Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02409:Sult2a4'

292213

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Sult2a4

Ensembl Gene

ENSMUSG00000074377

Gene Name

sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 4

Synonyms

Gm5584

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

IGL02409

Quality Score

Status

Chromosome

Chromosomal Location

13643602-13723516 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to T at 13718844 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tryptophan to Stop codon at position 133 (W133*)

Ref Sequence

ENSEMBL: ENSMUSP00000130490 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000108520] [ENSMUST00000165167]

AlphaFold

L7N245

Predicted Effect

probably null
Transcript: ENSMUST00000108520
AA Change: W134*

SMART Domains

Protein: ENSMUSP00000104160
Gene: ENSMUSG00000074377
AA Change: W134*

Domain	Start	End	E-Value	Type
Pfam:Sulfotransfer_3	5	205	1.5e-10	PFAM
Pfam:Sulfotransfer_1	34	278	1.2e-82	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000165167
AA Change: W133*

SMART Domains

Protein: ENSMUSP00000130490
Gene: ENSMUSG00000074377
AA Change: W133*

Domain	Start	End	E-Value	Type
Pfam:Sulfotransfer_1	33	277	1.3e-82	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: This is one of seven sulfotransferase family 2A genes in a chromosome 7 A1 cluster. [provided by RefSeq, May 2010]

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aqp4	T	A	18: 15,532,782 (GRCm39)	M104L	probably benign	Het
Cdkn1a	T	C	17: 29,317,428 (GRCm39)	V16A	probably benign	Het
Celsr2	C	A	3: 108,321,271 (GRCm39)	V514F	probably damaging	Het
Cmklr2	T	A	1: 63,222,875 (GRCm39)	N120I	probably damaging	Het
Cmya5	T	C	13: 93,226,706 (GRCm39)	N2794S	probably damaging	Het
Dnmt1	T	C	9: 20,837,793 (GRCm39)	T281A	probably benign	Het
Dock2	A	T	11: 34,451,204 (GRCm39)	N840K	probably benign	Het
Dscam	T	C	16: 96,621,088 (GRCm39)	N540S	possibly damaging	Het
Elavl1	A	T	8: 4,339,838 (GRCm39)	I248N	possibly damaging	Het
Fam120a	A	G	13: 49,120,835 (GRCm39)	V157A	probably benign	Het
Fcrl2	G	A	3: 87,160,030 (GRCm39)	P408L	probably benign	Het
Grin2b	T	A	6: 136,020,906 (GRCm39)	M132L	possibly damaging	Het
Herc2	T	A	7: 55,870,217 (GRCm39)		probably null	Het
Lrp1b	T	G	2: 41,335,208 (GRCm39)	K778T	possibly damaging	Het
Mapk10	T	A	5: 103,076,096 (GRCm39)	E389D	possibly damaging	Het
Ms4a7	G	T	19: 11,301,807 (GRCm39)	Y62*	probably null	Het
Muc5b	A	G	7: 141,415,075 (GRCm39)	T2674A	possibly damaging	Het
Nbeal1	T	C	1: 60,368,494 (GRCm39)	L2613P	probably benign	Het
Ncapg2	A	T	12: 116,384,337 (GRCm39)	Y266F	probably damaging	Het
Or10a3m	A	G	7: 108,313,366 (GRCm39)	I269V	probably benign	Het
Or14j6	T	C	17: 38,214,679 (GRCm39)	Y81H	probably damaging	Het
Or1j14	T	A	2: 36,418,165 (GRCm39)	V247E	probably damaging	Het
Or4c110	C	T	2: 88,832,254 (GRCm39)	C126Y	possibly damaging	Het
Pkd1	T	A	17: 24,792,597 (GRCm39)	I1428N	probably benign	Het
Ppil4	T	C	10: 7,674,328 (GRCm39)		probably benign	Het
Rev3l	T	C	10: 39,697,144 (GRCm39)	V547A	possibly damaging	Het
Rgsl1	T	C	1: 153,701,989 (GRCm39)	K155R	possibly damaging	Het
Skap2	T	C	6: 51,884,938 (GRCm39)	D234G	possibly damaging	Het
Tbc1d2b	C	T	9: 90,104,405 (GRCm39)	S579N	probably benign	Het
Tdrkh	T	A	3: 94,337,919 (GRCm39)		probably benign	Het
Thumpd2	A	T	17: 81,340,117 (GRCm39)	F377L	probably damaging	Het
Tmem132d	T	C	5: 127,861,952 (GRCm39)	D723G	probably damaging	Het
Tnfrsf23	A	T	7: 143,222,308 (GRCm39)	L168Q	probably damaging	Het
Ttn	T	C	2: 76,784,974 (GRCm39)	T818A	unknown	Het
Uox	A	T	3: 146,330,381 (GRCm39)	D130V	probably benign	Het
Vmn2r45	T	C	7: 8,488,727 (GRCm39)	Y101C	probably benign	Het
Wdr1	C	T	5: 38,688,453 (GRCm39)	D161N	probably benign	Het

Other mutations in Sult2a4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00557:Sult2a4	APN	7	13,718,870 (GRCm39)	missense	probably damaging	1.00
IGL00835:Sult2a4	APN	7	13,643,714 (GRCm39)	missense	probably benign	0.01
IGL02078:Sult2a4	APN	7	13,723,469 (GRCm39)	missense	probably benign	0.02
IGL02970:Sult2a4	APN	7	13,643,831 (GRCm39)	splice site	probably benign
IGL03201:Sult2a4	APN	7	13,665,692 (GRCm39)	missense	probably damaging	0.97
R0827:Sult2a4	UTSW	7	13,718,886 (GRCm39)	missense	probably benign	0.03
R1484:Sult2a4	UTSW	7	13,643,726 (GRCm39)	missense	probably benign
R1523:Sult2a4	UTSW	7	13,643,785 (GRCm39)	nonsense	probably null
R1613:Sult2a4	UTSW	7	13,723,420 (GRCm39)	missense	probably damaging	0.98
R2127:Sult2a4	UTSW	7	13,649,185 (GRCm39)	missense	probably damaging	0.99
R2372:Sult2a4	UTSW	7	13,649,225 (GRCm39)	missense	probably benign	0.15
R3161:Sult2a4	UTSW	7	13,723,396 (GRCm39)	missense	probably benign	0.17
R5181:Sult2a4	UTSW	7	13,722,316 (GRCm39)	missense	probably benign	0.04
R7124:Sult2a4	UTSW	7	13,722,320 (GRCm39)	nonsense	probably null
R7983:Sult2a4	UTSW	7	13,649,152 (GRCm39)	missense	probably damaging	1.00
R8214:Sult2a4	UTSW	7	13,723,401 (GRCm39)	missense	probably benign	0.10
R9508:Sult2a4	UTSW	7	13,723,437 (GRCm39)	missense	probably benign	0.01
X0028:Sult2a4	UTSW	7	13,722,166 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16