Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02415:Xrra1'

292394

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Xrra1

Ensembl Gene

ENSMUSG00000035211

Gene Name

X-ray radiation resistance associated 1

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.066) question?

Stock #

IGL02415

Quality Score

Status

Chromosome

Chromosomal Location

99859116-99917822 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 99915943 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Lysine at position 573 (E573K)

Ref Sequence

ENSEMBL: ENSMUSP00000035929 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000036155] [ENSMUST00000080817]

AlphaFold

Q3U3V8

Predicted Effect

probably benign
Transcript: ENSMUST00000036155
AA Change: E573K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000035929
Gene: ENSMUSG00000035211
AA Change: E573K

Domain	Start	End	E-Value	Type
low complexity region	41	52	N/A	INTRINSIC
Blast:LRR	144	168	4e-6	BLAST
LRR	191	214	2.02e-1	SMART
LRR	232	253	1.67e2	SMART
LRR	257	278	6.41e1	SMART
LRR	371	398	4.09e1	SMART
low complexity region	748	756	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000080817

SMART Domains

Protein: ENSMUSP00000079631
Gene: ENSMUSG00000058761

Domain	Start	End	E-Value	Type
low complexity region	2	27	N/A	INTRINSIC
low complexity region	32	46	N/A	INTRINSIC
RING	61	96	3.16e-1	SMART
Blast:RING	133	176	7e-8	BLAST
low complexity region	302	314	N/A	INTRINSIC
low complexity region	649	661	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000208270

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000208449

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110059G10Rik	T	C	9: 122,947,991	D124G	probably benign	Het
Adamts13	T	A	2: 26,989,283	I616N	possibly damaging	Het
Adamts3	T	C	5: 89,706,647		probably null	Het
Amy1	T	C	3: 113,563,585	I202V	probably benign	Het
Bdp1	G	A	13: 100,089,408	T322I	probably damaging	Het
Cep295	A	G	9: 15,353,020	L110S	probably damaging	Het
Cep72	T	C	13: 74,050,154	D369G	probably benign	Het
Chd3	A	T	11: 69,348,913		probably benign	Het
Ckmt2	G	A	13: 91,863,340		probably benign	Het
Cyp2s1	T	C	7: 25,808,137	T296A	probably damaging	Het
E2f5	T	A	3: 14,603,897	V283E	probably benign	Het
F5	A	G	1: 164,191,929	T658A	probably damaging	Het
Fam102b	A	G	3: 108,980,292	Y219H	probably damaging	Het
Gml	A	T	15: 74,816,440	Y59*	probably null	Het
Kmo	A	T	1: 175,649,323		probably benign	Het
Krt25	A	T	11: 99,322,572	I107N	probably damaging	Het
Llgl2	A	G	11: 115,853,285	M773V	probably damaging	Het
Lyst	G	A	13: 13,660,956	C1741Y	probably benign	Het
Med12	T	C	X: 101,281,790	V761A	probably damaging	Het
Mrpl19	T	C	6: 81,963,961	T150A	probably benign	Het
Muc2	G	T	7: 141,751,872	E646*	probably null	Het
Muc20	T	A	16: 32,794,681	T109S	unknown	Het
Nr2f6	T	C	8: 71,374,512	T382A	probably benign	Het
Nrap	A	G	19: 56,382,309	I172T	probably damaging	Het
Olfr1434	A	G	19: 12,283,498	Y150C	probably benign	Het
Olfr911-ps1	T	C	9: 38,524,112	C127R	probably benign	Het
P3h1	A	T	4: 119,247,955	Q710L	probably benign	Het
Parvb	A	G	15: 84,292,815	H185R	probably damaging	Het
Pkhd1	A	G	1: 20,414,421	I1970T	probably damaging	Het
Pkhd1	T	C	1: 20,522,759	Y1710C	probably damaging	Het
Plxna2	C	A	1: 194,643,964	R69S	probably damaging	Het
Rad51ap2	A	G	12: 11,456,929	N284S	possibly damaging	Het
Reln	T	A	5: 21,971,951	S1906C	possibly damaging	Het
Rln1	T	C	19: 29,334,398	R67G	probably damaging	Het
Shcbp1	C	T	8: 4,754,239	V224I	possibly damaging	Het
Slc13a4	A	G	6: 35,283,237		probably null	Het
Stx6	A	G	1: 155,193,313	E195G	possibly damaging	Het
Sult2b1	G	T	7: 45,742,085	D90E	possibly damaging	Het
Taok1	A	G	11: 77,540,240		probably benign	Het
Tbx15	A	T	3: 99,352,510	M566L	probably benign	Het
Tcaf1	C	T	6: 42,686,650	A99T	probably benign	Het
Tcf20	T	A	15: 82,853,459	M1264L	probably benign	Het
Tenm4	G	A	7: 96,874,074	V1571M	probably damaging	Het
Ttc39a	A	G	4: 109,431,529		probably benign	Het
Ubr1	C	A	2: 120,970,603		probably benign	Het
Ulk1	T	C	5: 110,787,621	D926G	probably damaging	Het
Vmn2r110	T	C	17: 20,583,771	I181V	probably benign	Het
Vmn2r66	G	A	7: 85,006,812	T332I	probably damaging	Het
Wdr1	C	A	5: 38,531,110	D161Y	probably damaging	Het
Wnt7a	T	C	6: 91,394,557	Y141C	probably damaging	Het
Zfp334	G	T	2: 165,381,851	Q91K	possibly damaging	Het

Other mutations in Xrra1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01782:Xrra1	APN	7	99875194	missense	possibly damaging	0.76
IGL01938:Xrra1	APN	7	99879469	critical splice donor site	probably null
IGL02064:Xrra1	APN	7	99914204	missense	probably damaging	1.00
IGL02286:Xrra1	APN	7	99914227	missense	possibly damaging	0.62
R0332:Xrra1	UTSW	7	99876242	missense	probably damaging	1.00
R0465:Xrra1	UTSW	7	99879371	missense	probably benign	0.00
R0533:Xrra1	UTSW	7	99875145	splice site	probably null
R0601:Xrra1	UTSW	7	99910968	missense	possibly damaging	0.95
R1539:Xrra1	UTSW	7	99871357	missense	probably damaging	1.00
R1672:Xrra1	UTSW	7	99898440	missense	probably benign	0.00
R1687:Xrra1	UTSW	7	99876244	missense	probably damaging	1.00
R1962:Xrra1	UTSW	7	99911020	missense	probably damaging	1.00
R2504:Xrra1	UTSW	7	99897596	missense	probably damaging	1.00
R4765:Xrra1	UTSW	7	99906568	missense	probably benign	0.19
R4967:Xrra1	UTSW	7	99906523	missense	probably damaging	0.99
R5213:Xrra1	UTSW	7	99898483	missense	possibly damaging	0.47
R5663:Xrra1	UTSW	7	99886043	missense	probably damaging	1.00
R5986:Xrra1	UTSW	7	99876255	missense	probably benign	0.40
R6256:Xrra1	UTSW	7	99914464	missense	probably damaging	0.99
R6269:Xrra1	UTSW	7	99917472	missense	probably damaging	1.00
R7234:Xrra1	UTSW	7	99914249	missense	possibly damaging	0.49
R7316:Xrra1	UTSW	7	99876216	critical splice acceptor site	probably null
R7655:Xrra1	UTSW	7	99910982	missense	probably benign	0.10
R7656:Xrra1	UTSW	7	99910982	missense	probably benign	0.10
R8688:Xrra1	UTSW	7	99906545	missense	probably damaging	1.00
R8788:Xrra1	UTSW	7	99906554	missense	probably benign	0.02
R9016:Xrra1	UTSW	7	99876255	missense	probably benign	0.11
R9196:Xrra1	UTSW	7	99914492	critical splice donor site	probably null
R9233:Xrra1	UTSW	7	99867367	missense	probably benign
R9545:Xrra1	UTSW	7	99886127	missense	possibly damaging	0.46
R9641:Xrra1	UTSW	7	99911881	missense	probably benign	0.05
R9742:Xrra1	UTSW	7	99914453	missense	probably benign	0.40
X0017:Xrra1	UTSW	7	99916100	missense	probably damaging	1.00
X0021:Xrra1	UTSW	7	99898486	missense	possibly damaging	0.63

Posted On

2015-04-16