Incidental Mutation 'IGL02414:Gpr85'
| ID |
292379 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Gpr85
|
| Ensembl Gene |
ENSMUSG00000048216 |
| Gene Name |
G protein-coupled receptor 85 |
| Synonyms |
2900026B03Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.189)
|
| Stock # |
IGL02414
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
13834457-13839941 bp(-) (GRCm39) |
| Type of Mutation |
utr 5 prime |
| DNA Base Change (assembly) |
A to T
at 13836909 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000111155
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000060442]
[ENSMUST00000115491]
[ENSMUST00000115492]
|
| AlphaFold |
P60894 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000060442
|
| SMART Domains |
Protein: ENSMUSP00000053837
Gene: ENSMUSG00000048216
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
37 |
338 |
4.1e-38 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115491
|
| SMART Domains |
Protein: ENSMUSP00000111154
Gene: ENSMUSG00000048216
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
37 |
338 |
4.1e-38 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115492
|
| SMART Domains |
Protein: ENSMUSP00000111155
Gene: ENSMUSG00000048216
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
37 |
338 |
1.6e-32 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000127072
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the G protein-coupled receptor (GPCR) family, such as GPR85, have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli, such as neurotransmitters, hormones, or light, induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins (Matsumoto et al., 2000 [PubMed 10833454]).[supplied by OMIM, Aug 2008]
PHENOTYPE: Mice homozygous for a knock-out allele display a significant increase in brain weight and enhanced contextual memory in a fear-conditioning task but no additional behavioral abnormalities. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 24 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ada |
C |
T |
2: 163,571,960 (GRCm39) |
D273N |
probably benign |
Het |
| Btbd9 |
A |
C |
17: 30,439,533 (GRCm39) |
C551W |
possibly damaging |
Het |
| Casp2 |
T |
A |
6: 42,257,380 (GRCm39) |
L443H |
probably damaging |
Het |
| Cdhr3 |
A |
G |
12: 33,092,503 (GRCm39) |
Y703H |
possibly damaging |
Het |
| Clta |
T |
C |
4: 44,030,274 (GRCm39) |
|
probably benign |
Het |
| Cstdc2 |
T |
G |
2: 148,692,598 (GRCm39) |
K68T |
possibly damaging |
Het |
| Dnah8 |
A |
G |
17: 30,919,387 (GRCm39) |
D1120G |
probably benign |
Het |
| Ece2 |
A |
G |
16: 20,459,456 (GRCm39) |
D597G |
probably damaging |
Het |
| Etfdh |
A |
G |
3: 79,511,403 (GRCm39) |
V526A |
probably damaging |
Het |
| Gm14496 |
T |
A |
2: 181,633,198 (GRCm39) |
D60E |
probably benign |
Het |
| Hivep1 |
C |
A |
13: 42,308,385 (GRCm39) |
S208R |
probably damaging |
Het |
| Kif1b |
A |
G |
4: 149,283,771 (GRCm39) |
I1252T |
probably damaging |
Het |
| Knl1 |
T |
C |
2: 118,900,804 (GRCm39) |
V835A |
possibly damaging |
Het |
| Or2d4 |
A |
T |
7: 106,543,965 (GRCm39) |
M81K |
probably benign |
Het |
| Or5ac25 |
C |
T |
16: 59,182,077 (GRCm39) |
C168Y |
probably damaging |
Het |
| Ppwd1 |
T |
G |
13: 104,359,645 (GRCm39) |
I119L |
probably benign |
Het |
| Prex1 |
T |
C |
2: 166,451,748 (GRCm39) |
K410R |
probably damaging |
Het |
| Prm2 |
C |
T |
16: 10,609,754 (GRCm39) |
|
probably benign |
Het |
| Psip1 |
T |
C |
4: 83,386,874 (GRCm39) |
T166A |
probably benign |
Het |
| Rtel1 |
T |
C |
2: 180,977,765 (GRCm39) |
V98A |
probably benign |
Het |
| Sdsl |
G |
A |
5: 120,600,124 (GRCm39) |
T91I |
probably damaging |
Het |
| Tas2r136 |
A |
G |
6: 132,754,494 (GRCm39) |
M211T |
possibly damaging |
Het |
| Trim43c |
A |
T |
9: 88,723,885 (GRCm39) |
|
probably null |
Het |
| Ttc1 |
T |
C |
11: 43,630,664 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Gpr85 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R0784:Gpr85
|
UTSW |
6 |
13,836,748 (GRCm39) |
missense |
probably benign |
0.25 |
|
R1356:Gpr85
|
UTSW |
6 |
13,836,146 (GRCm39) |
missense |
probably benign |
0.42 |
|
R2343:Gpr85
|
UTSW |
6 |
13,836,695 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3934:Gpr85
|
UTSW |
6 |
13,836,044 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3935:Gpr85
|
UTSW |
6 |
13,836,044 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3936:Gpr85
|
UTSW |
6 |
13,836,044 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4925:Gpr85
|
UTSW |
6 |
13,835,977 (GRCm39) |
missense |
probably benign |
0.26 |
|
R5313:Gpr85
|
UTSW |
6 |
13,836,301 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5586:Gpr85
|
UTSW |
6 |
13,836,000 (GRCm39) |
nonsense |
probably null |
|
|
R7043:Gpr85
|
UTSW |
6 |
13,835,876 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8458:Gpr85
|
UTSW |
6 |
13,836,848 (GRCm39) |
missense |
probably benign |
|
|
R8468:Gpr85
|
UTSW |
6 |
13,836,295 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8503:Gpr85
|
UTSW |
6 |
13,836,829 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9519:Gpr85
|
UTSW |
6 |
13,836,998 (GRCm39) |
start gained |
probably benign |
|
|
| Posted On |
2015-04-16 |
Incidental Mutation