Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02419:Misp'

292602

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Misp

Ensembl Gene

ENSMUSG00000035852

Gene Name

mitotic spindle positioning

Synonyms

9130017N09Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.066) question?

Stock #

IGL02419

Quality Score

Status

Chromosome

Chromosomal Location

79656853-79666286 bp(+) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

A to G at 79663705 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000151839 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000046833] [ENSMUST00000169041] [ENSMUST00000218687] [ENSMUST00000219305] [ENSMUST00000219734]

AlphaFold

Q9D279

Predicted Effect

probably benign
Transcript: ENSMUST00000046833

SMART Domains

Protein: ENSMUSP00000048893
Gene: ENSMUSG00000035852

Domain	Start	End	E-Value	Type
low complexity region	262	284	N/A	INTRINSIC
Pfam:AKAP2_C	294	643	2.2e-140	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000169041

SMART Domains

Protein: ENSMUSP00000130071
Gene: ENSMUSG00000035852

Domain	Start	End	E-Value	Type
low complexity region	262	284	N/A	INTRINSIC
Pfam:AKAP2_C	294	643	1.7e-150	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000218531

Predicted Effect

probably benign
Transcript: ENSMUST00000218687

Predicted Effect

probably benign
Transcript: ENSMUST00000219305

Predicted Effect

probably benign
Transcript: ENSMUST00000219734

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an actin-bundling protein involved in determining cell morphology and mitotic progression. The encoded protein is required for the proper positioning of the mitotic spindle. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Feb 2016]

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933402J07Rik	T	C	8: 88,312,727 (GRCm39)	F171L	possibly damaging	Het
Abca2	A	G	2: 25,336,849 (GRCm39)	N2291D	probably benign	Het
Adamts9	A	G	6: 92,773,978 (GRCm39)	V1145A	probably benign	Het
Adcy2	A	G	13: 69,130,482 (GRCm39)	V135A	probably benign	Het
Akr1c14	A	T	13: 4,130,617 (GRCm39)		probably null	Het
Aptx	G	T	4: 40,691,032 (GRCm39)	A229E	probably benign	Het
Ash1l	T	C	3: 88,892,872 (GRCm39)	S1584P	probably benign	Het
Catsper3	A	T	13: 55,955,881 (GRCm39)	T329S	possibly damaging	Het
Cntrl	A	G	2: 35,024,055 (GRCm39)	D27G	probably damaging	Het
Cobll1	A	T	2: 64,981,392 (GRCm39)	I98K	probably damaging	Het
Ctdp1	T	C	18: 80,463,799 (GRCm39)	K79R	probably damaging	Het
Cwf19l2	T	C	9: 3,418,777 (GRCm39)		probably null	Het
Cyp11b2	A	T	15: 74,722,904 (GRCm39)	F498Y	probably damaging	Het
Dnpep	A	G	1: 75,292,332 (GRCm39)	I162T	probably damaging	Het
Efcab9	T	C	11: 32,472,950 (GRCm39)	I166V	probably benign	Het
Ep400	A	T	5: 110,845,242 (GRCm39)		probably null	Het
Gata6	G	A	18: 11,054,220 (GRCm39)	G50R	probably damaging	Het
Gm9631	G	A	11: 121,834,478 (GRCm39)			Het
Grifin	T	C	5: 140,550,455 (GRCm39)	T20A	probably benign	Het
Hnf4a	A	T	2: 163,408,202 (GRCm39)	I352F	probably damaging	Het
Ifi204	T	C	1: 173,576,946 (GRCm39)	T552A	possibly damaging	Het
Ifi205	C	T	1: 173,845,180 (GRCm39)	A201T	probably damaging	Het
Kcnk6	A	G	7: 28,924,627 (GRCm39)	V259A	probably benign	Het
Kif21b	A	G	1: 136,079,005 (GRCm39)	N451S	probably benign	Het
Klhl24	T	A	16: 19,926,118 (GRCm39)	Y215*	probably null	Het
Lyst	G	A	13: 13,835,541 (GRCm39)	C1741Y	probably benign	Het
Mical1	A	G	10: 41,358,273 (GRCm39)	K429E	possibly damaging	Het
Mon2	T	C	10: 122,852,352 (GRCm39)	N1007S	probably benign	Het
Or10v1	A	T	19: 11,874,186 (GRCm39)	Y267F	probably benign	Het
Or14a260	C	A	7: 85,984,870 (GRCm39)	V245F	probably damaging	Het
Or51v8	A	T	7: 103,319,682 (GRCm39)	C185*	probably null	Het
Or8k41	T	A	2: 86,313,259 (GRCm39)	I276F	probably damaging	Het
Pex6	C	A	17: 47,035,361 (GRCm39)	T840N	possibly damaging	Het
Prox1	C	T	1: 189,893,327 (GRCm39)	A373T	probably benign	Het
Rapgef3	G	T	15: 97,648,171 (GRCm39)	N679K	probably benign	Het
Serpina3n	T	C	12: 104,379,777 (GRCm39)	V390A	possibly damaging	Het
Sirpb1a	A	G	3: 15,491,398 (GRCm39)	F23S	probably benign	Het
Slc44a3	T	C	3: 121,283,906 (GRCm39)	T449A	probably benign	Het
Smad6	G	A	9: 63,860,800 (GRCm39)		probably benign	Het
Sos2	C	T	12: 69,663,764 (GRCm39)	M573I	probably benign	Het
St8sia1	A	T	6: 142,774,661 (GRCm39)	I306N	probably damaging	Het
Tnks1bp1	T	C	2: 84,902,125 (GRCm39)	S1674P	possibly damaging	Het
Trim47	G	A	11: 115,997,027 (GRCm39)	R576W	probably damaging	Het
Wdr86	A	T	5: 24,927,702 (GRCm39)	I79N	probably damaging	Het
Wwp2	T	A	8: 108,276,447 (GRCm39)	V473D	probably damaging	Het
Zc3h12a	T	C	4: 125,013,581 (GRCm39)	T428A	probably benign	Het
Zfp592	A	G	7: 80,687,993 (GRCm39)	E973G	probably damaging	Het

Other mutations in Misp

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02565:Misp	APN	10	79,662,177 (GRCm39)	missense	probably benign	0.33
IGL02901:Misp	APN	10	79,662,771 (GRCm39)	missense	possibly damaging	0.70
R1118:Misp	UTSW	10	79,662,969 (GRCm39)	missense	probably benign	0.01
R1421:Misp	UTSW	10	79,662,681 (GRCm39)	missense	probably damaging	1.00
R1656:Misp	UTSW	10	79,661,777 (GRCm39)	missense	possibly damaging	0.75
R2864:Misp	UTSW	10	79,662,872 (GRCm39)	missense	probably benign	0.05
R3786:Misp	UTSW	10	79,661,795 (GRCm39)	missense	probably benign	0.23
R5035:Misp	UTSW	10	79,663,790 (GRCm39)	missense	probably benign	0.01
R5503:Misp	UTSW	10	79,662,552 (GRCm39)	missense	probably damaging	1.00
R5594:Misp	UTSW	10	79,662,977 (GRCm39)	missense	probably damaging	1.00
R5982:Misp	UTSW	10	79,663,728 (GRCm39)	nonsense	probably null
R6066:Misp	UTSW	10	79,662,146 (GRCm39)	missense	possibly damaging	0.66
R6236:Misp	UTSW	10	79,662,956 (GRCm39)	missense	probably benign	0.00
R7103:Misp	UTSW	10	79,662,999 (GRCm39)	missense	probably damaging	1.00
R8170:Misp	UTSW	10	79,662,300 (GRCm39)	missense	probably benign	0.39
R8479:Misp	UTSW	10	79,663,750 (GRCm39)	missense	possibly damaging	0.91
R8961:Misp	UTSW	10	79,663,823 (GRCm39)	missense	probably benign	0.01
R9430:Misp	UTSW	10	79,661,675 (GRCm39)	missense	probably benign

Posted On

2015-04-16