Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02415:Zfp334'

292390

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp334

Ensembl Gene

ENSMUSG00000017667

Gene Name

zinc finger protein 334

Synonyms

D2Ertd535e

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02415

Quality Score

Status

Chromosome

Chromosomal Location

165216184-165230179 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 165223771 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Lysine at position 91 (Q91K)

Ref Sequence

ENSEMBL: ENSMUSP00000099373 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000103084]

AlphaFold

A2A4U6

Predicted Effect

possibly damaging
Transcript: ENSMUST00000103084
AA Change: Q91K

PolyPhen 2 Score 0.697 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000099373
Gene: ENSMUSG00000017667
AA Change: Q91K

Domain	Start	End	E-Value	Type
KRAB	8	68	5.91e-35	SMART
ZnF_C2H2	236	258	5.42e-2	SMART
ZnF_C2H2	264	286	1.2e-3	SMART
ZnF_C2H2	292	314	6.99e-5	SMART
ZnF_C2H2	320	342	1.22e-4	SMART
ZnF_C2H2	348	370	3.39e-3	SMART
ZnF_C2H2	376	398	7.15e-2	SMART
ZnF_C2H2	404	426	1.69e-3	SMART
ZnF_C2H2	432	454	1.92e-2	SMART
ZnF_C2H2	460	482	3.16e-3	SMART
ZnF_C2H2	543	565	1.82e-3	SMART
ZnF_C2H2	571	593	3.69e-4	SMART
ZnF_C2H2	599	621	1.58e-3	SMART
ZnF_C2H2	627	649	1.38e-3	SMART
ZnF_C2H2	655	677	3.89e-3	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the C2H2 zinc finger family. The encoded protein contains a Krueppel-associated box, fourteen C2H2 zinc finger domains, and four C2H2-type/integrase DNA-binding domains. Decreased expression of this gene may be a marker for rheumatoid arthritis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110059G10Rik	T	C	9: 122,777,056 (GRCm39)	D124G	probably benign	Het
Adamts13	T	A	2: 26,879,295 (GRCm39)	I616N	possibly damaging	Het
Adamts3	T	C	5: 89,854,506 (GRCm39)		probably null	Het
Amy1	T	C	3: 113,357,234 (GRCm39)	I202V	probably benign	Het
Bdp1	G	A	13: 100,225,916 (GRCm39)	T322I	probably damaging	Het
Cep295	A	G	9: 15,264,316 (GRCm39)	L110S	probably damaging	Het
Cep72	T	C	13: 74,198,273 (GRCm39)	D369G	probably benign	Het
Chd3	A	T	11: 69,239,739 (GRCm39)		probably benign	Het
Ckmt2	G	A	13: 92,011,459 (GRCm39)		probably benign	Het
Cyp2s1	T	C	7: 25,507,562 (GRCm39)	T296A	probably damaging	Het
E2f5	T	A	3: 14,668,957 (GRCm39)	V283E	probably benign	Het
Eeig2	A	G	3: 108,887,608 (GRCm39)	Y219H	probably damaging	Het
F5	A	G	1: 164,019,498 (GRCm39)	T658A	probably damaging	Het
Gml	A	T	15: 74,688,289 (GRCm39)	Y59*	probably null	Het
Kmo	A	T	1: 175,476,889 (GRCm39)		probably benign	Het
Krt25	A	T	11: 99,213,398 (GRCm39)	I107N	probably damaging	Het
Llgl2	A	G	11: 115,744,111 (GRCm39)	M773V	probably damaging	Het
Lyst	G	A	13: 13,835,541 (GRCm39)	C1741Y	probably benign	Het
Med12	T	C	X: 100,325,396 (GRCm39)	V761A	probably damaging	Het
Mrpl19	T	C	6: 81,940,942 (GRCm39)	T150A	probably benign	Het
Muc2	G	T	7: 141,305,609 (GRCm39)	E646*	probably null	Het
Muc20	T	A	16: 32,615,051 (GRCm39)	T109S	unknown	Het
Nr2f6	T	C	8: 71,827,156 (GRCm39)	T382A	probably benign	Het
Nrap	A	G	19: 56,370,741 (GRCm39)	I172T	probably damaging	Het
Or5an1	A	G	19: 12,260,862 (GRCm39)	Y150C	probably benign	Het
Or8b47	T	C	9: 38,435,408 (GRCm39)	C127R	probably benign	Het
P3h1	A	T	4: 119,105,152 (GRCm39)	Q710L	probably benign	Het
Parvb	A	G	15: 84,177,016 (GRCm39)	H185R	probably damaging	Het
Pkhd1	A	G	1: 20,484,645 (GRCm39)	I1970T	probably damaging	Het
Pkhd1	T	C	1: 20,592,983 (GRCm39)	Y1710C	probably damaging	Het
Plxna2	C	A	1: 194,326,272 (GRCm39)	R69S	probably damaging	Het
Rad51ap2	A	G	12: 11,506,930 (GRCm39)	N284S	possibly damaging	Het
Reln	T	A	5: 22,176,949 (GRCm39)	S1906C	possibly damaging	Het
Rln1	T	C	19: 29,311,798 (GRCm39)	R67G	probably damaging	Het
Shcbp1	C	T	8: 4,804,239 (GRCm39)	V224I	possibly damaging	Het
Slc13a4	A	G	6: 35,260,172 (GRCm39)		probably null	Het
Stx6	A	G	1: 155,069,059 (GRCm39)	E195G	possibly damaging	Het
Sult2b1	G	T	7: 45,391,509 (GRCm39)	D90E	possibly damaging	Het
Taok1	A	G	11: 77,431,066 (GRCm39)		probably benign	Het
Tbx15	A	T	3: 99,259,826 (GRCm39)	M566L	probably benign	Het
Tcaf1	C	T	6: 42,663,584 (GRCm39)	A99T	probably benign	Het
Tcf20	T	A	15: 82,737,660 (GRCm39)	M1264L	probably benign	Het
Tenm4	G	A	7: 96,523,281 (GRCm39)	V1571M	probably damaging	Het
Ttc39a	A	G	4: 109,288,726 (GRCm39)		probably benign	Het
Ubr1	C	A	2: 120,801,084 (GRCm39)		probably benign	Het
Ulk1	T	C	5: 110,935,487 (GRCm39)	D926G	probably damaging	Het
Vmn2r110	T	C	17: 20,804,033 (GRCm39)	I181V	probably benign	Het
Vmn2r66	G	A	7: 84,656,020 (GRCm39)	T332I	probably damaging	Het
Wdr1	C	A	5: 38,688,453 (GRCm39)	D161Y	probably damaging	Het
Wnt7a	T	C	6: 91,371,539 (GRCm39)	Y141C	probably damaging	Het
Xrra1	G	A	7: 99,565,150 (GRCm39)	E573K	probably benign	Het

Other mutations in Zfp334

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02097:Zfp334	APN	2	165,223,643 (GRCm39)	nonsense	probably null
IGL02185:Zfp334	APN	2	165,228,869 (GRCm39)	utr 5 prime	probably benign
IGL02693:Zfp334	APN	2	165,222,433 (GRCm39)	missense	possibly damaging	0.80
ANU23:Zfp334	UTSW	2	165,223,017 (GRCm39)	missense	probably damaging	1.00
R0040:Zfp334	UTSW	2	165,223,492 (GRCm39)	missense	probably benign	0.45
R1332:Zfp334	UTSW	2	165,222,776 (GRCm39)	missense	probably damaging	1.00
R1579:Zfp334	UTSW	2	165,223,719 (GRCm39)	missense	probably damaging	0.98
R2429:Zfp334	UTSW	2	165,222,432 (GRCm39)	missense	probably damaging	1.00
R5556:Zfp334	UTSW	2	165,222,504 (GRCm39)	missense	probably benign
R5579:Zfp334	UTSW	2	165,222,407 (GRCm39)	nonsense	probably null
R6891:Zfp334	UTSW	2	165,224,644 (GRCm39)	missense	probably benign
R6918:Zfp334	UTSW	2	165,223,799 (GRCm39)	missense	possibly damaging	0.46
R8360:Zfp334	UTSW	2	165,225,278 (GRCm39)	missense	probably benign	0.00
R8998:Zfp334	UTSW	2	165,223,408 (GRCm39)	missense	possibly damaging	0.80
R9481:Zfp334	UTSW	2	165,222,271 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16