Incidental Mutation 'IGL00963:Zfp871'
ID 29328
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp871
Ensembl Gene ENSMUSG00000024298
Gene Name zinc finger protein 871
Synonyms 9030612M13Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL00963
Quality Score
Status
Chromosome 17
Chromosomal Location 32984470-33007261 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 32993726 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 483 (V483E)
Ref Sequence ENSEMBL: ENSMUSP00000127178 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057501] [ENSMUST00000159086]
AlphaFold G5E905
Predicted Effect probably benign
Transcript: ENSMUST00000057501
AA Change: V464E

PolyPhen 2 Score 0.246 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000050501
Gene: ENSMUSG00000024298
AA Change: V464E

DomainStartEndE-ValueType
KRAB 1 42 1.32e0 SMART
ZnF_C2H2 174 196 5.9e-3 SMART
ZnF_C2H2 202 224 6.32e-3 SMART
ZnF_C2H2 230 252 1.47e-3 SMART
ZnF_C2H2 258 280 3.63e-3 SMART
ZnF_C2H2 286 308 1.79e-2 SMART
ZnF_C2H2 314 336 4.79e-3 SMART
ZnF_C2H2 342 364 1.69e-3 SMART
ZnF_C2H2 370 392 2.79e-4 SMART
ZnF_C2H2 398 420 1.23e-5 SMART
ZnF_C2H2 426 448 1.2e-3 SMART
ZnF_C2H2 454 476 5.42e-2 SMART
ZnF_C2H2 482 504 8.6e-5 SMART
ZnF_C2H2 510 532 5.21e-4 SMART
ZnF_C2H2 538 560 3.11e-2 SMART
ZnF_C2H2 566 588 2.86e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000159086
AA Change: V483E

PolyPhen 2 Score 0.253 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000127178
Gene: ENSMUSG00000024298
AA Change: V483E

DomainStartEndE-ValueType
KRAB 4 61 2.18e-15 SMART
ZnF_C2H2 193 215 5.9e-3 SMART
ZnF_C2H2 221 243 6.32e-3 SMART
ZnF_C2H2 249 271 1.47e-3 SMART
ZnF_C2H2 277 299 3.63e-3 SMART
ZnF_C2H2 305 327 1.79e-2 SMART
ZnF_C2H2 333 355 4.79e-3 SMART
ZnF_C2H2 361 383 1.69e-3 SMART
ZnF_C2H2 389 411 2.79e-4 SMART
ZnF_C2H2 417 439 1.23e-5 SMART
ZnF_C2H2 445 467 1.2e-3 SMART
ZnF_C2H2 473 495 5.42e-2 SMART
ZnF_C2H2 501 523 8.6e-5 SMART
ZnF_C2H2 529 551 5.21e-4 SMART
ZnF_C2H2 557 579 3.11e-2 SMART
ZnF_C2H2 585 607 2.86e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000168337
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AI606181 A C 19: 41,582,228 (GRCm39) probably benign Het
Alyref2 C T 1: 171,331,816 (GRCm39) Q198* probably null Het
Ankrd13a T C 5: 114,939,863 (GRCm39) S497P probably damaging Het
Chd5 C A 4: 152,467,395 (GRCm39) N1644K probably damaging Het
Col13a1 T C 10: 61,674,476 (GRCm39) probably benign Het
Ctnna3 T A 10: 64,781,728 (GRCm39) D730E probably damaging Het
Dock11 A G X: 35,296,035 (GRCm39) Q1197R possibly damaging Het
Drosha T A 15: 12,926,083 (GRCm39) I1224N probably damaging Het
Dsc1 T C 18: 20,245,043 (GRCm39) K42R probably null Het
Engase A G 11: 118,373,824 (GRCm39) D322G probably damaging Het
Ephb2 T C 4: 136,386,262 (GRCm39) D829G probably benign Het
Fgfr2 C T 7: 129,830,491 (GRCm39) M47I probably damaging Het
Gad1-ps G T 10: 99,281,310 (GRCm39) noncoding transcript Het
Gatb A G 3: 85,526,255 (GRCm39) S378G probably benign Het
Hivep2 G A 10: 14,005,091 (GRCm39) S563N probably damaging Het
Irs2 G A 8: 11,055,867 (GRCm39) A855V probably benign Het
Jagn1 T C 6: 113,424,436 (GRCm39) S103P probably damaging Het
Kdm6a T A X: 18,112,665 (GRCm39) probably benign Het
Lmcd1 T C 6: 112,306,895 (GRCm39) C356R probably damaging Het
Mefv T A 16: 3,533,584 (GRCm39) Y229F possibly damaging Het
Myef2 T C 2: 124,957,395 (GRCm39) Y120C probably damaging Het
Myo9a T G 9: 59,807,655 (GRCm39) I2074S probably damaging Het
Nhs A G X: 160,630,045 (GRCm39) S337P probably damaging Het
Nphp4 T G 4: 152,622,318 (GRCm39) H566Q probably benign Het
Or2d2 A T 7: 106,728,272 (GRCm39) C109* probably null Het
Or52z13 T A 7: 103,246,844 (GRCm39) probably null Het
Pabpc2 C A 18: 39,908,390 (GRCm39) Q552K possibly damaging Het
Podn T A 4: 107,879,371 (GRCm39) N104I probably damaging Het
Rit1 T C 3: 88,633,738 (GRCm39) V94A probably damaging Het
Scn7a A T 2: 66,534,289 (GRCm39) probably benign Het
Septin4 A T 11: 87,474,199 (GRCm39) K29M possibly damaging Het
Sowahb T C 5: 93,191,870 (GRCm39) Y283C probably damaging Het
Srbd1 A T 17: 86,422,637 (GRCm39) W460R probably damaging Het
Svep1 T A 4: 58,072,791 (GRCm39) K2173* probably null Het
Tlr6 T C 5: 65,112,019 (GRCm39) N296S possibly damaging Het
Trpm8 A G 1: 88,307,549 (GRCm39) D1073G possibly damaging Het
Ttc28 A T 5: 111,434,255 (GRCm39) K2399* probably null Het
Ttn A G 2: 76,717,627 (GRCm39) probably benign Het
Uroc1 C T 6: 90,315,810 (GRCm39) T189I probably benign Het
Usp18 C T 6: 121,232,341 (GRCm39) Q122* probably null Het
Zfp420 T C 7: 29,574,518 (GRCm39) I246T probably damaging Het
Zfp644 T C 5: 106,786,503 (GRCm39) probably null Het
Other mutations in Zfp871
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00849:Zfp871 APN 17 32,994,873 (GRCm39) missense probably benign
IGL01687:Zfp871 APN 17 32,994,618 (GRCm39) missense probably benign 0.00
IGL02170:Zfp871 APN 17 32,994,662 (GRCm39) missense possibly damaging 0.72
IGL02399:Zfp871 APN 17 32,993,329 (GRCm39) missense probably benign 0.18
R0304:Zfp871 UTSW 17 32,993,408 (GRCm39) missense probably damaging 0.99
R1215:Zfp871 UTSW 17 32,994,946 (GRCm39) missense possibly damaging 0.70
R1444:Zfp871 UTSW 17 32,993,900 (GRCm39) missense possibly damaging 0.85
R1754:Zfp871 UTSW 17 32,994,308 (GRCm39) missense probably damaging 1.00
R1913:Zfp871 UTSW 17 32,994,891 (GRCm39) missense possibly damaging 0.53
R2018:Zfp871 UTSW 17 32,993,751 (GRCm39) missense probably damaging 1.00
R2180:Zfp871 UTSW 17 32,994,275 (GRCm39) missense probably damaging 1.00
R2881:Zfp871 UTSW 17 32,994,407 (GRCm39) missense probably damaging 1.00
R4422:Zfp871 UTSW 17 32,993,808 (GRCm39) missense probably benign 0.37
R4422:Zfp871 UTSW 17 32,993,807 (GRCm39) missense probably benign 0.39
R4979:Zfp871 UTSW 17 32,994,829 (GRCm39) missense probably damaging 0.99
R5564:Zfp871 UTSW 17 32,994,842 (GRCm39) missense possibly damaging 0.70
R6228:Zfp871 UTSW 17 32,994,858 (GRCm39) missense possibly damaging 0.50
R6232:Zfp871 UTSW 17 32,994,494 (GRCm39) frame shift probably null
R6233:Zfp871 UTSW 17 32,994,494 (GRCm39) frame shift probably null
R6234:Zfp871 UTSW 17 32,994,494 (GRCm39) frame shift probably null
R6474:Zfp871 UTSW 17 32,994,647 (GRCm39) missense possibly damaging 0.85
R7237:Zfp871 UTSW 17 32,994,289 (GRCm39) missense probably damaging 1.00
R7809:Zfp871 UTSW 17 32,993,826 (GRCm39) missense probably damaging 1.00
R8830:Zfp871 UTSW 17 32,993,901 (GRCm39) missense probably benign 0.03
R9219:Zfp871 UTSW 17 32,993,914 (GRCm39) missense probably benign 0.02
Posted On 2013-04-17