Incidental Mutation 'IGL02414:Or5ac25'
ID 292364
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or5ac25
Ensembl Gene ENSMUSG00000095706
Gene Name olfactory receptor family 5 subfamily AC member 25
Synonyms MOR182-6, GA_x54KRFPKG5P-55580232-55579315, MOR182-6, Olfr207, MOR182-9, Olfr208, GA_x54KRFPKG5P-55570276-55569359, Olfr209, GA_x54KRFPKG5P-55590495-55589578
Accession Numbers
Essential gene? Probably non essential (E-score: 0.118) question?
Stock # IGL02414
Quality Score
Status
Chromosome 16
Chromosomal Location 59181587-59182603 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 59182077 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 168 (C168Y)
Ref Sequence ENSEMBL: ENSMUSP00000147068 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055868] [ENSMUST00000208246] [ENSMUST00000208875] [ENSMUST00000213779]
AlphaFold L7N1X3
Predicted Effect probably damaging
Transcript: ENSMUST00000055868
AA Change: C168Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000053192
Gene: ENSMUSG00000095706
AA Change: C168Y

DomainStartEndE-ValueType
Pfam:7tm_4 30 304 1.3e-49 PFAM
Pfam:7TM_GPCR_Srsx 34 303 1.3e-6 PFAM
Pfam:7tm_1 40 289 6.2e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000208246
Predicted Effect probably damaging
Transcript: ENSMUST00000208875
AA Change: C168Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably benign
Transcript: ENSMUST00000213779
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ada C T 2: 163,571,960 (GRCm39) D273N probably benign Het
Btbd9 A C 17: 30,439,533 (GRCm39) C551W possibly damaging Het
Casp2 T A 6: 42,257,380 (GRCm39) L443H probably damaging Het
Cdhr3 A G 12: 33,092,503 (GRCm39) Y703H possibly damaging Het
Clta T C 4: 44,030,274 (GRCm39) probably benign Het
Cstdc2 T G 2: 148,692,598 (GRCm39) K68T possibly damaging Het
Dnah8 A G 17: 30,919,387 (GRCm39) D1120G probably benign Het
Ece2 A G 16: 20,459,456 (GRCm39) D597G probably damaging Het
Etfdh A G 3: 79,511,403 (GRCm39) V526A probably damaging Het
Gm14496 T A 2: 181,633,198 (GRCm39) D60E probably benign Het
Gpr85 A T 6: 13,836,909 (GRCm39) probably benign Het
Hivep1 C A 13: 42,308,385 (GRCm39) S208R probably damaging Het
Kif1b A G 4: 149,283,771 (GRCm39) I1252T probably damaging Het
Knl1 T C 2: 118,900,804 (GRCm39) V835A possibly damaging Het
Or2d4 A T 7: 106,543,965 (GRCm39) M81K probably benign Het
Ppwd1 T G 13: 104,359,645 (GRCm39) I119L probably benign Het
Prex1 T C 2: 166,451,748 (GRCm39) K410R probably damaging Het
Prm2 C T 16: 10,609,754 (GRCm39) probably benign Het
Psip1 T C 4: 83,386,874 (GRCm39) T166A probably benign Het
Rtel1 T C 2: 180,977,765 (GRCm39) V98A probably benign Het
Sdsl G A 5: 120,600,124 (GRCm39) T91I probably damaging Het
Tas2r136 A G 6: 132,754,494 (GRCm39) M211T possibly damaging Het
Trim43c A T 9: 88,723,885 (GRCm39) probably null Het
Ttc1 T C 11: 43,630,664 (GRCm39) probably benign Het
Other mutations in Or5ac25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01083:Or5ac25 APN 16 59,182,198 (GRCm39) missense probably damaging 1.00
IGL01137:Or5ac25 APN 16 59,182,335 (GRCm39) missense probably benign 0.01
IGL01383:Or5ac25 APN 16 59,182,316 (GRCm39) missense probably benign 0.10
IGL01913:Or5ac25 APN 16 59,182,294 (GRCm39) missense probably damaging 1.00
IGL01914:Or5ac25 APN 16 59,182,294 (GRCm39) missense probably damaging 1.00
IGL02125:Or5ac25 APN 16 59,181,879 (GRCm39) missense probably benign
IGL02512:Or5ac25 APN 16 59,182,171 (GRCm39) missense possibly damaging 0.95
PIT4495001:Or5ac25 UTSW 16 59,181,871 (GRCm39) missense probably damaging 0.99
R0029:Or5ac25 UTSW 16 59,181,904 (GRCm39) missense probably benign 0.00
R0531:Or5ac25 UTSW 16 59,182,171 (GRCm39) missense probably damaging 0.99
R1799:Or5ac25 UTSW 16 59,182,243 (GRCm39) missense probably benign 0.01
R1901:Or5ac25 UTSW 16 59,182,526 (GRCm39) missense probably benign 0.03
R1902:Or5ac25 UTSW 16 59,182,526 (GRCm39) missense probably benign 0.03
R1903:Or5ac25 UTSW 16 59,182,526 (GRCm39) missense probably benign 0.03
R1972:Or5ac25 UTSW 16 59,182,476 (GRCm39) missense probably damaging 0.96
R2471:Or5ac25 UTSW 16 59,181,944 (GRCm39) missense possibly damaging 0.79
R5013:Or5ac25 UTSW 16 59,182,067 (GRCm39) missense probably damaging 1.00
R5160:Or5ac25 UTSW 16 59,182,129 (GRCm39) missense probably damaging 1.00
R5883:Or5ac25 UTSW 16 59,182,078 (GRCm39) missense probably damaging 1.00
R6272:Or5ac25 UTSW 16 59,181,948 (GRCm39) missense possibly damaging 0.76
R6296:Or5ac25 UTSW 16 59,181,769 (GRCm39) missense probably benign 0.06
R6741:Or5ac25 UTSW 16 59,181,918 (GRCm39) missense probably damaging 1.00
R6928:Or5ac25 UTSW 16 59,181,826 (GRCm39) missense probably damaging 1.00
R7982:Or5ac25 UTSW 16 59,181,927 (GRCm39) missense probably benign
R8254:Or5ac25 UTSW 16 59,182,534 (GRCm39) missense probably benign 0.00
R8429:Or5ac25 UTSW 16 59,181,990 (GRCm39) missense possibly damaging 0.89
R8857:Or5ac25 UTSW 16 59,182,041 (GRCm39) missense probably damaging 1.00
R9596:Or5ac25 UTSW 16 59,181,942 (GRCm39) missense possibly damaging 0.50
R9611:Or5ac25 UTSW 16 59,182,242 (GRCm39) missense probably benign 0.04
R9658:Or5ac25 UTSW 16 59,182,106 (GRCm39) missense probably damaging 1.00
X0017:Or5ac25 UTSW 16 59,182,002 (GRCm39) missense probably damaging 0.97
Posted On 2015-04-16