Incidental Mutation 'IGL00942:Prss32'
ID29291
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prss32
Ensembl Gene ENSMUSG00000048992
Gene Nameprotease, serine 32
SynonymsmT5, tryptase-5, 2010001P08Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.095) question?
Stock #IGL00942
Quality Score
Status
Chromosome17
Chromosomal Location23843855-23859776 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) T to A at 23859160 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Stop codon at position 273 (C273*)
Ref Sequence ENSEMBL: ENSMUSP00000050389 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061725] [ENSMUST00000154347]
Predicted Effect probably null
Transcript: ENSMUST00000061725
AA Change: C273*
SMART Domains Protein: ENSMUSP00000050389
Gene: ENSMUSG00000048992
AA Change: C273*

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
low complexity region 24 34 N/A INTRINSIC
Tryp_SPc 53 292 2.75e-95 SMART
transmembrane domain 310 332 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144925
Predicted Effect probably benign
Transcript: ENSMUST00000154347
SMART Domains Protein: ENSMUSP00000116979
Gene: ENSMUSG00000048992

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
low complexity region 24 34 N/A INTRINSIC
SCOP:g1fiw.1 42 68 6e-8 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161395
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933416C03Rik A G 10: 116,113,436 S62P possibly damaging Het
Arap2 A C 5: 62,698,389 L568* probably null Het
Arfgef2 G A 2: 166,885,853 V1574M probably damaging Het
Arhgef12 C T 9: 42,982,000 R969H probably damaging Het
Cacng1 A T 11: 107,704,369 F127L probably benign Het
Cntnap5c T C 17: 57,769,598 V10A probably benign Het
Crtac1 T G 19: 42,323,794 D160A probably damaging Het
Csmd3 C T 15: 47,847,106 probably null Het
Grin3a A G 4: 49,770,589 F728L probably damaging Het
Hecw1 C T 13: 14,340,740 probably benign Het
Hist1h3a T C 13: 23,761,938 probably benign Het
Iyd C T 10: 3,554,070 C239F probably damaging Het
Madd A G 2: 91,170,578 V486A probably damaging Het
Map3k7 A G 4: 32,019,539 D533G probably damaging Het
Matk A G 10: 81,258,294 D20G probably benign Het
Mphosph10 A G 7: 64,389,755 S156P probably benign Het
Mtif2 G A 11: 29,538,753 E356K probably damaging Het
Ndufb10 T C 17: 24,724,184 probably null Het
Nipal3 A T 4: 135,468,593 L233Q possibly damaging Het
Olfr860 T C 9: 19,846,259 Y120C probably damaging Het
Prtg T C 9: 72,892,340 S807P possibly damaging Het
Ric3 T G 7: 109,054,412 E157D probably damaging Het
Ric3 T A 7: 109,054,413 E157V probably damaging Het
Slc16a14 G A 1: 84,922,871 T131I probably damaging Het
Slc1a2 A T 2: 102,739,814 N137Y probably damaging Het
Slc25a27 T C 17: 43,664,089 I94V probably benign Het
Slco1a1 G A 6: 141,946,628 T4I probably benign Het
Slf1 A T 13: 77,043,947 F923I possibly damaging Het
Ttll12 A C 15: 83,582,448 V306G possibly damaging Het
Tulp2 G A 7: 45,516,268 V97I possibly damaging Het
Vmn2r65 T G 7: 84,943,553 Q482P probably damaging Het
Wdr24 T A 17: 25,826,621 N443K probably benign Het
Other mutations in Prss32
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00843:Prss32 APN 17 23857362 missense probably damaging 1.00
IGL01593:Prss32 APN 17 23856008 missense probably benign 0.01
IGL01764:Prss32 APN 17 23856111 missense probably damaging 1.00
IGL02313:Prss32 APN 17 23856122 missense probably benign 0.17
IGL02625:Prss32 APN 17 23856236 missense possibly damaging 0.92
P0045:Prss32 UTSW 17 23859320 missense probably benign 0.23
R1867:Prss32 UTSW 17 23853894 missense probably benign 0.07
R1936:Prss32 UTSW 17 23856050 missense possibly damaging 0.84
R2184:Prss32 UTSW 17 23859323 missense probably benign 0.38
R4913:Prss32 UTSW 17 23859183 missense probably damaging 1.00
R5049:Prss32 UTSW 17 23859247 missense possibly damaging 0.68
R7076:Prss32 UTSW 17 23853921 missense possibly damaging 0.54
Posted On2013-04-17