Incidental Mutation 'IGL00896:Mog'
ID29232
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mog
Ensembl Gene ENSMUSG00000076439
Gene Namemyelin oligodendrocyte glycoprotein
SynonymsB230317G11Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.064) question?
Stock #IGL00896
Quality Score
Status
Chromosome17
Chromosomal Location37010743-37023398 bp(-) (GRCm38)
Type of Mutationsplice site (3 bp from exon)
DNA Base Change (assembly) T to A at 37017485 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000129489 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102665] [ENSMUST00000167275]
Predicted Effect probably null
Transcript: ENSMUST00000102665
SMART Domains Protein: ENSMUSP00000099726
Gene: ENSMUSG00000076439

DomainStartEndE-ValueType
low complexity region 4 27 N/A INTRINSIC
IGv 48 129 2.28e-16 SMART
transmembrane domain 156 178 N/A INTRINSIC
transmembrane domain 209 231 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000158194
Predicted Effect probably null
Transcript: ENSMUST00000167275
SMART Domains Protein: ENSMUSP00000129489
Gene: ENSMUSG00000076439

DomainStartEndE-ValueType
low complexity region 4 27 N/A INTRINSIC
IGv 48 129 2.28e-16 SMART
transmembrane domain 156 178 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
PHENOTYPE: While one line of homozygous mutant mice showed resistance to experimental autoimmune encephalomyelitis (EAE), another showed increased susceptibility. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438A13Rik A G 3: 37,039,462 T4352A probably benign Het
Adam6a A G 12: 113,545,410 T468A possibly damaging Het
Ankrd35 A G 3: 96,684,276 E626G probably damaging Het
Arhgef4 A G 1: 34,811,696 Y1812C possibly damaging Het
Aurkc T C 7: 7,002,514 Y260H possibly damaging Het
Cpb1 A G 3: 20,252,029 V329A probably benign Het
Cyp2d11 G T 15: 82,391,074 probably benign Het
Dnase1 G A 16: 4,039,212 S28N probably benign Het
Evpl C A 11: 116,222,584 E1427* probably null Het
Gimap6 T C 6: 48,702,460 N214S probably benign Het
Htr1f A T 16: 64,926,106 H274Q probably benign Het
Ipo9 A T 1: 135,400,059 V538E probably damaging Het
Lmf2 T C 15: 89,353,336 K308E probably benign Het
Myo19 T C 11: 84,909,498 V903A probably benign Het
Myt1l A G 12: 29,826,886 T179A unknown Het
Nckap1 C T 2: 80,580,953 V5M possibly damaging Het
Olfr382 T C 11: 73,516,341 N286S probably damaging Het
Olfr459 A T 6: 41,772,113 L62Q probably damaging Het
Olfr630 T C 7: 103,755,006 D193G probably damaging Het
Pcdhb5 T G 18: 37,322,785 probably null Het
Pcm1 C A 8: 41,276,123 Q711K possibly damaging Het
Pde6a A G 18: 61,220,792 D63G possibly damaging Het
Piezo1 T C 8: 122,497,870 M711V possibly damaging Het
Prrxl1 C T 14: 32,605,214 probably benign Het
Rev1 G A 1: 38,098,940 T88I probably damaging Het
Sntg1 A T 1: 8,595,410 probably null Het
Sult2a1 T A 7: 13,832,640 T137S probably benign Het
Txndc15 G A 13: 55,725,675 A283T probably damaging Het
Zswim8 A G 14: 20,716,001 E785G probably damaging Het
Other mutations in Mog
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02991:Mog UTSW 17 37023199 start codon destroyed probably null
R0200:Mog UTSW 17 37012419 missense probably damaging 0.97
R0972:Mog UTSW 17 37017532 missense probably benign 0.14
R1565:Mog UTSW 17 37017582 missense possibly damaging 0.73
R3623:Mog UTSW 17 37012446 missense possibly damaging 0.66
R3624:Mog UTSW 17 37012446 missense possibly damaging 0.66
R4079:Mog UTSW 17 37012410 missense probably damaging 1.00
R4772:Mog UTSW 17 37023157 missense unknown
R4944:Mog UTSW 17 37020541 missense probably damaging 0.99
R4991:Mog UTSW 17 37017489 splice site probably null
R5254:Mog UTSW 17 37012372 missense probably benign 0.18
R5963:Mog UTSW 17 37012348 nonsense probably null
R7257:Mog UTSW 17 37023127 missense unknown
R7498:Mog UTSW 17 37012092 splice site probably null
Posted On2013-04-17