Incidental Mutation 'IGL02409:Rgsl1'
ID 292240
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rgsl1
Ensembl Gene ENSMUSG00000042641
Gene Name regulator of G-protein signaling like 1
Synonyms 4930415K13Rik, Rgsl2
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02409
Quality Score
Status
Chromosome 1
Chromosomal Location 153655127-153719888 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 153701989 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Arginine at position 155 (K155R)
Ref Sequence ENSEMBL: ENSMUSP00000135642 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000124558] [ENSMUST00000185164]
AlphaFold A0A5F8MPV0
Predicted Effect possibly damaging
Transcript: ENSMUST00000124558
AA Change: K155R

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000135642
Gene: ENSMUSG00000042641
AA Change: K155R

DomainStartEndE-ValueType
low complexity region 122 136 N/A INTRINSIC
low complexity region 242 254 N/A INTRINSIC
low complexity region 316 325 N/A INTRINSIC
Pfam:RGS 644 754 7.1e-12 PFAM
transmembrane domain 956 973 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134030
Predicted Effect probably benign
Transcript: ENSMUST00000184095
Predicted Effect probably benign
Transcript: ENSMUST00000185164
AA Change: K190R

PolyPhen 2 Score 0.036 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000139340
Gene: ENSMUSG00000042641
AA Change: K190R

DomainStartEndE-ValueType
low complexity region 157 171 N/A INTRINSIC
low complexity region 277 289 N/A INTRINSIC
low complexity region 351 360 N/A INTRINSIC
Pfam:RGS 679 789 4.1e-11 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aqp4 T A 18: 15,532,782 (GRCm39) M104L probably benign Het
Cdkn1a T C 17: 29,317,428 (GRCm39) V16A probably benign Het
Celsr2 C A 3: 108,321,271 (GRCm39) V514F probably damaging Het
Cmklr2 T A 1: 63,222,875 (GRCm39) N120I probably damaging Het
Cmya5 T C 13: 93,226,706 (GRCm39) N2794S probably damaging Het
Dnmt1 T C 9: 20,837,793 (GRCm39) T281A probably benign Het
Dock2 A T 11: 34,451,204 (GRCm39) N840K probably benign Het
Dscam T C 16: 96,621,088 (GRCm39) N540S possibly damaging Het
Elavl1 A T 8: 4,339,838 (GRCm39) I248N possibly damaging Het
Fam120a A G 13: 49,120,835 (GRCm39) V157A probably benign Het
Fcrl2 G A 3: 87,160,030 (GRCm39) P408L probably benign Het
Grin2b T A 6: 136,020,906 (GRCm39) M132L possibly damaging Het
Herc2 T A 7: 55,870,217 (GRCm39) probably null Het
Lrp1b T G 2: 41,335,208 (GRCm39) K778T possibly damaging Het
Mapk10 T A 5: 103,076,096 (GRCm39) E389D possibly damaging Het
Ms4a7 G T 19: 11,301,807 (GRCm39) Y62* probably null Het
Muc5b A G 7: 141,415,075 (GRCm39) T2674A possibly damaging Het
Nbeal1 T C 1: 60,368,494 (GRCm39) L2613P probably benign Het
Ncapg2 A T 12: 116,384,337 (GRCm39) Y266F probably damaging Het
Or10a3m A G 7: 108,313,366 (GRCm39) I269V probably benign Het
Or14j6 T C 17: 38,214,679 (GRCm39) Y81H probably damaging Het
Or1j14 T A 2: 36,418,165 (GRCm39) V247E probably damaging Het
Or4c110 C T 2: 88,832,254 (GRCm39) C126Y possibly damaging Het
Pkd1 T A 17: 24,792,597 (GRCm39) I1428N probably benign Het
Ppil4 T C 10: 7,674,328 (GRCm39) probably benign Het
Rev3l T C 10: 39,697,144 (GRCm39) V547A possibly damaging Het
Skap2 T C 6: 51,884,938 (GRCm39) D234G possibly damaging Het
Sult2a4 C T 7: 13,718,844 (GRCm39) W133* probably null Het
Tbc1d2b C T 9: 90,104,405 (GRCm39) S579N probably benign Het
Tdrkh T A 3: 94,337,919 (GRCm39) probably benign Het
Thumpd2 A T 17: 81,340,117 (GRCm39) F377L probably damaging Het
Tmem132d T C 5: 127,861,952 (GRCm39) D723G probably damaging Het
Tnfrsf23 A T 7: 143,222,308 (GRCm39) L168Q probably damaging Het
Ttn T C 2: 76,784,974 (GRCm39) T818A unknown Het
Uox A T 3: 146,330,381 (GRCm39) D130V probably benign Het
Vmn2r45 T C 7: 8,488,727 (GRCm39) Y101C probably benign Het
Wdr1 C T 5: 38,688,453 (GRCm39) D161N probably benign Het
Other mutations in Rgsl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01372:Rgsl1 APN 1 153,701,887 (GRCm39) missense probably damaging 1.00
IGL02253:Rgsl1 APN 1 153,669,513 (GRCm39) missense probably damaging 1.00
IGL02345:Rgsl1 APN 1 153,679,755 (GRCm39) splice site probably null
IGL02587:Rgsl1 APN 1 153,675,684 (GRCm39) missense probably damaging 1.00
IGL02652:Rgsl1 APN 1 153,701,236 (GRCm39) missense probably damaging 1.00
IGL02797:Rgsl1 APN 1 153,683,454 (GRCm39) missense probably damaging 1.00
IGL03032:Rgsl1 APN 1 153,701,948 (GRCm39) missense possibly damaging 0.53
IGL03082:Rgsl1 APN 1 153,675,693 (GRCm39) missense possibly damaging 0.86
IGL03123:Rgsl1 APN 1 153,701,687 (GRCm39) missense probably damaging 1.00
IGL03213:Rgsl1 APN 1 153,701,587 (GRCm39) missense probably benign 0.12
IGL03410:Rgsl1 APN 1 153,669,501 (GRCm39) missense probably null 0.82
Bam UTSW 1 153,669,898 (GRCm39) missense probably benign 0.00
Candygram UTSW 1 153,697,245 (GRCm39) nonsense probably null
wham UTSW 1 153,678,038 (GRCm39) missense probably benign 0.02
IGL03050:Rgsl1 UTSW 1 153,701,422 (GRCm39) missense possibly damaging 0.60
PIT4519001:Rgsl1 UTSW 1 153,701,716 (GRCm39) missense possibly damaging 0.96
R0149:Rgsl1 UTSW 1 153,669,510 (GRCm39) missense probably damaging 1.00
R0536:Rgsl1 UTSW 1 153,701,927 (GRCm39) missense probably damaging 1.00
R0633:Rgsl1 UTSW 1 153,719,853 (GRCm39) missense possibly damaging 0.72
R0726:Rgsl1 UTSW 1 153,678,074 (GRCm39) missense probably damaging 1.00
R0839:Rgsl1 UTSW 1 153,677,980 (GRCm39) critical splice donor site probably null
R1240:Rgsl1 UTSW 1 153,660,937 (GRCm39) missense probably benign 0.18
R1355:Rgsl1 UTSW 1 153,683,507 (GRCm39) start codon destroyed probably null 0.23
R1491:Rgsl1 UTSW 1 153,701,672 (GRCm39) missense possibly damaging 0.93
R1688:Rgsl1 UTSW 1 153,680,422 (GRCm39) missense probably damaging 0.98
R1694:Rgsl1 UTSW 1 153,680,422 (GRCm39) missense probably damaging 0.98
R1842:Rgsl1 UTSW 1 153,675,543 (GRCm39) missense probably damaging 1.00
R2008:Rgsl1 UTSW 1 153,701,651 (GRCm39) missense possibly damaging 0.53
R2114:Rgsl1 UTSW 1 153,693,295 (GRCm39) missense probably benign
R2116:Rgsl1 UTSW 1 153,693,295 (GRCm39) missense probably benign
R2176:Rgsl1 UTSW 1 153,701,014 (GRCm39) splice site probably benign
R2229:Rgsl1 UTSW 1 153,698,104 (GRCm39) missense possibly damaging 0.72
R2895:Rgsl1 UTSW 1 153,703,294 (GRCm39) missense probably damaging 1.00
R3923:Rgsl1 UTSW 1 153,679,876 (GRCm39) critical splice acceptor site probably null
R4001:Rgsl1 UTSW 1 153,693,330 (GRCm39) missense probably damaging 1.00
R4434:Rgsl1 UTSW 1 153,678,087 (GRCm39) missense possibly damaging 0.52
R4489:Rgsl1 UTSW 1 153,703,282 (GRCm39) missense probably benign 0.27
R4649:Rgsl1 UTSW 1 153,693,328 (GRCm39) missense probably benign 0.01
R4925:Rgsl1 UTSW 1 153,688,023 (GRCm39) missense probably benign 0.01
R4928:Rgsl1 UTSW 1 153,669,514 (GRCm39) missense probably damaging 1.00
R5045:Rgsl1 UTSW 1 153,697,268 (GRCm39) nonsense probably null
R5304:Rgsl1 UTSW 1 153,703,238 (GRCm39) missense probably damaging 0.97
R5331:Rgsl1 UTSW 1 153,678,038 (GRCm39) missense probably benign 0.02
R5373:Rgsl1 UTSW 1 153,666,053 (GRCm39) missense probably benign 0.33
R5374:Rgsl1 UTSW 1 153,666,053 (GRCm39) missense probably benign 0.33
R5566:Rgsl1 UTSW 1 153,669,520 (GRCm39) missense probably damaging 1.00
R5649:Rgsl1 UTSW 1 153,701,639 (GRCm39) missense possibly damaging 0.93
R6062:Rgsl1 UTSW 1 153,675,618 (GRCm39) missense possibly damaging 0.72
R6142:Rgsl1 UTSW 1 153,687,984 (GRCm39) missense probably benign 0.01
R6158:Rgsl1 UTSW 1 153,679,767 (GRCm39) missense possibly damaging 0.72
R6184:Rgsl1 UTSW 1 153,703,194 (GRCm39) missense probably benign 0.08
R6273:Rgsl1 UTSW 1 153,703,211 (GRCm39) missense possibly damaging 0.96
R6384:Rgsl1 UTSW 1 153,703,291 (GRCm39) missense possibly damaging 0.86
R6419:Rgsl1 UTSW 1 153,698,117 (GRCm39) missense probably damaging 0.98
R6568:Rgsl1 UTSW 1 153,697,292 (GRCm39) missense possibly damaging 0.72
R6660:Rgsl1 UTSW 1 153,701,512 (GRCm39) missense possibly damaging 0.70
R6745:Rgsl1 UTSW 1 153,698,063 (GRCm39) missense probably benign 0.18
R6892:Rgsl1 UTSW 1 153,697,245 (GRCm39) nonsense probably null
R6974:Rgsl1 UTSW 1 153,675,568 (GRCm39) missense probably damaging 1.00
R7172:Rgsl1 UTSW 1 153,701,966 (GRCm39) missense possibly damaging 0.72
R7200:Rgsl1 UTSW 1 153,660,945 (GRCm39) missense probably benign 0.33
R7275:Rgsl1 UTSW 1 153,679,876 (GRCm39) critical splice acceptor site probably null
R7313:Rgsl1 UTSW 1 153,683,622 (GRCm39) critical splice acceptor site probably null
R7341:Rgsl1 UTSW 1 153,669,591 (GRCm39) missense probably benign 0.01
R7448:Rgsl1 UTSW 1 153,719,847 (GRCm39) critical splice donor site probably null
R7662:Rgsl1 UTSW 1 153,701,225 (GRCm39) missense probably benign
R7703:Rgsl1 UTSW 1 153,669,610 (GRCm39) missense possibly damaging 0.73
R7846:Rgsl1 UTSW 1 153,701,783 (GRCm39) missense possibly damaging 0.53
R8408:Rgsl1 UTSW 1 153,701,435 (GRCm39) missense possibly damaging 0.96
R8860:Rgsl1 UTSW 1 153,697,100 (GRCm39) nonsense probably null
R8894:Rgsl1 UTSW 1 153,698,119 (GRCm39) critical splice acceptor site probably null
R9043:Rgsl1 UTSW 1 153,717,567 (GRCm39) missense possibly damaging 0.73
R9187:Rgsl1 UTSW 1 153,669,613 (GRCm39) missense possibly damaging 0.53
R9280:Rgsl1 UTSW 1 153,669,898 (GRCm39) missense probably benign 0.00
R9326:Rgsl1 UTSW 1 153,679,768 (GRCm39) missense probably benign 0.01
R9388:Rgsl1 UTSW 1 153,693,355 (GRCm39) missense probably benign
R9479:Rgsl1 UTSW 1 153,657,445 (GRCm39) missense unknown
X0020:Rgsl1 UTSW 1 153,701,131 (GRCm39) missense probably benign 0.33
X0065:Rgsl1 UTSW 1 153,679,779 (GRCm39) missense possibly damaging 0.84
Z1177:Rgsl1 UTSW 1 153,701,734 (GRCm39) missense not run
Z1177:Rgsl1 UTSW 1 153,693,356 (GRCm39) missense possibly damaging 0.70
Posted On 2015-04-16