Incidental Mutation 'IGL02415:Vmn2r66'
| ID |
292382 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r66
|
| Ensembl Gene |
ENSMUSG00000094950 |
| Gene Name |
vomeronasal 2, receptor 66 |
| Synonyms |
F830104D24Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.073)
|
| Stock # |
IGL02415
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
84994645-85012020 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 85006812 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Isoleucine
at position 332
(T332I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000122645
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000124773]
|
| AlphaFold |
A0A3B2W842 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000124773
AA Change: T332I
PolyPhen 2
Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000122645
Gene: ENSMUSG00000094950
AA Change: T332I
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
463 |
5e-31 |
PFAM |
|
Pfam:NCD3G
|
507 |
559 |
6e-21 |
PFAM |
|
Pfam:7tm_3
|
589 |
827 |
3.8e-52 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 51 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110059G10Rik |
T |
C |
9: 122,947,991 (GRCm38) |
D124G |
probably benign |
Het |
| Adamts13 |
T |
A |
2: 26,989,283 (GRCm38) |
I616N |
possibly damaging |
Het |
| Adamts3 |
T |
C |
5: 89,706,647 (GRCm38) |
|
probably null |
Het |
| Amy1 |
T |
C |
3: 113,563,585 (GRCm38) |
I202V |
probably benign |
Het |
| Bdp1 |
G |
A |
13: 100,089,408 (GRCm38) |
T322I |
probably damaging |
Het |
| Cep295 |
A |
G |
9: 15,353,020 (GRCm38) |
L110S |
probably damaging |
Het |
| Cep72 |
T |
C |
13: 74,050,154 (GRCm38) |
D369G |
probably benign |
Het |
| Chd3 |
A |
T |
11: 69,348,913 (GRCm38) |
|
probably benign |
Het |
| Ckmt2 |
G |
A |
13: 91,863,340 (GRCm38) |
|
probably benign |
Het |
| Cyp2s1 |
T |
C |
7: 25,808,137 (GRCm38) |
T296A |
probably damaging |
Het |
| E2f5 |
T |
A |
3: 14,603,897 (GRCm38) |
V283E |
probably benign |
Het |
| F5 |
A |
G |
1: 164,191,929 (GRCm38) |
T658A |
probably damaging |
Het |
| Fam102b |
A |
G |
3: 108,980,292 (GRCm38) |
Y219H |
probably damaging |
Het |
| Gml |
A |
T |
15: 74,816,440 (GRCm38) |
Y59* |
probably null |
Het |
| Kmo |
A |
T |
1: 175,649,323 (GRCm38) |
|
probably benign |
Het |
| Krt25 |
A |
T |
11: 99,322,572 (GRCm38) |
I107N |
probably damaging |
Het |
| Llgl2 |
A |
G |
11: 115,853,285 (GRCm38) |
M773V |
probably damaging |
Het |
| Lyst |
G |
A |
13: 13,660,956 (GRCm38) |
C1741Y |
probably benign |
Het |
| Med12 |
T |
C |
X: 101,281,790 (GRCm38) |
V761A |
probably damaging |
Het |
| Mrpl19 |
T |
C |
6: 81,963,961 (GRCm38) |
T150A |
probably benign |
Het |
| Muc2 |
G |
T |
7: 141,751,872 (GRCm38) |
E646* |
probably null |
Het |
| Muc20 |
T |
A |
16: 32,794,681 (GRCm38) |
T109S |
unknown |
Het |
| Nr2f6 |
T |
C |
8: 71,374,512 (GRCm38) |
T382A |
probably benign |
Het |
| Nrap |
A |
G |
19: 56,382,309 (GRCm38) |
I172T |
probably damaging |
Het |
| Olfr1434 |
A |
G |
19: 12,283,498 (GRCm38) |
Y150C |
probably benign |
Het |
| Olfr911-ps1 |
T |
C |
9: 38,524,112 (GRCm38) |
C127R |
probably benign |
Het |
| P3h1 |
A |
T |
4: 119,247,955 (GRCm38) |
Q710L |
probably benign |
Het |
| Parvb |
A |
G |
15: 84,292,815 (GRCm38) |
H185R |
probably damaging |
Het |
| Pkhd1 |
T |
C |
1: 20,522,759 (GRCm38) |
Y1710C |
probably damaging |
Het |
| Pkhd1 |
A |
G |
1: 20,414,421 (GRCm38) |
I1970T |
probably damaging |
Het |
| Plxna2 |
C |
A |
1: 194,643,964 (GRCm38) |
R69S |
probably damaging |
Het |
| Rad51ap2 |
A |
G |
12: 11,456,929 (GRCm38) |
N284S |
possibly damaging |
Het |
| Reln |
T |
A |
5: 21,971,951 (GRCm38) |
S1906C |
possibly damaging |
Het |
| Rln1 |
T |
C |
19: 29,334,398 (GRCm38) |
R67G |
probably damaging |
Het |
| Shcbp1 |
C |
T |
8: 4,754,239 (GRCm38) |
V224I |
possibly damaging |
Het |
| Slc13a4 |
A |
G |
6: 35,283,237 (GRCm38) |
|
probably null |
Het |
| Stx6 |
A |
G |
1: 155,193,313 (GRCm38) |
E195G |
possibly damaging |
Het |
| Sult2b1 |
G |
T |
7: 45,742,085 (GRCm38) |
D90E |
possibly damaging |
Het |
| Taok1 |
A |
G |
11: 77,540,240 (GRCm38) |
|
probably benign |
Het |
| Tbx15 |
A |
T |
3: 99,352,510 (GRCm38) |
M566L |
probably benign |
Het |
| Tcaf1 |
C |
T |
6: 42,686,650 (GRCm38) |
A99T |
probably benign |
Het |
| Tcf20 |
T |
A |
15: 82,853,459 (GRCm38) |
M1264L |
probably benign |
Het |
| Tenm4 |
G |
A |
7: 96,874,074 (GRCm38) |
V1571M |
probably damaging |
Het |
| Ttc39a |
A |
G |
4: 109,431,529 (GRCm38) |
|
probably benign |
Het |
| Ubr1 |
C |
A |
2: 120,970,603 (GRCm38) |
|
probably benign |
Het |
| Ulk1 |
T |
C |
5: 110,787,621 (GRCm38) |
D926G |
probably damaging |
Het |
| Vmn2r110 |
T |
C |
17: 20,583,771 (GRCm38) |
I181V |
probably benign |
Het |
| Wdr1 |
C |
A |
5: 38,531,110 (GRCm38) |
D161Y |
probably damaging |
Het |
| Wnt7a |
T |
C |
6: 91,394,557 (GRCm38) |
Y141C |
probably damaging |
Het |
| Xrra1 |
G |
A |
7: 99,915,943 (GRCm38) |
E573K |
probably benign |
Het |
| Zfp334 |
G |
T |
2: 165,381,851 (GRCm38) |
Q91K |
possibly damaging |
Het |
|
| Other mutations in Vmn2r66 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00321:Vmn2r66
|
APN |
7 |
85,007,091 (GRCm38) |
missense |
probably benign |
|
|
IGL01562:Vmn2r66
|
APN |
7 |
85,007,287 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL01689:Vmn2r66
|
APN |
7 |
85,007,825 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02237:Vmn2r66
|
APN |
7 |
84,994,700 (GRCm38) |
missense |
probably benign |
|
|
IGL02439:Vmn2r66
|
APN |
7 |
85,005,247 (GRCm38) |
splice site |
probably benign |
|
|
IGL02545:Vmn2r66
|
APN |
7 |
85,006,590 (GRCm38) |
missense |
possibly damaging |
0.50 |
|
IGL02708:Vmn2r66
|
APN |
7 |
85,006,588 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02794:Vmn2r66
|
APN |
7 |
84,995,415 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02885:Vmn2r66
|
APN |
7 |
84,995,515 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02975:Vmn2r66
|
APN |
7 |
85,006,974 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL03027:Vmn2r66
|
APN |
7 |
84,995,569 (GRCm38) |
splice site |
probably benign |
|
|
IGL03081:Vmn2r66
|
APN |
7 |
85,007,930 (GRCm38) |
missense |
probably benign |
|
|
PIT4131001:Vmn2r66
|
UTSW |
7 |
84,995,093 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0098:Vmn2r66
|
UTSW |
7 |
85,005,757 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0504:Vmn2r66
|
UTSW |
7 |
85,006,815 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0557:Vmn2r66
|
UTSW |
7 |
84,994,764 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0617:Vmn2r66
|
UTSW |
7 |
84,995,276 (GRCm38) |
missense |
probably benign |
0.02 |
|
R0883:Vmn2r66
|
UTSW |
7 |
85,007,862 (GRCm38) |
missense |
probably benign |
|
|
R1159:Vmn2r66
|
UTSW |
7 |
84,995,405 (GRCm38) |
missense |
probably benign |
0.44 |
|
R1168:Vmn2r66
|
UTSW |
7 |
85,006,854 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R1172:Vmn2r66
|
UTSW |
7 |
85,005,591 (GRCm38) |
missense |
probably benign |
0.04 |
|
R1175:Vmn2r66
|
UTSW |
7 |
85,005,591 (GRCm38) |
missense |
probably benign |
0.04 |
|
R1538:Vmn2r66
|
UTSW |
7 |
84,994,958 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R1658:Vmn2r66
|
UTSW |
7 |
85,007,747 (GRCm38) |
missense |
probably benign |
0.07 |
|
R1937:Vmn2r66
|
UTSW |
7 |
84,995,136 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1989:Vmn2r66
|
UTSW |
7 |
85,011,993 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2698:Vmn2r66
|
UTSW |
7 |
84,995,399 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2890:Vmn2r66
|
UTSW |
7 |
85,011,819 (GRCm38) |
splice site |
probably null |
|
|
R3686:Vmn2r66
|
UTSW |
7 |
84,995,189 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R4152:Vmn2r66
|
UTSW |
7 |
85,005,592 (GRCm38) |
missense |
probably benign |
0.08 |
|
R4500:Vmn2r66
|
UTSW |
7 |
85,007,954 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4618:Vmn2r66
|
UTSW |
7 |
84,995,088 (GRCm38) |
missense |
possibly damaging |
0.62 |
|
R4656:Vmn2r66
|
UTSW |
7 |
85,011,996 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R4668:Vmn2r66
|
UTSW |
7 |
84,994,697 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4942:Vmn2r66
|
UTSW |
7 |
85,007,772 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5163:Vmn2r66
|
UTSW |
7 |
85,006,809 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5223:Vmn2r66
|
UTSW |
7 |
85,007,885 (GRCm38) |
missense |
probably benign |
|
|
R5377:Vmn2r66
|
UTSW |
7 |
85,006,818 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5512:Vmn2r66
|
UTSW |
7 |
85,007,941 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5611:Vmn2r66
|
UTSW |
7 |
85,005,743 (GRCm38) |
nonsense |
probably null |
|
|
R5749:Vmn2r66
|
UTSW |
7 |
85,006,771 (GRCm38) |
nonsense |
probably null |
|
|
R6131:Vmn2r66
|
UTSW |
7 |
84,995,016 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6183:Vmn2r66
|
UTSW |
7 |
84,995,558 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R6509:Vmn2r66
|
UTSW |
7 |
85,006,846 (GRCm38) |
missense |
probably benign |
0.12 |
|
R6930:Vmn2r66
|
UTSW |
7 |
85,012,008 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
R6992:Vmn2r66
|
UTSW |
7 |
85,005,228 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R7015:Vmn2r66
|
UTSW |
7 |
84,995,558 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R7302:Vmn2r66
|
UTSW |
7 |
85,005,215 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7516:Vmn2r66
|
UTSW |
7 |
85,011,968 (GRCm38) |
missense |
possibly damaging |
0.51 |
|
R7763:Vmn2r66
|
UTSW |
7 |
85,005,701 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7814:Vmn2r66
|
UTSW |
7 |
85,007,264 (GRCm38) |
missense |
probably benign |
0.02 |
|
R8077:Vmn2r66
|
UTSW |
7 |
85,006,885 (GRCm38) |
missense |
probably benign |
|
|
R8307:Vmn2r66
|
UTSW |
7 |
85,007,062 (GRCm38) |
missense |
probably benign |
|
|
R8315:Vmn2r66
|
UTSW |
7 |
84,994,724 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R8490:Vmn2r66
|
UTSW |
7 |
85,005,586 (GRCm38) |
critical splice donor site |
probably null |
|
|
R8511:Vmn2r66
|
UTSW |
7 |
85,006,818 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8781:Vmn2r66
|
UTSW |
7 |
84,995,147 (GRCm38) |
nonsense |
probably null |
|
|
R8812:Vmn2r66
|
UTSW |
7 |
85,005,685 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9203:Vmn2r66
|
UTSW |
7 |
85,005,742 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9277:Vmn2r66
|
UTSW |
7 |
85,011,956 (GRCm38) |
missense |
probably benign |
0.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation