GRCm39)	R489C	probably damaging	Het
Arsb	A	G	13: 93,930,670 (GRCm39)	T213A	probably benign	Het
Atg2a	T	A	19: 6,291,858 (GRCm39)	C11*	probably null	Het
B3galt6	A	T	4: 156,076,152 (GRCm39)	Y308N	probably damaging	Het
Cd226	A	G	18: 89,225,451 (GRCm39)	N116S	probably benign	Het
Crat	T	A	2: 30,297,146 (GRCm39)	D269V	probably damaging	Het
Crim1	T	A	17: 78,623,083 (GRCm39)	I427N	possibly damaging	Het
Dock3	T	C	9: 106,790,298 (GRCm39)		probably benign	Het
Dsg1c	T	A	18: 20,407,776 (GRCm39)	V374E	probably damaging	Het
Dtl	A	G	1: 191,273,352 (GRCm39)	S519P	probably benign	Het
Fastkd1	C	T	2: 69,532,945 (GRCm39)	R474H	probably benign	Het
Fbxo10	T	C	4: 45,058,361 (GRCm39)	T459A	possibly damaging	Het
Frmd4b	A	G	6: 97,272,770 (GRCm39)	L828P	probably damaging	Het
Gc	T	C	5: 89,593,255 (GRCm39)	S55G	probably benign	Het
Gm6455	T	G	5: 10,917,257 (GRCm39)		noncoding transcript	Het
Gnai2	T	C	9: 107,493,393 (GRCm39)	T280A	probably benign	Het
Jmjd1c	G	T	10: 67,062,161 (GRCm39)	A1505S	probably benign	Het
Lrriq1	T	C	10: 102,982,142 (GRCm39)	K1393E	probably benign	Het
Mcam	A	G	9: 44,051,547 (GRCm39)	N469D	probably benign	Het
Mrpl47	A	G	3: 32,790,789 (GRCm39)		probably null	Het
Mslnl	C	T	17: 25,966,972 (GRCm39)	A659V	possibly damaging	Het
Nlrp1a	A	G	11: 71,013,456 (GRCm39)	V598A	probably benign	Het
Npff	A	T	15: 102,433,000 (GRCm39)	L15Q	probably null	Het
Obsl1	G	T	1: 75,481,890 (GRCm39)	Q327K	probably damaging	Het
Or13a18	T	C	7: 140,190,844 (GRCm39)	V255A	probably damaging	Het
Or4c58	T	A	2: 89,675,315 (GRCm39)	M1L	probably benign	Het
Or52s1b	T	C	7: 102,822,658 (GRCm39)	Y62C	probably damaging	Het
Or7e165	A	T	9: 19,694,711 (GRCm39)	Y94F	probably benign	Het
Or8b50	G	A	9: 38,518,417 (GRCm39)	G219S	possibly damaging	Het
Pdzd2	T	A	15: 12,375,851 (GRCm39)	H1428L	probably benign	Het
Phldb1	T	C	9: 44,627,203 (GRCm39)	E414G	possibly damaging	Het
Reln	T	C	5: 22,106,617 (GRCm39)	D3251G	probably benign	Het
Secisbp2l	G	T	2: 125,582,789 (GRCm39)	S889*	probably null	Het
Setx	T	A	2: 29,023,942 (GRCm39)	C133S	probably damaging	Het
Slc22a29	A	C	19: 8,184,649 (GRCm39)	S214A	probably benign	Het
Slc30a5	A	C	13: 100,950,232 (GRCm39)	L285R	probably damaging	Het
Taar7a	T	G	10: 23,868,500 (GRCm39)	I294L	probably benign	Het
Tfap2b	T	A	1: 19,304,485 (GRCm39)	F414I	probably damaging	Het
Trpc4ap	A	T	2: 155,512,989 (GRCm39)	Y129N	possibly damaging	Het
Vmn2r94	T	C	17: 18,473,523 (GRCm39)	E501G	probably benign	Het
Xpot	T	C	10: 121,439,070 (GRCm39)	H709R	probably damaging	Het
Zfhx3	T	A	8: 109,682,004 (GRCm39)		probably benign	Het
Zscan22	T	G	7: 12,640,426 (GRCm39)	H223Q	probably benign	Het

Other mutations in Hmgn2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R4577:Hmgn2	UTSW	4	133,694,668 (GRCm39)	unclassified	probably benign
R5195:Hmgn2	UTSW	4	133,694,597 (GRCm39)	missense	probably benign	0.04
R5504:Hmgn2	UTSW	4	133,694,114 (GRCm39)	unclassified	probably benign

Posted On

2015-04-16