Incidental Mutation 'IGL02415:Gml'
ID 292399
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gml
Ensembl Gene ENSMUSG00000068349
Gene Name glycosylphosphatidylinositol anchored molecule like
Synonyms EG625599
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.053) question?
Stock # IGL02415
Quality Score
Status
Chromosome 15
Chromosomal Location 74813452-74818815 bp(-) (GRCm38)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 74816440 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 59 (Y59*)
Ref Sequence ENSEMBL: ENSMUSP00000140245 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096399] [ENSMUST00000096400] [ENSMUST00000164026] [ENSMUST00000185253] [ENSMUST00000188180]
AlphaFold E9PX31
Predicted Effect probably benign
Transcript: ENSMUST00000096399
SMART Domains Protein: ENSMUSP00000094130
Gene: ENSMUSG00000068600

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
LU 47 141 2.06e-7 SMART
Predicted Effect probably null
Transcript: ENSMUST00000096400
AA Change: Y59*
SMART Domains Protein: ENSMUSP00000094131
Gene: ENSMUSG00000068349
AA Change: Y59*

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
LU 47 141 2.3e-5 SMART
low complexity region 162 175 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000164026
AA Change: Y59*
SMART Domains Protein: ENSMUSP00000128174
Gene: ENSMUSG00000068349
AA Change: Y59*

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
LU 47 141 2.3e-5 SMART
low complexity region 162 175 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000185253
AA Change: Y59*
SMART Domains Protein: ENSMUSP00000140245
Gene: ENSMUSG00000068349
AA Change: Y59*

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:UPAR_LY6 49 104 3.8e-3 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000188180
SMART Domains Protein: ENSMUSP00000141185
Gene: ENSMUSG00000068600

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Blast:LU 47 80 2e-15 BLAST
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110059G10Rik T C 9: 122,947,991 D124G probably benign Het
Adamts13 T A 2: 26,989,283 I616N possibly damaging Het
Adamts3 T C 5: 89,706,647 probably null Het
Amy1 T C 3: 113,563,585 I202V probably benign Het
Bdp1 G A 13: 100,089,408 T322I probably damaging Het
Cep295 A G 9: 15,353,020 L110S probably damaging Het
Cep72 T C 13: 74,050,154 D369G probably benign Het
Chd3 A T 11: 69,348,913 probably benign Het
Ckmt2 G A 13: 91,863,340 probably benign Het
Cyp2s1 T C 7: 25,808,137 T296A probably damaging Het
E2f5 T A 3: 14,603,897 V283E probably benign Het
F5 A G 1: 164,191,929 T658A probably damaging Het
Fam102b A G 3: 108,980,292 Y219H probably damaging Het
Kmo A T 1: 175,649,323 probably benign Het
Krt25 A T 11: 99,322,572 I107N probably damaging Het
Llgl2 A G 11: 115,853,285 M773V probably damaging Het
Lyst G A 13: 13,660,956 C1741Y probably benign Het
Med12 T C X: 101,281,790 V761A probably damaging Het
Mrpl19 T C 6: 81,963,961 T150A probably benign Het
Muc2 G T 7: 141,751,872 E646* probably null Het
Muc20 T A 16: 32,794,681 T109S unknown Het
Nr2f6 T C 8: 71,374,512 T382A probably benign Het
Nrap A G 19: 56,382,309 I172T probably damaging Het
Olfr1434 A G 19: 12,283,498 Y150C probably benign Het
Olfr911-ps1 T C 9: 38,524,112 C127R probably benign Het
P3h1 A T 4: 119,247,955 Q710L probably benign Het
Parvb A G 15: 84,292,815 H185R probably damaging Het
Pkhd1 A G 1: 20,414,421 I1970T probably damaging Het
Pkhd1 T C 1: 20,522,759 Y1710C probably damaging Het
Plxna2 C A 1: 194,643,964 R69S probably damaging Het
Rad51ap2 A G 12: 11,456,929 N284S possibly damaging Het
Reln T A 5: 21,971,951 S1906C possibly damaging Het
Rln1 T C 19: 29,334,398 R67G probably damaging Het
Shcbp1 C T 8: 4,754,239 V224I possibly damaging Het
Slc13a4 A G 6: 35,283,237 probably null Het
Stx6 A G 1: 155,193,313 E195G possibly damaging Het
Sult2b1 G T 7: 45,742,085 D90E possibly damaging Het
Taok1 A G 11: 77,540,240 probably benign Het
Tbx15 A T 3: 99,352,510 M566L probably benign Het
Tcaf1 C T 6: 42,686,650 A99T probably benign Het
Tcf20 T A 15: 82,853,459 M1264L probably benign Het
Tenm4 G A 7: 96,874,074 V1571M probably damaging Het
Ttc39a A G 4: 109,431,529 probably benign Het
Ubr1 C A 2: 120,970,603 probably benign Het
Ulk1 T C 5: 110,787,621 D926G probably damaging Het
Vmn2r110 T C 17: 20,583,771 I181V probably benign Het
Vmn2r66 G A 7: 85,006,812 T332I probably damaging Het
Wdr1 C A 5: 38,531,110 D161Y probably damaging Het
Wnt7a T C 6: 91,394,557 Y141C probably damaging Het
Xrra1 G A 7: 99,915,943 E573K probably benign Het
Zfp334 G T 2: 165,381,851 Q91K possibly damaging Het
Other mutations in Gml
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01113:Gml APN 15 74813727 missense probably benign 0.00
IGL01161:Gml APN 15 74813839 missense probably damaging 1.00
R0674:Gml UTSW 15 74813860 missense probably damaging 1.00
R1716:Gml UTSW 15 74813816 missense possibly damaging 0.81
R1757:Gml UTSW 15 74813613 unclassified probably benign
R1827:Gml UTSW 15 74816431 missense probably benign 0.00
R1941:Gml UTSW 15 74817171 missense probably damaging 0.99
R3783:Gml UTSW 15 74813672 missense probably damaging 0.98
R4007:Gml UTSW 15 74813699 missense possibly damaging 0.59
R5326:Gml UTSW 15 74816450 missense probably damaging 1.00
R7378:Gml UTSW 15 74817121 missense possibly damaging 0.89
R7790:Gml UTSW 15 74813613 unclassified probably benign
R8298:Gml UTSW 15 74813692 missense probably damaging 1.00
Posted On 2015-04-16