Incidental Mutation 'IGL02416:Vmn1r8'
ID292432
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r8
Ensembl Gene ENSMUSG00000061208
Gene Namevomeronasal 1 receptor 8
SynonymsV1rc32
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.066) question?
Stock #IGL02416
Quality Score
Status
Chromosome6
Chromosomal Location57032284-57037391 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 57036620 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Glycine at position 219 (R219G)
Ref Sequence ENSEMBL: ENSMUSP00000154298 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078186] [ENSMUST00000227706] [ENSMUST00000228690]
Predicted Effect probably damaging
Transcript: ENSMUST00000078186
AA Change: R219G

PolyPhen 2 Score 0.970 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000093561
Gene: ENSMUSG00000061208
AA Change: R219G

DomainStartEndE-ValueType
Pfam:V1R 28 293 1.2e-58 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000227706
AA Change: R219G

PolyPhen 2 Score 0.970 (Sensitivity: 0.77; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000228690
AA Change: R219G

PolyPhen 2 Score 0.970 (Sensitivity: 0.77; Specificity: 0.96)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamdec1 T C 14: 68,572,833 N227S probably null Het
Adgrf5 T G 17: 43,444,980 probably null Het
Arid2 G A 15: 96,350,055 G116D possibly damaging Het
Arsa T A 15: 89,474,788 H225L probably damaging Het
Atf6 T A 1: 170,747,157 K571* probably null Het
Bicdl1 A C 5: 115,663,885 L38R probably damaging Het
Cct4 T C 11: 23,002,868 S515P probably damaging Het
Celsr3 A C 9: 108,832,119 D1388A probably damaging Het
Clca2 T C 3: 145,085,016 T432A probably benign Het
Des T A 1: 75,362,728 probably null Het
Dock11 T A X: 36,020,086 V1119E probably damaging Het
Dysf A G 6: 84,192,914 N1763S possibly damaging Het
Emilin1 A G 5: 30,917,788 S458G possibly damaging Het
Fhdc1 T G 3: 84,445,228 M897L probably benign Het
Foxj1 T C 11: 116,332,003 S325G probably benign Het
Gm5407 A G 16: 49,296,887 noncoding transcript Het
Gm6576 T C 15: 27,025,987 noncoding transcript Het
Hells G A 19: 38,964,627 S743N probably benign Het
Ighv2-9-1 A T 12: 113,770,111 L30Q probably damaging Het
Iqgap1 A T 7: 80,726,038 L1363H probably damaging Het
Lrp2 T C 2: 69,469,633 D3025G probably damaging Het
Mef2d C T 3: 88,156,502 R79C probably damaging Het
Mical1 G T 10: 41,484,810 probably null Het
Micu2 A T 14: 57,923,965 V300E probably damaging Het
Mmgt2 T C 11: 62,664,877 L17P probably damaging Het
Olfr1182 A G 2: 88,446,830 I36T probably benign Het
Olfr371 T A 8: 85,231,033 C179* probably null Het
Olfr873 A T 9: 20,300,245 E15V probably benign Het
Pigb A G 9: 73,017,432 S482P probably benign Het
Pkd1l2 T A 8: 117,040,835 T1239S possibly damaging Het
Pou1f1 T C 16: 65,531,956 I187T probably damaging Het
Prox1 C T 1: 190,161,130 A373T probably benign Het
Rabgap1 T C 2: 37,561,950 I954T probably benign Het
Scube3 T G 17: 28,164,136 C429W probably damaging Het
Slco6b1 T A 1: 96,924,333 noncoding transcript Het
Strc A T 2: 121,369,058 I1300N probably damaging Het
Tdrd6 T A 17: 43,624,738 R1806S probably benign Het
Trpm8 T A 1: 88,360,716 L860Q probably damaging Het
Wdr48 A G 9: 119,924,760 S649G probably damaging Het
Other mutations in Vmn1r8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01569:Vmn1r8 APN 6 57036287 missense possibly damaging 0.70
IGL01820:Vmn1r8 APN 6 57036668 missense possibly damaging 0.94
IGL02496:Vmn1r8 APN 6 57036571 missense probably damaging 1.00
IGL02930:Vmn1r8 APN 6 57036594 missense probably benign 0.03
IGL02954:Vmn1r8 APN 6 57036330 missense probably benign 0.03
IGL03235:Vmn1r8 APN 6 57036761 nonsense probably null
IGL03353:Vmn1r8 APN 6 57036791 missense probably benign 0.03
PIT4494001:Vmn1r8 UTSW 6 57036727 missense probably benign 0.01
R0656:Vmn1r8 UTSW 6 57036588 missense probably benign 0.35
R1328:Vmn1r8 UTSW 6 57036293 missense possibly damaging 0.94
R1846:Vmn1r8 UTSW 6 57036428 missense probably benign 0.06
R2083:Vmn1r8 UTSW 6 57036340 missense probably benign 0.21
R3683:Vmn1r8 UTSW 6 57036275 missense probably damaging 1.00
R4134:Vmn1r8 UTSW 6 57036720 missense probably benign
R4754:Vmn1r8 UTSW 6 57035967 start codon destroyed probably null 1.00
R4857:Vmn1r8 UTSW 6 57036353 missense probably benign 0.00
R5787:Vmn1r8 UTSW 6 57036259 missense probably damaging 1.00
R6158:Vmn1r8 UTSW 6 57036289 missense probably benign 0.00
R6711:Vmn1r8 UTSW 6 57036459 missense probably damaging 1.00
R6971:Vmn1r8 UTSW 6 57036415 missense probably damaging 1.00
R8066:Vmn1r8 UTSW 6 57036434 missense probably benign 0.03
R8261:Vmn1r8 UTSW 6 57036173 missense probably benign 0.00
Posted On2015-04-16