Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00942:Prss32'

29291

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Prss32

Ensembl Gene

ENSMUSG00000048992

Gene Name

serine protease 32

Synonyms

mT5, 2010001P08Rik, tryptase-5

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.089) question?

Stock #

IGL00942

Quality Score

Status

Chromosome

Chromosomal Location

24072746-24078750 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 24078134 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 273 (C273*)

Ref Sequence

ENSEMBL: ENSMUSP00000050389 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000061725] [ENSMUST00000154347]

AlphaFold

E9Q409

Predicted Effect

probably null
Transcript: ENSMUST00000061725
AA Change: C273*

SMART Domains

Protein: ENSMUSP00000050389
Gene: ENSMUSG00000048992
AA Change: C273*

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
low complexity region	24	34	N/A	INTRINSIC
Tryp_SPc	53	292	2.75e-95	SMART
transmembrane domain	310	332	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000144925

Predicted Effect

probably benign
Transcript: ENSMUST00000154347

SMART Domains

Protein: ENSMUSP00000116979
Gene: ENSMUSG00000048992

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
low complexity region	24	34	N/A	INTRINSIC
SCOP:g1fiw.1	42	68	6e-8	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000161395

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arap2	A	C	5: 62,855,732 (GRCm39)	L568*	probably null	Het
Arfgef2	G	A	2: 166,727,773 (GRCm39)	V1574M	probably damaging	Het
Arhgef12	C	T	9: 42,893,296 (GRCm39)	R969H	probably damaging	Het
Cacng1	A	T	11: 107,595,195 (GRCm39)	F127L	probably benign	Het
Cntnap5c	T	C	17: 58,076,593 (GRCm39)	V10A	probably benign	Het
Crtac1	T	G	19: 42,312,233 (GRCm39)	D160A	probably damaging	Het
Csmd3	C	T	15: 47,710,502 (GRCm39)		probably null	Het
Grin3a	A	G	4: 49,770,589 (GRCm39)	F728L	probably damaging	Het
H3c1	T	C	13: 23,945,921 (GRCm39)		probably benign	Het
Hecw1	C	T	13: 14,515,325 (GRCm39)		probably benign	Het
Iyd	C	T	10: 3,554,070 (GRCm38)	C239F	probably damaging	Het
Madd	A	G	2: 91,000,923 (GRCm39)	V486A	probably damaging	Het
Map3k7	A	G	4: 32,019,539 (GRCm39)	D533G	probably damaging	Het
Matk	A	G	10: 81,094,128 (GRCm39)	D20G	probably benign	Het
Mphosph10	A	G	7: 64,039,503 (GRCm39)	S156P	probably benign	Het
Mtif2	G	A	11: 29,488,753 (GRCm39)	E356K	probably damaging	Het
Ndufb10	T	C	17: 24,943,158 (GRCm39)		probably null	Het
Nipal3	A	T	4: 135,195,904 (GRCm39)	L233Q	possibly damaging	Het
Or7e169	T	C	9: 19,757,555 (GRCm39)	Y120C	probably damaging	Het
Prtg	T	C	9: 72,799,622 (GRCm39)	S807P	possibly damaging	Het
Ric3	T	G	7: 108,653,619 (GRCm39)	E157D	probably damaging	Het
Ric3	T	A	7: 108,653,620 (GRCm39)	E157V	probably damaging	Het
Slc16a14	G	A	1: 84,900,592 (GRCm39)	T131I	probably damaging	Het
Slc1a2	A	T	2: 102,570,159 (GRCm39)	N137Y	probably damaging	Het
Slc25a27	T	C	17: 43,974,980 (GRCm39)	I94V	probably benign	Het
Slco1a1	G	A	6: 141,892,354 (GRCm39)	T4I	probably benign	Het
Slf1	A	T	13: 77,192,066 (GRCm39)	F923I	possibly damaging	Het
Taf7l2	A	G	10: 115,949,341 (GRCm39)	S62P	possibly damaging	Het
Ttll12	A	C	15: 83,466,649 (GRCm39)	V306G	possibly damaging	Het
Tulp2	G	A	7: 45,165,692 (GRCm39)	V97I	possibly damaging	Het
Vmn2r65	T	G	7: 84,592,761 (GRCm39)	Q482P	probably damaging	Het
Wdr24	T	A	17: 26,045,595 (GRCm39)	N443K	probably benign	Het

Other mutations in Prss32

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00843:Prss32	APN	17	24,076,336 (GRCm39)	missense	probably damaging	1.00
IGL01593:Prss32	APN	17	24,074,982 (GRCm39)	missense	probably benign	0.01
IGL01764:Prss32	APN	17	24,075,085 (GRCm39)	missense	probably damaging	1.00
IGL02313:Prss32	APN	17	24,075,096 (GRCm39)	missense	probably benign	0.17
IGL02625:Prss32	APN	17	24,075,210 (GRCm39)	missense	possibly damaging	0.92
P0045:Prss32	UTSW	17	24,078,294 (GRCm39)	missense	probably benign	0.23
R1867:Prss32	UTSW	17	24,072,868 (GRCm39)	missense	probably benign	0.07
R1936:Prss32	UTSW	17	24,075,024 (GRCm39)	missense	possibly damaging	0.84
R2184:Prss32	UTSW	17	24,078,297 (GRCm39)	missense	probably benign	0.38
R4913:Prss32	UTSW	17	24,078,157 (GRCm39)	missense	probably damaging	1.00
R5049:Prss32	UTSW	17	24,078,221 (GRCm39)	missense	possibly damaging	0.68
R7076:Prss32	UTSW	17	24,072,895 (GRCm39)	missense	possibly damaging	0.54
R9135:Prss32	UTSW	17	24,078,199 (GRCm39)	missense	possibly damaging	0.56

Posted On

2013-04-17