Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00904:Vmn2r100'

29247

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r100

Ensembl Gene

ENSMUSG00000091859

Gene Name

vomeronasal 2, receptor 100

Synonyms

EG627537

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

IGL00904

Quality Score

Status

Chromosome

Chromosomal Location

19504732-19535231 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 19526000 bp

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Glycine at position 474 (C474G)

Ref Sequence

ENSEMBL: ENSMUSP00000156263 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000166081] [ENSMUST00000231465]

Predicted Effect

probably damaging
Transcript: ENSMUST00000166081
AA Change: C537G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000128350
Gene: ENSMUSG00000091859
AA Change: C537G

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:ANF_receptor	83	456	7.4e-41	PFAM
Pfam:NCD3G	510	563	1.9e-21	PFAM
Pfam:7tm_3	594	831	2.6e-51	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000231465
AA Change: C474G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aak1	G	T	6: 86,946,153	G236C	probably damaging	Het
Abi1	C	T	2: 22,941,930	R404Q	possibly damaging	Het
Atp8b3	C	T	10: 80,528,764	G532R	probably damaging	Het
Bysl	C	T	17: 47,601,871	M331I	probably benign	Het
Cndp1	A	G	18: 84,611,665	S468P	probably benign	Het
Esd	A	G	14: 74,749,688	*266W	probably null	Het
F5	T	C	1: 164,194,009	V1351A	probably benign	Het
Fchsd2	A	G	7: 101,271,622	D454G	probably benign	Het
Fndc1	T	A	17: 7,756,363	M1415L	probably benign	Het
Ghr	T	A	15: 3,328,120	Y222F	probably benign	Het
Gm6583	G	A	5: 112,355,128	R237*	probably null	Het
Gtf3c2	C	T	5: 31,172,858	S299N	probably damaging	Het
Ice1	C	T	13: 70,602,289	D93N	probably damaging	Het
Ints7	T	A	1: 191,596,164		probably null	Het
Kif18a	A	G	2: 109,292,126	D182G	probably damaging	Het
Mcm9	A	T	10: 53,622,921	H308Q	possibly damaging	Het
Mesp2	A	G	7: 79,812,653	D319G	probably benign	Het
Mrpl55	T	A	11: 59,205,673	S84T	probably benign	Het
Mybpc3	T	C	2: 91,120,029	V123A	probably benign	Het
Myom1	T	C	17: 71,099,949		probably benign	Het
Nfia	C	T	4: 98,065,386	P325S	probably damaging	Het
Notch4	T	C	17: 34,575,561		probably null	Het
Npepps	A	C	11: 97,258,306	V130G	probably damaging	Het
Olfr1356	A	T	10: 78,847,763	S51T	probably damaging	Het
Pja2	G	T	17: 64,283,531	T669K	probably damaging	Het
Rnf112	G	T	11: 61,452,784	D98E	probably damaging	Het
Rsl1d1	G	A	16: 11,199,694	T136I	probably damaging	Het
Samsn1	A	T	16: 75,909,120		probably benign	Het
Slc6a9	T	C	4: 117,864,617	L280P	probably damaging	Het
Svep1	T	C	4: 58,097,398	N1382D	probably benign	Het
Vmn2r74	C	T	7: 85,957,580	R186H	probably benign	Het
Wdr7	T	C	18: 63,796,231	I1046T	probably benign	Het

Other mutations in Vmn2r100

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00912:Vmn2r100	APN	17	19531392	missense	possibly damaging	0.95
IGL01107:Vmn2r100	APN	17	19521356	missense	probably damaging	1.00
IGL01517:Vmn2r100	APN	17	19521963	missense	probably benign	0.37
IGL01594:Vmn2r100	APN	17	19531233	missense	possibly damaging	0.52
IGL01657:Vmn2r100	APN	17	19525916	missense	possibly damaging	0.89
IGL01822:Vmn2r100	APN	17	19504838	missense	probably null	0.00
IGL02020:Vmn2r100	APN	17	19504938	missense	possibly damaging	0.78
IGL02060:Vmn2r100	APN	17	19521254	missense	possibly damaging	0.79
IGL02126:Vmn2r100	APN	17	19521242	splice site	probably benign
IGL02142:Vmn2r100	APN	17	19522321	missense	probably damaging	1.00
IGL02308:Vmn2r100	APN	17	19521335	missense	possibly damaging	0.90
IGL02407:Vmn2r100	APN	17	19521508	missense	probably damaging	0.98
IGL02469:Vmn2r100	APN	17	19531285	nonsense	probably null
IGL03088:Vmn2r100	APN	17	19522039	missense	probably benign	0.27
IGL03181:Vmn2r100	APN	17	19531945	missense	probably damaging	1.00
IGL03405:Vmn2r100	APN	17	19531924	missense	probably damaging	1.00
H8562:Vmn2r100	UTSW	17	19521490	missense	possibly damaging	0.87
R0012:Vmn2r100	UTSW	17	19504874	missense	probably benign
R0012:Vmn2r100	UTSW	17	19526034	missense	probably damaging	0.99
R0044:Vmn2r100	UTSW	17	19522179	missense	possibly damaging	0.46
R0109:Vmn2r100	UTSW	17	19522120	missense	possibly damaging	0.80
R0111:Vmn2r100	UTSW	17	19522120	missense	possibly damaging	0.80
R0112:Vmn2r100	UTSW	17	19522120	missense	possibly damaging	0.80
R0149:Vmn2r100	UTSW	17	19521247	critical splice acceptor site	probably null
R0355:Vmn2r100	UTSW	17	19531320	missense	probably benign	0.00
R0395:Vmn2r100	UTSW	17	19522120	missense	possibly damaging	0.80
R0396:Vmn2r100	UTSW	17	19522120	missense	possibly damaging	0.80
R0453:Vmn2r100	UTSW	17	19522120	missense	possibly damaging	0.80
R0465:Vmn2r100	UTSW	17	19531530	missense	probably damaging	0.98
R0477:Vmn2r100	UTSW	17	19522514	missense	probably benign	0.00
R0510:Vmn2r100	UTSW	17	19522120	missense	possibly damaging	0.80
R0512:Vmn2r100	UTSW	17	19522120	missense	possibly damaging	0.80
R0514:Vmn2r100	UTSW	17	19522120	missense	possibly damaging	0.80
R0518:Vmn2r100	UTSW	17	19521916	missense	probably damaging	1.00
R0521:Vmn2r100	UTSW	17	19521916	missense	probably damaging	1.00
R0555:Vmn2r100	UTSW	17	19522120	missense	possibly damaging	0.80
R0608:Vmn2r100	UTSW	17	19522120	missense	possibly damaging	0.80
R0959:Vmn2r100	UTSW	17	19523524	missense	possibly damaging	0.95
R1114:Vmn2r100	UTSW	17	19531999	missense	probably damaging	1.00
R2027:Vmn2r100	UTSW	17	19522072	missense	probably benign	0.02
R2049:Vmn2r100	UTSW	17	19522050	missense	probably benign	0.00
R2224:Vmn2r100	UTSW	17	19522372	missense	probably benign	0.03
R2226:Vmn2r100	UTSW	17	19522372	missense	probably benign	0.03
R3618:Vmn2r100	UTSW	17	19523430	missense	probably benign
R3715:Vmn2r100	UTSW	17	19532010	missense	probably damaging	0.99
R4120:Vmn2r100	UTSW	17	19531953	missense	probably damaging	1.00
R4152:Vmn2r100	UTSW	17	19523419	frame shift	probably null
R4153:Vmn2r100	UTSW	17	19523419	frame shift	probably null
R4154:Vmn2r100	UTSW	17	19523419	frame shift	probably null
R4200:Vmn2r100	UTSW	17	19522535	missense	probably benign	0.29
R4632:Vmn2r100	UTSW	17	19531954	missense	probably damaging	1.00
R4720:Vmn2r100	UTSW	17	19522526	missense	probably benign	0.02
R4761:Vmn2r100	UTSW	17	19521368	missense	possibly damaging	0.47
R4831:Vmn2r100	UTSW	17	19521410	missense	probably benign	0.28
R4951:Vmn2r100	UTSW	17	19532038	missense	probably benign	0.01
R5211:Vmn2r100	UTSW	17	19525995	missense	possibly damaging	0.67
R5553:Vmn2r100	UTSW	17	19504848	missense	possibly damaging	0.64
R5657:Vmn2r100	UTSW	17	19504916	missense	probably benign	0.31
R5883:Vmn2r100	UTSW	17	19523524	missense	probably benign
R5912:Vmn2r100	UTSW	17	19531809	missense	probably damaging	0.99
R6141:Vmn2r100	UTSW	17	19522314	missense	probably benign	0.07
R6146:Vmn2r100	UTSW	17	19522260	missense	probably benign	0.04
R6500:Vmn2r100	UTSW	17	19522093	missense	probably damaging	1.00
R6575:Vmn2r100	UTSW	17	19521409	missense	probably benign	0.12
R6647:Vmn2r100	UTSW	17	19522523	missense	probably benign	0.00
R7038:Vmn2r100	UTSW	17	19505001	missense	possibly damaging	0.76
R7052:Vmn2r100	UTSW	17	19531294	missense	possibly damaging	0.95
R7170:Vmn2r100	UTSW	17	19531971	missense	probably benign	0.00
R7209:Vmn2r100	UTSW	17	19531314	missense	not run
R7312:Vmn2r100	UTSW	17	19522034	missense	probably benign	0.01
X0062:Vmn2r100	UTSW	17	19531390	missense	possibly damaging	0.89

Posted On

2013-04-17