Incidental Mutation 'IGL02414:Gpr85'
ID292379
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr85
Ensembl Gene ENSMUSG00000048216
Gene NameG protein-coupled receptor 85
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.223) question?
Stock #IGL02414
Quality Score
Status
Chromosome6
Chromosomal Location13834458-13839942 bp(-) (GRCm38)
Type of Mutationutr 5 prime
DNA Base Change (assembly) A to T at 13836910 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000111155 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060442] [ENSMUST00000115491] [ENSMUST00000115492]
Predicted Effect probably benign
Transcript: ENSMUST00000060442
SMART Domains Protein: ENSMUSP00000053837
Gene: ENSMUSG00000048216

DomainStartEndE-ValueType
Pfam:7tm_1 37 338 4.1e-38 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000115491
SMART Domains Protein: ENSMUSP00000111154
Gene: ENSMUSG00000048216

DomainStartEndE-ValueType
Pfam:7tm_1 37 338 4.1e-38 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000115492
SMART Domains Protein: ENSMUSP00000111155
Gene: ENSMUSG00000048216

DomainStartEndE-ValueType
Pfam:7tm_1 37 338 1.6e-32 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127072
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the G protein-coupled receptor (GPCR) family, such as GPR85, have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli, such as neurotransmitters, hormones, or light, induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins (Matsumoto et al., 2000 [PubMed 10833454]).[supplied by OMIM, Aug 2008]
PHENOTYPE: Mice homozygous for a knock-out allele display a significant increase in brain weight and enhanced contextual memory in a fear-conditioning task but no additional behavioral abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9230104L09Rik T G 2: 148,850,678 K68T possibly damaging Het
Ada C T 2: 163,730,040 D273N probably benign Het
Btbd9 A C 17: 30,220,559 C551W possibly damaging Het
Casp2 T A 6: 42,280,446 L443H probably damaging Het
Cdhr3 A G 12: 33,042,504 Y703H possibly damaging Het
Clta T C 4: 44,030,274 probably benign Het
Dnah8 A G 17: 30,700,413 D1120G probably benign Het
Ece2 A G 16: 20,640,706 D597G probably damaging Het
Etfdh A G 3: 79,604,096 V526A probably damaging Het
Gm14496 T A 2: 181,991,405 D60E probably benign Het
Hivep1 C A 13: 42,154,909 S208R probably damaging Het
Kif1b A G 4: 149,199,314 I1252T probably damaging Het
Knl1 T C 2: 119,070,323 V835A possibly damaging Het
Olfr209 C T 16: 59,361,714 C168Y probably damaging Het
Olfr710 A T 7: 106,944,758 M81K probably benign Het
Ppwd1 T G 13: 104,223,137 I119L probably benign Het
Prex1 T C 2: 166,609,828 K410R probably damaging Het
Prm2 C T 16: 10,791,890 probably benign Het
Psip1 T C 4: 83,468,637 T166A probably benign Het
Rtel1 T C 2: 181,335,972 V98A probably benign Het
Sdsl G A 5: 120,462,059 T91I probably damaging Het
Tas2r136 A G 6: 132,777,531 M211T possibly damaging Het
Trim43c A T 9: 88,841,832 probably null Het
Ttc1 T C 11: 43,739,837 probably benign Het
Other mutations in Gpr85
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0784:Gpr85 UTSW 6 13836749 missense probably benign 0.25
R1356:Gpr85 UTSW 6 13836147 missense probably benign 0.42
R2343:Gpr85 UTSW 6 13836696 missense probably damaging 1.00
R3934:Gpr85 UTSW 6 13836045 missense probably benign 0.02
R3935:Gpr85 UTSW 6 13836045 missense probably benign 0.02
R3936:Gpr85 UTSW 6 13836045 missense probably benign 0.02
R4925:Gpr85 UTSW 6 13835978 missense probably benign 0.26
R5313:Gpr85 UTSW 6 13836302 missense probably damaging 1.00
R5586:Gpr85 UTSW 6 13836001 nonsense probably null
R7043:Gpr85 UTSW 6 13835877 missense probably damaging 1.00
Posted On2015-04-16