Incidental Mutation 'IGL02409:Fcrl2'
| ID |
292226 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Fcrl2
|
| Ensembl Gene |
ENSMUSG00000015852 |
| Gene Name |
Fc receptor like 2 |
| Synonyms |
Fcrls, IFGP2, 2810439C17Rik, Msr2, Fcrh2, moFcRH2sc |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.063)
|
| Stock # |
IGL02409
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
3 |
| Chromosomal Location |
87158318-87171046 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 87160030 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Proline to Leucine
at position 408
(P408L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000088508
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000090986]
|
| AlphaFold |
Q9EQY5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000090986
AA Change: P408L
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000088508
Gene: ENSMUSG00000015852
AA Change: P408L
| Domain | Start | End | E-Value | Type |
|---|
|
IG
|
23 |
106 |
1.32e-3 |
SMART |
|
IGc2
|
122 |
186 |
2.77e-6 |
SMART |
|
IGc2
|
226 |
291 |
1.09e-4 |
SMART |
|
IG
|
315 |
396 |
1e-3 |
SMART |
|
SR
|
402 |
503 |
7.29e-36 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Female homozygous mutant mice are larger than controls and show increased mean body weight, total tissue mass, lean body mass and total body fat. Homozygous mutant mice eshow a decreased mean percentage of CD8 cells in the peripheral blood. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 37 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aqp4 |
T |
A |
18: 15,532,782 (GRCm39) |
M104L |
probably benign |
Het |
| Cdkn1a |
T |
C |
17: 29,317,428 (GRCm39) |
V16A |
probably benign |
Het |
| Celsr2 |
C |
A |
3: 108,321,271 (GRCm39) |
V514F |
probably damaging |
Het |
| Cmklr2 |
T |
A |
1: 63,222,875 (GRCm39) |
N120I |
probably damaging |
Het |
| Cmya5 |
T |
C |
13: 93,226,706 (GRCm39) |
N2794S |
probably damaging |
Het |
| Dnmt1 |
T |
C |
9: 20,837,793 (GRCm39) |
T281A |
probably benign |
Het |
| Dock2 |
A |
T |
11: 34,451,204 (GRCm39) |
N840K |
probably benign |
Het |
| Dscam |
T |
C |
16: 96,621,088 (GRCm39) |
N540S |
possibly damaging |
Het |
| Elavl1 |
A |
T |
8: 4,339,838 (GRCm39) |
I248N |
possibly damaging |
Het |
| Fam120a |
A |
G |
13: 49,120,835 (GRCm39) |
V157A |
probably benign |
Het |
| Grin2b |
T |
A |
6: 136,020,906 (GRCm39) |
M132L |
possibly damaging |
Het |
| Herc2 |
T |
A |
7: 55,870,217 (GRCm39) |
|
probably null |
Het |
| Lrp1b |
T |
G |
2: 41,335,208 (GRCm39) |
K778T |
possibly damaging |
Het |
| Mapk10 |
T |
A |
5: 103,076,096 (GRCm39) |
E389D |
possibly damaging |
Het |
| Ms4a7 |
G |
T |
19: 11,301,807 (GRCm39) |
Y62* |
probably null |
Het |
| Muc5b |
A |
G |
7: 141,415,075 (GRCm39) |
T2674A |
possibly damaging |
Het |
| Nbeal1 |
T |
C |
1: 60,368,494 (GRCm39) |
L2613P |
probably benign |
Het |
| Ncapg2 |
A |
T |
12: 116,384,337 (GRCm39) |
Y266F |
probably damaging |
Het |
| Or10a3m |
A |
G |
7: 108,313,366 (GRCm39) |
I269V |
probably benign |
Het |
| Or14j6 |
T |
C |
17: 38,214,679 (GRCm39) |
Y81H |
probably damaging |
Het |
| Or1j14 |
T |
A |
2: 36,418,165 (GRCm39) |
V247E |
probably damaging |
Het |
| Or4c110 |
C |
T |
2: 88,832,254 (GRCm39) |
C126Y |
possibly damaging |
Het |
| Pkd1 |
T |
A |
17: 24,792,597 (GRCm39) |
I1428N |
probably benign |
Het |
| Ppil4 |
T |
C |
10: 7,674,328 (GRCm39) |
|
probably benign |
Het |
| Rev3l |
T |
C |
10: 39,697,144 (GRCm39) |
V547A |
possibly damaging |
Het |
| Rgsl1 |
T |
C |
1: 153,701,989 (GRCm39) |
K155R |
possibly damaging |
Het |
| Skap2 |
T |
C |
6: 51,884,938 (GRCm39) |
D234G |
possibly damaging |
Het |
| Sult2a4 |
C |
T |
7: 13,718,844 (GRCm39) |
W133* |
probably null |
Het |
| Tbc1d2b |
C |
T |
9: 90,104,405 (GRCm39) |
S579N |
probably benign |
Het |
| Tdrkh |
T |
A |
3: 94,337,919 (GRCm39) |
|
probably benign |
Het |
| Thumpd2 |
A |
T |
17: 81,340,117 (GRCm39) |
F377L |
probably damaging |
Het |
| Tmem132d |
T |
C |
5: 127,861,952 (GRCm39) |
D723G |
probably damaging |
Het |
| Tnfrsf23 |
A |
T |
7: 143,222,308 (GRCm39) |
L168Q |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,784,974 (GRCm39) |
T818A |
unknown |
Het |
| Uox |
A |
T |
3: 146,330,381 (GRCm39) |
D130V |
probably benign |
Het |
| Vmn2r45 |
T |
C |
7: 8,488,727 (GRCm39) |
Y101C |
probably benign |
Het |
| Wdr1 |
C |
T |
5: 38,688,453 (GRCm39) |
D161N |
probably benign |
Het |
|
| Other mutations in Fcrl2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01568:Fcrl2
|
APN |
3 |
87,163,986 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01959:Fcrl2
|
APN |
3 |
87,166,939 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02677:Fcrl2
|
APN |
3 |
87,166,694 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02957:Fcrl2
|
APN |
3 |
87,169,501 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
IGL02974:Fcrl2
|
APN |
3 |
87,164,704 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02992:Fcrl2
|
APN |
3 |
87,166,773 (GRCm39) |
missense |
probably damaging |
0.99 |
|
BB001:Fcrl2
|
UTSW |
3 |
87,166,840 (GRCm39) |
missense |
probably damaging |
0.99 |
|
BB011:Fcrl2
|
UTSW |
3 |
87,166,840 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0052:Fcrl2
|
UTSW |
3 |
87,164,085 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0052:Fcrl2
|
UTSW |
3 |
87,164,085 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0131:Fcrl2
|
UTSW |
3 |
87,166,266 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R1171:Fcrl2
|
UTSW |
3 |
87,164,167 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1319:Fcrl2
|
UTSW |
3 |
87,169,484 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1522:Fcrl2
|
UTSW |
3 |
87,164,014 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R1696:Fcrl2
|
UTSW |
3 |
87,166,825 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1742:Fcrl2
|
UTSW |
3 |
87,166,350 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R2156:Fcrl2
|
UTSW |
3 |
87,164,648 (GRCm39) |
missense |
probably benign |
0.43 |
|
R2255:Fcrl2
|
UTSW |
3 |
87,164,655 (GRCm39) |
nonsense |
probably null |
|
|
R2257:Fcrl2
|
UTSW |
3 |
87,166,928 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2434:Fcrl2
|
UTSW |
3 |
87,164,005 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2680:Fcrl2
|
UTSW |
3 |
87,164,656 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3552:Fcrl2
|
UTSW |
3 |
87,166,717 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4866:Fcrl2
|
UTSW |
3 |
87,170,773 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R4883:Fcrl2
|
UTSW |
3 |
87,166,922 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R5654:Fcrl2
|
UTSW |
3 |
87,164,851 (GRCm39) |
missense |
probably benign |
|
|
R5771:Fcrl2
|
UTSW |
3 |
87,170,775 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5917:Fcrl2
|
UTSW |
3 |
87,164,094 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6349:Fcrl2
|
UTSW |
3 |
87,159,803 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6562:Fcrl2
|
UTSW |
3 |
87,164,635 (GRCm39) |
missense |
probably benign |
|
|
R6954:Fcrl2
|
UTSW |
3 |
87,170,983 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R7059:Fcrl2
|
UTSW |
3 |
87,164,647 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7188:Fcrl2
|
UTSW |
3 |
87,166,830 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7201:Fcrl2
|
UTSW |
3 |
87,159,934 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7369:Fcrl2
|
UTSW |
3 |
87,164,008 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R7431:Fcrl2
|
UTSW |
3 |
87,166,233 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7610:Fcrl2
|
UTSW |
3 |
87,160,004 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7924:Fcrl2
|
UTSW |
3 |
87,166,840 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8018:Fcrl2
|
UTSW |
3 |
87,166,933 (GRCm39) |
nonsense |
probably null |
|
|
R8280:Fcrl2
|
UTSW |
3 |
87,166,364 (GRCm39) |
nonsense |
probably null |
|
|
R8981:Fcrl2
|
UTSW |
3 |
87,164,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9368:Fcrl2
|
UTSW |
3 |
87,164,906 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R9477:Fcrl2
|
UTSW |
3 |
87,159,803 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9522:Fcrl2
|
UTSW |
3 |
87,164,101 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
| Posted On |
2015-04-16 |
Incidental Mutation