Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02415:Gml'

292399

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gml

Ensembl Gene

ENSMUSG00000068349

Gene Name

glycosylphosphatidylinositol anchored molecule like

Synonyms

EG625599

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.101) question?

Stock #

IGL02415

Quality Score

Status

Chromosome

Chromosomal Location

74813452-74818815 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 74816440 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 59 (Y59*)

Ref Sequence

ENSEMBL: ENSMUSP00000140245 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000096399] [ENSMUST00000096400] [ENSMUST00000164026] [ENSMUST00000185253] [ENSMUST00000188180]

Predicted Effect

probably benign
Transcript: ENSMUST00000096399

SMART Domains

Protein: ENSMUSP00000094130
Gene: ENSMUSG00000068600

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
LU	47	141	2.06e-7	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000096400
AA Change: Y59*

SMART Domains

Protein: ENSMUSP00000094131
Gene: ENSMUSG00000068349
AA Change: Y59*

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
LU	47	141	2.3e-5	SMART
low complexity region	162	175	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000164026
AA Change: Y59*

SMART Domains

Protein: ENSMUSP00000128174
Gene: ENSMUSG00000068349
AA Change: Y59*

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
LU	47	141	2.3e-5	SMART
low complexity region	162	175	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000185253
AA Change: Y59*

SMART Domains

Protein: ENSMUSP00000140245
Gene: ENSMUSG00000068349
AA Change: Y59*

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:UPAR_LY6	49	104	3.8e-3	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000188180

SMART Domains

Protein: ENSMUSP00000141185
Gene: ENSMUSG00000068600

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Blast:LU	47	80	2e-15	BLAST

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110059G10Rik	T	C	9: 122,947,991	D124G	probably benign	Het
Adamts13	T	A	2: 26,989,283	I616N	possibly damaging	Het
Adamts3	T	C	5: 89,706,647		probably null	Het
Amy1	T	C	3: 113,563,585	I202V	probably benign	Het
Bdp1	G	A	13: 100,089,408	T322I	probably damaging	Het
Cep295	A	G	9: 15,353,020	L110S	probably damaging	Het
Cep72	T	C	13: 74,050,154	D369G	probably benign	Het
Chd3	A	T	11: 69,348,913		probably benign	Het
Ckmt2	G	A	13: 91,863,340		probably benign	Het
Cyp2s1	T	C	7: 25,808,137	T296A	probably damaging	Het
E2f5	T	A	3: 14,603,897	V283E	probably benign	Het
F5	A	G	1: 164,191,929	T658A	probably damaging	Het
Fam102b	A	G	3: 108,980,292	Y219H	probably damaging	Het
Kmo	A	T	1: 175,649,323		probably benign	Het
Krt25	A	T	11: 99,322,572	I107N	probably damaging	Het
Llgl2	A	G	11: 115,853,285	M773V	probably damaging	Het
Lyst	G	A	13: 13,660,956	C1741Y	probably benign	Het
Med12	T	C	X: 101,281,790	V761A	probably damaging	Het
Mrpl19	T	C	6: 81,963,961	T150A	probably benign	Het
Muc2	G	T	7: 141,751,872	E646*	probably null	Het
Muc20	T	A	16: 32,794,681	T109S	unknown	Het
Nr2f6	T	C	8: 71,374,512	T382A	probably benign	Het
Nrap	A	G	19: 56,382,309	I172T	probably damaging	Het
Olfr1434	A	G	19: 12,283,498	Y150C	probably benign	Het
Olfr911-ps1	T	C	9: 38,524,112	C127R	probably benign	Het
P3h1	A	T	4: 119,247,955	Q710L	probably benign	Het
Parvb	A	G	15: 84,292,815	H185R	probably damaging	Het
Pkhd1	A	G	1: 20,414,421	I1970T	probably damaging	Het
Pkhd1	T	C	1: 20,522,759	Y1710C	probably damaging	Het
Plxna2	C	A	1: 194,643,964	R69S	probably damaging	Het
Rad51ap2	A	G	12: 11,456,929	N284S	possibly damaging	Het
Reln	T	A	5: 21,971,951	S1906C	possibly damaging	Het
Rln1	T	C	19: 29,334,398	R67G	probably damaging	Het
Shcbp1	C	T	8: 4,754,239	V224I	possibly damaging	Het
Slc13a4	A	G	6: 35,283,237		probably null	Het
Stx6	A	G	1: 155,193,313	E195G	possibly damaging	Het
Sult2b1	G	T	7: 45,742,085	D90E	possibly damaging	Het
Taok1	A	G	11: 77,540,240		probably benign	Het
Tbx15	A	T	3: 99,352,510	M566L	probably benign	Het
Tcaf1	C	T	6: 42,686,650	A99T	probably benign	Het
Tcf20	T	A	15: 82,853,459	M1264L	probably benign	Het
Tenm4	G	A	7: 96,874,074	V1571M	probably damaging	Het
Ttc39a	A	G	4: 109,431,529		probably benign	Het
Ubr1	C	A	2: 120,970,603		probably benign	Het
Ulk1	T	C	5: 110,787,621	D926G	probably damaging	Het
Vmn2r110	T	C	17: 20,583,771	I181V	probably benign	Het
Vmn2r66	G	A	7: 85,006,812	T332I	probably damaging	Het
Wdr1	C	A	5: 38,531,110	D161Y	probably damaging	Het
Wnt7a	T	C	6: 91,394,557	Y141C	probably damaging	Het
Xrra1	G	A	7: 99,915,943	E573K	probably benign	Het
Zfp334	G	T	2: 165,381,851	Q91K	possibly damaging	Het

Other mutations in Gml

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01113:Gml	APN	15	74813727	missense	probably benign	0.00
IGL01161:Gml	APN	15	74813839	missense	probably damaging	1.00
R0674:Gml	UTSW	15	74813860	missense	probably damaging	1.00
R1716:Gml	UTSW	15	74813816	missense	possibly damaging	0.81
R1757:Gml	UTSW	15	74813613	unclassified	probably benign
R1827:Gml	UTSW	15	74816431	missense	probably benign	0.00
R1941:Gml	UTSW	15	74817171	missense	probably damaging	0.99
R3783:Gml	UTSW	15	74813672	missense	probably damaging	0.98
R4007:Gml	UTSW	15	74813699	missense	possibly damaging	0.59
R5326:Gml	UTSW	15	74816450	missense	probably damaging	1.00
R7378:Gml	UTSW	15	74817121	missense	possibly damaging	0.89
R7790:Gml	UTSW	15	74813613	unclassified	probably benign

Posted On

2015-04-16