Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02415:Taok1'

292429

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Taok1

Ensembl Gene

ENSMUSG00000017291

Gene Name

TAO kinase 1

Synonyms

D130018F14Rik, 2810468K05Rik

Accession Numbers

Is this an essential gene?

Possibly essential (E-score: 0.584) question?

Stock #

IGL02415

Quality Score

Status

Chromosome

Chromosomal Location

77529162-77607815 bp(-) (GRCm38)

Type of Mutation

unclassified

DNA Base Change (assembly)

A to G at 77540240 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000017435] [ENSMUST00000058496]

AlphaFold

Q5F2E8

Predicted Effect

probably benign
Transcript: ENSMUST00000017435

SMART Domains

Protein: ENSMUSP00000017435
Gene: ENSMUSG00000017291

Domain	Start	End	E-Value	Type
S_TKc	28	281	3.26e-87	SMART
low complexity region	327	335	N/A	INTRINSIC
low complexity region	350	370	N/A	INTRINSIC
coiled coil region	458	651	N/A	INTRINSIC
coiled coil region	792	878	N/A	INTRINSIC
low complexity region	914	930	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000058496

SMART Domains

Protein: ENSMUSP00000055470
Gene: ENSMUSG00000017291

Domain	Start	End	E-Value	Type
S_TKc	28	281	3.26e-87	SMART
low complexity region	327	335	N/A	INTRINSIC
low complexity region	350	370	N/A	INTRINSIC
coiled coil region	458	651	N/A	INTRINSIC
coiled coil region	792	878	N/A	INTRINSIC
low complexity region	914	930	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000120228

Predicted Effect

probably benign
Transcript: ENSMUST00000145676

Predicted Effect

probably benign
Transcript: ENSMUST00000147386

SMART Domains

Protein: ENSMUSP00000116682
Gene: ENSMUSG00000000686

Domain	Start	End	E-Value	Type
low complexity region	33	47	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110059G10Rik	T	C	9: 122,947,991	D124G	probably benign	Het
Adamts13	T	A	2: 26,989,283	I616N	possibly damaging	Het
Adamts3	T	C	5: 89,706,647		probably null	Het
Amy1	T	C	3: 113,563,585	I202V	probably benign	Het
Bdp1	G	A	13: 100,089,408	T322I	probably damaging	Het
Cep295	A	G	9: 15,353,020	L110S	probably damaging	Het
Cep72	T	C	13: 74,050,154	D369G	probably benign	Het
Chd3	A	T	11: 69,348,913		probably benign	Het
Ckmt2	G	A	13: 91,863,340		probably benign	Het
Cyp2s1	T	C	7: 25,808,137	T296A	probably damaging	Het
E2f5	T	A	3: 14,603,897	V283E	probably benign	Het
F5	A	G	1: 164,191,929	T658A	probably damaging	Het
Fam102b	A	G	3: 108,980,292	Y219H	probably damaging	Het
Gml	A	T	15: 74,816,440	Y59*	probably null	Het
Kmo	A	T	1: 175,649,323		probably benign	Het
Krt25	A	T	11: 99,322,572	I107N	probably damaging	Het
Llgl2	A	G	11: 115,853,285	M773V	probably damaging	Het
Lyst	G	A	13: 13,660,956	C1741Y	probably benign	Het
Med12	T	C	X: 101,281,790	V761A	probably damaging	Het
Mrpl19	T	C	6: 81,963,961	T150A	probably benign	Het
Muc2	G	T	7: 141,751,872	E646*	probably null	Het
Muc20	T	A	16: 32,794,681	T109S	unknown	Het
Nr2f6	T	C	8: 71,374,512	T382A	probably benign	Het
Nrap	A	G	19: 56,382,309	I172T	probably damaging	Het
Olfr1434	A	G	19: 12,283,498	Y150C	probably benign	Het
Olfr911-ps1	T	C	9: 38,524,112	C127R	probably benign	Het
P3h1	A	T	4: 119,247,955	Q710L	probably benign	Het
Parvb	A	G	15: 84,292,815	H185R	probably damaging	Het
Pkhd1	A	G	1: 20,414,421	I1970T	probably damaging	Het
Pkhd1	T	C	1: 20,522,759	Y1710C	probably damaging	Het
Plxna2	C	A	1: 194,643,964	R69S	probably damaging	Het
Rad51ap2	A	G	12: 11,456,929	N284S	possibly damaging	Het
Reln	T	A	5: 21,971,951	S1906C	possibly damaging	Het
Rln1	T	C	19: 29,334,398	R67G	probably damaging	Het
Shcbp1	C	T	8: 4,754,239	V224I	possibly damaging	Het
Slc13a4	A	G	6: 35,283,237		probably null	Het
Stx6	A	G	1: 155,193,313	E195G	possibly damaging	Het
Sult2b1	G	T	7: 45,742,085	D90E	possibly damaging	Het
Tbx15	A	T	3: 99,352,510	M566L	probably benign	Het
Tcaf1	C	T	6: 42,686,650	A99T	probably benign	Het
Tcf20	T	A	15: 82,853,459	M1264L	probably benign	Het
Tenm4	G	A	7: 96,874,074	V1571M	probably damaging	Het
Ttc39a	A	G	4: 109,431,529		probably benign	Het
Ubr1	C	A	2: 120,970,603		probably benign	Het
Ulk1	T	C	5: 110,787,621	D926G	probably damaging	Het
Vmn2r110	T	C	17: 20,583,771	I181V	probably benign	Het
Vmn2r66	G	A	7: 85,006,812	T332I	probably damaging	Het
Wdr1	C	A	5: 38,531,110	D161Y	probably damaging	Het
Wnt7a	T	C	6: 91,394,557	Y141C	probably damaging	Het
Xrra1	G	A	7: 99,915,943	E573K	probably benign	Het
Zfp334	G	T	2: 165,381,851	Q91K	possibly damaging	Het

Other mutations in Taok1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01598:Taok1	APN	11	77571684	missense	probably damaging	1.00
IGL01629:Taok1	APN	11	77538204	missense	possibly damaging	0.63
IGL02198:Taok1	APN	11	77575677	splice site	probably benign
IGL02392:Taok1	APN	11	77549352	missense	probably benign	0.13
IGL02428:Taok1	APN	11	77549277	missense	probably benign	0.01
IGL02972:Taok1	APN	11	77559758	missense	probably benign	0.04
IGL03200:Taok1	APN	11	77575652	nonsense	probably null
IGL03203:Taok1	APN	11	77540085	missense	probably damaging	0.96
IGL03292:Taok1	APN	11	77540136	missense	probably benign	0.07
IGL03351:Taok1	APN	11	77560328	missense	probably damaging	0.96
R7569_taok1_653	UTSW	11	77555614	missense	probably benign	0.06
R0070:Taok1	UTSW	11	77553717	missense	probably benign
R0497:Taok1	UTSW	11	77573804	missense	probably damaging	0.97
R0535:Taok1	UTSW	11	77553704	missense	probably benign	0.00
R0558:Taok1	UTSW	11	77559844	missense	possibly damaging	0.89
R0653:Taok1	UTSW	11	77578724	critical splice donor site	probably null
R1249:Taok1	UTSW	11	77571637	missense	probably damaging	1.00
R1424:Taok1	UTSW	11	77549364	missense	probably benign	0.00
R1597:Taok1	UTSW	11	77579800	missense	probably benign	0.31
R2112:Taok1	UTSW	11	77571646	missense	probably benign	0.01
R3716:Taok1	UTSW	11	77541810	missense	probably benign	0.09
R4013:Taok1	UTSW	11	77559833	missense	possibly damaging	0.95
R4058:Taok1	UTSW	11	77549438	missense	probably benign	0.05
R4831:Taok1	UTSW	11	77553674	missense	probably null	0.34
R5036:Taok1	UTSW	11	77549331	missense	probably benign	0.01
R5917:Taok1	UTSW	11	77560318	missense	probably damaging	0.99
R6271:Taok1	UTSW	11	77573783	missense	probably damaging	1.00
R6286:Taok1	UTSW	11	77553773	missense	probably benign	0.00
R6860:Taok1	UTSW	11	77541801	missense	probably benign	0.01
R6933:Taok1	UTSW	11	77555653	missense	probably benign
R7139:Taok1	UTSW	11	77571633	missense	probably damaging	1.00
R7143:Taok1	UTSW	11	77537988	missense	probably benign
R7305:Taok1	UTSW	11	77541674	nonsense	probably null
R7340:Taok1	UTSW	11	77579817	missense	possibly damaging	0.89
R7508:Taok1	UTSW	11	77545326	missense	probably damaging	0.97
R7569:Taok1	UTSW	11	77555614	missense	probably benign	0.06
R7753:Taok1	UTSW	11	77537899	missense	probably benign	0.29
R8064:Taok1	UTSW	11	77549304	nonsense	probably null
R8130:Taok1	UTSW	11	77579833	missense	possibly damaging	0.84
R8332:Taok1	UTSW	11	77541719	missense	possibly damaging	0.93
R8768:Taok1	UTSW	11	77553886	missense	probably damaging	1.00
R8775:Taok1	UTSW	11	77579806	missense	probably benign	0.42
R8775-TAIL:Taok1	UTSW	11	77579806	missense	probably benign	0.42
Z1176:Taok1	UTSW	11	77559926	missense	probably benign	0.00

Posted On

2015-04-16