Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02425:Vmn2r26'

292856

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r26

Ensembl Gene

ENSMUSG00000096630

Gene Name

vomeronasal 2, receptor 26

Synonyms

V2r1b

Accession Numbers

Is this an essential gene?

Possibly non essential (E-score: 0.328) question?

Stock #

IGL02425

Quality Score

Status

Chromosome

Chromosomal Location

124024758-124062035 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 124061818 bp

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 784 (E784G)

Ref Sequence

ENSEMBL: ENSMUSP00000032238 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032238]

Predicted Effect

probably damaging
Transcript: ENSMUST00000032238
AA Change: E784G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000032238
Gene: ENSMUSG00000096630
AA Change: E784G

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	82	471	1.5e-31	PFAM
Pfam:NCD3G	519	572	4.6e-25	PFAM
Pfam:7tm_3	603	840	1.5e-55	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000158682

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal vomeronasal sensory neuron physiology and avnosmia. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
8430423G03Rik	A	G	5: 148,950,662		probably benign	Het
Adam4	C	T	12: 81,421,328	R173H	probably benign	Het
Akap12	A	G	10: 4,356,034	E948G	possibly damaging	Het
Akr1c12	T	C	13: 4,273,750	Y184C	probably damaging	Het
Avil	T	C	10: 127,018,447	V761A	probably benign	Het
Bahd1	T	A	2: 118,919,164	F480L	probably benign	Het
Bicral	T	C	17: 46,808,454	T714A	probably benign	Het
Col4a3bp	T	C	13: 96,609,882	I263T	probably damaging	Het
Csgalnact1	C	A	8: 68,401,492	G219V	probably damaging	Het
Cyp2d34	C	T	15: 82,618,279	V219I	probably benign	Het
Dsn1	A	G	2: 156,996,747	V316A	probably damaging	Het
Errfi1	T	A	4: 150,866,356	F80L	probably benign	Het
Fam221b	A	G	4: 43,660,642		probably null	Het
Fgd6	G	A	10: 94,074,202	G790R	probably benign	Het
Fn1	T	C	1: 71,641,143		probably benign	Het
Gldn	T	A	9: 54,338,721	Y519N	probably damaging	Het
Il18r1	T	C	1: 40,491,221		probably benign	Het
Itpr2	A	G	6: 146,391,321	V380A	probably damaging	Het
Kcnab1	T	C	3: 65,302,179	Y154H	possibly damaging	Het
Lama1	T	C	17: 67,811,485	V2564A	probably benign	Het
Lca5	T	C	9: 83,399,721	T337A	probably damaging	Het
Lrp1	A	G	10: 127,571,887		probably null	Het
Moxd1	A	G	10: 24,279,436	N245S	probably benign	Het
Napepld	T	C	5: 21,683,442	E3G	probably benign	Het
Nr1d2	T	C	14: 18,222,011	T87A	probably benign	Het
Nudt4	T	A	10: 95,549,383	T149S	probably benign	Het
Rad18	A	T	6: 112,620,898	D219E	probably damaging	Het
Ryr2	T	C	13: 11,745,674	I1508V	probably damaging	Het
Setx	G	A	2: 29,148,408	S1635N	probably benign	Het
Slc6a19	A	G	13: 73,691,800	V121A	probably benign	Het
Snapc4	T	C	2: 26,368,200	D736G	probably damaging	Het
Spink5	T	C	18: 43,990,744		probably null	Het
Strip1	T	C	3: 107,614,646	I739V	probably benign	Het
Tmem161a	T	C	8: 70,176,927		probably null	Het
Top1mt	T	C	15: 75,676,121	T39A	probably benign	Het
Trpm1	T	C	7: 64,240,427	M926T	probably damaging	Het
Ttn	T	A	2: 76,757,280	K19744*	probably null	Het
Wnk1	A	G	6: 119,963,454	F774S	probably damaging	Het
Zfp317	T	A	9: 19,643,613	Y101*	probably null	Het

Other mutations in Vmn2r26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01070:Vmn2r26	APN	6	124061607	missense	probably benign	0.00
IGL01370:Vmn2r26	APN	6	124061756	missense	probably benign	0.08
IGL01603:Vmn2r26	APN	6	124053874	missense	probably damaging	1.00
IGL01651:Vmn2r26	APN	6	124050673	missense	probably benign	0.01
IGL02282:Vmn2r26	APN	6	124061625	missense	probably damaging	1.00
IGL02551:Vmn2r26	APN	6	124026141	missense	probably benign	0.11
IGL02690:Vmn2r26	APN	6	124026132	missense	probably benign	0.14
IGL03002:Vmn2r26	APN	6	124039795	missense	possibly damaging	0.78
IGL03270:Vmn2r26	APN	6	124050819	missense	probably benign	0.16
R0032:Vmn2r26	UTSW	6	124039899	missense	possibly damaging	0.72
R0052:Vmn2r26	UTSW	6	124062033	makesense	probably null
R0083:Vmn2r26	UTSW	6	124053981	splice site	probably null
R0682:Vmn2r26	UTSW	6	124061170	missense	probably damaging	0.97
R1061:Vmn2r26	UTSW	6	124061644	missense	probably benign	0.12
R1077:Vmn2r26	UTSW	6	124053913	missense	probably benign	0.00
R1263:Vmn2r26	UTSW	6	124050708	missense	probably benign
R1579:Vmn2r26	UTSW	6	124039747	missense	probably benign	0.00
R1741:Vmn2r26	UTSW	6	124061472	missense	probably damaging	1.00
R1834:Vmn2r26	UTSW	6	124061410	missense	possibly damaging	0.54
R1838:Vmn2r26	UTSW	6	124024771	missense	probably benign
R1956:Vmn2r26	UTSW	6	124053887	missense	probably damaging	1.00
R1996:Vmn2r26	UTSW	6	124061185	missense	probably damaging	1.00
R2140:Vmn2r26	UTSW	6	124061237	missense	probably benign	0.01
R2327:Vmn2r26	UTSW	6	124039749	missense	probably benign	0.07
R2417:Vmn2r26	UTSW	6	124061350	missense	probably damaging	1.00
R3930:Vmn2r26	UTSW	6	124025979	missense	probably benign
R4490:Vmn2r26	UTSW	6	124050738	missense	possibly damaging	0.47
R4629:Vmn2r26	UTSW	6	124061191	missense	possibly damaging	0.50
R4655:Vmn2r26	UTSW	6	124061416	missense	probably damaging	1.00
R4709:Vmn2r26	UTSW	6	124053965	missense	probably damaging	1.00
R4992:Vmn2r26	UTSW	6	124026111	missense	probably benign	0.00
R5297:Vmn2r26	UTSW	6	124061873	missense	probably damaging	1.00
R5482:Vmn2r26	UTSW	6	124061326	missense	possibly damaging	0.88
R5517:Vmn2r26	UTSW	6	124050717	missense	probably damaging	1.00
R5737:Vmn2r26	UTSW	6	124039449	missense	probably benign	0.00
R5739:Vmn2r26	UTSW	6	124025966	missense	probably benign	0.00
R5873:Vmn2r26	UTSW	6	124061674	missense	probably benign	0.01
R5907:Vmn2r26	UTSW	6	124039871	missense	probably benign	0.00
R6086:Vmn2r26	UTSW	6	124039560	missense	possibly damaging	0.48
R6134:Vmn2r26	UTSW	6	124061485	missense	probably damaging	0.97
R6391:Vmn2r26	UTSW	6	124061389	missense	probably damaging	1.00
R6428:Vmn2r26	UTSW	6	124026080	missense	probably benign	0.17
R6637:Vmn2r26	UTSW	6	124061691	missense	probably damaging	1.00
R6927:Vmn2r26	UTSW	6	124039098	missense	possibly damaging	0.93
R6953:Vmn2r26	UTSW	6	124039782	missense	probably benign	0.00
R7173:Vmn2r26	UTSW	6	124061296	missense	probably benign	0.16
R7206:Vmn2r26	UTSW	6	124039768	missense	probably benign	0.17
R7208:Vmn2r26	UTSW	6	124061989	missense	probably damaging	1.00
R7283:Vmn2r26	UTSW	6	124025955	missense	probably damaging	0.97
R7506:Vmn2r26	UTSW	6	124039741	missense	probably benign	0.00
R7672:Vmn2r26	UTSW	6	124039647	missense	probably benign	0.25
R7674:Vmn2r26	UTSW	6	124039362	missense	probably benign
R7696:Vmn2r26	UTSW	6	124061535	missense	possibly damaging	0.94
R7716:Vmn2r26	UTSW	6	124061745	missense	probably damaging	1.00
R7831:Vmn2r26	UTSW	6	124039799	nonsense	probably null
R7914:Vmn2r26	UTSW	6	124039799	nonsense	probably null
R8063:Vmn2r26	UTSW	6	124024955	missense	probably benign	0.00
RF010:Vmn2r26	UTSW	6	124039489	missense	possibly damaging	0.90

Posted On

2015-04-16