Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02409:Tmem132d'

292241

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem132d

Ensembl Gene

ENSMUSG00000034310

Gene Name

transmembrane protein 132D

Synonyms

C630028F04Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.133) question?

Stock #

IGL02409

Quality Score

Status

Chromosome

Chromosomal Location

127860555-128510141 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 127861952 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 723 (D723G)

Ref Sequence

ENSEMBL: ENSMUSP00000043633 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000044441]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000044441
AA Change: D723G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000043633
Gene: ENSMUSG00000034310
AA Change: D723G

Domain	Start	End	E-Value	Type
signal peptide	1	30	N/A	INTRINSIC
Pfam:TMEM132D_N	49	178	1.9e-59	PFAM
Pfam:TMEM132	435	778	3.9e-150	PFAM
Pfam:TMEM132D_C	884	970	1.9e-37	PFAM
low complexity region	998	1011	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aqp4	T	A	18: 15,532,782 (GRCm39)	M104L	probably benign	Het
Cdkn1a	T	C	17: 29,317,428 (GRCm39)	V16A	probably benign	Het
Celsr2	C	A	3: 108,321,271 (GRCm39)	V514F	probably damaging	Het
Cmklr2	T	A	1: 63,222,875 (GRCm39)	N120I	probably damaging	Het
Cmya5	T	C	13: 93,226,706 (GRCm39)	N2794S	probably damaging	Het
Dnmt1	T	C	9: 20,837,793 (GRCm39)	T281A	probably benign	Het
Dock2	A	T	11: 34,451,204 (GRCm39)	N840K	probably benign	Het
Dscam	T	C	16: 96,621,088 (GRCm39)	N540S	possibly damaging	Het
Elavl1	A	T	8: 4,339,838 (GRCm39)	I248N	possibly damaging	Het
Fam120a	A	G	13: 49,120,835 (GRCm39)	V157A	probably benign	Het
Fcrl2	G	A	3: 87,160,030 (GRCm39)	P408L	probably benign	Het
Grin2b	T	A	6: 136,020,906 (GRCm39)	M132L	possibly damaging	Het
Herc2	T	A	7: 55,870,217 (GRCm39)		probably null	Het
Lrp1b	T	G	2: 41,335,208 (GRCm39)	K778T	possibly damaging	Het
Mapk10	T	A	5: 103,076,096 (GRCm39)	E389D	possibly damaging	Het
Ms4a7	G	T	19: 11,301,807 (GRCm39)	Y62*	probably null	Het
Muc5b	A	G	7: 141,415,075 (GRCm39)	T2674A	possibly damaging	Het
Nbeal1	T	C	1: 60,368,494 (GRCm39)	L2613P	probably benign	Het
Ncapg2	A	T	12: 116,384,337 (GRCm39)	Y266F	probably damaging	Het
Or10a3m	A	G	7: 108,313,366 (GRCm39)	I269V	probably benign	Het
Or14j6	T	C	17: 38,214,679 (GRCm39)	Y81H	probably damaging	Het
Or1j14	T	A	2: 36,418,165 (GRCm39)	V247E	probably damaging	Het
Or4c110	C	T	2: 88,832,254 (GRCm39)	C126Y	possibly damaging	Het
Pkd1	T	A	17: 24,792,597 (GRCm39)	I1428N	probably benign	Het
Ppil4	T	C	10: 7,674,328 (GRCm39)		probably benign	Het
Rev3l	T	C	10: 39,697,144 (GRCm39)	V547A	possibly damaging	Het
Rgsl1	T	C	1: 153,701,989 (GRCm39)	K155R	possibly damaging	Het
Skap2	T	C	6: 51,884,938 (GRCm39)	D234G	possibly damaging	Het
Sult2a4	C	T	7: 13,718,844 (GRCm39)	W133*	probably null	Het
Tbc1d2b	C	T	9: 90,104,405 (GRCm39)	S579N	probably benign	Het
Tdrkh	T	A	3: 94,337,919 (GRCm39)		probably benign	Het
Thumpd2	A	T	17: 81,340,117 (GRCm39)	F377L	probably damaging	Het
Tnfrsf23	A	T	7: 143,222,308 (GRCm39)	L168Q	probably damaging	Het
Ttn	T	C	2: 76,784,974 (GRCm39)	T818A	unknown	Het
Uox	A	T	3: 146,330,381 (GRCm39)	D130V	probably benign	Het
Vmn2r45	T	C	7: 8,488,727 (GRCm39)	Y101C	probably benign	Het
Wdr1	C	T	5: 38,688,453 (GRCm39)	D161N	probably benign	Het

Other mutations in Tmem132d

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Tmem132d	APN	5	127,861,896 (GRCm39)	missense	possibly damaging	0.77
IGL01393:Tmem132d	APN	5	127,861,702 (GRCm39)	missense	probably benign	0.31
IGL01482:Tmem132d	APN	5	128,346,270 (GRCm39)	missense	probably damaging	0.96
IGL01785:Tmem132d	APN	5	128,061,379 (GRCm39)	missense	probably benign	0.00
IGL02539:Tmem132d	APN	5	127,861,043 (GRCm39)	missense	probably benign	0.01
IGL03411:Tmem132d	APN	5	128,061,347 (GRCm39)	nonsense	probably null
R0113:Tmem132d	UTSW	5	127,861,657 (GRCm39)	missense	probably benign	0.11
R0420:Tmem132d	UTSW	5	127,941,710 (GRCm39)	missense	probably benign	0.26
R0437:Tmem132d	UTSW	5	127,866,849 (GRCm39)	missense	probably damaging	0.99
R0468:Tmem132d	UTSW	5	128,346,267 (GRCm39)	missense	probably damaging	1.00
R0564:Tmem132d	UTSW	5	127,861,842 (GRCm39)	missense	probably damaging	1.00
R0659:Tmem132d	UTSW	5	128,061,351 (GRCm39)	missense	possibly damaging	0.94
R0924:Tmem132d	UTSW	5	128,061,503 (GRCm39)	splice site	probably benign
R1209:Tmem132d	UTSW	5	127,861,934 (GRCm39)	missense	probably damaging	1.00
R1333:Tmem132d	UTSW	5	127,861,923 (GRCm39)	missense	probably benign
R1378:Tmem132d	UTSW	5	128,346,011 (GRCm39)	missense	probably benign	0.43
R1741:Tmem132d	UTSW	5	127,861,922 (GRCm39)	missense	probably benign	0.30
R1753:Tmem132d	UTSW	5	127,866,919 (GRCm39)	missense	probably benign	0.02
R1944:Tmem132d	UTSW	5	127,860,828 (GRCm39)	makesense	probably null
R1974:Tmem132d	UTSW	5	128,346,263 (GRCm39)	missense	probably damaging	0.99
R2035:Tmem132d	UTSW	5	127,869,522 (GRCm39)	missense	probably damaging	1.00
R2065:Tmem132d	UTSW	5	127,861,505 (GRCm39)	missense	probably benign
R2074:Tmem132d	UTSW	5	128,346,195 (GRCm39)	missense	probably damaging	1.00
R2276:Tmem132d	UTSW	5	127,872,987 (GRCm39)	missense	probably damaging	1.00
R2297:Tmem132d	UTSW	5	128,345,608 (GRCm39)	missense	possibly damaging	0.69
R2424:Tmem132d	UTSW	5	127,941,663 (GRCm39)	missense	probably benign	0.09
R2902:Tmem132d	UTSW	5	127,860,832 (GRCm39)	missense	probably benign
R3053:Tmem132d	UTSW	5	127,869,538 (GRCm39)	missense	probably benign	0.15
R3836:Tmem132d	UTSW	5	127,861,949 (GRCm39)	missense	probably damaging	1.00
R4127:Tmem132d	UTSW	5	128,345,884 (GRCm39)	missense	probably benign	0.35
R4236:Tmem132d	UTSW	5	128,509,389 (GRCm39)	missense	possibly damaging	0.89
R4358:Tmem132d	UTSW	5	128,061,405 (GRCm39)	missense	possibly damaging	0.92
R4610:Tmem132d	UTSW	5	128,061,360 (GRCm39)	missense	probably benign	0.29
R4686:Tmem132d	UTSW	5	127,869,674 (GRCm39)	missense	possibly damaging	0.55
R4814:Tmem132d	UTSW	5	128,061,328 (GRCm39)	missense	probably benign	0.01
R4883:Tmem132d	UTSW	5	128,346,366 (GRCm39)	missense	possibly damaging	0.79
R4883:Tmem132d	UTSW	5	128,346,364 (GRCm39)	missense	probably damaging	0.99
R4939:Tmem132d	UTSW	5	127,873,139 (GRCm39)	missense	probably damaging	1.00
R5579:Tmem132d	UTSW	5	127,873,064 (GRCm39)	missense	possibly damaging	0.67
R5652:Tmem132d	UTSW	5	127,861,859 (GRCm39)	missense	possibly damaging	0.88
R5801:Tmem132d	UTSW	5	127,861,964 (GRCm39)	missense	possibly damaging	0.50
R5900:Tmem132d	UTSW	5	128,346,336 (GRCm39)	missense	probably damaging	1.00
R5980:Tmem132d	UTSW	5	127,861,662 (GRCm39)	missense	probably benign	0.13
R6048:Tmem132d	UTSW	5	128,346,181 (GRCm39)	missense	probably benign	0.03
R6057:Tmem132d	UTSW	5	127,861,934 (GRCm39)	missense	probably damaging	1.00
R6084:Tmem132d	UTSW	5	127,861,164 (GRCm39)	missense	probably benign	0.06
R6505:Tmem132d	UTSW	5	127,861,502 (GRCm39)	missense	probably benign	0.00
R6522:Tmem132d	UTSW	5	127,860,832 (GRCm39)	missense	probably benign
R6540:Tmem132d	UTSW	5	128,345,596 (GRCm39)	missense	possibly damaging	0.87
R6717:Tmem132d	UTSW	5	127,861,485 (GRCm39)	missense	probably benign
R7158:Tmem132d	UTSW	5	128,214,083 (GRCm39)	missense	possibly damaging	0.81
R7287:Tmem132d	UTSW	5	128,061,415 (GRCm39)	missense	probably damaging	0.96
R7526:Tmem132d	UTSW	5	127,861,205 (GRCm39)	nonsense	probably null
R7826:Tmem132d	UTSW	5	127,866,953 (GRCm39)	missense	probably damaging	1.00
R7864:Tmem132d	UTSW	5	127,860,980 (GRCm39)	missense	probably damaging	1.00
R8124:Tmem132d	UTSW	5	127,869,624 (GRCm39)	missense	probably damaging	1.00
R8543:Tmem132d	UTSW	5	128,345,799 (GRCm39)	missense	probably benign	0.00
R8694:Tmem132d	UTSW	5	127,869,495 (GRCm39)	missense	probably benign	0.06
R8936:Tmem132d	UTSW	5	127,869,676 (GRCm39)	missense	probably damaging	1.00
R9017:Tmem132d	UTSW	5	128,346,316 (GRCm39)	missense	probably benign	0.00
R9017:Tmem132d	UTSW	5	127,866,936 (GRCm39)	missense	probably benign	0.00
R9163:Tmem132d	UTSW	5	127,869,570 (GRCm39)	missense	possibly damaging	0.82
R9257:Tmem132d	UTSW	5	127,861,491 (GRCm39)	nonsense	probably null
R9645:Tmem132d	UTSW	5	128,346,075 (GRCm39)	missense	probably damaging	1.00
R9667:Tmem132d	UTSW	5	128,061,375 (GRCm39)	missense	possibly damaging	0.79
R9711:Tmem132d	UTSW	5	127,869,579 (GRCm39)	missense	possibly damaging	0.94

Posted On

2015-04-16