Incidental Mutation 'IGL00954:Or10al6'
ID 29312
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10al6
Ensembl Gene ENSMUSG00000083947
Gene Name olfactory receptor family 10 subfamily AL member 6
Synonyms GA_x6K02T2PSCP-2230932-2231897, MOR263-10, Olfr122
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # IGL00954
Quality Score
Status
Chromosome 17
Chromosomal Location 38079533-38083511 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 38083505 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 329 (N329K)
Ref Sequence ENSEMBL: ENSMUSP00000113170 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000119082] [ENSMUST00000172582] [ENSMUST00000217119]
AlphaFold W4VSP0
Predicted Effect probably benign
Transcript: ENSMUST00000119082
AA Change: N329K

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000113170
Gene: ENSMUSG00000083947
AA Change: N329K

DomainStartEndE-ValueType
Pfam:7tm_4 46 323 2.2e-58 PFAM
Pfam:7TM_GPCR_Srsx 50 320 2.7e-6 PFAM
Pfam:7tm_1 56 305 3.8e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000172582
AA Change: N320K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000134283
Gene: ENSMUSG00000083947
AA Change: N320K

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 41 311 9.5e-8 PFAM
Pfam:7tm_1 47 296 7.8e-36 PFAM
Pfam:7tm_4 145 289 1e-46 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215449
Predicted Effect probably benign
Transcript: ENSMUST00000217119
AA Change: N320K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ablim3 C T 18: 61,972,756 (GRCm39) probably benign Het
Alox5 A T 6: 116,431,260 (GRCm39) V56D probably damaging Het
Atp1a2 A G 1: 172,118,201 (GRCm39) S158P probably damaging Het
B3glct T A 5: 149,619,902 (GRCm39) M19K probably benign Het
BC049715 A T 6: 136,817,093 (GRCm39) E111V possibly damaging Het
Casp8ap2 C A 4: 32,645,403 (GRCm39) T1492K probably damaging Het
Cfap221 T C 1: 119,861,939 (GRCm39) E612G probably damaging Het
Cttnbp2 C A 6: 18,381,061 (GRCm39) K868N possibly damaging Het
Dpy19l2 T A 9: 24,494,114 (GRCm39) N672I probably damaging Het
Ei24 A T 9: 36,701,166 (GRCm39) I51N probably damaging Het
Gdi2 T C 13: 3,606,467 (GRCm39) V181A probably benign Het
Ggt1 G A 10: 75,420,697 (GRCm39) R354Q probably benign Het
Hao1 A G 2: 134,340,181 (GRCm39) I370T possibly damaging Het
Hnrnpm C A 17: 33,868,876 (GRCm39) R517L probably damaging Het
Jag2 G T 12: 112,884,026 (GRCm39) S184R possibly damaging Het
Kctd16 A G 18: 40,391,853 (GRCm39) D147G probably benign Het
Kiss1r T C 10: 79,757,834 (GRCm39) L396P probably damaging Het
Krt86 C T 15: 101,371,741 (GRCm39) H104Y probably benign Het
Lrrc66 G T 5: 73,765,741 (GRCm39) T434K possibly damaging Het
Macroh2a1 A G 13: 56,222,132 (GRCm39) S340P possibly damaging Het
Mcm5 A T 8: 75,836,740 (GRCm39) N64Y possibly damaging Het
Mroh2b A T 15: 4,932,536 (GRCm39) Y54F probably damaging Het
Or7g18 T A 9: 18,787,369 (GRCm39) S249T probably benign Het
Osgep T A 14: 51,153,619 (GRCm39) I320F probably benign Het
Pcdh18 T A 3: 49,710,838 (GRCm39) D159V probably damaging Het
Phf20l1 G A 15: 66,513,757 (GRCm39) V978I probably damaging Het
Phospho1 T A 11: 95,721,909 (GRCm39) V193E probably damaging Het
Pip4k2b T C 11: 97,635,331 (GRCm39) K34E probably damaging Het
Plb1 T C 5: 32,455,858 (GRCm39) probably benign Het
Safb2 A G 17: 56,885,639 (GRCm39) probably null Het
Sgsh T A 11: 119,237,311 (GRCm39) E434D probably benign Het
Tkt C T 14: 30,291,052 (GRCm39) H355Y probably damaging Het
Tmem128 A G 5: 38,419,389 (GRCm39) N47S probably damaging Het
Tmem232 A G 17: 65,807,148 (GRCm39) I15T probably damaging Het
Tns1 A C 1: 73,964,128 (GRCm39) V1501G probably damaging Het
Vmn2r24 G A 6: 123,792,596 (GRCm39) C641Y probably damaging Het
Vmn2r77 A G 7: 86,449,975 (GRCm39) T74A probably benign Het
Zfp820 T C 17: 22,038,860 (GRCm39) Y156C probably damaging Het
Other mutations in Or10al6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01338:Or10al6 APN 17 38,082,730 (GRCm39) missense possibly damaging 0.90
IGL01447:Or10al6 APN 17 38,083,122 (GRCm39) missense probably damaging 1.00
PIT4514001:Or10al6 UTSW 17 38,082,758 (GRCm39) missense probably damaging 1.00
R0402:Or10al6 UTSW 17 38,083,284 (GRCm39) missense probably damaging 1.00
R0830:Or10al6 UTSW 17 38,082,804 (GRCm39) missense probably damaging 0.99
R2018:Or10al6 UTSW 17 38,083,467 (GRCm39) missense probably benign 0.00
R4258:Or10al6 UTSW 17 38,082,949 (GRCm39) missense probably damaging 1.00
R6371:Or10al6 UTSW 17 38,083,326 (GRCm39) missense probably benign
R6481:Or10al6 UTSW 17 38,083,194 (GRCm39) missense probably damaging 1.00
R7468:Or10al6 UTSW 17 38,082,910 (GRCm39) missense probably damaging 1.00
R7492:Or10al6 UTSW 17 38,082,571 (GRCm39) missense possibly damaging 0.53
R8114:Or10al6 UTSW 17 38,082,880 (GRCm39) missense possibly damaging 0.67
R8172:Or10al6 UTSW 17 38,083,326 (GRCm39) missense probably benign
R8728:Or10al6 UTSW 17 38,082,642 (GRCm39) missense probably damaging 1.00
R8894:Or10al6 UTSW 17 38,082,940 (GRCm39) missense probably damaging 1.00
R9659:Or10al6 UTSW 17 38,082,880 (GRCm39) missense probably damaging 0.99
Z1177:Or10al6 UTSW 17 38,083,082 (GRCm39) missense possibly damaging 0.95
Posted On 2013-04-17