Incidental Mutation 'IGL00942:Wdr24'
ID 29292
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Wdr24
Ensembl Gene ENSMUSG00000025737
Gene Name WD repeat domain 24
Synonyms
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL00942
Quality Score
Status
Chromosome 17
Chromosomal Location 26042601-26047704 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 26045595 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 443 (N443K)
Ref Sequence ENSEMBL: ENSMUSP00000026833 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026832] [ENSMUST00000026833] [ENSMUST00000044911] [ENSMUST00000123582] [ENSMUST00000133595]
AlphaFold Q8CFJ9
Predicted Effect probably benign
Transcript: ENSMUST00000026832
SMART Domains Protein: ENSMUSP00000026832
Gene: ENSMUSG00000025736

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
JmjC 140 271 5.27e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000026833
AA Change: N443K

PolyPhen 2 Score 0.196 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000026833
Gene: ENSMUSG00000025737
AA Change: N443K

DomainStartEndE-ValueType
Blast:WD40 19 53 6e-8 BLAST
WD40 68 103 2.13e1 SMART
WD40 109 149 5.77e-5 SMART
WD40 152 192 4.48e-2 SMART
WD40 196 236 1.48e-11 SMART
WD40 244 282 1.66e0 SMART
WD40 286 327 2.48e0 SMART
low complexity region 605 623 N/A INTRINSIC
Blast:RING 743 780 2e-7 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000044911
SMART Domains Protein: ENSMUSP00000040431
Gene: ENSMUSG00000039615

DomainStartEndE-ValueType
low complexity region 9 19 N/A INTRINSIC
TPR 27 60 2.43e1 SMART
TPR 61 94 1.48e-7 SMART
TPR 95 128 4.52e-3 SMART
low complexity region 168 180 N/A INTRINSIC
Ubox 231 294 1.27e-28 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123560
Predicted Effect probably benign
Transcript: ENSMUST00000123582
SMART Domains Protein: ENSMUSP00000119840
Gene: ENSMUSG00000025736

DomainStartEndE-ValueType
low complexity region 158 172 N/A INTRINSIC
low complexity region 194 208 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123692
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160349
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160829
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180868
Predicted Effect noncoding transcript
Transcript: ENSMUST00000175335
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160275
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144589
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143296
Predicted Effect probably benign
Transcript: ENSMUST00000133595
SMART Domains Protein: ENSMUSP00000122744
Gene: ENSMUSG00000025736

DomainStartEndE-ValueType
transmembrane domain 55 74 N/A INTRINSIC
JmjC 185 316 5.27e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000152434
SMART Domains Protein: ENSMUSP00000119378
Gene: ENSMUSG00000025736

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arap2 A C 5: 62,855,732 (GRCm39) L568* probably null Het
Arfgef2 G A 2: 166,727,773 (GRCm39) V1574M probably damaging Het
Arhgef12 C T 9: 42,893,296 (GRCm39) R969H probably damaging Het
Cacng1 A T 11: 107,595,195 (GRCm39) F127L probably benign Het
Cntnap5c T C 17: 58,076,593 (GRCm39) V10A probably benign Het
Crtac1 T G 19: 42,312,233 (GRCm39) D160A probably damaging Het
Csmd3 C T 15: 47,710,502 (GRCm39) probably null Het
Grin3a A G 4: 49,770,589 (GRCm39) F728L probably damaging Het
H3c1 T C 13: 23,945,921 (GRCm39) probably benign Het
Hecw1 C T 13: 14,515,325 (GRCm39) probably benign Het
Iyd C T 10: 3,554,070 (GRCm38) C239F probably damaging Het
Madd A G 2: 91,000,923 (GRCm39) V486A probably damaging Het
Map3k7 A G 4: 32,019,539 (GRCm39) D533G probably damaging Het
Matk A G 10: 81,094,128 (GRCm39) D20G probably benign Het
Mphosph10 A G 7: 64,039,503 (GRCm39) S156P probably benign Het
Mtif2 G A 11: 29,488,753 (GRCm39) E356K probably damaging Het
Ndufb10 T C 17: 24,943,158 (GRCm39) probably null Het
Nipal3 A T 4: 135,195,904 (GRCm39) L233Q possibly damaging Het
Or7e169 T C 9: 19,757,555 (GRCm39) Y120C probably damaging Het
Prss32 T A 17: 24,078,134 (GRCm39) C273* probably null Het
Prtg T C 9: 72,799,622 (GRCm39) S807P possibly damaging Het
Ric3 T G 7: 108,653,619 (GRCm39) E157D probably damaging Het
Ric3 T A 7: 108,653,620 (GRCm39) E157V probably damaging Het
Slc16a14 G A 1: 84,900,592 (GRCm39) T131I probably damaging Het
Slc1a2 A T 2: 102,570,159 (GRCm39) N137Y probably damaging Het
Slc25a27 T C 17: 43,974,980 (GRCm39) I94V probably benign Het
Slco1a1 G A 6: 141,892,354 (GRCm39) T4I probably benign Het
Slf1 A T 13: 77,192,066 (GRCm39) F923I possibly damaging Het
Taf7l2 A G 10: 115,949,341 (GRCm39) S62P possibly damaging Het
Ttll12 A C 15: 83,466,649 (GRCm39) V306G possibly damaging Het
Tulp2 G A 7: 45,165,692 (GRCm39) V97I possibly damaging Het
Vmn2r65 T G 7: 84,592,761 (GRCm39) Q482P probably damaging Het
Other mutations in Wdr24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01700:Wdr24 APN 17 26,044,802 (GRCm39) missense probably damaging 1.00
IGL01763:Wdr24 APN 17 26,045,164 (GRCm39) missense probably benign 0.20
IGL02567:Wdr24 APN 17 26,043,322 (GRCm39) missense probably damaging 0.99
IGL03100:Wdr24 APN 17 26,044,681 (GRCm39) missense possibly damaging 0.47
R0012:Wdr24 UTSW 17 26,046,087 (GRCm39) missense probably benign
R0799:Wdr24 UTSW 17 26,045,102 (GRCm39) missense probably damaging 1.00
R1015:Wdr24 UTSW 17 26,047,212 (GRCm39) missense probably benign 0.12
R1276:Wdr24 UTSW 17 26,046,441 (GRCm39) missense probably benign 0.02
R1297:Wdr24 UTSW 17 26,046,322 (GRCm39) missense possibly damaging 0.90
R1934:Wdr24 UTSW 17 26,043,240 (GRCm39) missense possibly damaging 0.89
R2030:Wdr24 UTSW 17 26,045,017 (GRCm39) missense probably benign 0.38
R2069:Wdr24 UTSW 17 26,045,256 (GRCm39) missense probably damaging 1.00
R2508:Wdr24 UTSW 17 26,043,273 (GRCm39) missense possibly damaging 0.52
R4601:Wdr24 UTSW 17 26,047,181 (GRCm39) splice site probably null
R4604:Wdr24 UTSW 17 26,047,479 (GRCm39) missense probably damaging 1.00
R4894:Wdr24 UTSW 17 26,045,101 (GRCm39) missense probably damaging 1.00
R5068:Wdr24 UTSW 17 26,044,753 (GRCm39) missense possibly damaging 0.77
R5088:Wdr24 UTSW 17 26,047,181 (GRCm39) splice site probably null
R5104:Wdr24 UTSW 17 26,043,565 (GRCm39) missense probably damaging 1.00
R5498:Wdr24 UTSW 17 26,043,535 (GRCm39) missense probably damaging 1.00
R5719:Wdr24 UTSW 17 26,047,314 (GRCm39) critical splice donor site probably null
R5892:Wdr24 UTSW 17 26,046,960 (GRCm39) missense probably benign 0.00
R5975:Wdr24 UTSW 17 26,046,102 (GRCm39) missense probably benign 0.37
R6084:Wdr24 UTSW 17 26,043,504 (GRCm39) missense probably damaging 0.99
R6106:Wdr24 UTSW 17 26,043,579 (GRCm39) missense probably benign
R6114:Wdr24 UTSW 17 26,043,579 (GRCm39) missense probably benign
R6116:Wdr24 UTSW 17 26,043,579 (GRCm39) missense probably benign
R6165:Wdr24 UTSW 17 26,045,395 (GRCm39) missense probably benign 0.18
R6175:Wdr24 UTSW 17 26,045,552 (GRCm39) missense probably damaging 1.00
R6331:Wdr24 UTSW 17 26,044,650 (GRCm39) missense possibly damaging 0.61
R6548:Wdr24 UTSW 17 26,046,899 (GRCm39) missense probably damaging 0.99
R6984:Wdr24 UTSW 17 26,047,209 (GRCm39) missense possibly damaging 0.93
R7485:Wdr24 UTSW 17 26,045,101 (GRCm39) missense probably damaging 1.00
R7583:Wdr24 UTSW 17 26,044,804 (GRCm39) missense probably null 1.00
R7770:Wdr24 UTSW 17 26,046,070 (GRCm39) missense probably benign 0.04
R8086:Wdr24 UTSW 17 26,045,101 (GRCm39) missense probably damaging 1.00
R8164:Wdr24 UTSW 17 26,044,923 (GRCm39) splice site probably null
R9210:Wdr24 UTSW 17 26,043,472 (GRCm39) missense probably benign 0.00
R9212:Wdr24 UTSW 17 26,043,472 (GRCm39) missense probably benign 0.00
R9567:Wdr24 UTSW 17 26,043,190 (GRCm39) missense probably damaging 0.98
R9667:Wdr24 UTSW 17 26,046,301 (GRCm39) missense possibly damaging 0.55
X0022:Wdr24 UTSW 17 26,043,246 (GRCm39) missense probably damaging 0.99
Z1177:Wdr24 UTSW 17 26,044,661 (GRCm39) missense probably benign 0.29
Posted On 2013-04-17