Incidental Mutation 'IGL02417:Gpr89'
ID292499
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr89
Ensembl Gene ENSMUSG00000028096
Gene NameG protein-coupled receptor 89
Synonyms4933412D19Rik, SH120
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.326) question?
Stock #IGL02417
Quality Score
Status
Chromosome3
Chromosomal Location96868281-96905346 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) A to T at 96897425 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Stop codon at position 38 (Y38*)
Ref Sequence ENSEMBL: ENSMUSP00000116016 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029738] [ENSMUST00000154750]
Predicted Effect probably null
Transcript: ENSMUST00000029738
AA Change: Y38*
SMART Domains Protein: ENSMUSP00000029738
Gene: ENSMUSG00000028096
AA Change: Y38*

DomainStartEndE-ValueType
transmembrane domain 4 26 N/A INTRINSIC
transmembrane domain 38 60 N/A INTRINSIC
transmembrane domain 75 97 N/A INTRINSIC
transmembrane domain 110 127 N/A INTRINSIC
Pfam:GPHR_N 140 207 1.1e-31 PFAM
Pfam:ABA_GPCR 276 446 4.9e-46 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139599
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146645
Predicted Effect probably null
Transcript: ENSMUST00000154750
AA Change: Y38*
SMART Domains Protein: ENSMUSP00000116016
Gene: ENSMUSG00000028096
AA Change: Y38*

DomainStartEndE-ValueType
transmembrane domain 4 26 N/A INTRINSIC
transmembrane domain 38 60 N/A INTRINSIC
transmembrane domain 75 97 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199586
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap5 T A 12: 52,518,353 N702K probably damaging Het
Atm T C 9: 53,479,695 T1860A probably benign Het
Bicdl1 A T 5: 115,673,158 H231Q probably damaging Het
C2cd5 A C 6: 143,041,492 D470E probably damaging Het
Chd5 T C 4: 152,367,294 F688L probably damaging Het
Cul3 T C 1: 80,322,902 Y74C probably damaging Het
Dhx16 A G 17: 35,892,537 E1042G probably damaging Het
Dnah11 A G 12: 118,057,180 L1966P probably damaging Het
Dpy19l1 A T 9: 24,475,386 I204N possibly damaging Het
Drd2 T C 9: 49,402,259 probably benign Het
Fasn A G 11: 120,820,340 V228A probably damaging Het
Fggy T C 4: 95,849,609 W148R probably benign Het
Gm9631 G A 11: 121,943,652 Het
H2-M1 G A 17: 36,672,134 H22Y possibly damaging Het
Kdm3b T A 18: 34,808,577 S574T probably benign Het
Kmt2c C T 5: 25,373,020 V753I probably benign Het
Lcn9 T C 2: 25,823,680 F73L possibly damaging Het
Lnpep T C 17: 17,544,903 T762A possibly damaging Het
Lrp2 C T 2: 69,461,305 C3510Y probably damaging Het
Nlrp3 T A 11: 59,566,023 probably benign Het
Olfr1469 A G 19: 13,410,895 T109A possibly damaging Het
Olfr292 A G 7: 86,694,819 Y121C probably damaging Het
Olfr347 A T 2: 36,734,344 I8F probably benign Het
Pcnx3 A T 19: 5,686,481 V176E possibly damaging Het
Phlpp1 T C 1: 106,392,714 S1480P probably benign Het
Ppfia3 T C 7: 45,341,717 R1027G probably damaging Het
Rnf216 A G 5: 143,068,910 Y628H possibly damaging Het
Sh3bp1 G A 15: 78,901,499 R4Q probably damaging Het
Skint9 A G 4: 112,414,138 probably benign Het
Slc25a51 A G 4: 45,400,074 S39P probably benign Het
Smarca4 C T 9: 21,701,090 R1558C probably damaging Het
Spag9 A G 11: 94,116,741 S1224G probably benign Het
Spdl1 G T 11: 34,813,354 Q551K probably benign Het
Sugt1 A G 14: 79,610,258 I183V probably benign Het
Th G A 7: 142,899,906 S19L probably damaging Het
Tmprss11g A G 5: 86,490,891 V246A probably benign Het
Tnfaip8l2 T C 3: 95,140,403 T50A probably benign Het
Tox3 G T 8: 90,258,131 T140K possibly damaging Het
Unc50 T A 1: 37,437,450 Y205* probably null Het
Vmn2r83 A T 10: 79,479,047 K376N probably benign Het
Other mutations in Gpr89
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00421:Gpr89 APN 3 96898523 missense probably damaging 1.00
IGL00757:Gpr89 APN 3 96871534 missense probably benign 0.00
IGL01114:Gpr89 APN 3 96893549 missense probably damaging 0.98
explorer UTSW 3 96880069 splice site probably null
R0207:Gpr89 UTSW 3 96871480 missense probably damaging 0.99
R0650:Gpr89 UTSW 3 96897324 splice site probably benign
R0704:Gpr89 UTSW 3 96880168 critical splice acceptor site probably null
R1496:Gpr89 UTSW 3 96905210 missense probably benign 0.00
R1869:Gpr89 UTSW 3 96875659 missense probably benign 0.16
R1913:Gpr89 UTSW 3 96875633 missense possibly damaging 0.91
R2264:Gpr89 UTSW 3 96872515 missense probably damaging 0.99
R2276:Gpr89 UTSW 3 96897427 missense probably damaging 1.00
R3822:Gpr89 UTSW 3 96892944 missense probably benign 0.03
R3922:Gpr89 UTSW 3 96890899 missense probably damaging 1.00
R4984:Gpr89 UTSW 3 96905196 missense probably benign 0.02
R5761:Gpr89 UTSW 3 96892880 missense probably damaging 1.00
R6185:Gpr89 UTSW 3 96890833 missense probably damaging 0.99
R7063:Gpr89 UTSW 3 96875698 missense probably damaging 1.00
R7164:Gpr89 UTSW 3 96871398 missense probably benign 0.04
R7172:Gpr89 UTSW 3 96880069 splice site probably null
R7215:Gpr89 UTSW 3 96880088 missense probably damaging 1.00
R7536:Gpr89 UTSW 3 96890893 missense probably damaging 0.96
R7708:Gpr89 UTSW 3 96880625 missense possibly damaging 0.81
R7849:Gpr89 UTSW 3 96871490 nonsense probably null
R7932:Gpr89 UTSW 3 96871490 nonsense probably null
RF019:Gpr89 UTSW 3 96905193 missense probably benign
Posted On2015-04-16