Incidental Mutation 'IGL02416:Or7e177'
ID 292437
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or7e177
Ensembl Gene ENSMUSG00000049028
Gene Name olfactory receptor family 7 subfamily E member 177
Synonyms Olfr873, GA_x6K02T2PVTD-14040245-14041204, MOR145-2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # IGL02416
Quality Score
Status
Chromosome 9
Chromosomal Location 20211507-20212466 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 20211541 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Valine at position 15 (E15V)
Ref Sequence ENSEMBL: ENSMUSP00000153816 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053919] [ENSMUST00000075717] [ENSMUST00000215540]
AlphaFold E9PX82
Predicted Effect probably benign
Transcript: ENSMUST00000053919
AA Change: E12V

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000054778
Gene: ENSMUSG00000049028
AA Change: E12V

DomainStartEndE-ValueType
Pfam:7tm_4 41 317 1.7e-52 PFAM
Pfam:7TM_GPCR_Srsx 45 315 1.6e-8 PFAM
Pfam:7tm_1 51 300 3e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000075717
AA Change: E16V

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000075135
Gene: ENSMUSG00000049028
AA Change: E16V

DomainStartEndE-ValueType
Pfam:7tm_4 45 321 6.2e-43 PFAM
Pfam:7TM_GPCR_Srsx 49 309 3e-8 PFAM
Pfam:7tm_1 55 304 1.5e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212393
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212793
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213057
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213445
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217193
Predicted Effect probably benign
Transcript: ENSMUST00000215540
AA Change: E15V

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216567
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamdec1 T C 14: 68,810,282 (GRCm39) N227S probably null Het
Adgrf5 T G 17: 43,755,871 (GRCm39) probably null Het
Arid2 G A 15: 96,247,936 (GRCm39) G116D possibly damaging Het
Arsa T A 15: 89,358,991 (GRCm39) H225L probably damaging Het
Atf6 T A 1: 170,574,726 (GRCm39) K571* probably null Het
Bicdl1 A C 5: 115,801,944 (GRCm39) L38R probably damaging Het
Cct4 T C 11: 22,952,868 (GRCm39) S515P probably damaging Het
Celsr3 A C 9: 108,709,318 (GRCm39) D1388A probably damaging Het
Clca3a2 T C 3: 144,790,777 (GRCm39) T432A probably benign Het
Des T A 1: 75,339,372 (GRCm39) probably null Het
Dock11 T A X: 35,283,739 (GRCm39) V1119E probably damaging Het
Dysf A G 6: 84,169,896 (GRCm39) N1763S possibly damaging Het
Emilin1 A G 5: 31,075,132 (GRCm39) S458G possibly damaging Het
Fhdc1 T G 3: 84,352,535 (GRCm39) M897L probably benign Het
Foxj1 T C 11: 116,222,829 (GRCm39) S325G probably benign Het
Gm5407 A G 16: 49,117,250 (GRCm39) noncoding transcript Het
Gm6576 T C 15: 27,026,073 (GRCm39) noncoding transcript Het
Hells G A 19: 38,953,071 (GRCm39) S743N probably benign Het
Ighv2-9-1 A T 12: 113,733,731 (GRCm39) L30Q probably damaging Het
Iqgap1 A T 7: 80,375,786 (GRCm39) L1363H probably damaging Het
Lrp2 T C 2: 69,299,977 (GRCm39) D3025G probably damaging Het
Mef2d C T 3: 88,063,809 (GRCm39) R79C probably damaging Het
Mical1 G T 10: 41,360,806 (GRCm39) probably null Het
Micu2 A T 14: 58,161,422 (GRCm39) V300E probably damaging Het
Mmgt2 T C 11: 62,555,703 (GRCm39) L17P probably damaging Het
Or4p21 A G 2: 88,277,174 (GRCm39) I36T probably benign Het
Or7c19 T A 8: 85,957,662 (GRCm39) C179* probably null Het
Pigb A G 9: 72,924,714 (GRCm39) S482P probably benign Het
Pkd1l2 T A 8: 117,767,574 (GRCm39) T1239S possibly damaging Het
Pou1f1 T C 16: 65,328,842 (GRCm39) I187T probably damaging Het
Prox1 C T 1: 189,893,327 (GRCm39) A373T probably benign Het
Rabgap1 T C 2: 37,451,962 (GRCm39) I954T probably benign Het
Scube3 T G 17: 28,383,110 (GRCm39) C429W probably damaging Het
Slco6b1 T A 1: 96,852,058 (GRCm39) noncoding transcript Het
Strc A T 2: 121,199,539 (GRCm39) I1300N probably damaging Het
Tdrd6 T A 17: 43,935,629 (GRCm39) R1806S probably benign Het
Trpm8 T A 1: 88,288,438 (GRCm39) L860Q probably damaging Het
Vmn1r8 A G 6: 57,013,605 (GRCm39) R219G probably damaging Het
Wdr48 A G 9: 119,753,826 (GRCm39) S649G probably damaging Het
Other mutations in Or7e177
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02122:Or7e177 APN 9 20,211,880 (GRCm39) missense probably damaging 1.00
IGL02268:Or7e177 APN 9 20,211,588 (GRCm39) missense probably damaging 1.00
IGL03124:Or7e177 APN 9 20,212,459 (GRCm39) missense probably benign 0.00
R0147:Or7e177 UTSW 9 20,212,387 (GRCm39) missense probably damaging 1.00
R0148:Or7e177 UTSW 9 20,212,387 (GRCm39) missense probably damaging 1.00
R0266:Or7e177 UTSW 9 20,212,454 (GRCm39) missense probably benign 0.01
R0831:Or7e177 UTSW 9 20,211,861 (GRCm39) missense probably benign 0.20
R1456:Or7e177 UTSW 9 20,212,134 (GRCm39) missense probably benign 0.35
R1894:Or7e177 UTSW 9 20,211,633 (GRCm39) missense probably benign 0.23
R1928:Or7e177 UTSW 9 20,212,354 (GRCm39) missense probably benign 0.12
R2135:Or7e177 UTSW 9 20,211,593 (GRCm39) missense probably benign 0.00
R2379:Or7e177 UTSW 9 20,211,963 (GRCm39) missense possibly damaging 0.87
R2911:Or7e177 UTSW 9 20,211,775 (GRCm39) missense possibly damaging 0.60
R3788:Or7e177 UTSW 9 20,211,666 (GRCm39) missense probably benign 0.13
R4657:Or7e177 UTSW 9 20,211,919 (GRCm39) missense probably damaging 1.00
R5754:Or7e177 UTSW 9 20,212,390 (GRCm39) missense probably damaging 1.00
R6291:Or7e177 UTSW 9 20,211,899 (GRCm39) missense probably damaging 1.00
R6410:Or7e177 UTSW 9 20,211,748 (GRCm39) missense probably damaging 1.00
R7014:Or7e177 UTSW 9 20,211,959 (GRCm39) nonsense probably null
R7521:Or7e177 UTSW 9 20,212,036 (GRCm39) missense probably benign 0.00
R8201:Or7e177 UTSW 9 20,212,317 (GRCm39) missense probably damaging 1.00
R8355:Or7e177 UTSW 9 20,211,715 (GRCm39) missense probably damaging 1.00
R8455:Or7e177 UTSW 9 20,211,715 (GRCm39) missense probably damaging 1.00
R8523:Or7e177 UTSW 9 20,212,093 (GRCm39) missense probably benign 0.10
R8874:Or7e177 UTSW 9 20,212,069 (GRCm39) missense possibly damaging 0.95
R9283:Or7e177 UTSW 9 20,212,419 (GRCm39) missense possibly damaging 0.61
R9397:Or7e177 UTSW 9 20,211,748 (GRCm39) missense possibly damaging 0.50
R9595:Or7e177 UTSW 9 20,211,661 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16