Incidental Mutation 'IGL02415:Olfr911-ps1'
ID292384
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr911-ps1
Ensembl Gene ENSMUSG00000062621
Gene Nameolfactory receptor 911, pseudogene 1
SynonymsMOR165-1, MOR166-1, GA_x6K02T2PVTD-32247224-32248163, GA_x6K02T2PVTD-32223906-32224841, Olfr909
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.054) question?
Stock #IGL02415
Quality Score
Status
Chromosome9
Chromosomal Location38521580-38527133 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 38524112 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Arginine at position 127 (C127R)
Ref Sequence ENSEMBL: ENSMUSP00000150446 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074987] [ENSMUST00000216496]
Predicted Effect probably benign
Transcript: ENSMUST00000074987
AA Change: C127R

PolyPhen 2 Score 0.417 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000074515
Gene: ENSMUSG00000062621
AA Change: C127R

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.2e-46 PFAM
Pfam:7tm_1 41 290 9.8e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216496
AA Change: C127R

PolyPhen 2 Score 0.417 (Sensitivity: 0.89; Specificity: 0.90)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110059G10Rik T C 9: 122,947,991 D124G probably benign Het
Adamts13 T A 2: 26,989,283 I616N possibly damaging Het
Adamts3 T C 5: 89,706,647 probably null Het
Amy1 T C 3: 113,563,585 I202V probably benign Het
Bdp1 G A 13: 100,089,408 T322I probably damaging Het
Cep295 A G 9: 15,353,020 L110S probably damaging Het
Cep72 T C 13: 74,050,154 D369G probably benign Het
Chd3 A T 11: 69,348,913 probably benign Het
Ckmt2 G A 13: 91,863,340 probably benign Het
Cyp2s1 T C 7: 25,808,137 T296A probably damaging Het
E2f5 T A 3: 14,603,897 V283E probably benign Het
F5 A G 1: 164,191,929 T658A probably damaging Het
Fam102b A G 3: 108,980,292 Y219H probably damaging Het
Gml A T 15: 74,816,440 Y59* probably null Het
Kmo A T 1: 175,649,323 probably benign Het
Krt25 A T 11: 99,322,572 I107N probably damaging Het
Llgl2 A G 11: 115,853,285 M773V probably damaging Het
Lyst G A 13: 13,660,956 C1741Y probably benign Het
Med12 T C X: 101,281,790 V761A probably damaging Het
Mrpl19 T C 6: 81,963,961 T150A probably benign Het
Muc2 G T 7: 141,751,872 E646* probably null Het
Muc20 T A 16: 32,794,681 T109S unknown Het
Nr2f6 T C 8: 71,374,512 T382A probably benign Het
Nrap A G 19: 56,382,309 I172T probably damaging Het
Olfr1434 A G 19: 12,283,498 Y150C probably benign Het
P3h1 A T 4: 119,247,955 Q710L probably benign Het
Parvb A G 15: 84,292,815 H185R probably damaging Het
Pkhd1 A G 1: 20,414,421 I1970T probably damaging Het
Pkhd1 T C 1: 20,522,759 Y1710C probably damaging Het
Plxna2 C A 1: 194,643,964 R69S probably damaging Het
Rad51ap2 A G 12: 11,456,929 N284S possibly damaging Het
Reln T A 5: 21,971,951 S1906C possibly damaging Het
Rln1 T C 19: 29,334,398 R67G probably damaging Het
Shcbp1 C T 8: 4,754,239 V224I possibly damaging Het
Slc13a4 A G 6: 35,283,237 probably null Het
Stx6 A G 1: 155,193,313 E195G possibly damaging Het
Sult2b1 G T 7: 45,742,085 D90E possibly damaging Het
Taok1 A G 11: 77,540,240 probably benign Het
Tbx15 A T 3: 99,352,510 M566L probably benign Het
Tcaf1 C T 6: 42,686,650 A99T probably benign Het
Tcf20 T A 15: 82,853,459 M1264L probably benign Het
Tenm4 G A 7: 96,874,074 V1571M probably damaging Het
Ttc39a A G 4: 109,431,529 probably benign Het
Ubr1 C A 2: 120,970,603 probably benign Het
Ulk1 T C 5: 110,787,621 D926G probably damaging Het
Vmn2r110 T C 17: 20,583,771 I181V probably benign Het
Vmn2r66 G A 7: 85,006,812 T332I probably damaging Het
Wdr1 C A 5: 38,531,110 D161Y probably damaging Het
Wnt7a T C 6: 91,394,557 Y141C probably damaging Het
Xrra1 G A 7: 99,915,943 E573K probably benign Het
Zfp334 G T 2: 165,381,851 Q91K possibly damaging Het
Other mutations in Olfr911-ps1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01025:Olfr911-ps1 APN 9 38523733 utr 5 prime probably benign
IGL02319:Olfr911-ps1 APN 9 38523870 missense probably damaging 0.97
IGL02536:Olfr911-ps1 APN 9 38524164 missense probably damaging 1.00
IGL02702:Olfr911-ps1 APN 9 38524560 missense probably damaging 1.00
IGL02926:Olfr911-ps1 APN 9 38523725 utr 5 prime probably benign
R0499:Olfr911-ps1 UTSW 9 38524505 missense probably benign 0.01
R0662:Olfr911-ps1 UTSW 9 38524026 missense probably damaging 0.99
R0799:Olfr911-ps1 UTSW 9 38524141 missense probably benign 0.01
R1186:Olfr911-ps1 UTSW 9 38524157 missense probably damaging 0.97
R1681:Olfr911-ps1 UTSW 9 38524117 missense probably benign 0.03
R3522:Olfr911-ps1 UTSW 9 38523785 missense probably damaging 1.00
R5820:Olfr911-ps1 UTSW 9 38524599 missense possibly damaging 0.52
R6597:Olfr911-ps1 UTSW 9 38524004 missense probably benign 0.00
R7721:Olfr911-ps1 UTSW 9 38523717 critical splice acceptor site probably null
R7846:Olfr911-ps1 UTSW 9 38524379 missense probably benign 0.00
R7985:Olfr911-ps1 UTSW 9 38523943 missense probably damaging 1.00
R8339:Olfr911-ps1 UTSW 9 38524421 missense probably damaging 1.00
R8460:Olfr911-ps1 UTSW 9 38516630 unclassified probably benign
Z1088:Olfr911-ps1 UTSW 9 38523859 missense probably damaging 1.00
Posted On2015-04-16