Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02437:Zscan20'

293325

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zscan20

Ensembl Gene

ENSMUSG00000061894

Gene Name

zinc finger and SCAN domains 20

Synonyms

Zfp31

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.230) question?

Stock #

IGL02437

Quality Score

Status

Chromosome

Chromosomal Location

128477332-128503891 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 128482210 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 484 (T484I)

Ref Sequence

ENSEMBL: ENSMUSP00000095487 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000097877] [ENSMUST00000135309]

AlphaFold

B2KFW1

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000084276

Predicted Effect

probably damaging
Transcript: ENSMUST00000097877
AA Change: T484I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000095487
Gene: ENSMUSG00000061894
AA Change: T484I

Domain	Start	End	E-Value	Type
SCAN	41	147	1.31e-54	SMART
low complexity region	275	284	N/A	INTRINSIC
SANT	314	378	8.04e-1	SMART
SANT	475	539	4.85e-3	SMART
ZnF_C2H2	725	747	2.61e1	SMART
ZnF_C2H2	753	775	9.88e-5	SMART
ZnF_C2H2	781	803	1.12e-3	SMART
ZnF_C2H2	862	884	3.21e-4	SMART
ZnF_C2H2	890	912	1.04e-3	SMART
ZnF_C2H2	918	940	1.56e-2	SMART
ZnF_C2H2	946	968	2.84e-5	SMART
ZnF_C2H2	974	996	4.54e-4	SMART
ZnF_C2H2	1002	1024	1.47e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000135309

SMART Domains

Protein: ENSMUSP00000119338
Gene: ENSMUSG00000061894

Domain	Start	End	E-Value	Type
SCAN	41	147	1.31e-54	SMART
low complexity region	279	293	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A930011G23Rik	A	G	5: 99,377,236 (GRCm39)	S404P	probably damaging	Het
A930011G23Rik	G	A	5: 99,377,241 (GRCm39)	P402L	probably damaging	Het
Abca16	T	G	7: 120,132,952 (GRCm39)	C1294G	probably benign	Het
Abca7	T	A	10: 79,844,223 (GRCm39)	S1410T	probably damaging	Het
Abhd12	T	C	2: 150,676,289 (GRCm39)	D356G	probably benign	Het
BC004004	T	C	17: 29,517,671 (GRCm39)	L295P	probably damaging	Het
Bpifc	T	C	10: 85,824,595 (GRCm39)	S215G	probably damaging	Het
Bptf	C	T	11: 106,965,521 (GRCm39)	M1109I	probably benign	Het
Brat1	C	T	5: 140,698,563 (GRCm39)	A245V	possibly damaging	Het
Cask	G	A	X: 13,403,860 (GRCm39)	T16I	probably damaging	Het
Cemip2	T	C	19: 21,789,342 (GRCm39)		probably null	Het
Cibar2	T	C	8: 120,901,525 (GRCm39)	E60G	probably damaging	Het
Clic6	A	T	16: 92,327,817 (GRCm39)	I541F	probably damaging	Het
Clnk	C	T	5: 38,931,909 (GRCm39)		probably null	Het
Cntnap1	T	A	11: 101,077,677 (GRCm39)	I1113N	probably damaging	Het
Csgalnact1	C	A	8: 68,854,144 (GRCm39)	G219V	probably damaging	Het
Cyp26a1	T	C	19: 37,686,943 (GRCm39)	S132P	probably benign	Het
Cyp4f13	G	T	17: 33,149,582 (GRCm39)	H85N	probably benign	Het
Dcaf15	C	T	8: 84,828,445 (GRCm39)	G215D	probably damaging	Het
Dip2a	T	C	10: 76,134,101 (GRCm39)	T500A	probably benign	Het
Gbe1	T	A	16: 70,231,546 (GRCm39)		probably benign	Het
Gli2	T	A	1: 118,763,733 (GRCm39)	I1473F	probably damaging	Het
Gm5129	A	T	5: 29,940,861 (GRCm39)		probably benign	Het
Hdgf	C	T	3: 87,821,792 (GRCm39)	R168C	probably damaging	Het
Heph	A	G	X: 95,516,633 (GRCm39)	T342A	probably benign	Het
Kdelr3	T	C	15: 79,409,988 (GRCm39)	Y158H	probably damaging	Het
Lamb3	C	T	1: 193,010,253 (GRCm39)	R289C	probably damaging	Het
Leng8	C	T	7: 4,145,092 (GRCm39)	A164V	probably damaging	Het
Ltn1	T	C	16: 87,194,889 (GRCm39)	T1337A	probably benign	Het
Mast3	C	A	8: 71,233,202 (GRCm39)	R316L	possibly damaging	Het
Nampt	A	G	12: 32,880,215 (GRCm39)	Y36C	probably damaging	Het
Ncapd3	T	A	9: 26,975,264 (GRCm39)		probably benign	Het
Nipbl	T	C	15: 8,388,558 (GRCm39)	D354G	probably damaging	Het
Nsd1	A	T	13: 55,461,254 (GRCm39)	R2494W	probably damaging	Het
Nt5c1a	A	G	4: 123,108,034 (GRCm39)	N239S	probably benign	Het
Ogfr	A	G	2: 180,231,329 (GRCm39)	E19G	possibly damaging	Het
Or11h4b	A	T	14: 50,918,657 (GRCm39)	S145T	probably benign	Het
Or4c58	A	G	2: 89,675,128 (GRCm39)	L63P	probably damaging	Het
Pcna	A	T	2: 132,093,155 (GRCm39)		probably benign	Het
Pdia3	T	A	2: 121,264,129 (GRCm39)	V326E	probably damaging	Het
Phf8	T	A	X: 150,414,356 (GRCm39)	L1002Q	possibly damaging	Het
Rhobtb2	T	C	14: 70,033,365 (GRCm39)	E535G	probably damaging	Het
Rusc2	G	T	4: 43,415,545 (GRCm39)	D284Y	probably damaging	Het
Samd8	A	G	14: 21,825,491 (GRCm39)	Y212C	probably benign	Het
Sash3	C	A	X: 47,247,672 (GRCm39)	Q169K	probably benign	Het
Scyl1	C	T	19: 5,816,224 (GRCm39)	G324S	probably damaging	Het
Sec62	G	A	3: 30,872,996 (GRCm39)	G360R	unknown	Het
Sis	T	C	3: 72,826,947 (GRCm39)		probably null	Het
Slc6a1	T	A	6: 114,285,578 (GRCm39)	I338N	probably damaging	Het
Snrnp200	A	G	2: 127,058,030 (GRCm39)	D264G	probably damaging	Het
Tgm3	G	T	2: 129,871,961 (GRCm39)		probably null	Het
Tnrc6b	T	G	15: 80,764,658 (GRCm39)	L720R	probably damaging	Het
Tspyl4	A	T	10: 34,174,228 (GRCm39)	Q240L	probably damaging	Het
Tube1	G	A	10: 39,016,846 (GRCm39)	V80I	probably damaging	Het
Uap1l1	C	T	2: 25,253,945 (GRCm39)	V304M	probably damaging	Het
Wtap	T	C	17: 13,186,620 (GRCm39)	N309S	probably benign	Het
Zfp518a	G	A	19: 40,903,061 (GRCm39)	G997R	probably damaging	Het
Zfyve26	T	C	12: 79,315,621 (GRCm39)	D1285G	probably benign	Het

Other mutations in Zscan20

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00552:Zscan20	APN	4	128,480,428 (GRCm39)	missense	probably damaging	0.99
IGL01454:Zscan20	APN	4	128,483,334 (GRCm39)	missense	probably benign	0.01
IGL01934:Zscan20	APN	4	128,486,277 (GRCm39)	missense	possibly damaging	0.94
IGL02288:Zscan20	APN	4	128,480,436 (GRCm39)	missense	probably damaging	1.00
IGL02336:Zscan20	APN	4	128,479,587 (GRCm39)	missense	probably damaging	1.00
IGL02385:Zscan20	APN	4	128,498,392 (GRCm39)	missense	possibly damaging	0.66
IGL02450:Zscan20	APN	4	128,480,450 (GRCm39)	missense	probably damaging	0.99
R0034:Zscan20	UTSW	4	128,479,455 (GRCm39)	missense	probably damaging	0.96
R0034:Zscan20	UTSW	4	128,479,455 (GRCm39)	missense	probably damaging	0.96
R0070:Zscan20	UTSW	4	128,479,675 (GRCm39)	missense	possibly damaging	0.73
R0142:Zscan20	UTSW	4	128,479,630 (GRCm39)	missense	probably benign	0.38
R0496:Zscan20	UTSW	4	128,485,682 (GRCm39)	missense	probably benign	0.42
R0567:Zscan20	UTSW	4	128,483,243 (GRCm39)	critical splice donor site	probably null
R1333:Zscan20	UTSW	4	128,481,889 (GRCm39)	missense	possibly damaging	0.61
R1716:Zscan20	UTSW	4	128,480,334 (GRCm39)	missense	probably damaging	0.96
R2302:Zscan20	UTSW	4	128,482,057 (GRCm39)	missense	probably damaging	1.00
R3870:Zscan20	UTSW	4	128,480,218 (GRCm39)	missense	probably damaging	1.00
R4611:Zscan20	UTSW	4	128,481,899 (GRCm39)	missense	probably benign	0.00
R4884:Zscan20	UTSW	4	128,481,958 (GRCm39)	missense	possibly damaging	0.56
R4972:Zscan20	UTSW	4	128,486,152 (GRCm39)	missense	probably benign	0.39
R5033:Zscan20	UTSW	4	128,479,921 (GRCm39)	missense	probably benign	0.01
R5160:Zscan20	UTSW	4	128,486,275 (GRCm39)	missense	possibly damaging	0.69
R5182:Zscan20	UTSW	4	128,480,504 (GRCm39)	missense	possibly damaging	0.71
R5214:Zscan20	UTSW	4	128,482,109 (GRCm39)	missense	probably benign	0.00
R5345:Zscan20	UTSW	4	128,481,914 (GRCm39)	missense	probably benign	0.04
R5863:Zscan20	UTSW	4	128,480,141 (GRCm39)	nonsense	probably null
R6217:Zscan20	UTSW	4	128,498,327 (GRCm39)	missense	probably damaging	1.00
R6597:Zscan20	UTSW	4	128,479,539 (GRCm39)	missense	probably damaging	0.96
R6751:Zscan20	UTSW	4	128,479,668 (GRCm39)	missense	probably damaging	1.00
R6852:Zscan20	UTSW	4	128,483,515 (GRCm39)	missense	probably damaging	1.00
R7172:Zscan20	UTSW	4	128,479,469 (GRCm39)	nonsense	probably null
R7338:Zscan20	UTSW	4	128,481,943 (GRCm39)	missense	probably benign
R7805:Zscan20	UTSW	4	128,479,599 (GRCm39)	missense	probably damaging	1.00
R8063:Zscan20	UTSW	4	128,480,028 (GRCm39)	missense	probably benign	0.01
R8244:Zscan20	UTSW	4	128,479,759 (GRCm39)	missense	probably benign	0.32
R8421:Zscan20	UTSW	4	128,479,620 (GRCm39)	missense	probably damaging	1.00
R8752:Zscan20	UTSW	4	128,479,480 (GRCm39)	missense	probably damaging	1.00
R8939:Zscan20	UTSW	4	128,498,315 (GRCm39)	missense	probably benign	0.00
R8971:Zscan20	UTSW	4	128,479,848 (GRCm39)	missense	probably damaging	1.00
R8971:Zscan20	UTSW	4	128,479,847 (GRCm39)	missense	probably damaging	1.00
R9149:Zscan20	UTSW	4	128,481,914 (GRCm39)	missense	probably benign	0.15
R9458:Zscan20	UTSW	4	128,480,639 (GRCm39)	critical splice acceptor site	probably null

Posted On

2015-04-16