Incidental Mutation 'IGL02428:Vmn2r32'
ID 292983
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r32
Ensembl Gene ENSMUSG00000096743
Gene Name vomeronasal 2, receptor 32
Synonyms V2r5
Accession Numbers
Essential gene? Probably non essential (E-score: 0.206) question?
Stock # IGL02428
Quality Score
Status
Chromosome 7
Chromosomal Location 7466968-7482972 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 7477283 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Methionine at position 369 (I369M)
Ref Sequence ENSEMBL: ENSMUSP00000092462 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094866]
AlphaFold K7N686
Predicted Effect probably benign
Transcript: ENSMUST00000094866
AA Change: I369M

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000092462
Gene: ENSMUSG00000096743
AA Change: I369M

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 73 470 3.6e-33 PFAM
Pfam:NCD3G 512 565 8.1e-21 PFAM
Pfam:7tm_3 598 833 9.5e-55 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700024G13Rik T C 14: 32,110,205 (GRCm39) probably benign Het
AB124611 C T 9: 21,440,221 (GRCm39) S69L possibly damaging Het
Abca6 G A 11: 110,069,618 (GRCm39) A1566V possibly damaging Het
Ahnak A G 19: 8,992,197 (GRCm39) I4494V possibly damaging Het
Ascc3 T A 10: 50,721,791 (GRCm39) Y2081* probably null Het
Cdc42bpb T C 12: 111,289,561 (GRCm39) T423A probably benign Het
Cdh6 T A 15: 13,064,516 (GRCm39) I125F possibly damaging Het
Csgalnact1 C A 8: 68,854,144 (GRCm39) G219V probably damaging Het
Csmd2 T C 4: 128,368,609 (GRCm39) L1845P possibly damaging Het
Epha4 A G 1: 77,483,385 (GRCm39) V208A possibly damaging Het
Fanci A G 7: 79,094,264 (GRCm39) probably benign Het
Fezf2 T C 14: 12,344,494 (GRCm38) E231G probably damaging Het
Flnc A G 6: 29,451,484 (GRCm39) D1566G probably damaging Het
Gm11565 A G 11: 99,805,811 (GRCm39) T68A probably benign Het
Ifng G A 10: 118,281,159 (GRCm39) R154H probably damaging Het
Il1r1 G A 1: 40,352,392 (GRCm39) E521K possibly damaging Het
Irf3 G T 7: 44,648,163 (GRCm39) L9F probably damaging Het
Jade1 T G 3: 41,568,374 (GRCm39) I814S probably benign Het
Kcnh1 G A 1: 192,019,851 (GRCm39) W365* probably null Het
Kif16b T C 2: 142,514,280 (GRCm39) T1209A possibly damaging Het
Mcur1 A T 13: 43,695,203 (GRCm39) S324T probably damaging Het
Mgat2 C A 12: 69,231,558 (GRCm39) A44E probably benign Het
Nox1 A G X: 133,008,583 (GRCm39) probably benign Het
Oga A T 19: 45,753,940 (GRCm39) W645R probably damaging Het
Or52ae7 A T 7: 103,119,590 (GRCm39) I115F probably benign Het
Or5ak23 A G 2: 85,244,537 (GRCm39) S229P probably benign Het
Pcnt A T 10: 76,265,090 (GRCm39) I340N probably damaging Het
Pde11a T C 2: 75,877,189 (GRCm39) E760G possibly damaging Het
Per3 C T 4: 151,102,674 (GRCm39) probably null Het
Rabep1 G A 11: 70,808,306 (GRCm39) A421T probably benign Het
Rint1 C T 5: 23,999,450 (GRCm39) Q80* probably null Het
Rnaset2b G A 17: 7,248,568 (GRCm39) probably null Het
Sccpdh T C 1: 179,508,070 (GRCm39) Y237H probably benign Het
Scn10a T A 9: 119,520,628 (GRCm39) T91S probably damaging Het
Spock1 A G 13: 57,592,245 (GRCm39) probably benign Het
Stat1 A G 1: 52,182,125 (GRCm39) probably benign Het
Svil A G 18: 5,118,203 (GRCm39) E2212G probably damaging Het
Taok1 T A 11: 77,440,103 (GRCm39) R635W probably benign Het
Vmn1r39 A G 6: 66,781,946 (GRCm39) I124T probably benign Het
Other mutations in Vmn2r32
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02140:Vmn2r32 APN 7 7,479,696 (GRCm39) missense probably damaging 0.97
IGL02333:Vmn2r32 APN 7 7,467,143 (GRCm39) missense probably damaging 1.00
IGL02406:Vmn2r32 APN 7 7,479,709 (GRCm39) missense probably benign
IGL02484:Vmn2r32 APN 7 7,467,116 (GRCm39) missense probably damaging 1.00
IGL03277:Vmn2r32 APN 7 7,477,251 (GRCm39) missense probably benign 0.23
IGL03366:Vmn2r32 APN 7 7,467,029 (GRCm39) missense probably damaging 0.99
R1055:Vmn2r32 UTSW 7 7,477,326 (GRCm39) nonsense probably null
R1695:Vmn2r32 UTSW 7 7,466,991 (GRCm39) missense probably benign 0.01
R2172:Vmn2r32 UTSW 7 7,477,614 (GRCm39) missense probably damaging 0.99
R2262:Vmn2r32 UTSW 7 7,477,618 (GRCm39) missense probably benign
R3150:Vmn2r32 UTSW 7 7,475,554 (GRCm39) missense probably benign
R4362:Vmn2r32 UTSW 7 7,482,857 (GRCm39) nonsense probably null
R4432:Vmn2r32 UTSW 7 7,482,918 (GRCm39) missense probably damaging 0.98
R4851:Vmn2r32 UTSW 7 7,482,953 (GRCm39) missense possibly damaging 0.59
R4949:Vmn2r32 UTSW 7 7,467,083 (GRCm39) missense probably benign 0.22
R5990:Vmn2r32 UTSW 7 7,482,809 (GRCm39) missense probably damaging 0.97
R6083:Vmn2r32 UTSW 7 7,467,209 (GRCm39) missense probably benign 0.15
R6084:Vmn2r32 UTSW 7 7,467,209 (GRCm39) missense probably benign 0.15
R6116:Vmn2r32 UTSW 7 7,467,092 (GRCm39) missense probably damaging 1.00
R6263:Vmn2r32 UTSW 7 7,479,691 (GRCm39) missense possibly damaging 0.90
R6889:Vmn2r32 UTSW 7 7,475,573 (GRCm39) missense possibly damaging 0.82
R7286:Vmn2r32 UTSW 7 7,482,807 (GRCm39) missense probably benign 0.21
R7390:Vmn2r32 UTSW 7 7,482,851 (GRCm39) missense probably benign 0.00
R7412:Vmn2r32 UTSW 7 7,477,212 (GRCm39) missense possibly damaging 0.53
R7508:Vmn2r32 UTSW 7 7,470,373 (GRCm39) missense possibly damaging 0.87
R8812:Vmn2r32 UTSW 7 7,477,669 (GRCm39) missense probably damaging 1.00
R8968:Vmn2r32 UTSW 7 7,477,204 (GRCm39) missense probably benign 0.00
R9331:Vmn2r32 UTSW 7 7,467,402 (GRCm39) nonsense probably null
R9358:Vmn2r32 UTSW 7 7,477,197 (GRCm39) missense probably damaging 1.00
Z1177:Vmn2r32 UTSW 7 7,477,160 (GRCm39) missense probably damaging 0.98
Posted On 2015-04-16