Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02428:Vmn2r32'

292983

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r32

Ensembl Gene

ENSMUSG00000096743

Gene Name

vomeronasal 2, receptor 32

Synonyms

V2r5

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.215) question?

Stock #

IGL02428

Quality Score

Status

Chromosome

Chromosomal Location

7463015-7479973 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 7474284 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Methionine at position 369 (I369M)

Ref Sequence

ENSEMBL: ENSMUSP00000092462 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094866]

AlphaFold

K7N686

Predicted Effect

probably benign
Transcript: ENSMUST00000094866
AA Change: I369M

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000092462
Gene: ENSMUSG00000096743
AA Change: I369M

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	470	3.6e-33	PFAM
Pfam:NCD3G	512	565	8.1e-21	PFAM
Pfam:7tm_3	598	833	9.5e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700024G13Rik	T	C	14: 32,388,248		probably benign	Het
AB124611	C	T	9: 21,528,925	S69L	possibly damaging	Het
Abca6	G	A	11: 110,178,792	A1566V	possibly damaging	Het
Ahnak	A	G	19: 9,014,833	I4494V	possibly damaging	Het
Ascc3	T	A	10: 50,845,695	Y2081*	probably null	Het
Cdc42bpb	T	C	12: 111,323,127	T423A	probably benign	Het
Cdh6	T	A	15: 13,064,430	I125F	possibly damaging	Het
Csgalnact1	C	A	8: 68,401,492	G219V	probably damaging	Het
Csmd2	T	C	4: 128,474,816	L1845P	possibly damaging	Het
Epha4	A	G	1: 77,506,748	V208A	possibly damaging	Het
Fanci	A	G	7: 79,444,516		probably benign	Het
Fezf2	T	C	14: 12,344,494	E231G	probably damaging	Het
Flnc	A	G	6: 29,451,485	D1566G	probably damaging	Het
Gm11565	A	G	11: 99,914,985	T68A	probably benign	Het
Ifng	G	A	10: 118,445,254	R154H	probably damaging	Het
Il1r1	G	A	1: 40,313,232	E521K	possibly damaging	Het
Irf3	G	T	7: 44,998,739	L9F	probably damaging	Het
Jade1	T	G	3: 41,613,939	I814S	probably benign	Het
Kcnh1	G	A	1: 192,337,543	W365*	probably null	Het
Kif16b	T	C	2: 142,672,360	T1209A	possibly damaging	Het
Mcur1	A	T	13: 43,541,727	S324T	probably damaging	Het
Mgat2	C	A	12: 69,184,784	A44E	probably benign	Het
Mgea5	A	T	19: 45,765,501	W645R	probably damaging	Het
Nox1	A	G	X: 134,107,834		probably benign	Het
Olfr608	A	T	7: 103,470,383	I115F	probably benign	Het
Olfr993	A	G	2: 85,414,193	S229P	probably benign	Het
Pcnt	A	T	10: 76,429,256	I340N	probably damaging	Het
Pde11a	T	C	2: 76,046,845	E760G	possibly damaging	Het
Per3	C	T	4: 151,018,217		probably null	Het
Rabep1	G	A	11: 70,917,480	A421T	probably benign	Het
Rint1	C	T	5: 23,794,452	Q80*	probably null	Het
Rnaset2b	G	A	17: 6,981,169		probably null	Het
Sccpdh	T	C	1: 179,680,505	Y237H	probably benign	Het
Scn10a	T	A	9: 119,691,562	T91S	probably damaging	Het
Spock1	A	G	13: 57,444,432		probably benign	Het
Stat1	A	G	1: 52,142,966		probably benign	Het
Svil	A	G	18: 5,118,203	E2212G	probably damaging	Het
Taok1	T	A	11: 77,549,277	R635W	probably benign	Het
Vmn1r39	A	G	6: 66,804,962	I124T	probably benign	Het

Other mutations in Vmn2r32

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02140:Vmn2r32	APN	7	7476697	missense	probably damaging	0.97
IGL02333:Vmn2r32	APN	7	7464144	missense	probably damaging	1.00
IGL02406:Vmn2r32	APN	7	7476710	missense	probably benign
IGL02484:Vmn2r32	APN	7	7464117	missense	probably damaging	1.00
IGL03277:Vmn2r32	APN	7	7474252	missense	probably benign	0.23
IGL03366:Vmn2r32	APN	7	7464030	missense	probably damaging	0.99
R1055:Vmn2r32	UTSW	7	7474327	nonsense	probably null
R1695:Vmn2r32	UTSW	7	7463992	missense	probably benign	0.01
R2172:Vmn2r32	UTSW	7	7474615	missense	probably damaging	0.99
R2262:Vmn2r32	UTSW	7	7474619	missense	probably benign
R3150:Vmn2r32	UTSW	7	7472555	missense	probably benign
R4362:Vmn2r32	UTSW	7	7479858	nonsense	probably null
R4432:Vmn2r32	UTSW	7	7479919	missense	probably damaging	0.98
R4851:Vmn2r32	UTSW	7	7479954	missense	possibly damaging	0.59
R4949:Vmn2r32	UTSW	7	7464084	missense	probably benign	0.22
R5990:Vmn2r32	UTSW	7	7479810	missense	probably damaging	0.97
R6083:Vmn2r32	UTSW	7	7464210	missense	probably benign	0.15
R6084:Vmn2r32	UTSW	7	7464210	missense	probably benign	0.15
R6116:Vmn2r32	UTSW	7	7464093	missense	probably damaging	1.00
R6263:Vmn2r32	UTSW	7	7476692	missense	possibly damaging	0.90
R6889:Vmn2r32	UTSW	7	7472574	missense	possibly damaging	0.82
R7286:Vmn2r32	UTSW	7	7479808	missense	probably benign	0.21
R7390:Vmn2r32	UTSW	7	7479852	missense	probably benign	0.00
R7412:Vmn2r32	UTSW	7	7474213	missense	possibly damaging	0.53
R7508:Vmn2r32	UTSW	7	7467374	missense	possibly damaging	0.87
R8812:Vmn2r32	UTSW	7	7474670	missense	probably damaging	1.00
R8968:Vmn2r32	UTSW	7	7474205	missense	probably benign	0.00
R9331:Vmn2r32	UTSW	7	7464403	nonsense	probably null
R9358:Vmn2r32	UTSW	7	7474198	missense	probably damaging	1.00
Z1177:Vmn2r32	UTSW	7	7474161	missense	probably damaging	0.98

Posted On

2015-04-16