Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02430:Zfp160'

293100

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp160

Ensembl Gene

ENSMUSG00000067942

Gene Name

zinc finger protein 160

Synonyms

6720480D16Rik, 6720480D16Rik

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02430

Quality Score

Status

Chromosome

Chromosomal Location

21008903-21043070 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 21025530 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Histidine at position 114 (L114H)

Ref Sequence

ENSEMBL: ENSMUSP00000155977 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000088811] [ENSMUST00000231482] [ENSMUST00000232320] [ENSMUST00000232354] [ENSMUST00000232473] [ENSMUST00000232595] [ENSMUST00000232663]

AlphaFold

E9Q459

Predicted Effect

possibly damaging
Transcript: ENSMUST00000088811
AA Change: L114H

PolyPhen 2 Score 0.760 (Sensitivity: 0.85; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000086191
Gene: ENSMUSG00000067942
AA Change: L114H

Domain	Start	End	E-Value	Type
KRAB	8	68	1.91e-29	SMART
low complexity region	100	110	N/A	INTRINSIC
ZnF_C2H2	146	168	1.69e-3	SMART
ZnF_C2H2	174	196	2.91e-2	SMART
ZnF_C2H2	202	224	1.4e-4	SMART
ZnF_C2H2	230	252	3.89e-3	SMART
ZnF_C2H2	258	280	1.72e-4	SMART
ZnF_C2H2	286	308	4.94e-5	SMART
ZnF_C2H2	314	336	2.12e-4	SMART
ZnF_C2H2	342	364	1.12e-3	SMART
ZnF_C2H2	370	392	1.2e-3	SMART
ZnF_C2H2	398	420	6.42e-4	SMART
ZnF_C2H2	426	448	9.08e-4	SMART
ZnF_C2H2	454	476	1.84e-4	SMART
ZnF_C2H2	482	504	1.5e-4	SMART
ZnF_C2H2	510	532	3.44e-4	SMART
ZnF_C2H2	538	560	1.12e-3	SMART
ZnF_C2H2	566	588	2.27e-4	SMART
ZnF_C2H2	594	616	1.04e-3	SMART
ZnF_C2H2	622	644	1.13e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000231482

Predicted Effect

probably benign
Transcript: ENSMUST00000232320

Predicted Effect

possibly damaging
Transcript: ENSMUST00000232354
AA Change: L114H

PolyPhen 2 Score 0.760 (Sensitivity: 0.85; Specificity: 0.92)

Predicted Effect

probably benign
Transcript: ENSMUST00000232473

Predicted Effect

probably benign
Transcript: ENSMUST00000232595

Predicted Effect

probably benign
Transcript: ENSMUST00000232663

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arhgap33	T	C	7: 30,522,760	E1249G	probably benign	Het
C8a	G	A	4: 104,817,522	T540I	probably damaging	Het
Clcnkb	C	A	4: 141,409,390	W388L	possibly damaging	Het
Cnbp	A	T	6: 87,845,178	Y114*	probably null	Het
Col13a1	A	G	10: 61,874,751	V337A	probably benign	Het
Cyp2e1	A	G	7: 140,770,226	K275E	probably damaging	Het
Dchs1	A	G	7: 105,771,971	V414A	probably benign	Het
Ebf1	G	A	11: 44,924,576		probably null	Het
Gabbr1	C	T	17: 37,056,308	R198*	probably null	Het
Gm12800	A	G	4: 101,910,280	Y242C	probably benign	Het
Gpaa1	T	C	15: 76,332,188	S36P	possibly damaging	Het
Hipk1	A	G	3: 103,760,655	V532A	probably damaging	Het
Klhl18	A	T	9: 110,437,401	C217S	probably benign	Het
Lmntd1	T	A	6: 145,413,414	T191S	probably benign	Het
Ltbp2	T	A	12: 84,799,401	Y925F	probably damaging	Het
Lvrn	A	G	18: 46,894,730	I871V	probably benign	Het
Mrgprb1	A	G	7: 48,447,661	S168P	possibly damaging	Het
Olfr495	A	T	7: 108,395,722	I201F	probably benign	Het
Olfr739	A	G	14: 50,425,151	I211V	probably benign	Het
Pcnx	T	A	12: 81,919,322	N754K	possibly damaging	Het
Plaa	A	T	4: 94,582,573	M442K	probably benign	Het
Pole3	T	C	4: 62,524,819	N28S	possibly damaging	Het
Prlr	A	G	15: 10,325,391	K4E	probably damaging	Het
Rp1l1	A	T	14: 64,029,286	T774S	probably benign	Het
Selp	C	A	1: 164,126,383	P84Q	probably damaging	Het
Sh3bp4	T	A	1: 89,153,163	W901R	probably null	Het
Slc6a20b	A	G	9: 123,597,240	Y527H	probably damaging	Het
Slit3	T	A	11: 35,177,774		probably null	Het
Spidr	C	T	16: 16,114,910	D169N	probably damaging	Het
Sstr2	T	C	11: 113,624,804	L183P	probably damaging	Het
Tmem62	C	T	2: 120,986,662	T233I	probably damaging	Het
Uba7	A	G	9: 107,979,468		probably benign	Het
Ubc	A	T	5: 125,387,570	I231N	probably damaging	Het
Ubl3	A	T	5: 148,551,956	D8E	probably benign	Het
Unc5a	A	G	13: 55,002,482	I465M	probably damaging	Het
Vmn2r106	A	G	17: 20,278,896	I251T	probably benign	Het
Vwa8	T	C	14: 78,934,645		probably null	Het
Washc5	A	G	15: 59,366,291	Y195H	probably damaging	Het
Wdr27	A	C	17: 14,901,800	S615A	probably damaging	Het
Zfp523	T	C	17: 28,195,139		probably benign	Het

Other mutations in Zfp160

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00714:Zfp160	APN	17	21026702	missense	probably benign
IGL01019:Zfp160	APN	17	21020826	missense	possibly damaging	0.68
R0412:Zfp160	UTSW	17	21026877	missense	probably damaging	0.97
R0600:Zfp160	UTSW	17	21027006	missense	probably benign	0.00
R2146:Zfp160	UTSW	17	21026982	missense	probably benign	0.13
R2157:Zfp160	UTSW	17	21020828	missense	probably benign	0.23
R2411:Zfp160	UTSW	17	21025745	missense	possibly damaging	0.94
R2904:Zfp160	UTSW	17	21025649	missense	probably benign	0.00
R4249:Zfp160	UTSW	17	21025738	missense	probably benign	0.11
R4896:Zfp160	UTSW	17	21020081	missense	probably benign	0.00
R5106:Zfp160	UTSW	17	21026761	missense	probably damaging	0.99
R5342:Zfp160	UTSW	17	21020733	missense	possibly damaging	0.95
R5352:Zfp160	UTSW	17	21026852	missense	probably benign	0.02
R6193:Zfp160	UTSW	17	21026862	missense	probably benign	0.24
R6230:Zfp160	UTSW	17	21026445	missense	probably benign	0.38
R6753:Zfp160	UTSW	17	21020734	missense	probably benign	0.02
R6928:Zfp160	UTSW	17	21041462	missense	probably benign	0.04
R7040:Zfp160	UTSW	17	21026532	missense	probably damaging	1.00
R7255:Zfp160	UTSW	17	21025487	missense	probably benign	0.18
R7497:Zfp160	UTSW	17	21026193	missense	probably benign	0.08
R7510:Zfp160	UTSW	17	21026393	missense	probably benign	0.00
R7540:Zfp160	UTSW	17	21025660	nonsense	probably null
R7627:Zfp160	UTSW	17	21027008	missense	probably damaging	0.99
R8169:Zfp160	UTSW	17	21027036	missense	probably damaging	0.97
R8240:Zfp160	UTSW	17	21026088	missense	probably damaging	0.99
R8330:Zfp160	UTSW	17	21026051	missense	probably damaging	1.00
R8367:Zfp160	UTSW	17	21025542	missense	probably benign	0.22
R8802:Zfp160	UTSW	17	21026605	missense	probably damaging	1.00
R9183:Zfp160	UTSW	17	21020092	missense	possibly damaging	0.84
Z1177:Zfp160	UTSW	17	21026890	missense	probably damaging	1.00

Posted On

2015-04-16