Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02429:Oas1c'

293035

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Oas1c

Ensembl Gene

ENSMUSG00000001166

Gene Name

2'-5' oligoadenylate synthetase 1C

Synonyms

Oasl5

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02429

Quality Score

Status

Chromosome

Chromosomal Location

120938259-120950579 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 120940133 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Isoleucine at position 344 (M344I)

Ref Sequence

ENSEMBL: ENSMUSP00000112584 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000117193] [ENSMUST00000125547]

AlphaFold

Q924S2

Predicted Effect

probably benign
Transcript: ENSMUST00000117193
AA Change: M344I

PolyPhen 2 Score 0.300 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000112584
Gene: ENSMUSG00000001166
AA Change: M344I

Domain	Start	End	E-Value	Type
Pfam:OAS1_C	168	354	1.4e-76	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000125547

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000130045

SMART Domains

Protein: ENSMUSP00000122510
Gene: ENSMUSG00000001166

Domain	Start	End	E-Value	Type
Pfam:OAS1_C	89	146	3e-23	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000201006

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acmsd	A	T	1: 127,687,453 (GRCm39)	D245V	probably damaging	Het
Adamts16	G	A	13: 70,935,289 (GRCm39)		probably benign	Het
Arhgap36	A	G	X: 48,583,583 (GRCm39)	D77G	possibly damaging	Het
Asap1	A	T	15: 64,039,589 (GRCm39)	M187K	probably damaging	Het
Aspm	T	C	1: 139,407,548 (GRCm39)	V2145A	probably benign	Het
Ccn6	T	C	10: 39,030,989 (GRCm39)	N178S	probably benign	Het
Cd46	T	C	1: 194,767,732 (GRCm39)	T110A	probably benign	Het
Chl1	T	A	6: 103,641,770 (GRCm39)		probably benign	Het
Clca3b	A	G	3: 144,533,896 (GRCm39)	L493S	probably damaging	Het
Col11a2	C	T	17: 34,261,266 (GRCm39)	T72M	probably damaging	Het
Cyfip1	T	A	7: 55,521,730 (GRCm39)		probably benign	Het
Frmd4b	T	C	6: 97,302,390 (GRCm39)		probably benign	Het
Glyr1	A	G	16: 4,837,240 (GRCm39)	M397T	probably benign	Het
Golm2	A	G	2: 121,742,468 (GRCm39)	T306A	probably benign	Het
Gtf2a1l	G	T	17: 88,976,141 (GRCm39)	M1I	probably null	Het
Hdac4	A	G	1: 91,940,417 (GRCm39)	L154P	probably benign	Het
Ints8	A	T	4: 11,231,720 (GRCm39)	C422S	probably damaging	Het
Kng2	T	A	16: 22,830,829 (GRCm39)	K160I	probably damaging	Het
Lrrc23	C	A	6: 124,755,130 (GRCm39)	A136S	probably damaging	Het
Ltf	T	C	9: 110,855,193 (GRCm39)	I402T	possibly damaging	Het
Lyst	G	A	13: 13,835,541 (GRCm39)	C1741Y	probably benign	Het
Mfsd4a	T	C	1: 131,956,237 (GRCm39)	H509R	probably benign	Het
Mthfd1l	A	G	10: 4,039,334 (GRCm39)	K782E	probably damaging	Het
Mvb12b	G	A	2: 33,717,800 (GRCm39)	R114W	probably damaging	Het
Myh4	A	T	11: 67,149,808 (GRCm39)	K1818*	probably null	Het
Myo1h	C	T	5: 114,497,799 (GRCm39)		probably benign	Het
Ncapd3	T	A	9: 27,000,598 (GRCm39)	S1402T	probably benign	Het
Nutm2	A	G	13: 50,623,516 (GRCm39)	N71S	probably benign	Het
Or10g7	T	A	9: 39,905,138 (GRCm39)	F11I	probably benign	Het
Phldb1	A	G	9: 44,612,247 (GRCm39)	L1019P	probably damaging	Het
Plxnc1	T	C	10: 94,718,453 (GRCm39)	E494G	probably benign	Het
Pole	T	C	5: 110,447,666 (GRCm39)	I734T	probably benign	Het
Ppp1r3b	T	C	8: 35,851,769 (GRCm39)	S203P	probably benign	Het
Pth2r	G	T	1: 65,385,998 (GRCm39)	M240I	probably benign	Het
Ptprr	T	A	10: 116,109,672 (GRCm39)	F394I	probably damaging	Het
Rabgef1	T	C	5: 130,239,329 (GRCm39)	S265P	possibly damaging	Het
Rbpjl	A	G	2: 164,255,815 (GRCm39)	D353G	possibly damaging	Het
Rfc3	A	G	5: 151,574,596 (GRCm39)	Y8H	probably benign	Het
Rph3a	A	T	5: 121,118,187 (GRCm39)		probably null	Het
Runx1t1	A	T	4: 13,865,294 (GRCm39)		probably benign	Het
Slc37a1	T	A	17: 31,519,483 (GRCm39)		probably null	Het
Slc38a10	T	C	11: 120,025,714 (GRCm39)		probably benign	Het
Slc38a6	T	C	12: 73,397,342 (GRCm39)	V328A	probably benign	Het
Slf2	T	C	19: 44,930,167 (GRCm39)	S415P	probably benign	Het
Spata17	C	A	1: 186,872,631 (GRCm39)	R60L	possibly damaging	Het
Svil	T	A	18: 5,118,369 (GRCm39)	D2237E	probably benign	Het
Swap70	T	A	7: 109,863,179 (GRCm39)	N169K	probably benign	Het
Tnfrsf11a	A	G	1: 105,755,443 (GRCm39)	D505G	probably benign	Het
Traf1	A	G	2: 34,839,115 (GRCm39)	V70A	probably benign	Het
Traf3	T	A	12: 111,209,899 (GRCm39)	V165E	probably benign	Het
Trpc5	T	C	X: 143,194,795 (GRCm39)	E570G	probably damaging	Het
Ubash3a	A	G	17: 31,460,279 (GRCm39)	N601S	probably benign	Het
Vmn2r30	C	T	7: 7,337,243 (GRCm39)	C131Y	possibly damaging	Het
Vmn2r43	T	C	7: 8,258,551 (GRCm39)	I221V	probably benign	Het
Vmn2r97	T	A	17: 19,150,596 (GRCm39)	V481E	possibly damaging	Het

Other mutations in Oas1c

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00586:Oas1c	APN	5	120,946,744 (GRCm39)	missense	probably benign	0.00
IGL01472:Oas1c	APN	5	120,940,986 (GRCm39)	missense	probably damaging	1.00
IGL01931:Oas1c	APN	5	120,943,560 (GRCm39)	missense	probably benign	0.20
IGL02498:Oas1c	APN	5	120,943,591 (GRCm39)	missense	possibly damaging	0.83
IGL02696:Oas1c	APN	5	120,943,528 (GRCm39)	missense	probably benign	0.44
IGL02957:Oas1c	APN	5	120,943,478 (GRCm39)	nonsense	probably null
sandshrew	UTSW	5	120,946,204 (GRCm39)	missense	probably damaging	0.99
R0562:Oas1c	UTSW	5	120,943,669 (GRCm39)	splice site	probably benign
R1819:Oas1c	UTSW	5	120,946,800 (GRCm39)	missense	possibly damaging	0.89
R1853:Oas1c	UTSW	5	120,946,060 (GRCm39)	missense	probably damaging	1.00
R1937:Oas1c	UTSW	5	120,941,049 (GRCm39)	missense	probably benign	0.00
R2248:Oas1c	UTSW	5	120,940,926 (GRCm39)	missense	possibly damaging	0.48
R2258:Oas1c	UTSW	5	120,941,082 (GRCm39)	missense	probably null	1.00
R2570:Oas1c	UTSW	5	120,943,503 (GRCm39)	missense	probably benign	0.05
R3965:Oas1c	UTSW	5	120,946,783 (GRCm39)	missense	probably damaging	1.00
R4164:Oas1c	UTSW	5	120,946,204 (GRCm39)	missense	probably damaging	0.99
R5146:Oas1c	UTSW	5	120,940,159 (GRCm39)	missense	probably benign	0.08
R5875:Oas1c	UTSW	5	120,943,627 (GRCm39)	missense	probably damaging	1.00
R5938:Oas1c	UTSW	5	120,943,598 (GRCm39)	missense	probably benign	0.05
R7219:Oas1c	UTSW	5	120,940,957 (GRCm39)	missense	probably damaging	1.00
R7443:Oas1c	UTSW	5	120,943,484 (GRCm39)	missense	probably damaging	1.00
R7451:Oas1c	UTSW	5	120,940,207 (GRCm39)	missense	possibly damaging	0.57
R7578:Oas1c	UTSW	5	120,940,244 (GRCm39)	missense	probably damaging	1.00
R7788:Oas1c	UTSW	5	120,939,107 (GRCm39)	missense	probably benign
R8891:Oas1c	UTSW	5	120,946,126 (GRCm39)	missense	probably benign	0.00
R9013:Oas1c	UTSW	5	120,943,497 (GRCm39)	missense	probably damaging	1.00
R9544:Oas1c	UTSW	5	120,946,202 (GRCm39)	missense	probably benign	0.36
R9588:Oas1c	UTSW	5	120,946,202 (GRCm39)	missense	probably benign	0.36

Posted On

2015-04-16