Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02418:Tcp11l2'

292529

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tcp11l2

Ensembl Gene

ENSMUSG00000020034

Gene Name

t-complex 11 (mouse) like 2

Synonyms

E430026E19Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.087) question?

Stock #

IGL02418

Quality Score

Status

Chromosome

Chromosomal Location

84576626-84614359 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 84613606 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 478 (Y478*)

Ref Sequence

ENSEMBL: ENSMUSP00000020223 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000020223]

AlphaFold

Q8K1H7

Predicted Effect

probably null
Transcript: ENSMUST00000020223
AA Change: Y478*

SMART Domains

Protein: ENSMUSP00000020223
Gene: ENSMUSG00000020034
AA Change: Y478*

Domain	Start	End	E-Value	Type
low complexity region	11	21	N/A	INTRINSIC
low complexity region	36	55	N/A	INTRINSIC
Pfam:Tcp11	77	497	5.8e-103	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000158471

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000181277

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abi3bp	T	A	16: 56,604,116		probably benign	Het
Acsbg2	A	G	17: 56,849,730	V436A	probably benign	Het
Afap1l1	T	C	18: 61,752,577	D156G	probably damaging	Het
AI481877	A	T	4: 59,049,075		probably benign	Het
Arhgap21	G	A	2: 20,880,900	R489C	probably damaging	Het
Arhgap26	G	A	18: 39,357,567		probably benign	Het
Bbs5	T	G	2: 69,655,505	*89G	probably null	Het
Ceacam5	A	T	7: 17,759,434	Y794F	possibly damaging	Het
Ces3b	T	C	8: 105,085,647	V176A	probably damaging	Het
Cfi	A	G	3: 129,848,812	H105R	probably benign	Het
Chat	C	T	14: 32,446,949	V210I	possibly damaging	Het
Chd1l	A	G	3: 97,581,099	S534P	probably benign	Het
Cyb5rl	T	C	4: 107,070,985	L106P	probably damaging	Het
Cyp21a1	A	G	17: 34,804,188		probably benign	Het
Dnah12	T	C	14: 26,773,722	C1436R	probably damaging	Het
Flg2	T	A	3: 93,201,054	F130I	probably benign	Het
Fryl	T	A	5: 73,110,176		probably benign	Het
Galnt10	T	C	11: 57,781,168	V428A	probably benign	Het
Ganab	A	G	19: 8,911,069	D496G	probably null	Het
Gapvd1	T	C	2: 34,730,518	T44A	probably benign	Het
Gm17093	T	A	14: 44,520,728	M122K	unknown	Het
Gm5356	A	T	8: 89,187,436		noncoding transcript	Het
Gmppa	G	T	1: 75,439,020	G126C	probably damaging	Het
Il23r	T	C	6: 67,490,672	H37R	possibly damaging	Het
Itga11	A	G	9: 62,744,632	I349V	probably benign	Het
Lrrc42	A	T	4: 107,243,336	Y159*	probably null	Het
Mettl11b	A	T	1: 163,703,156	V238E	probably damaging	Het
Naa16	C	A	14: 79,383,366	R57L	probably damaging	Het
Olfr967	A	G	9: 39,750,491	Y35C	probably damaging	Het
Oxtr	A	T	6: 112,477,239	H21Q	probably damaging	Het
Paqr7	A	G	4: 134,506,973	Y47C	probably damaging	Het
Paxbp1	A	C	16: 91,034,112	C459G	probably damaging	Het
Pnp2	C	T	14: 50,963,836	R222C	possibly damaging	Het
Rtl1	T	C	12: 109,590,449	D1652G	probably damaging	Het
Spata4	C	A	8: 54,609,943	N294K	probably benign	Het
Tcte1	T	A	17: 45,541,202	S454T	probably benign	Het
Tex45	T	A	8: 3,476,080	F78I	probably damaging	Het
Thsd4	C	T	9: 60,428,315	V105I	probably damaging	Het
Tmem117	T	A	15: 94,931,884	I200N	probably benign	Het
Tpgs1	G	A	10: 79,669,455	V16M	probably benign	Het
Ttn	G	T	2: 76,967,103	T539K	probably benign	Het
Usp24	A	G	4: 106,436,360	S2542G	probably benign	Het
Vmn2r44	A	T	7: 8,377,865	L343H	probably damaging	Het
Zmat2	T	A	18: 36,794,339	Y21N	probably damaging	Het
Zyx	C	T	6: 42,357,393	A517V	probably damaging	Het

Other mutations in Tcp11l2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00725:Tcp11l2	APN	10	84594710	missense	possibly damaging	0.82
IGL00845:Tcp11l2	APN	10	84604983	missense	possibly damaging	0.95
IGL02375:Tcp11l2	APN	10	84605068	critical splice donor site	probably null
IGL03325:Tcp11l2	APN	10	84604900	missense	possibly damaging	0.76
R0031:Tcp11l2	UTSW	10	84591140	missense	probably damaging	0.98
R0591:Tcp11l2	UTSW	10	84604594	missense	probably benign	0.05
R1563:Tcp11l2	UTSW	10	84584944	missense	probably damaging	0.96
R1607:Tcp11l2	UTSW	10	84613487	missense	probably damaging	1.00
R1840:Tcp11l2	UTSW	10	84604599	missense	probably damaging	0.98
R2144:Tcp11l2	UTSW	10	84613499	missense	probably damaging	1.00
R2251:Tcp11l2	UTSW	10	84605069	critical splice donor site	probably null
R4289:Tcp11l2	UTSW	10	84605073	splice site	probably null
R4639:Tcp11l2	UTSW	10	84584936	missense	probably damaging	1.00
R4844:Tcp11l2	UTSW	10	84613691	missense	probably benign	0.00
R4973:Tcp11l2	UTSW	10	84591163	missense	probably damaging	0.98
R5264:Tcp11l2	UTSW	10	84613660	missense	probably damaging	1.00
R5970:Tcp11l2	UTSW	10	84594797	splice site	probably benign
R6966:Tcp11l2	UTSW	10	84591269	missense	possibly damaging	0.79
R7250:Tcp11l2	UTSW	10	84587241	critical splice donor site	probably null
R7535:Tcp11l2	UTSW	10	84594659	missense	possibly damaging	0.67
R7565:Tcp11l2	UTSW	10	84587134	missense	probably damaging	1.00
R7619:Tcp11l2	UTSW	10	84594758	missense	probably damaging	1.00
R7774:Tcp11l2	UTSW	10	84604983	missense	possibly damaging	0.95
R8145:Tcp11l2	UTSW	10	84608616	missense	probably damaging	1.00
R8379:Tcp11l2	UTSW	10	84613605	missense	probably damaging	1.00
R8458:Tcp11l2	UTSW	10	84613532	nonsense	probably null
R8821:Tcp11l2	UTSW	10	84613658	missense	probably damaging	1.00
R8831:Tcp11l2	UTSW	10	84613658	missense	probably damaging	1.00
RF008:Tcp11l2	UTSW	10	84613524	missense	probably damaging	0.99

Posted On

2015-04-16