Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00952:Foxn2'

29306

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Foxn2

Ensembl Gene

ENSMUSG00000034998

Gene Name

forkhead box N2

Synonyms

Fkh19, 6030465J18Rik, HTLF, 3230402J05Rik

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.254) question?

Stock #

IGL00952

Quality Score

Status

Chromosome

Chromosomal Location

88748139-88797961 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 88783308 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Arginine at position 188 (C188R)

Ref Sequence

ENSEMBL: ENSMUSP00000107857 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000112238] [ENSMUST00000141052]

AlphaFold

E9Q7L6

Predicted Effect

probably benign
Transcript: ENSMUST00000112238
AA Change: C188R

PolyPhen 2 Score 0.031 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000107857
Gene: ENSMUSG00000034998
AA Change: C188R

Domain	Start	End	E-Value	Type
FH	110	202	7.42e-50	SMART
low complexity region	314	323	N/A	INTRINSIC
low complexity region	348	358	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134107

Predicted Effect

probably benign
Transcript: ENSMUST00000141052

SMART Domains

Protein: ENSMUSP00000118378
Gene: ENSMUSG00000034998

Domain	Start	End	E-Value	Type
FH	110	203	2.15e-37	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a forkhead domain binding protein and may function in the transcriptional regulation of the human T-cell leukemia virus long terminal repeat. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1810009J06Rik	T	G	6: 40,941,733 (GRCm39)	I4S	probably benign	Het
Abca8b	A	G	11: 109,859,886 (GRCm39)		probably null	Het
Aftph	A	T	11: 20,677,483 (GRCm39)	V42E	probably damaging	Het
AI467606	A	G	7: 126,691,874 (GRCm39)	S150G	probably damaging	Het
Art4	T	C	6: 136,831,818 (GRCm39)	N108D	possibly damaging	Het
B9d1	G	A	11: 61,403,504 (GRCm39)	V167I	possibly damaging	Het
Ccdc47	A	T	11: 106,094,358 (GRCm39)		probably null	Het
Ccdc96	T	A	5: 36,642,424 (GRCm39)		probably benign	Het
Cfap44	A	G	16: 44,241,638 (GRCm39)	I670V	probably benign	Het
Col18a1	T	G	10: 76,905,813 (GRCm39)	K909Q	possibly damaging	Het
Col8a2	A	G	4: 126,203,584 (GRCm39)	Y59C	probably damaging	Het
Coro6	A	T	11: 77,359,291 (GRCm39)	D288V	probably damaging	Het
Cul4a	C	T	8: 13,196,562 (GRCm39)	L739F	probably damaging	Het
Dmxl2	C	T	9: 54,324,166 (GRCm39)	V1073I	probably damaging	Het
Dnah11	T	C	12: 118,160,386 (GRCm39)	T115A	possibly damaging	Het
Fdx2	A	G	9: 20,984,558 (GRCm39)		probably null	Het
Flnc	C	T	6: 29,459,546 (GRCm39)	Q2549*	probably null	Het
Hnrnpm	C	A	17: 33,868,876 (GRCm39)	R517L	probably damaging	Het
Ilf3	T	C	9: 21,307,347 (GRCm39)	L343P	probably damaging	Het
Itgb2l	C	T	16: 96,227,950 (GRCm39)	G518S	probably damaging	Het
Itpr2	T	A	6: 146,060,459 (GRCm39)	I2486F	probably damaging	Het
Kat2a	A	G	11: 100,596,977 (GRCm39)	V681A	probably damaging	Het
Kif17	A	G	4: 137,990,019 (GRCm39)	N69S	possibly damaging	Het
Kif26b	G	A	1: 178,759,770 (GRCm39)	D2106N	probably damaging	Het
Klf6	A	G	13: 5,911,680 (GRCm39)	T15A	probably benign	Het
Lyst	A	G	13: 13,852,692 (GRCm39)	T2231A	probably benign	Het
Mark4	T	C	7: 19,165,749 (GRCm39)	T515A	possibly damaging	Het
Mast3	A	T	8: 71,233,327 (GRCm39)		probably benign	Het
Nalcn	T	C	14: 123,586,201 (GRCm39)	K722R	probably benign	Het
Ncf2	G	A	1: 152,711,857 (GRCm39)	E524K	probably benign	Het
Or56a3b	A	G	7: 104,771,614 (GRCm39)		probably null	Het
Or5p81	A	G	7: 108,267,445 (GRCm39)	N274S	possibly damaging	Het
Or5w12	A	T	2: 87,502,159 (GRCm39)	I184N	probably damaging	Het
Or8c17	A	T	9: 38,179,801 (GRCm39)		probably benign	Het
Plcg2	A	T	8: 118,333,956 (GRCm39)	M910L	probably benign	Het
Pramel14	T	C	4: 143,719,894 (GRCm39)	H157R	probably benign	Het
Rai1	A	T	11: 60,078,818 (GRCm39)	K961*	probably null	Het
Rsph14	T	C	10: 74,865,601 (GRCm39)	D112G	probably benign	Het
Sgo1	T	A	17: 53,994,275 (GRCm39)	D59V	probably damaging	Het
Slc22a29	A	T	19: 8,195,221 (GRCm39)	V138E	probably damaging	Het
Slc9a1	T	A	4: 133,143,693 (GRCm39)	V393D	probably damaging	Het
Smg6	A	G	11: 74,819,974 (GRCm39)	R82G	probably benign	Het
Sppl3	T	C	5: 115,212,935 (GRCm39)	S55P	probably benign	Het
Srsf12	A	C	4: 33,226,103 (GRCm39)	Q122P	possibly damaging	Het
Tas1r2	T	C	4: 139,382,563 (GRCm39)	M67T	probably benign	Het
Thnsl1	G	A	2: 21,216,767 (GRCm39)	V174I	possibly damaging	Het
Thumpd1	A	G	7: 119,316,232 (GRCm39)	V239A	possibly damaging	Het
Tnxb	T	G	17: 34,932,102 (GRCm39)	Y2212D	probably damaging	Het
Trim40	T	C	17: 37,193,289 (GRCm39)	*213W	probably null	Het
Ttc16	T	C	2: 32,660,259 (GRCm39)	D183G	probably damaging	Het

Other mutations in Foxn2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00685:Foxn2	APN	17	88,770,305 (GRCm39)	missense	probably benign	0.02
IGL02232:Foxn2	APN	17	88,770,479 (GRCm39)	missense	probably benign	0.03
IGL02882:Foxn2	APN	17	88,770,375 (GRCm39)	missense	probably damaging	1.00
IGL02974:Foxn2	APN	17	88,770,543 (GRCm39)	missense	probably damaging	1.00
R1170:Foxn2	UTSW	17	88,781,094 (GRCm39)	critical splice acceptor site	probably benign
R1826:Foxn2	UTSW	17	88,794,233 (GRCm39)	missense	possibly damaging	0.87
R3825:Foxn2	UTSW	17	88,791,837 (GRCm39)	missense	probably damaging	0.98
R4761:Foxn2	UTSW	17	88,770,136 (GRCm39)	splice site	probably null
R5914:Foxn2	UTSW	17	88,770,138 (GRCm39)	splice site	probably null
R6735:Foxn2	UTSW	17	88,794,223 (GRCm39)	missense	probably benign
R7461:Foxn2	UTSW	17	88,794,311 (GRCm39)	missense	possibly damaging	0.93
R7613:Foxn2	UTSW	17	88,794,311 (GRCm39)	missense	possibly damaging	0.93
X0026:Foxn2	UTSW	17	88,794,161 (GRCm39)	missense	probably benign	0.00

Posted On

2013-04-17