Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02419:Olfr624'

292576

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfr624

Ensembl Gene

ENSMUSG00000045780

Gene Name

olfactory receptor 624

Synonyms

MOR4-2P, GA_x6K02T2PBJ9-6394126-6393197

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.098) question?

Stock #

IGL02419

Quality Score

Status

Chromosome

Chromosomal Location

103665461-103671191 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 103670475 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 185 (C185*)

Ref Sequence

ENSEMBL: ENSMUSP00000049938 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000062144]

AlphaFold

F8VQI7

Predicted Effect

probably null
Transcript: ENSMUST00000062144
AA Change: C185*

SMART Domains

Protein: ENSMUSP00000049938
Gene: ENSMUSG00000045780
AA Change: C185*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	27	306	3.3e-138	PFAM
Pfam:7tm_1	37	288	1.8e-19	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933402J07Rik	T	C	8: 87,586,099	F171L	possibly damaging	Het
Abca2	A	G	2: 25,446,837	N2291D	probably benign	Het
Adamts9	A	G	6: 92,796,997	V1145A	probably benign	Het
Adcy2	A	G	13: 68,982,363	V135A	probably benign	Het
Akr1c14	A	T	13: 4,080,617		probably null	Het
Aptx	G	T	4: 40,691,032	A229E	probably benign	Het
Ash1l	T	C	3: 88,985,565	S1584P	probably benign	Het
Catsper3	A	T	13: 55,808,068	T329S	possibly damaging	Het
Cntrl	A	G	2: 35,134,043	D27G	probably damaging	Het
Cobll1	A	T	2: 65,151,048	I98K	probably damaging	Het
Ctdp1	T	C	18: 80,420,584	K79R	probably damaging	Het
Cwf19l2	T	C	9: 3,418,777		probably null	Het
Cyp11b2	A	T	15: 74,851,055	F498Y	probably damaging	Het
Dnpep	A	G	1: 75,315,688	I162T	probably damaging	Het
Efcab9	T	C	11: 32,522,950	I166V	probably benign	Het
Ep400	A	T	5: 110,697,376		probably null	Het
Gata6	G	A	18: 11,054,220	G50R	probably damaging	Het
Gm9631	G	A	11: 121,943,652			Het
Grifin	T	C	5: 140,564,700	T20A	probably benign	Het
Hnf4a	A	T	2: 163,566,282	I352F	probably damaging	Het
Ifi204	T	C	1: 173,749,380	T552A	possibly damaging	Het
Ifi205	C	T	1: 174,017,614	A201T	probably damaging	Het
Kcnk6	A	G	7: 29,225,202	V259A	probably benign	Het
Kif21b	A	G	1: 136,151,267	N451S	probably benign	Het
Klhl24	T	A	16: 20,107,368	Y215*	probably null	Het
Lyst	G	A	13: 13,660,956	C1741Y	probably benign	Het
Mical1	A	G	10: 41,482,277	K429E	possibly damaging	Het
Misp	A	G	10: 79,827,871		probably benign	Het
Mon2	T	C	10: 123,016,447	N1007S	probably benign	Het
Olfr1420	A	T	19: 11,896,822	Y267F	probably benign	Het
Olfr228	T	A	2: 86,482,915	I276F	probably damaging	Het
Olfr307	C	A	7: 86,335,662	V245F	probably damaging	Het
Pex6	C	A	17: 46,724,435	T840N	possibly damaging	Het
Prox1	C	T	1: 190,161,130	A373T	probably benign	Het
Rapgef3	G	T	15: 97,750,290	N679K	probably benign	Het
Serpina3n	T	C	12: 104,413,518	V390A	possibly damaging	Het
Sirpb1a	A	G	3: 15,426,338	F23S	probably benign	Het
Slc44a3	T	C	3: 121,490,257	T449A	probably benign	Het
Smad6	G	A	9: 63,953,518		probably benign	Het
Sos2	C	T	12: 69,616,990	M573I	probably benign	Het
St8sia1	A	T	6: 142,828,935	I306N	probably damaging	Het
Tnks1bp1	T	C	2: 85,071,781	S1674P	possibly damaging	Het
Trim47	G	A	11: 116,106,201	R576W	probably damaging	Het
Wdr86	A	T	5: 24,722,704	I79N	probably damaging	Het
Wwp2	T	A	8: 107,549,815	V473D	probably damaging	Het
Zc3h12a	T	C	4: 125,119,788	T428A	probably benign	Het
Zfp592	A	G	7: 81,038,245	E973G	probably damaging	Het

Other mutations in Olfr624

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02536:Olfr624	APN	7	103,670,957 (GRCm38)	missense	possibly damaging	0.78
IGL02684:Olfr624	APN	7	103,670,384 (GRCm38)	missense	probably benign	0.06
FR4548:Olfr624	UTSW	7	103,670,967 (GRCm38)	nonsense	probably null
FR4548:Olfr624	UTSW	7	103,670,960 (GRCm38)	small insertion	probably benign
FR4976:Olfr624	UTSW	7	103,670,966 (GRCm38)	small insertion	probably benign
R0295:Olfr624	UTSW	7	103,670,311 (GRCm38)	missense	probably damaging	1.00
R0518:Olfr624	UTSW	7	103,670,489 (GRCm38)	missense	possibly damaging	0.56
R0521:Olfr624	UTSW	7	103,670,489 (GRCm38)	missense	possibly damaging	0.56
R1352:Olfr624	UTSW	7	103,670,311 (GRCm38)	missense	probably damaging	1.00
R1779:Olfr624	UTSW	7	103,670,638 (GRCm38)	missense	probably benign	0.15
R1878:Olfr624	UTSW	7	103,670,182 (GRCm38)	missense	probably damaging	1.00
R1965:Olfr624	UTSW	7	103,670,896 (GRCm38)	missense	probably damaging	1.00
R2162:Olfr624	UTSW	7	103,670,872 (GRCm38)	missense	possibly damaging	0.95
R2316:Olfr624	UTSW	7	103,670,467 (GRCm38)	missense	probably damaging	0.97
R3792:Olfr624	UTSW	7	103,670,146 (GRCm38)	missense	probably damaging	1.00
R3848:Olfr624	UTSW	7	103,670,701 (GRCm38)	missense	probably damaging	0.99
R4120:Olfr624	UTSW	7	103,671,014 (GRCm38)	missense	probably benign
R4183:Olfr624	UTSW	7	103,670,971 (GRCm38)	missense	possibly damaging	0.87
R4853:Olfr624	UTSW	7	103,670,803 (GRCm38)	missense	probably damaging	1.00
R6351:Olfr624	UTSW	7	103,670,956 (GRCm38)	missense	possibly damaging	0.50
R7717:Olfr624	UTSW	7	103,670,945 (GRCm38)	missense	probably benign
R9091:Olfr624	UTSW	7	103,670,917 (GRCm38)	missense	probably damaging	1.00
R9270:Olfr624	UTSW	7	103,670,917 (GRCm38)	missense	probably damaging	1.00
R9273:Olfr624	UTSW	7	103,670,426 (GRCm38)	missense	probably benign	0.03
R9378:Olfr624	UTSW	7	103,670,182 (GRCm38)	missense	probably damaging	1.00
X0026:Olfr624	UTSW	7	103,670,395 (GRCm38)	missense	probably benign

Posted On

2015-04-16