Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02415:Zfp334'

292390

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp334

Ensembl Gene

ENSMUSG00000017667

Gene Name

zinc finger protein 334

Synonyms

D2Ertd535e

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02415

Quality Score

Status

Chromosome

Chromosomal Location

165374264-165388259 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 165381851 bp

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Lysine at position 91 (Q91K)

Ref Sequence

ENSEMBL: ENSMUSP00000099373 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000103084]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000103084
AA Change: Q91K

PolyPhen 2 Score 0.697 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000099373
Gene: ENSMUSG00000017667
AA Change: Q91K

Domain	Start	End	E-Value	Type
KRAB	8	68	5.91e-35	SMART
ZnF_C2H2	236	258	5.42e-2	SMART
ZnF_C2H2	264	286	1.2e-3	SMART
ZnF_C2H2	292	314	6.99e-5	SMART
ZnF_C2H2	320	342	1.22e-4	SMART
ZnF_C2H2	348	370	3.39e-3	SMART
ZnF_C2H2	376	398	7.15e-2	SMART
ZnF_C2H2	404	426	1.69e-3	SMART
ZnF_C2H2	432	454	1.92e-2	SMART
ZnF_C2H2	460	482	3.16e-3	SMART
ZnF_C2H2	543	565	1.82e-3	SMART
ZnF_C2H2	571	593	3.69e-4	SMART
ZnF_C2H2	599	621	1.58e-3	SMART
ZnF_C2H2	627	649	1.38e-3	SMART
ZnF_C2H2	655	677	3.89e-3	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the C2H2 zinc finger family. The encoded protein contains a Krueppel-associated box, fourteen C2H2 zinc finger domains, and four C2H2-type/integrase DNA-binding domains. Decreased expression of this gene may be a marker for rheumatoid arthritis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110059G10Rik	T	C	9: 122,947,991	D124G	probably benign	Het
Adamts13	T	A	2: 26,989,283	I616N	possibly damaging	Het
Adamts3	T	C	5: 89,706,647		probably null	Het
Amy1	T	C	3: 113,563,585	I202V	probably benign	Het
Bdp1	G	A	13: 100,089,408	T322I	probably damaging	Het
Cep295	A	G	9: 15,353,020	L110S	probably damaging	Het
Cep72	T	C	13: 74,050,154	D369G	probably benign	Het
Chd3	A	T	11: 69,348,913		probably benign	Het
Ckmt2	G	A	13: 91,863,340		probably benign	Het
Cyp2s1	T	C	7: 25,808,137	T296A	probably damaging	Het
E2f5	T	A	3: 14,603,897	V283E	probably benign	Het
F5	A	G	1: 164,191,929	T658A	probably damaging	Het
Fam102b	A	G	3: 108,980,292	Y219H	probably damaging	Het
Gml	A	T	15: 74,816,440	Y59*	probably null	Het
Kmo	A	T	1: 175,649,323		probably benign	Het
Krt25	A	T	11: 99,322,572	I107N	probably damaging	Het
Llgl2	A	G	11: 115,853,285	M773V	probably damaging	Het
Lyst	G	A	13: 13,660,956	C1741Y	probably benign	Het
Med12	T	C	X: 101,281,790	V761A	probably damaging	Het
Mrpl19	T	C	6: 81,963,961	T150A	probably benign	Het
Muc2	G	T	7: 141,751,872	E646*	probably null	Het
Muc20	T	A	16: 32,794,681	T109S	unknown	Het
Nr2f6	T	C	8: 71,374,512	T382A	probably benign	Het
Nrap	A	G	19: 56,382,309	I172T	probably damaging	Het
Olfr1434	A	G	19: 12,283,498	Y150C	probably benign	Het
Olfr911-ps1	T	C	9: 38,524,112	C127R	probably benign	Het
P3h1	A	T	4: 119,247,955	Q710L	probably benign	Het
Parvb	A	G	15: 84,292,815	H185R	probably damaging	Het
Pkhd1	A	G	1: 20,414,421	I1970T	probably damaging	Het
Pkhd1	T	C	1: 20,522,759	Y1710C	probably damaging	Het
Plxna2	C	A	1: 194,643,964	R69S	probably damaging	Het
Rad51ap2	A	G	12: 11,456,929	N284S	possibly damaging	Het
Reln	T	A	5: 21,971,951	S1906C	possibly damaging	Het
Rln1	T	C	19: 29,334,398	R67G	probably damaging	Het
Shcbp1	C	T	8: 4,754,239	V224I	possibly damaging	Het
Slc13a4	A	G	6: 35,283,237		probably null	Het
Stx6	A	G	1: 155,193,313	E195G	possibly damaging	Het
Sult2b1	G	T	7: 45,742,085	D90E	possibly damaging	Het
Taok1	A	G	11: 77,540,240		probably benign	Het
Tbx15	A	T	3: 99,352,510	M566L	probably benign	Het
Tcaf1	C	T	6: 42,686,650	A99T	probably benign	Het
Tcf20	T	A	15: 82,853,459	M1264L	probably benign	Het
Tenm4	G	A	7: 96,874,074	V1571M	probably damaging	Het
Ttc39a	A	G	4: 109,431,529		probably benign	Het
Ubr1	C	A	2: 120,970,603		probably benign	Het
Ulk1	T	C	5: 110,787,621	D926G	probably damaging	Het
Vmn2r110	T	C	17: 20,583,771	I181V	probably benign	Het
Vmn2r66	G	A	7: 85,006,812	T332I	probably damaging	Het
Wdr1	C	A	5: 38,531,110	D161Y	probably damaging	Het
Wnt7a	T	C	6: 91,394,557	Y141C	probably damaging	Het
Xrra1	G	A	7: 99,915,943	E573K	probably benign	Het

Other mutations in Zfp334

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02097:Zfp334	APN	2	165381723	nonsense	probably null
IGL02185:Zfp334	APN	2	165386949	utr 5 prime	probably benign
IGL02693:Zfp334	APN	2	165380513	missense	possibly damaging	0.80
ANU23:Zfp334	UTSW	2	165381097	missense	probably damaging	1.00
R0040:Zfp334	UTSW	2	165381572	missense	probably benign	0.45
R1332:Zfp334	UTSW	2	165380856	missense	probably damaging	1.00
R1579:Zfp334	UTSW	2	165381799	missense	probably damaging	0.98
R2429:Zfp334	UTSW	2	165380512	missense	probably damaging	1.00
R5556:Zfp334	UTSW	2	165380584	missense	probably benign
R5579:Zfp334	UTSW	2	165380487	nonsense	probably null
R6891:Zfp334	UTSW	2	165382724	missense	probably benign
R6918:Zfp334	UTSW	2	165381879	missense	possibly damaging	0.46
R8360:Zfp334	UTSW	2	165383358	missense	probably benign	0.00

Posted On

2015-04-16