Incidental Mutation 'IGL02417:Gpr89'
ID 292499
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr89
Ensembl Gene ENSMUSG00000028096
Gene Name G protein-coupled receptor 89
Synonyms SH120, 4933412D19Rik
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.383) question?
Stock # IGL02417
Quality Score
Status
Chromosome 3
Chromosomal Location 96775630-96812662 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 96804741 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 38 (Y38*)
Ref Sequence ENSEMBL: ENSMUSP00000116016 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029738] [ENSMUST00000154750]
AlphaFold Q8BS95
Predicted Effect probably null
Transcript: ENSMUST00000029738
AA Change: Y38*
SMART Domains Protein: ENSMUSP00000029738
Gene: ENSMUSG00000028096
AA Change: Y38*

DomainStartEndE-ValueType
transmembrane domain 4 26 N/A INTRINSIC
transmembrane domain 38 60 N/A INTRINSIC
transmembrane domain 75 97 N/A INTRINSIC
transmembrane domain 110 127 N/A INTRINSIC
Pfam:GPHR_N 140 207 1.1e-31 PFAM
Pfam:ABA_GPCR 276 446 4.9e-46 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139599
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146645
Predicted Effect probably null
Transcript: ENSMUST00000154750
AA Change: Y38*
SMART Domains Protein: ENSMUSP00000116016
Gene: ENSMUSG00000028096
AA Change: Y38*

DomainStartEndE-ValueType
transmembrane domain 4 26 N/A INTRINSIC
transmembrane domain 38 60 N/A INTRINSIC
transmembrane domain 75 97 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199586
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap5 T A 12: 52,565,136 (GRCm39) N702K probably damaging Het
Atm T C 9: 53,390,995 (GRCm39) T1860A probably benign Het
Bicdl1 A T 5: 115,811,217 (GRCm39) H231Q probably damaging Het
C2cd5 A C 6: 142,987,218 (GRCm39) D470E probably damaging Het
Chd5 T C 4: 152,451,751 (GRCm39) F688L probably damaging Het
Cul3 T C 1: 80,300,619 (GRCm39) Y74C probably damaging Het
Dhx16 A G 17: 36,203,429 (GRCm39) E1042G probably damaging Het
Dnah11 A G 12: 118,020,915 (GRCm39) L1966P probably damaging Het
Dpy19l1 A T 9: 24,386,682 (GRCm39) I204N possibly damaging Het
Drd2 T C 9: 49,313,559 (GRCm39) probably benign Het
Fasn A G 11: 120,711,166 (GRCm39) V228A probably damaging Het
Fggy T C 4: 95,737,846 (GRCm39) W148R probably benign Het
Gm9631 G A 11: 121,834,478 (GRCm39) Het
H2-M1 G A 17: 36,983,026 (GRCm39) H22Y possibly damaging Het
Kdm3b T A 18: 34,941,630 (GRCm39) S574T probably benign Het
Kmt2c C T 5: 25,578,018 (GRCm39) V753I probably benign Het
Lcn9 T C 2: 25,713,692 (GRCm39) F73L possibly damaging Het
Lnpep T C 17: 17,765,165 (GRCm39) T762A possibly damaging Het
Lrp2 C T 2: 69,291,649 (GRCm39) C3510Y probably damaging Het
Nlrp3 T A 11: 59,456,849 (GRCm39) probably benign Het
Or14c39 A G 7: 86,344,027 (GRCm39) Y121C probably damaging Het
Or1j18 A T 2: 36,624,356 (GRCm39) I8F probably benign Het
Or5b3 A G 19: 13,388,259 (GRCm39) T109A possibly damaging Het
Pcnx3 A T 19: 5,736,509 (GRCm39) V176E possibly damaging Het
Phlpp1 T C 1: 106,320,444 (GRCm39) S1480P probably benign Het
Ppfia3 T C 7: 44,991,141 (GRCm39) R1027G probably damaging Het
Rnf216 A G 5: 143,054,665 (GRCm39) Y628H possibly damaging Het
Sh3bp1 G A 15: 78,785,699 (GRCm39) R4Q probably damaging Het
Skint9 A G 4: 112,271,335 (GRCm39) probably benign Het
Slc25a51 A G 4: 45,400,074 (GRCm39) S39P probably benign Het
Smarca4 C T 9: 21,612,386 (GRCm39) R1558C probably damaging Het
Spag9 A G 11: 94,007,567 (GRCm39) S1224G probably benign Het
Spdl1 G T 11: 34,704,181 (GRCm39) Q551K probably benign Het
Sugt1 A G 14: 79,847,698 (GRCm39) I183V probably benign Het
Th G A 7: 142,453,643 (GRCm39) S19L probably damaging Het
Tmprss11g A G 5: 86,638,750 (GRCm39) V246A probably benign Het
Tnfaip8l2 T C 3: 95,047,714 (GRCm39) T50A probably benign Het
Tox3 G T 8: 90,984,759 (GRCm39) T140K possibly damaging Het
Unc50 T A 1: 37,476,531 (GRCm39) Y205* probably null Het
Vmn2r83 A T 10: 79,314,881 (GRCm39) K376N probably benign Het
Other mutations in Gpr89
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00421:Gpr89 APN 3 96,805,839 (GRCm39) missense probably damaging 1.00
IGL00757:Gpr89 APN 3 96,778,850 (GRCm39) missense probably benign 0.00
IGL01114:Gpr89 APN 3 96,800,865 (GRCm39) missense probably damaging 0.98
explorer UTSW 3 96,787,385 (GRCm39) splice site probably null
R0207:Gpr89 UTSW 3 96,778,796 (GRCm39) missense probably damaging 0.99
R0650:Gpr89 UTSW 3 96,804,640 (GRCm39) splice site probably benign
R0704:Gpr89 UTSW 3 96,787,484 (GRCm39) critical splice acceptor site probably null
R1496:Gpr89 UTSW 3 96,812,526 (GRCm39) missense probably benign 0.00
R1869:Gpr89 UTSW 3 96,782,975 (GRCm39) missense probably benign 0.16
R1913:Gpr89 UTSW 3 96,782,949 (GRCm39) missense possibly damaging 0.91
R2264:Gpr89 UTSW 3 96,779,831 (GRCm39) missense probably damaging 0.99
R2276:Gpr89 UTSW 3 96,804,743 (GRCm39) missense probably damaging 1.00
R3822:Gpr89 UTSW 3 96,800,260 (GRCm39) missense probably benign 0.03
R3922:Gpr89 UTSW 3 96,798,215 (GRCm39) missense probably damaging 1.00
R4984:Gpr89 UTSW 3 96,812,512 (GRCm39) missense probably benign 0.02
R5761:Gpr89 UTSW 3 96,800,196 (GRCm39) missense probably damaging 1.00
R6185:Gpr89 UTSW 3 96,798,149 (GRCm39) missense probably damaging 0.99
R7063:Gpr89 UTSW 3 96,783,014 (GRCm39) missense probably damaging 1.00
R7164:Gpr89 UTSW 3 96,778,714 (GRCm39) missense probably benign 0.04
R7172:Gpr89 UTSW 3 96,787,385 (GRCm39) splice site probably null
R7215:Gpr89 UTSW 3 96,787,404 (GRCm39) missense probably damaging 1.00
R7536:Gpr89 UTSW 3 96,798,209 (GRCm39) missense probably damaging 0.96
R7708:Gpr89 UTSW 3 96,787,941 (GRCm39) missense possibly damaging 0.81
R7849:Gpr89 UTSW 3 96,778,806 (GRCm39) nonsense probably null
R8273:Gpr89 UTSW 3 96,812,505 (GRCm39) missense probably benign
R9643:Gpr89 UTSW 3 96,780,813 (GRCm39) missense probably damaging 0.97
RF019:Gpr89 UTSW 3 96,812,509 (GRCm39) missense probably benign
Posted On 2015-04-16